ライフサイエンスコーパス: membrane fusion

1 ntributed to the regulation of HSV-1-induced membrane fusion.

2 has the most elusive role during EBV-induced membrane fusion.

3 bies virus) mediate both cell attachment and membrane fusion.

4 zippering of the SNARE complex, and triggers membrane fusion.

5 ing, which serves as a power stroke to drive membrane fusion.

6 eptide into the target membrane, followed by membrane fusion.

7 ion of proteins with cellular membranes, and membrane fusion.

8 spike protein must be triggered, leading to membrane fusion.

9 on conformation, i.e., before activation for membrane fusion.

10 r whether dysferlin regulates SNARE-mediated membrane fusion.

11 rated that flunarizine specifically prevents membrane fusion.

12 ologs (LC3, GABARAP, and GATE-16) to mediate membrane fusion.

13 al entry) or cell-cell (syncytium formation) membrane fusion.

14 he vesicle (v)-SNARE on the vesicle to drive membrane fusion.

15 is a ubiquitous recognition event preceding membrane fusion.

16 specific regions of G and F interact during membrane fusion.

17 n, which is required for outer mitochondrial membrane fusion.

18 d for further analysis all block HA-mediated membrane fusion.

19 binding of its cognate SNARE partners during membrane fusion.

20 e concerning the mechanism of virus-mediated membrane fusion.

21 se classes block hemagglutinin (HA)-mediated membrane fusion.

22 tein spike mediates host cell attachment and membrane fusion.

23 mbrane are crucial for triggering exocytotic membrane fusion.

24 cell receptors and for catalyzing virus-cell membrane fusion.

25 which binds cellular receptors and mediates membrane fusion.

26 protein degradation to DNA damage repair and membrane fusion.

27 tein binds to host cell receptors to mediate membrane fusion.

28 virus envelope glycoprotein (GPC) to prevent membrane fusion.

29 Upon activation, F mediates virus-host membrane fusion.

30 ruited to the exocytic site near the time of membrane fusion.

31 ein Ov8 can significantly enhance, cell-cell membrane fusion.

32 a slower alternative mode of SNARE-mediated membrane fusion.

33 or host cell attachment, endosomal entry and membrane fusion.

34 s enhanced GRASP65 oligomerization and Golgi membrane fusion.

35 of hemagglutinin (HA) and blocks HA-mediated membrane fusion.

36 functions, deacidification and inhibition of membrane fusion.

37 or G) and fusion (F) glycoproteins, mediate membrane fusion.

38 proteins acted in concert to drive efficient membrane fusion.

39 glycoproteins and prime them for virus-cell membrane fusion.

40 paradigm coliphage lambda mediate efficient membrane fusion.

41 sion in that self-contacts are eliminated by membrane fusion.

42 e to both FIP and AS-48 without compromising membrane fusion.

43 cells in early response to virosome-induced membrane fusion.

44 at fusion sites and thus supports efficient membrane fusion.

45 e initial attachment but prior to viral/cell membrane fusion.

46 ab GTPase Ypt7, and vacuolar SNAREs to drive membrane fusion.

47 and Cdc42, also reduced self-contact-induced membrane fusion.

48 of cellular factors necessary for virus-cell membrane fusion.

49 nd the viral fusion glycoprotein F result in membrane fusion.

50 s insert into the host membrane and initiate membrane fusion.

51 n for receptor binding and a stem domain for membrane fusion.

52 D63 stimulates pH-activated LUJV GP-mediated membrane fusion.

53 post-F) state at the time of virus-host cell membrane fusion.

54 n, and GP2 is responsible for low pH-induced membrane fusion.

55 e the basic mechanism by which they catalyze membrane fusion.

56 hreonine 206-an early molecular event during membrane fusion.

57 efined assembly intermediates on the path to membrane fusion.

58 onformational rearrangements associated with membrane fusion.

59 rotein incorporation, lipid composition, and membrane fusion.

60 that enable homodimerization and subsequent membrane fusion.

61 lfish" genetic element from cell to cell via membrane fusion.

