ライフサイエンスコーパス: membrane attack complex

1 posits of IgG, IgM, and the C5b-9 complement membrane attack complex.

2 ts and promoting efficient generation of the membrane attack complex.

3 C5 cleavage and prevents the assembly of the membrane attack complex.

4 ve changed perceptions of the nature of this membrane attack complex.

5 plement protein C5 initiates assembly of the membrane attack complex.

6 nd may facilitate assembly of the complement membrane attack complex.

7 ment molecule effecting cytotoxicity was the membrane attack complex.

8 e pathways as well as the neo-epitope of the membrane attack complex.

9 lement injury by inhibiting formation of the membrane attack complex.

10 n of C5b, the initial component of the lytic membrane attack complex.

11 q, C3d, as well as C4BP and factor H but not membrane attack complex.

12 tection was due to the inability to form the membrane attack complex.

13 lement, regulating production of C5a and the membrane attack complex.

14 ting bactericidal activity of the complement membrane attack complex.

15 ation to diverse osmotic stressors including membrane attack complexes.

16 tly reduced formations of anaphylatoxins and membrane-attack complexes.

17 ent components C1q and C3, in the absence of membrane attack complex activation and neutrophil infilt

18 ctor B siRNA resulted in decreased levels of membrane attack complex and angiogenic factors-vascular

19 evaluated the pathogenic roles of complement membrane attack complex and CD59, a key regulator that i

20 ces in understanding of the structure of the membrane attack complex and its by-product the fluid-pha

21 arkedly inhibits formation of the complement membrane attack complex and neutrophil elastase release,

22 9 to preformed C5b-C7 and C5b-C8 to form the membrane attack complex and no effect on the rate of C3a

23 Killing was mediated by complement membrane attack complex and not augmented in the presenc

24 ckout mice exhibited increased levels of the membrane attack complex and of vascular endothelial grow

25 The membrane attack complex and other pore-forming proteins

26 Membrane attack complexes and other osmotic stressors, n

27 of the host cell to lysis by its complement membrane attack complex, apparently by blocking the hCD5

28 of receptors for C3a and C5a, as well as the membrane attack complex, as effector mechanisms in the p

29 red activation of complement and assembly of membrane attack complex, as it was inhibited by soluble

30 t shows that the human CD59 protein inhibits membrane attack complex assembly and reduces tissue dama

31 ence, we suggest a model for an irreversible membrane attack complex assembly in which the C7 FIMs, b

32 teins C3 and C4, which do not participate in membrane attack complex assembly, suggests that this pro

33 ey RCA member that controls formation of the membrane attack complex at the terminal stage of the com

34 ivated C5b that occur during assembly of the membrane attack complex, but they likely involve some, p

35 2 gC-null virus, or whether formation of the membrane attack complex by C6 to C9 is required for neut

36 1-INH spares the alternative pathway and the membrane attack complex (C5-9) so innate antibacterial d

37 actor-alpha, IL-1beta, IL-10, and complement membrane attack complex C5b-9 concentrations using enzym

38 n of C4 and C3, as well as generation of the membrane attack complex C5b-9.

39 complex, but not lytic pore formation by the membrane attack complex C5b-9.

40 lex, thereby preventing the formation of the membrane attack complex (C5b-9 of complement).

41 s generates anaphylatoxins (C3a and C5a) and membrane attack complex (C5b-9) and opsonizes targeted c

42 Membrane attack complex (C5b-9) formation and Gram's sta

43 A critical role of the complement membrane attack complex (C5b-9) in mediating hyperacute

44 n that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement.

45 Selected biopsy specimens were stained for membrane attack complex, class I major histocompatibilit

46 As part of the membrane attack complex complement protein C9 is respons

47 embrane attack complex; it also binds to the membrane attack complex components C6 and C7 with high a

48 anaphylatoxin-mediated inflammation and the membrane attack complex contribute to tissue injury.

49 ordingly, endothelial cell activation by the membrane attack complex depends on both transcriptional

50 enders R. conorii more susceptible to C3 and membrane attack complex deposition and to complement-med

51 plement inhibition, which leads to increased membrane attack complex deposition and VEGF expression.

52 eas HH402/VV62 hRPE cells showed significant membrane attack complex deposition following ingestion o

53 Excitotoxic sensitization did not increase membrane attack complex deposition on cortical neurons a

54 ions precedes, follows, or is independent of membrane attack complex deposition, what is the mechanis

55 r the third component of complement, C3, and membrane attack complex deposition.

56 vity and a marked reduction in tissue C3 and membrane attack complex deposition.

