ライフサイエンスコーパス: membrane lipid

1 in contrast to an overall decrease in total membrane lipid.

2 endocytosis is specialized for transport of membrane lipid.

3 tion should be extendable to other important membrane lipids.

4 erol dibiphytanyl glycerol tetraether (GDGT) membrane lipids.

5 r, little is known about their regulation by membrane lipids.

6 ng spectra from dispersions of the extracted membrane lipids.

7 nvolved gangliosides GT1b and GD1a and a few membrane lipids.

8 way further contact with the polar group of membrane lipids.

9 habitat by structural modification of their membrane lipids.

10 nvironments, and interactions with endosomal membrane lipids.

11 stable dimers and do not selectively retain membrane lipids.

12 AG is produced from fatty acids of preformed membrane lipids.

13 a TH1 domain, which interacts directly with membrane lipids.

14 e in metabolism of both triacylglycerols and membrane lipids.

15 rong regulation of ganglioside catabolism by membrane lipids.

16 lates roughly with the hydrophobicity of the membrane lipids.

17 enced by the composition and organization of membrane lipids.

18 ilin and Rho kinase by perturbing the plasma membrane lipids.

19 uence of the interactions between eukaryotic membrane lipids.

20 ent compositional patterns of stress-induced membrane lipids.

21 revealed clade-specific gene sets regulating membrane lipids.

22 teraction by influencing the organization of membrane lipids.

23 et poorly studied molecules among biological membrane lipids.

24 ed by a novel negative-feedback mechanism on membrane lipids.

25 otherwise known for their abilities to bind membrane lipids [21, 22] and scaffold protein complex fo

26 t, rather, was mediated by a range of acidic membrane lipids, a functional interaction between PI(4,5

27 In contrast to membrane lipids, a pool of biotinylatable membrane prote

28 this system expands the known repertoire of membrane lipids acting as substrates for amino acid modi

29 Evidence suggests that membrane lipids affect proteins through interactions of

30 Membrane lipids affect the innate immune response, which

31 mpositions (i.e., contents of storage lipid, membrane lipid, albumin, other proteins, and water) and

32 Outer membrane lipid alterations of current microbiological in

33 Aminoacylation of membrane lipids alters the biochemical properties of the

34 bial biomass at this depth, as determined by membrane lipid analysis.

35 early steps of biosynthesis of lipid A, the membrane lipid anchor of lipopolysaccharide.

36 of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is further supp

37 -localized GPAT enzyme responsible for plant membrane lipid and oil biosynthesis.

38 astic differences between viral and cellular membrane lipid and protein compositions and curvatures e

39 astic differences between viral and cellular membrane lipid and protein compositions and curvatures e

40 ature combined with functional modulation by membrane lipid and water vestibules.

41 amily F-BAR domain proteins bind directly to membrane lipids and are associated with actin dynamics a

42 t depend on apical and basal distribution of membrane lipids and are essential for embryonic and post

43 oration of serine during the biosynthesis of membrane lipids and because lipid composition of HIV par

44 Membrane lipids and cellular water (soft matter) are bec

45 o PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2+).

46 expression of gGlcT1 increased the influx of membrane lipids and fatty acids without altering the flu

47 ade, in part, from hydrolysis of chloroplast membrane lipids and in part, by a continual transfer of

48 ion includes direct interaction of NM2s with membrane lipids and indirect interaction by association

49 omains are driven by intrinsic properties of membrane lipids and integral as well as membrane-associa

50 It is driven by intrinsic properties of membrane lipids and integral as well as membrane-associa

51 approximately 90% of SH2 domains bind plasma membrane lipids and many have high phosphoinositide spec

52 specific example of how interactions between membrane lipids and membrane-bound proteins can influenc

53 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of th

54 dependent on the intrinsic curvature of the membrane lipids and on GTP.

55 rays of giant liposomes from a wide range of membrane lipids and protein compositions is demonstrated

56 tated by domains enriched in specific plasma membrane lipids and proteins that resemble liquid-ordere

57 which cells exchange large amounts of outer membrane lipids and proteins upon contact.

58 OS damage mitochondrial proteins, mtDNA, and membrane lipids and release them in the cytosol.

59 ng, suggesting a dynamic competition between membrane lipids and RNA for the same binding sites in NC

60 ubstrates for beta-oxidation, precursors for membrane lipids and signaling molecules.

61 trol that determines acyl chain flux between membrane lipids and triglycerides during nitrogen stress

62 ntly by preventing S1PR2 activation by viral membrane lipids, and antimicrobial peptide release from

63 on is associated with significant changes to membrane lipids, and formation of diverse bioactive lipi

64 ne and sphingomyelin specifically over other membrane lipids, and that cell surface binding and inter

65 hexaenoic acid is robustly incorporated into membrane lipids, and this incorporation leads to signifi

66 hows higher affinity for Detergent-Insoluble Membranes lipids, and targets yellow fluorescent protein

67 r membrane molecular organization is how the membrane lipids are packed.

68 % of cellular dry weight, and 86-100% of the membrane lipids are replaced with amino- or glycolipids.

