ライフサイエンスコーパス: membrane domain

1 an unspecified way with the a-subunit in the membrane domain.

2 termembrane space and probably stabilize the membrane domain.

3 rom the protein surface to the center of the membrane domain.

4 and maintaining this unique neuronal plasma membrane domain.

5 d ionizable residues along the center of the membrane domain.

6 very of this transporter to the outer plasma membrane domain.

7 uter membrane protein-like beta-barrel trans-membrane domain.

8 nge of equivalent sites on the c ring of the membrane domain.

9 complex I/NDH-1) contains a peripheral and a membrane domain.

10 created by solubilization of a common FC/PL membrane domain.

11 restricting F-actin formation to the correct membrane domain.

12 CBS domain and Pro-sigma(K) cleavage by the membrane domain.

13 s correct nuclear placement toward the inner membrane domain.

14 ctase (NDH-1) consists of a peripheral and a membrane domain.

15 ificity identical to that of the entire Scap membrane domain.

16 rophilic peripheral domain and a hydrophobic membrane domain.

17 nsmitter binding sites and the middle of the membrane domain.

18 odynamically drive proton pumping across its membrane domain.

19 ary for delineating the nascent za from this membrane domain.

20 chieved by recruiting Par6 and DaPKC to this membrane domain.

21 ry-related locations in four subunits of the membrane domain.

22 2, an LYR protein, to the matrix face of the membrane domain.

23 n be distributed in rigid and loosely packed membrane domains.

24 elination nor the establishment of polarized membrane domains.

25 dule that targets them to specific endocytic membrane domains.

26 ts receptor enrichment through Caveolin-rich membrane domains.

27 pendent reorganization of PI(4,5)P2-enriched membrane domains.

28 ly enriched at apical and basal polar plasma membrane domains.

29 expansion and contraction of specific plasma membrane domains.

30 ally or direct assembly to tetherin-negative membrane domains.

31 the bone-facing ruffled membrane from other membrane domains.

32 lipid packing of both ordered and disordered membrane domains.

33 tein distribution and retention in different membrane domains.

34 ) did not fractionate in detergent-resistant membrane domains.

35 egulate the function and dynamics of ordered membrane domains.

36 endent phosphatidylserine-binding peripheral membrane domains.

37 nal changes to the extracellular side of the membrane domains.

38 c peptide at the N terminus and no predicted membrane domains.

39 n of signaling platforms in cholesterol-rich membrane domains.

40 rds (apical) (rather than rootwards (basal)) membrane domains.

41 d cells with distinct apical and basolateral membrane domains.

42 ins may be similarly targeted to specialized membrane domains.

43 L-shaped enzyme consists of hydrophilic and membrane domains.

44 molecules between grana and stroma thylakoid membrane domains.

45 dent, HA and NA occupy distinct but adjacent membrane domains.

46 d two distinct and mutually exclusive plasma membrane domains.

47 le existence and significance of specialized membrane domains.

48 mponents that segregate into nanometer-scale membrane domains.

49 translocation of ICAM-1 into caveolin-1-rich membrane domains.

50 2 interacts with HER2 in specific actin-rich membrane domains.

51 translocation of ICAM-1 into caveolin-1-rich membrane domains.

52 CBS domain conformational changes to channel membrane domains.

53 or the repartitioning of proteins within the membrane domains.

54 zation and clustering of K-Ras4B in distinct membrane domains.

55 receptor co-localization in cholesterol-rich membrane domains.

56 The addition of actin filaments reorganized membrane domains.

57 lymers that change the curvature of cellular membrane domains.

58 role in the dynamic assembly of specialized membrane domains.

59 lulose synthase complexes (CSCs) into narrow membrane domains.

60 ely homologous membrane proteins in distinct membrane domains.

61 eening approach identified residues on trans-membrane domains 1alpha, 5, and 7 on one face of B(0)AT3

62 tified a single hydrophobic residue in trans-membrane domain 7 of class II glucose transporters as a

63 polyunsaturated fats on the organization of membrane domains across a spectrum of membrane models, i

64 euron-glia interactions establish functional membrane domains along myelinated axons.