57 rovascular depletion, and that microvascular membrane attack complex deposits in dermatomyositis resu

58 The condition is of interest because membrane attack complex deposits result in shedding of c

59 ion of C3(-/-) and C4(-/-) mice lacked C3 or membrane attack complex deposits, despite having IgG dep

60 ency of CD59a, the membrane inhibitor of the membrane attack complex, did not induce an increase in n

61 Furthermore, we demonstrated that the membrane attack complex directly induced gene expression

62 The membrane attack complex does not appear to play a major

63 ain, whereas the heavy chain contains the FI membrane attack complex domain (FIMAC), CD5 domain, and

64 CD59, an inhibitor of the terminal cytolytic membrane attack complex, effectively protected the cells

65 ss executed either by the complement-related membrane attack complex, exotoxins, or cytotoxic T cells

66 ain plasma serine protease with one factor I-membrane attack complex (FIMAC) domain, one CD5 domain,

67 (-/-) mice is mediated through inhibition of membrane attack complex formation and not through C5a-in

68 of a subset of these mutated Abs to inhibit membrane attack complex formation as tested in a hemolys

69 -binding protein to bacteria, which enhances membrane attack complex formation on M. catarrhalis and

70 d in a loss of TER, which required transient membrane attack complex formation, activation of the alt

71 Interestingly, sublethal complement membrane attack complex formation, but not the anaphylat

72 unrelated to its function as an inhibitor of membrane attack complex formation.

73 nized with activated complement factor 3 and membrane attack complex from serum compared with the oth

74 to the MDR phenotype may result in abnormal membrane attack complex function.

75 to mediate effects; (ii) the multimolecular membrane attack complex generated from the five terminal

76 ting that complement activation to the C5b-9 membrane attack complex had a casual role in renal failu

77 of C6, a component of the terminal cytolytic membrane attack complex, had no effect on outcome after

78 ed proteins, endothelin-1 and the complement membrane attack complex have been recently identified as

79 C6-deficient rats, which cannot form the membrane attack complex, have a normal neuropathic pain

80 n of complement components C3 and C5b-9 (the membrane attack complex), however, was reduced on the su

81 ight on the important pathogenic role of the membrane attack complex in abdominal aortic aneurysm.

82 Insertion of the membrane attack complex in cell membranes of vascular en

83 diate formation of the proinflammatory C5b-9 membrane attack complex, in functionally active form abl

84 with the role of C5, possibly by forming the membrane attack complex, in limiting OLG apoptosis in EA

85 and CD59, a key regulator that inhibits the membrane attack complex, in the development of abdominal

86 red protein that is functionally active as a membrane attack complex inhibitor.

87 r findings show that absent C3aR-, C5aR-, or membrane attack complex-initiated effector mechanisms ea

88 It is not clear whether membrane attack complex is activated by antibody-depende

89 e after ischemic stroke, indicating that the membrane attack complex is not involved in mediating inj

90 ken together, our findings indicate that the membrane-attack complex is a key mediator of streaming.

91 In contrast, when the assembly of the membrane-attack complex is not properly regulated, as in

92 o C5b, the first step in the assembly of the membrane attack complex; it also binds to the membrane a

93 in that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell memb

94 ent by inhibiting formation of the cytolytic membrane attack complex (MAC or C5b-9).

95 Membrane attack complex (MAC) accumulation correlated wi

96 analysis were used to detect the presence of membrane attack complex (MAC) and C3 activation products

97 nied by endothelial deposition of C3 and the membrane attack complex (MAC) and medullary capillary th

98 D choroids to determine the abundance of the membrane attack complex (MAC) and performed immunofluore

99 loid peptide (A beta) and complement-derived membrane attack complex (MAC) are co-localized in senile

100 5b-9 complement components that comprise the membrane attack complex (MAC) are unclear.

101 lassical pathway leading to the formation of membrane attack complex (MAC) as the effector of cell in

102 In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase

103 plement regulator CD59a, designed to inhibit membrane attack complex (MAC) assembly at sites of C3b/i

104 CD59 is a key regulator of complement membrane attack complex (MAC) assembly.

105 I)-anchored protein that prevents complement membrane attack complex (MAC) assembly.

106 The C6 deficiency prevents the formation of membrane attack complex (MAC) by C5b-C9.

107 PGK interacted with the membrane attack complex (MAC) components C5, C7, and C9,

108 Membrane attack complex (MAC) deposition in the arthriti

109 Western blot analysis further revealed that membrane attack complex (MAC) expression was up-regulate

110 t C3frag accumulation on activated surfaces, membrane attack complex (MAC) formation and hemolysis of

111 ion of complement activation by Crry, and of membrane attack complex (MAC) formation by CD59 was equa

112 as C5a receptor antagonism and prevention of membrane attack complex (MAC) formation did not have a s

113 Terminal complement membrane attack complex (MAC) formation is induced initi

114 We have shown that membrane attack complex (MAC) formation via the activati

115 to monkeys as demonstrated by inhibition of membrane attack complex (MAC) formation.