62 s suggest revisions to the SNARE paradigm of membrane fusion.

63 ral changes that mediate viral entry through membrane fusion.

64 ep in SNARE complex assembly, and stimulates membrane fusion.

65 rus entry because it mediates viral and host membrane fusion.

66 glycoprotein that can significantly enhance membrane fusion.

67 s into a parallel four-helix bundle to drive membrane fusion.

68 e viral F protein that is required to elicit membrane fusion.

69 d in gK-mediated regulation of virus-induced membrane fusion.

70 ered (ld) phase boundary to facilitate viral membrane fusion.

71 nel so as to synchronize calcium influx with membrane fusion.

72 which carries out the process of virus-cell membrane fusion.

73 imum required OvHV-2 glycoproteins to induce membrane fusion.

74 NARE-binding proteins catalyze intracellular membrane fusion.

75 for a twofold role of K in the mechanism of membrane fusion: 1) to bring opposing membranes into clo

76 omplexes are the core molecular machinery of membrane fusion, a fundamental process that drives inter

77 o and in vivo The N20A mutation also reduced membrane fusion activity and viral virulence in guinea p

78 Membrane fusion activity is required for early biogenesi

79 hese findings indicate that a deficit in the membrane fusion activity of atlastin1 may be a key contr

80 ation has been shown to be important for the membrane fusion activity of recombinantly expressed GPC.

81 y decreasing the threshold for activation of membrane fusion activity triggered by the host factors c

82 use their surface glycoproteins to catalyze membrane fusion, an essential cell entry step.

83 formation of the SNARE complex required for membrane fusion and also increases the rate of exocytosi

84 n host species specificity and transmission, membrane fusion and associated properties of HA stabilit

85 he conformational changes of DNA cages drive membrane fusion and bending with predictable outcomes, o

86 ntial but still poorly characterized role in membrane fusion and cell tropism.

87 ceptor (SNARE) proteins play a major role in membrane fusion and contribute to cell expansion, signal

88 embrane and functions in mitochondrial inner membrane fusion and cristae maintenance.

89 range of conformational changes that lead to membrane fusion and delivery of the viral nucleocapsid i

90 timately leading to gp41-mediated virus-cell membrane fusion and entry.

91 Membrane fusion and fission are vital for eukaryotic lif

92 eins is known to function in many eukaryotic membrane fusion and fission events.

93 Dynamin-like proteins (DLPs) mediate various membrane fusion and fission processes within the cell, w

94 that inactivate the RTKs and deliver them by membrane fusion and fission to late endosomes.

95 e protein hemagglutinin (HA), which triggers membrane fusion and genome release under acidic conditio

96 ctive than WQ in blocking HIV-1 Env-mediated membrane fusion and had higher levels of binding affinit

97 ternalized PS strongly promotes Env-mediated membrane fusion and HIV-1 infection.

98 , a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication.

99 protein receptors (SNAREs) mediate cellular membrane fusion and intracellular vesicle trafficking in

100 Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizin

101 f MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral

102 he data support a role of V-ATPase c-ring in membrane fusion and neuronal communication.

103 licated in non-canonical functions including membrane fusion and neurotransmitter release.

104 ggest a novel mechanism underlying filovirus membrane fusion and provide a potential cellular target

105 he atlastin GTPase is sufficient to catalyze membrane fusion and required to form the ER network, at

106 s, which is extended in cells defective for membrane fusion and significantly lengthened and more va

107 Inhibition of gB/gHgL-mediated membrane fusion and structural comparisons with herpesvi

108 (AS-48) have similar efficacies in blocking membrane fusion and syncytium formation mediated by meas

109 at the TMD of VAMP2 plays a critical role in membrane fusion and that the structural mobility provide

110 that network maintenance requires continuous membrane fusion and that Yop1p favours the generation of

111 ly been shown to drive endoplasmic reticulum membrane fusion and three-way junction formation.

112 ional changes that result in virus-host cell membrane fusion and viral entry.

113 brane fusion is distinct from SNARE-mediated membrane fusion, and many details remain unclear.