65 on complexes that are positioned at specific membrane domains along the myelin unit.

66 s in increased activated integrin in buoyant membrane domains along with increased association betwee

67 During catalysis, the MalFG membrane domain alternates between inward and outward fa

68 reveals a previously uncharacterized helical membrane domain and a periplasmic facing soluble domain.

69 one of the seven hydrophobic subunits in the membrane domain and bears three transmembrane segments (

70 ructure of these linkers, extending from the membrane domain and including the CaVbeta-binding site,

71 wed by the extracellular domain, most of the membrane domain and the gate.

72 a C-terminal hydrophobic, potentially trans-membrane domain and were described as type I transmembra

73 in Are2p relocalization to detergent-soluble membrane domains and a significant decrease (53-36%) in

74 s in the basal state are already confined in membrane domains and are associated with clathrin.

75 We characterized these membrane domains and determined their lateral dynamics b

76 m cells by developing apical and basolateral membrane domains and form sheets of cells connected by j

77 proteins composed of multiple alpha-helical membrane domains and large cytoplasmic C-termini contain

78 ossible to generate hierarchically-organized membrane domains and microscale 2-D array patterns of do

79 f proteins that are important for organizing membrane domains and receptor signaling and regulating t

80 Membrane domains and the underlying actin cytoskeleton c

81 ls and cell adhesion molecules within plasma membrane domains and thereby promote physiological activ

82 nt of both TNFR1 localization to low density membrane domains and to TNF-induced receptor internaliza

83 we demonstrated that FPs constitute distinct membrane "domains" and that their characteristic 10-nm p

84 d biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposit

85 flecting distinct structural motifs in their membrane domains, and distinct metabolisms of the host o

86 e in apical membrane at the expense of other membrane domains, and that both proteins can do this ind

87 yoelectron tomography shows that the induced membrane domains are equivalent in size and caveolin den

88 iverge at bud emergence when distinct plasma-membrane domains are formed and separated by a septin ri

89 ter receptor dynamics, suggesting that these membrane domains are not involved in beta(2)AR confineme

90 separation may explain why micrometer-scale membrane domains are observed in isolated, cytoskeleton-

91 The link continues over the entire membrane domain as a flexible central axis of charged an

92 ed to move through cellular compartments and membrane domains as intact groups of protomers.

93 calised in association with milk fat globule membrane domains as they contain both hydrophobic and hy

94 sing and others confined in 100-600-nm-sized membrane domains as well as immobile receptors.

95 ture of HSPCs resulted in disruption of this membrane domain, as evidenced by disruption of polarity

96 e of LAMP1(+) lysosomes, with some lysosomal membrane domains associated with endosomes.

97 on, indicating efficient sorting into plasma membrane domains associated with T cell activation; this

98 dies and interact, via their plus ends, with membrane domains associated with the PCP proteins Frizzl

99 l structure of the Esherichia coli complex I membrane domain at 3.0 A resolution.

100 uited from endothelial filopodia to discrete membrane domains at cell-cell contacts.

101 roscopy in live cells, we identify PIP2-rich membrane domains at sites of vesicle fusion.

102 icating polarity information from asymmetric membrane domains at the apical junctions, through MTs, t

103 d localization and its relationship with the membrane domains at which it assembles.

104 lycosylation sites, signal peptides or trans-membrane domains between African and Brazilian strains.

105 lation for targeting and function of AnkG in membrane domain biogenesis at epithelial lateral membran

106 rix of the organelle, and is attached to the membrane domain by central and peripheral stalks.

107 The bacterial F1 domain is attached to the membrane domain by peripheral and central stalks.

108 membrane and supports the stability of this membrane domain by repressing the Crumbs-containing apic

109 Disruption of cholesterol-rich membrane domains by filipin inhibits Plvap Ab/SOD endocy

110 ynaptic vesicles (SVs) fuse at a specialized membrane domain called the active zone (AZ), covered by

111 Cholesterol-enriched membrane domains called lipid rafts influence the functi

112 clear, with possible roles in COPII binding, membrane domain chaperoning, and lipid organization.