116 The complement membrane attack complex (MAC) forms transmembrane pores

117 Moreover, both IgG and complement membrane attack complex (MAC) immunoreactivity was evide

118 pore-forming terminal complement component, membrane attack complex (MAC) in pSC and nerve terminal

119 7BL/6 mice revealed the deposition of C3 and membrane attack complex (MAC) in the neovascular complex

120 olves lysis of cells by the insertion of the membrane attack complex (MAC) in the plasma membrane.

121 The complement membrane attack complex (MAC) is formed by the sequentia

122 ement cascade and subsequent assembly of the membrane attack complex (MAC) occur in a number of patho

123 Cell surface assembly of the membrane attack complex (MAC) of complement occurs in a

124 Assembly of the membrane attack complex (MAC) of complement on EC membra

125 that inhibits the formation of the cytolytic membrane attack complex (MAC) of complement on host cell

126 ory protein CD59 increases deposition of the membrane attack complex (MAC) of complement, contributin

127 ed membrane-bound inhibitor of the cytolytic membrane attack complex (MAC) of complement.

128 oprotein CD59 inhibits assembly of the C5b-9 membrane attack complex (MAC) of human complement.

129 he principle cellular inhibitor of the C5b-9 membrane attack complex (MAC) of human complement.

130 The membrane attack complex (MAC) of the complement system i

131 mmodation by preventing the formation of the membrane attack complex (MAC) on the accommodated graft.

132 f complement results in the formation of the membrane attack complex (MAC) on the cell surface, resul

133 bits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcu

134 minal complement proteins C5b to C9 form the membrane attack complex (MAC) pore.

135 study, we examined whether HCV regulates the membrane attack complex (MAC) via complement component C

136 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacteria

137 ower levels of recipient C7 protein, soluble membrane attack complex (MAC), and IL-1beta expression c

138 ity of C5(-/-) mice to assemble the terminal membrane attack complex (MAC), as determined by compleme

139 igated the interactions among the complement membrane attack complex (MAC), CCL2, and VEGF that occur

140 t with rCD59-APT542 blocked the formation of membrane attack complex (MAC), increased apoptosis and d

141 he activity of the C9 component of the C5b-9 membrane attack complex (MAC), thereby protecting human

142 It plays an essential role in the membrane attack complex (MAC), which forms a lethal pore

143 Both C5a and the membrane attack complex (MAC), which is formed by the te

144 , we show that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement

145 that form during assembly of the complement membrane attack complex (MAC).

146 assemble into a multimolecular complex, the membrane attack complex (MAC).

147 and C9) that interact to form the cytolytic membrane attack complex (MAC).

148 -bound inhibitor of the cytolytic complement membrane attack complex (MAC).

149 ittle attention has been paid to that of the membrane attack complex (MAC).

150 C9 and thereby prevents the formation of the membrane attack complex (MAC).

151 components C1q, C3, factor B, factor H, and membrane attack complex (MAC).

152 hat culminates in formation of the cytolytic membrane attack complex (MAC).

153 The membrane attack complex (MAC)/perforin-like protein comp

154 lminating in the formation and deposition of membrane attack complex (MAC, C5b-9) in nerve membranes.

155 In addition, assembly of the membrane-attack complex (MAC) on ECs induced a 3-fold in

156 rial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement.

157 orm a porelike structure referred to as the "membrane attack complex" (MAC).

158 IR for C4d and C5b-9 (membrane attack complex, MAC) was observed in small numb

159 Complement membrane attack complexes (MACs) promote inflammatory fu

160 e terminates in the cell-surface assembly of membrane attack complexes (MACs), which promote inflamma

161 in immunosuppressed C6D rats, suggesting the membrane attack complex may play a minor role in recipie

162 Human C8 is one of five components of the membrane attack complex of complement (MAC).

163 Human C8 is one of five components of the membrane attack complex of complement (MAC).

164 h is one of five components of the cytolytic membrane attack complex of complement (MAC).

165 become resistant against cytotoxicity by the membrane attack complex of complement (MAC).

166 poptosis and EC activation and injury by the membrane attack complex of complement are important mech

167 CD59 blocks formation of the membrane attack complex of complement by inhibiting bind

168 Both LTx and the membrane attack complex of complement form membrane pore

169 We investigated the potential role of the membrane attack complex of complement in primary nonfunc

170 Formation of the cytolytic membrane attack complex of complement on host cells is i

171 CD59, an inhibitor of the terminal cytolytic membrane attack complex of complement, had no effect on

172 shown that generation of sublytic C5b-9, the membrane attack complex of complement, induces oligodend

173 nd the subsequent formation of the cytolytic membrane attack complex of complement.