114 in inhomogeneous membranes, thereby inhibit membrane fusion, and thus may be useful natural viral en

115 (S) glycoproteins mediate receptor binding, membrane fusion, and virus entry and determine host rang

116 SNARE proteins-core machinery for membrane fusion-are incorporated into COPII vesicles by

117 o study OvHV-2 glycoproteins responsible for membrane fusion as a part of the entry mechanism, we dev

118 we characterize the GATE-16/GABARAP-mediated membrane fusion as a phenomenon of full membrane fusion,

119 )-triggered exocytosis and actively promotes membrane fusion as well as fusion pore expansion.

120 nism, we developed a virus-free cell-to-cell membrane fusion assay to identify the minimum required O

121 tations were validated in a luciferase-based membrane fusion assay, using transfected fusion and hema

122 neurons, heterologous expression systems, or membrane fusion assays in vitro, whereas little is known

123 ble increase in heat stability and underwent membrane fusion at a lower pH; collectively, these prope

124 Membrane fusion at endomembranes requires cross-talk bet

125 lity of ectopically expressed GPC to mediate membrane fusion at endosomal pH.

126 invasion by the malaria parasite and gamete membrane fusion at fertilization.

127 Further GTP hydrolysis triggers local outer membrane fusion at the periphery of the contact region.

128 Membrane fusion at vacuoles requires a consecutive actio

129 on that prolonged interference with cellular membrane fusion/autophagosome maturation could have unfa

130 AMP721, which assembles with SYP121 to drive membrane fusion, binds to the KAT1 K(+) channel via two

131 e in intracellular trafficking by catalyzing membrane fusion, but assigning SNAREs to specific intrac

132 3 (RHD3) has been demonstrated to mediate ER membrane fusion, but how exactly RHD3 is involved in the

133 been related to both membrane expansion and membrane fusion, but the underlying molecular mechanisms

134 nstitute the core machinery of intracellular membrane fusion, but vesicular SNAREs localize to specif

135 malian uncoordinated-18c (Munc18c) regulates membrane fusion by activating syntaxin-4 (STX-4) to bind

136 ocation and different models of catalysis of membrane fusion by HAfp.

137 s into the mechanisms of mitochondrial outer membrane fusion by investigating the structure of mitofu

138 nvestigation of other types of intracellular membrane fusion by using appropriate alternative protein

139 Vesiculoviruses enter cells by membrane fusion, driven by a large, low-pH-induced, conf

140 hich is responsible for viral-host endosomal membrane fusion during a productive ISAV infection.

141 s (SNAREs) constitute the core machinery for membrane fusion during eukaryotic cell vesicular traffic

142 neutralizing antibodies, which suggests that membrane fusion during the entry of the pseudotyped viri

143 fusion domain is important for activation of membrane fusion during viral entry and that in the absen

144 membrane fluidity, which inhibits virus-cell membrane fusion during viral entry.

145 virus glycoprotein complex gB/gH-gL mediates membrane fusion during virion entry and cell-cell fusion

146 nsible for Ebola virus (EBOV) attachment and membrane fusion during virus entry.

147 triggered by low pH in the endosome to cause membrane fusion; during egress, HA contributes to virus

148 essential roles in catalyzing intracellular membrane fusion events although the assembly pathway and

149 Although membrane fusion events are essential for the formation o

150 rlin as a calcium-sensing SNARE effector for membrane fusion events.

151 protein that participates in SNARE-mediated membrane fusion events.

152 and allowed direct observation of individual membrane-fusion events at SNARE densities as low as one

153 Multiple membrane-fusion events mediated by SNARE molecules have

154 calculate an entire least energy pathway of membrane fusion, from stalk formation, to pore creation,

155 forms a trimer carrying receptor-binding and membrane fusion functions.

156 of thylakoid membranes, proteins involved in membrane fusion have yet to be identified in photosynthe

157 direct interaction between gL and gB in EBV membrane fusion.IMPORTANCE EBV predominantly infects epi

158 fever, enters cells by macropinocytosis and membrane fusion in a late endosomal compartment.