113 oyls and farnesyl for ordered and disordered membrane domains, clustered tH molecules segregate to th

114 egulates formation and maintenance of plasma membrane domains, clusters signaling complexes, and cont

115 CSs) function to facilitate the formation of membrane domains composed of specialized lipids, protein

116 Eisosomes are plasma membrane domains concentrating lipids, transporters, and

117 form the conducting pore using four repeated membrane domains connected by intracellular linkers.

118 and a hydrophobic ring of c-subunits in the membrane domain constitute the enzyme's rotor.

119 The membrane domain contains six additional subunits named A

120 The membrane domain contains three antiporter-like subunits

121 The membrane domain crystallized as a symmetric dimer, with

122 s into molecularly and functionally distinct membrane domains depends on axoglial junctions that func

123 o nor internalization from these low density membrane domains depends upon CAV-1 or FLOT-2.

124 tivation induces helix movement in the HtrII membrane domain diagnostic of transducer activation.

125 ms for channel localization, and may feature membrane domains each with distinct roles in excitation.

126 Blocking LTCCs within this Cav-3 membrane domain eliminated a small fraction of the LTCC

127 ct with osteoblasts in vitro via a polarized membrane domain enriched in adhesion molecules such as t

128 actively cycling cells, display a polarized membrane domain enriched in tetraspanins that mediates h

129 An apical plasma membrane domain enriched in the regulatory phospholipid

130 ab22aQ64L mutant caused fragmentation of TGN membrane domains enriched for ATP7A.

131 been amended to account for the existence of membrane domains enriched in certain phospholipids.

132 ment, lipid rafts, which are phase-separated membrane domains enriched in cholesterol and saturated l

133 for the two lipids, whereas the presence of membrane domains enriched in one of the two lipids shoul

134 he C-terminal half of the protein contains a membrane domain essential for transfer.

135 clustering in neurons and are important for membrane domain establishment and maintenance in many ce

136 Co-existing disordered and ordered (raft) membrane domains exist in Borrelia burgdorferi, the caus

137 ants, the epidermis, and its outer (lateral) membrane domain facing the environment are continuously

138 e as a functional protein key for organizing membrane domains for cellular signalling.

139 ar the nucleotide-binding domains and in the membrane domains, for transporter embedded in a biologic

140 uoles, Ltc1 was required for sterol-enriched membrane domain formation in response to stress.

141 This region can be replaced by a putative membrane domain from another, unrelated protein, and thu

142 oke for the conformational switch of the two membrane domains from the inward-facing conformation to

143 on ubiquitously modulates Ca homeostasis and membrane domain function in cells that express NCX prote

144 ne domains (rafts) is a key to understanding membrane domain function, it is important to define the

145 The membrane domains have functional significance; radixin,

146 , two transmembrane helices (3 and 4) in the membrane domains have their cytoplasmic extensions in cl

147 ing sites and alphaM2-alphaM3 linkers in the membrane domain--have the highest varphi-values (change

148 n in the intracellular linker between alpha1 membrane domains I and II (I-II linker).

149 assemble asymmetrically at polarized plasma membrane domains in a co-dependent and AP-1-dependent ma

150 ese results provide evidence for the role of membrane domains in BCR signaling and a plausible mechan

151 The existence of nanometer scale membrane domains in binary lipid mixtures has been shown

152 sion depletes uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a

153 asolateral determinants specify and maintain membrane domains in epithelia.

154 gregation of distinct and mutually exclusive membrane domains in epithelial cells.

155 is, but whether vesicles fuse into PIP2-rich membrane domains in live cells and whether PIP2 is metab

156 calated disc, NaV1.5 is present in different membrane domains in myocytes and interacts with several

157 such as the lipids, in defining specialized membrane domains in PD remains unknown.

158 evidence for the involvement of specialized membrane domains in signal transduction.