174 brane protein that inhibits formation of the membrane attack complex of complement.

175 Human C8 is one of five components of the membrane attack complex of complement.

176 ored protein that regulates formation of the membrane attack complex of complement.

177 hereby preventing formation of the cytolytic membrane attack complex of complement.

178 nchored molecule, regulates formation of the membrane attack complex of the complement cascade.

179 ms membrane pores in a manner similar to the membrane-attack complex of C.

180 imicrobial peptides, and the assembly of the membrane-attack complexes of the immune system.

181 otoxic effects through the deposition of the membrane attack complex on oligodendrocytes.

182 Immunohistochemical studies showed membrane attack complex on small blood vessels in 6 of 8

183 ting that lysis was caused by formation of a membrane attack complex on the cell surface.

184 independent manner to assemble the cytolytic membrane attack complex on their membranes, whereas astr

185 e used human panel reactive antibody to form membrane attack complexes on allogeneic endothelial cell

186 enuated deposition of C3 fragments and C5b-9 membrane attack complexes on cell surfaces.

187 erum killing by preventing the deposition of membrane attack complexes on the bacterial cell surface.

188 and C9) that interact to form the cytolytic membrane attack complex, or MAC.

189 and C-terminal modules and a central 40-kDa membrane attack complex perforin (MACPF) domain that has

190 e-forming member of an ancient branch of the Membrane Attack Complex-Perforin/Cholesterol-Dependent C

191 Perforin contains a membrane attack complex/perforin (MACPF) domain and olig

192 le, described in this manuscript, contains a membrane attack complex/perforin (MACPF) domain present

193 Two groups of PZ-encoded proteins, the membrane attack complex/perforin (MACPF) domain protein

194 ntervening 40-kDa segment referred to as the membrane attack complex/perforin (MACPF) domain.

195 ntervening 40-kDa segment referred to as the membrane attack complex/perforin (MACPF) domain.

196 Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found i

197 egment of each protein is referred to as the membrane attack complex/perforin domain (MACPF).

198 n extended middle segment referred to as the membrane attack complex/perforin region (MACPF), and a p

199 ron microscopy and fitted the C8alpha-MACPF (membrane attack complex/perforin)-C8gamma co-crystal str

200 Membrane attack complex/perforin-like (MACPF) proteins c

201 Membrane attack complex/perforin/cholesterol-dependent c

202 t CD59 (a potent inhibitor of the complement membrane attack complex present on red blood cells) was

203 of many genes, complement, particularly the membrane attack complex, primarily induces release of IL

204 suggest that (i) nonlethal assemblies of the membrane attack complex promote intracellular killing an

205 ng of anaphylatoxin receptors or assembly of membrane attack complex promotes cell dedifferentiation,

206 At a sublytic dose, the C5b-9 membrane attack complex protects oligodendrocytes (OLG)

207 nal aortic aneurysm model, deficiency of the membrane attack complex regulator CD59 in ApoE-null mice

208 urons and produced only a small reduction of membrane attack complex removal, because of a selective

209 and, deficiency of CD59, an inhibitor of the membrane attack complex, resulted in significantly incre

210 ELISAs for SC5b-9, the soluble membrane attack complex, showed that production of SC5b-

211 CD59 is a potent inhibitor of membrane attack complex that mediates complement-depende

212 ortant findings related to the deposition of membrane attack complex, the character of the inflammato

213 protein that restricts the formation of the membrane attack complex, thereby inhibiting induction of

214 C5b,6, thereby reducing the capacity of the membrane attack complex to bind to and lyse the target c

215 Quantification of the binding of the C5b-9 membrane attack complex to cells during complement activ

216 ion pathways were involved in generating the membrane attack complex to directly injure MSCs.

217 in coupled with functional impairment of the membrane attack complex underscore HCV-mediated attenuat

218 Rather than inducing cytolysis, membrane attack complexes upregulated inflammatory genes

219 ammatory metabolite C5a and formation of the membrane attack complex via C5b.

220 position of C3, C3 activation fragments, and membrane attack complex was observed in the eyes of Lewi

221 Deposition of the membrane attack complex was observed on endothelial cell

222 r C3aR- or C5aR-mediated inflammation or the membrane attack complex was pathogenic.

223 y or pharmacologically inhibited assembly of membrane attack complex were subjected to hypoxia-ischem

224 2/II62 hRPE cells were more resistant to the membrane attack complex, whereas HH402/VV62 hRPE cells s

225 5a and C5b(T), the latter forming a C5b(T)-9 membrane attack complex with significantly more lytic ac