159 uncovers a role of the exocyst in promoting membrane fusion in addition to vesicle tethering.

160 und that filovirus infection and GP-mediated membrane fusion in cultured cells were remarkably suppre

161 pletion of TSPAN9 specifically decreases SFV membrane fusion in endosomes.

162 k between PIPs and established regulators of membrane fusion in late endocytic trafficking.

163 et cells by endocytosis and low pH-dependent membrane fusion in late endosomes.

164 exocytosis is impaired at the late stage of membrane fusion in Ophn1 knock-out mice and OPHN1-silenc

165 s a proteolytic processing step and triggers membrane fusion in response to acidic pH--a strategy com

166 formation during homotypic vacuolar lysosome membrane fusion in Saccharomyces cerevisiae Using cell-f

167 es VCIP135 deubiquitinase activity and Golgi membrane fusion in the cell cycle remains unknown.

168 onformational rearrangements associated with membrane fusion in the low pH of the endosome.

169 (SNARE) proteins are the main catalysts for membrane fusion in the secretory pathway of eukaryotic c

170 plexes were unable to facilitate gB-mediated membrane fusion in transient-expression cell-cell fusion

171 (PA) in membranes and mediates PA-dependent membrane fusion in vitro.

172 endency for binding to membranes and driving membrane fusion in vitro.

173 ch lacks a transmembrane domain, can support membrane fusion in vivo is uncertain, as is the precise

174 rus spike proteins, receptor recognition and membrane fusion, in the context of the corresponding fun

175 east vacuole requires four SNAREs to trigger membrane fusion including the soluble Qc-SNARE Vam7.

176 E proteins catalyze many forms of biological membrane fusion, including Ca(2+)-triggered exocytosis.

177 ated membrane fusion as a phenomenon of full membrane fusion, independently demonstrating vesicle agg

178 Membrane fusion induced by the envelope glycoprotein ena

179 The use of VopQ as a membrane fusion inhibitor in this manner now provides co

180 ALEK)3, has been used as a minimal model for membrane fusion, inspired by SNARE proteins.

181 By following the population kinetics of membrane fusion intermediates imaged by cryo-ET, we foun

182 virions shares common requirements with the membrane fusion involved in HSV-1 entry and HSV-1-mediat

183 Alphaherpesvirus-mediated membrane fusion is a complex and highly regulated proces

184 Protein-mediated membrane fusion is an essential step in many fundamental

185 Virus-cell membrane fusion is an important step for a successful vi

186 eport that the activation energy of complete membrane fusion is at the lowest range of these theoreti

187 roles of viral glycoproteins responsible for membrane fusion is critical toward understanding viral e

188 The mechanism of Atlastin-mediated membrane fusion is distinct from SNARE-mediated membrane

189 Membrane fusion is essential for eukaryotic life, requir

190 Membrane fusion is essential for intracellular protein s

191 Membrane fusion is essential for paramyxovirus entry int

192 Membrane fusion is essential in a myriad of eukaryotic c

193 ing of mechanisms governing alphaherpesvirus membrane fusion is expected to inform the rational desig

194 Membrane fusion is induced by SNARE complexes that are a

195 The inhibitory effect of ethanol on liposome-membrane fusion is large enough to provide a possible bi

196 e tethering of the secretory vesicles before membrane fusion is mediated by the exocyst, an essential

197 simultaneously to ensure that true, nonleaky membrane fusion is monitored.

198 Membrane fusion is orchestrated via interaction of the r

199 Previously we showed that membrane fusion is required for TANGO1-dependent export

200 indicate that while autophagosomal-lysosomal membrane fusion is sensitive to inhibition of SNARE prim

201 ssays that require Munc18-1 and Munc13-1 for membrane fusion is stimulated by the D326K mutation and

202 Membrane fusion is subsequently initiated by a conformat

203 Membrane fusion is the cell's delivery process, enabling

204 In the tripartite GPC complex, pH-dependent membrane fusion is triggered through a poorly understood

205 Although the mechanism of virus-membrane fusion is well studied, we still know relativel

206 ies, highly stable postfusion F (found after membrane fusion) is also able to induce neutralizing ant

207 uired for p97/p47-mediated postmitotic Golgi membrane fusion, is phosphorylated at multiple sites dur

208 c (gp160)3 cleaved to (gp120/gp41)3] induces membrane fusion, leading to viral entry.