159 us, our data identify the unique role of the membrane domains in the regulation of the number of surf

160 technique, to measure the size of nanoscopic membrane domains in unilamellar vesicles with unpreceden

161 nd they variously associate with specialized membrane domains, in a polarized fashion, to intercellul

162 n of CD11b integrin into detergent resistant membrane domains; in turn, CD11b recruits the microtubul

163 One membrane domain, including the stereocilia basal tapers

164 ) coordinates protein composition of diverse membrane domains, including epithelial lateral membranes

165 e number of AChR clusters associated with Ld membrane domains increased concomitantly.

166 To identify possible membrane domains, individual hydrophobic domains from VP

167 om ER exit sites onto liquid-ordered vacuole membrane domains, initiating micro-lipophagy.

168 ich in PI(4,5)P2 and inward budding of these membrane domains into the lumen of GUVs.

169 Detergent-resistant membrane domains, into which GPI-linked proteins partiti

170 Caveolae are invaginated plasma membrane domains involved in mechanosensing, signaling,

171 alization of signaling receptors to distinct membrane domains is a potential source of signaling outp

172 that TJ-mediated separation of apical-basal membrane domains is established prior to equilibration o

173 ts reveal that vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-depen

174 However, how AnkG itself localizes to these membrane domains is not understood.

175 ells specify morphologically distinct plasma membrane domains is poorly understood.

176 -dependent translocation to PIP2-rich plasma membrane domains is required for its activity.

177 1 (Cav-1), an integral component of caveolar membrane domains, is expressed in several retinal cell t

178 eover, precise EXO84b placement at the outer membrane domain itself requires ACT7 function.

179 We observed nanometer-scale plasma membrane domains, known as protein islands, on naive T c

180 The membrane domain MalFG may be naturally stable in the inw

181 ed the tricellular vertices as a specialized membrane domain marked by the integral membrane protein

182 The data support the notion that 6TM AC membrane domains may operate as receptors which directly

183 otic spindle midzone, here named the midzone membrane domain (MMD), is essential for spindle disassem

184 es located between the binding sites and the membrane domain (N95, A96, Y127, and I49).

185 e-acting factor involved in keeping specific membrane domains next to the callose wall to prevent for

186 Three antiporter-like subunits in the membrane domain, NuoL, NuoM, and NuoN (ND5, ND4 and ND2,

187 In addition, the membrane domain of AE1 (mdAE1) efficiently mediated anio

188 Overexpression of the membrane domain of Arabidopsis (Arabidopsis thaliana) HM

189 of subcomplex Ibeta, a large portion of the membrane domain of B. taurus complex I that contains two

190 hat does not require covalent binding to the membrane domain of ClC-7.

191 dium ions instead, and three subunits in the membrane domain of complex I are closely related to subu

192 we report the alpha-helical structure of the membrane domain of complex I from Escherichia coli at 3.

193 mistic molecular dynamics simulations of the membrane domain of complex I from Escherichia coli.

194 nits L, M, and N of the proton-translocating membrane domain of complex I.

195 transgenic mice expressing in the liver the membrane domain of HMGCR (HMGCR (TM1-8)), a region neces

196 Our results show that the membrane domain of HMGR contributes to ER morphogenesis

197 The membrane domain of NHE1 is sufficient for ion exchange.

198 culum lumen side of the fifth putative trans-membrane domain of NS4B and the mutation may render the

199 We show that the membrane domain of plant HMGR suffices to trigger ER pro

200 porter protein to be expressed at the apical membrane domain of polarized epithelia.

201 t the cytoplasmic site adjacent to the trans-membrane domain of PRLR-L was responsible for inhibitory

202 the Proregion of Pro-sigma(K) loops into the membrane domain of SpoIVFB, and the rest of Pro-sigma(K)

203 ristic properties of the PTP; therefore, the membrane domain of subunit b does not contribute to the

204 HAP1-Deltab and HAP1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, respectively,

205 otein (OSCP) to the catalytic domain and the membrane domain of subunit b to subunit a.