209 critical and conserved element of the viral membrane fusion machinery, and neutralize viral entry by

210 or, by a TMD from a protein unrelated to the membrane fusion machinery, or by artificial leucine-vali

211 unc18-1, a core component of the presynaptic membrane-fusion machinery, cause infantile early epilept

212 us infection, including receptor binding and membrane fusion, making it a potential target for the de

213 agents that target this novel aspect of GPC membrane fusion may be useful in the treatment of arenav

214 ication of OvHV-2 glycoproteins that mediate membrane fusion may help identify viral and/or cellular

215 ther, our data suggest an autophagy-specific membrane fusion mechanism in which oligomeric ATG14 dire

216 urified components enables detailed study of membrane fusion mechanisms.

217 systematic exploration of the HSV entry and membrane fusion mechanisms.

218 ide a structural basis to support a model of membrane fusion mediated by progressive S protein destab

219 We showed that efficient ER membrane fusion mediated by RHD3 requires a proper dimer

220 ng ability that is required for efficient ER membrane fusion mediated by RHD3.

221 were shown to interfere with low pH-induced membrane fusion mediated by the H1 and H5 (group 1) hema

222 enter the target cell via direct viral-cell membrane fusion mediated by two membrane glycoproteins:

223 recognized for their promising potential in membrane fusion-mediated delivery of bioactive molecules

224 Intracellular membrane fusion mediates diverse processes including cel

225 Lysosomal membrane fusion mediates the last step of the autophagy

226 During protein-mediated membrane fusion, membrane proteins are often excluded fr

227 observations reveal novel details about HCV membrane fusion; moreover, flunarizine and related compo

228 The membrane fusion necessary for vesicle trafficking is dri

229 Neuronal exocytotic membrane fusion occurs on a fast timescale and is depend

230 e compartment to make it more permissive for membrane fusion of early-penetrating viruses.

231 m the alternative STING pathway triggered by membrane fusion of enveloped RNA viruses.

232 We introduce a novel assay for membrane fusion of solid supported membranes on silica b

233 eceptor remains indispensable for initiating membrane fusion of syncytial strains.

234 Homotypic membrane fusion of the endoplasmic reticulum (ER) is med

235 amin-related GTPase atlastin (ATL) catalyzes membrane fusion of the endoplasmic reticulum and thus es

236 sion experiments revealed that LY6E promotes membrane fusion of the viral entry step.

237 op in the glycoprotein molecule and prevents membrane fusion of the viral envelope with cellular memb

238 magglutinin conformational change drives the membrane fusion of viral and endosomal membranes at low

239 c18c's role in mediating ectopic basolateral membrane fusion of ZGs contributes to the initiation of

240 the E2 the loop from residues 864 to 881 in membrane fusion, only synthetic peptides that were based

241 antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA.

242 her mutations (N37A and R55A) did not affect membrane fusion or viral growth in vitro but significant

243 ia a previously uncharacterized rapid plasma membrane fusion pathway that functions at low temperatur

244 Membrane fusion proceeds through an intermediate called

245 PC expression and processing but also in the membrane fusion process during viral entry.

246 ons of G/H/HN and F that interact during the membrane fusion process remain relatively unknown though

247 SEM imaging detailed the membrane-fusion process in four stages leading to full a

248 ber of externally facing SNAREs to study the membrane-fusion process.

249 SF) is known to be crucial for intracellular membrane fusion processes, but its role in autophagy rem

250 n the context of headless and full-length HN membrane fusion promotion.

251 novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of th

252 to a binding domain for interaction with the membrane fusion protein MacA.