206 MP2) in HtrII that bridge the photoreceptive membrane domain of the complex and the cytoplasmic outpu

207 The membrane domain of the enzyme extends approximately 180

208 e enzyme's catalytic domain and crossing the membrane domain of the enzyme via two alpha-helices.

209 h the ring of c-subunits that constitute the membrane domain of the enzyme's rotor.

210 cipation in proton translocation through the membrane domain of the enzyme.

211 r turns counterclockwise (as viewed from the membrane domain of the intact enzyme) in 120 degrees ste

212 mplex borders the cylinder-like nuclear pore-membrane domain of the nuclear envelope.

213 cted MAS NMR to describe the dynamics of the membrane domain of the Outer membrane protein A of Klebs

214 stitution (G4946E), located within the trans-membrane domain of the RyR, though the exact role of thi

215 MA8 and propose a copper pathway through the membrane domain of these transporters.

216 A sequence based clustering of membrane domains of class III ACs and quorum-sensing rec

217 discussed in the context of partitioning to membrane domains of different lipid composition.

218 e comprehensive mutational landscapes in the membrane domains of Glycophorin A and the ErbB2 oncogene

219 ctions specifically localized to basolateral membrane domains of hepatocytes, the precise roles of ac

220 partitioning of receptor ligands in discrete membrane domains of target cells is an important determi

221 and profoundly modified the organization of membrane domains of the alpha-subunit.

222 Membrane domains of the chloroplast envelope are located

223 Here, by directly imaging micron-scale membrane domains of yeast vacuoles both in vivo and cell

224 xistence, nature, and role of highly ordered membrane domains, often referred to as lipid rafts, have

225 ust activate aPKC within a spatially defined membrane domain on one side of the cell in response to s

226 Both consist of a membrane domain on which sits a globular periplasmic dom

227 revealed the coexistence of highly distinct membrane domains on individual cell surfaces.

228 ctional expression of AE1, the cytosolic and membrane domains operate independently.

229 The linker plus either the N-terminal membrane domain or the C-terminal cystathione-beta-synth

230 We modeled plasma membrane domain organization using Langmuir monolayers o

231 clear position at the inner epidermal plasma membrane domain oriented to the cortical cells during ce

232 of a unique trypsin cleavage site within the membrane domain (out of 16 potential Lys and Arg sites).

233 SM) that are known to assemble into specific membrane domains play a role in the organization and fun

234 ocalized in the L(o) domain resulted in this membrane domain preferentially coating the PEG-rich bud

235 embrane composition has implications for how membrane domain properties may be regulated in vivo.

236 CASPARIAN STRIP MEMBRANE DOMAIN PROTEINS (CASPs) are four-membrane-span

237 trafficking and the polar placement of outer membrane domain proteins require further exploration.

238 Therefore, the epidermis and the outer membrane domain provide important selective and protecti

239 localization, or nonlocalization, in ordered membrane domains (rafts) is a key to understanding membr

240 embrane inhomogeneities, e.g., the so-called membrane domains, rafts, stalks, etc., lead to different

241 on the full length KpOmpA as well as on its membrane domain, reconstituted in liposomes or in deterg

242 In cells, membrane domains regulate membrane dynamics and biochemi

243 e mechanisms underlying recruitment to these membrane domains remain incompletely understood.

244 y transduction proteins to these specialized membrane domains remain poorly understood.

245 I3Kgamma and further define the Rab-mediated membrane domains required for signaling.

246 Redox-coupled proton translocation in the membrane domain requires long-range energy transfer thro

247 Biophysical understanding of membrane domains requires accurate knowledge of their st

248 e the separation and identification of lipid membrane domain residents, or the characterization of ch

249 fusion at the apical and basolateral plasma membrane domains, respectively, but how these proteins a

250 mpartments, the organization and function of membrane domains rich in DHA-containing phospholipids, a

251 x sphingolipids, but also as an organizer of membrane domains segregating receptors and signalosomes.

252 in the axon initial segment are confined to membrane domains separated by periodically spaced actin

253 However, whether protein concentration and membrane domain stability affect Ras clustering in a rev

254 Caveolae are protein-dense plasma membrane domains structurally composed of caveolin-1 or

255 3beta3-domain, peripheral stalk, and, in the membrane domain, subunit a and associated supernumerary

256 ulted in excess surface area of L(o) or L(d) membrane domains such that, upon division, this excess p

257 tion has shown the importance of specialized membrane domains, such as lipid rafts, protein-lipid com

258 rate that nucleocytoplasmic transport at the membrane domain surrounding the mitotic spindle midzone,

259 mic microclusters (MCs) within a specialized membrane domain termed the immunological synapse (IS).

260 Much evidence suggests that membrane domains, termed lipid rafts, which are enriched

261 protein interactions and a carboxyl-terminal membrane domain that carries out the transport function.

262 ssociation of the anionic Asp-139 toward the membrane domain that couples to conformational changes i

263 fferent type of sphingolipid-enriched plasma membrane domain that depends upon cortical actin.

264 sting because they represent a novel type of membrane domain that is important for plasma membrane or

265 Thus, MLRs provide an active membrane domain that tethers and reorganizes the cytoske

266 s PMP22 is localized to cholesterol-enriched membrane domains that are closely linked with the underl

267 ns also organize the highly localized plasma membrane domains that are important in STIM1-ORAI1 signa

268 s are cholesterol- and sphingolipid-enriched membrane domains that are thought to form transient sign

269 Gap junctions (GJs) represent connexin-rich membrane domains that connect interiors of adjoining cel

270 The clusters induce the formation of ordered membrane domains that exclude the dye 1,1'-dioctadecyl-3

271 barrier to the stability of phase-separated membrane domains that increases in significance as the m

272 of a signaling and transport complex within membrane domains that is necessary for phosphorylation a

273 Caveolae are membrane domains that may influence cell signaling by se

274 and plasma membrane, respectively, to create membrane domains that partition upstream regulators of t

275 ding site being located partially within the membrane domain, the possibility has to be considered th

276 of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary

277 the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components

278 tons across its complete approximately 200-A membrane domain, thermodynamically driving synthesis of

279 st-binding domains to the pore-forming trans-membrane domain (TMD), and validated these, to our knowl

280 r prevents TNFR1 localization to low density membrane domains, TNF-induced internalization of TNFR1,

281 iate state until MalK binds and converts the membrane domain to the inward-facing state.

282 asymmetrically segregate their apical plasma membrane domain to the nascent daughter cells.

283 At these epidermal plasma membrane domains, TWD1 colocalizes with nonpolar ABCB1.

284 Moreover, monovalent CTxB does not stabilize membrane domains, unlike wild-type CTxB.

285 ional changes that are transduced to channel membrane domains via the H-I loop.

286 Nanoclustering of K-Ras, related to nonraft membrane domains, was enhanced in intact plasma membrane

287 Because collagenases lack an integral membrane domain, we hypothesized that receptors for extr

288 rane upon store depletion to the juxtaplasma membrane domain, where it interacts with intracellular d

289 vity is accompanied by formation of distinct membrane domains which differ in local membrane fluidity

290 CASPs show high stability in their membrane domain, which presents all the hallmarks of a m

291 GLDH is attached to a membrane domain, which represents a major fragment of th

292 most CASPLs were able to integrate the CASP membrane domain, which suggests that CASPLs share with C

293 this time, this neuron acquires specialized membrane domains while undergoing extensive polarity rem

294 from the cytoplasmic membrane, generating a membrane domain with distinct lipid composition.

295 d of an endoplasmic reticulum (ER)-anchoring membrane domain with low sequence similarity among eukar

296 n and removal of Rabs to create time-limited membrane domains with a unique composition, and can expl

297 ble for the establishment and maintenance of membrane domains with different composition.

298 l cells and neurons exhibit different plasma membrane domains with distinct protein compositions.

299 Membrane domains within stereocilia thus define regions

300 Hence, the V-ATPase membrane domain would allow the exocytotic machinery to