253 of the outer membrane component MtrE and the membrane fusion protein MtrC, obtained by a combination

254 by deletion of mitochondrial outer or inner membrane fusion proteins (Fzo1p or Mgm1p) leads to decre

255 ) proteins comprise a unique family of viral membrane fusion proteins dedicated to inducing cell-cell

256 Viral membrane fusion proteins of class I are trimers in which

257 HAP2 that reveal homology to class II viral membrane fusion proteins.

258 thought to be energetically unfavourable for membrane fusion, rafts have long been implicated in many

259 alovirus (HCMV), which are known to use cell membrane fusion rather than endocytosis to enter fibrobl

260 lular and molecular mechanisms of the gamete membrane fusion reaction.

261 molecular arrangement of SNARE complexes in membrane fusion reactions are not well understood.

262 nd mediate virtually all known intracellular membrane fusion reactions on which exocytosis and traffi

263 ction of the transmembrane domains (TMDs) in membrane fusion remains controversial.

264 Rapid membrane fusion requires tethering and Sec1-Munc18 (SM)

265 Membrane fusion requires that nearly flat lipid bilayers

266 engaging the host receptor and in mediating membrane fusion, respectively.

267 rotein, mediate virus binding and subsequent membrane fusion, respectively.

268 dered incapable of pH-induced triggering for membrane fusion, resulting in lysosomal degradation.

269 important to the regulation of HSV-1-induced membrane fusion since mutating N58 to alanine (N58A) cau

270 though both otoferlin and synaptotagmin bind membrane fusion SNARE proteins, only otoferlin interacts

271 SSP plays an essential role in mediating the membrane fusion step as well as in other yet-to-be-deter

272 used a marked reduction of cell entry at the membrane fusion step, and while this mutant virus was vi

273 Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a ST

274 eptor-binding subunit, GP1, and a viral-host membrane fusion subunit, GP2.

275 ed for efficient homodimer formation and for membrane fusion suggesting a functional role for Sec22 h

276 s of SARS-CoV and MHV also failed to mediate membrane fusion, suggesting that these pFPs are also the

277 also the first such analysis of a prokaryote membrane fusion system.

278 Since most membrane fusion systems are not genetically tractable, o

279 CoRA-dependent decrease in the rate of viral membrane fusion that extends the lifetime of the interme

280 esentative protein complexes responsible for membrane fusion, the HIV-1 glycoprotein 41 and the synap

281 ing and extracellular vesicles for efficient membrane fusion, the resulting ligand-displaying extrace

282 GP2 in close proximity at critical steps of membrane fusion, their structures in membrane environmen

283 long before exocytosis, and near the time of membrane fusion, they diffuse away.

284 For the case of HIV gp41-mediated membrane fusion, this apparent contradiction can be reso

285 ies suggest that platelets use both modes of membrane fusion to control the extent of agonist-induced

286 This pathway may link outer membrane fusion to lipids homeostasis.

287 , and L (gB, gH, and gL) were able to induce membrane fusion together but not when expressed individu

288 Understanding the molecular mechanism of membrane fusion triggering may allow development of new

289 erization and intracellular transport or for membrane fusion triggering.

290 assay that enables real-time measurements of membrane fusion using live cells.

291 it is yet to be determined how acid-induced membrane fusion varies with virus strain and influences

292 ve concentrations stimulated SNARE-dependent membrane fusion when vesicle-tethering activity was redu

293 The formation of the ER requires homotypic membrane fusion, which is mediated by a family of Dynami

294 Membrane fusion, which is the key process for both initi

295 HV-2 gB, gH, and gL are sufficient to induce membrane fusion, while glycoprotein Ov8 plays an enhanci

296 dding the surface of the virus to facilitate membrane fusion with a target cell membrane.

297 ass II, indicating that its ability to block membrane fusion with B cells represents a defect in gB a

298 d binds HLA class II to activate gB-mediated membrane fusion with B cells.

299 i-gHgL antibodies, CL40 and CL59, that block membrane fusion with both B cells and epithelial cells.

300 Ca(2+) release is required for endolysosomal membrane fusion with intracellular organelles.