69 The receptors, along with membrane lipids, are normally returned to the plasma mem

70 t of hydrophobic and ionic interactions with membrane lipids as well as of specific protein-protein i

71 regulated by dynamic changes in GTPases and membrane lipids, as well as Ca2+ signalling.

72 ction of Gin4 is highly localized control of membrane lipid asymmetry and is necessary for optimal cy

73 Collapse of membrane lipid asymmetry is a hallmark of blood coagulat

74 together with the Mla system preserves outer membrane lipid asymmetry.

75 r that is important for maintenance of outer membrane lipid asymmetry.

76 ergent n-dodecyl-beta-maltoside (beta-DM) or membrane lipids, at (+)-447 and (-)-494 nm.

77 tion likely involves sequestering vulnerable membrane lipids away from reactive oxygen species.

78 elta may provide a direct connection between membrane lipid-based signaling, energy metabolism and gr

79 With this approach, more than 50 membrane lipids belonging to 9 classes were quantified i

80 ulations and polar headgroup compositions of membrane lipids between the epipelagic (</= 100 m) and d

81 proteins requires their extraction from the membrane lipid bilayer and subsequent proteasome-mediate

82 Although the properties of the cell plasma membrane lipid bilayer are broadly understood to affect

83 rged regions in SNARE proteins in the plasma membrane lipid bilayer to facilitate docking of vesicles

84 still considered mere building blocks of the membrane lipid bilayer, but the subsequent realization t

85 cess between the water-filled translocon and membrane lipid bilayer, suggesting that partitioning is

86 understood about the effect of alphaS on the membrane lipid bilayer.

87 of new protein functional states within the membrane lipid bilayer.

88 ges in interactions of the TM helices of the membrane lipid bilayer.

89 RE proteins in synaptic or secretory vesicle membrane lipid bilayers with positively charged regions

90 s information about the balance of forces in membrane lipid bilayers.

91 Our data indicate that impairment of the membrane lipid binding activity of Cb and a consequent d

92 sphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phosp

93 Regulation of membrane lipid biosynthesis is critical for cell functio

94 plastid to endoplasmic reticulum pathway for membrane lipid biosynthesis is required for the cold str

95 ranes; these included nucleotide catabolism, membrane lipid breakdown and increased creatine metaboli

96 reveal a crucial role for TAG metabolism in membrane lipid breakdown, fatty acid turnover, and plant

97 rum lysolipids, potentially originating from membrane lipid breakdown.

98 4,5)P2) is a minor component of total plasma membrane lipids, but it has a substantial role in the re

99 Usually C2 domains bind membrane lipids, but that of PLCgamma2 docks in a Ca(2+)

100 y 4E10 suggest that 4E10 also interacts with membrane lipids, but the antibody regions contacting lip

101 and for trafficking of membrane proteins and membrane lipids, but the role of asymmetry in regulating

102 To elucidate how a membrane lipid can specify trafficking in these pathways

103 However, CDR responses depend on membrane lipids, can be modified by cholesterol-clusteri

104 tructures containing the inner mitochondrial membrane lipid cardiolipin (CL), leading to protein conf

105 Cell envelope outer membrane lipids change systematically from hydrophilic l

106 ty and specificity through interactions with membrane lipid components.

107 dome with 118 different lipids suggests that membrane lipid composition and adaptation mechanisms in

108 folding cooperativity, depends distinctly on membrane lipid composition and correlates to the degree

109 to 6.4% of the dry weight without affecting membrane lipid composition and plant growth.

110 al wall with a dynamics tightly regulated by membrane lipid composition and the cortical cytoskeleton

111 crease from 15 degrees C to 25 degrees C and membrane lipid composition assessed.

112 NbSACPD-C plays a critical role maintaining membrane lipid composition in ovule development for fema

113 to adjust the acyl composition of organelle membrane lipid composition in response to cold stress.

114 n topology can be changed simply by changing membrane lipid composition independent of other cellular

115 asma membrane properties, demonstrating that membrane lipid composition is a biochemical control para

116 The membrane lipid composition is tightly regulated by the c

117 Plasma membrane lipid composition must be maintained during gro

118 d by the scarcity of comparative data on the membrane lipid composition of cultivated representatives

119 The membrane lipid composition of tgd1-1 sdp1-4 and tgd1-1 p

120 The membrane lipid composition of the other planktonic archa

121 homodimer peptide structure as a function of membrane lipid composition or the presence of an anionic

122 Here, we show that plasma membrane lipid composition plays a key role in coordinat

123 showed that molecular genetic alterations in membrane lipid composition result in many phenotypes, an

124 temperature, leading to the modification of membrane lipid composition to ensure optimal biochemical

125 23-55 monomer and homodimer as a function of membrane lipid composition using a multiscale simulation

126 Alteration of the DSM 10140 membrane lipid composition using modified growth medium

127 Membrane lipid composition varies greatly within submemb

128 ink between the major energy-sensing kinase, membrane lipid composition, and transcription.

129 on defects, temperature sensitivity, altered membrane lipid composition, elevated envelope-related st

130 t some forms of signaling require a distinct membrane lipid composition, found at cilia.

131 ric C991-55 is relatively insensitive to the membrane lipid composition, in agreement with experiment

132 than in lipid vesicles (i.e. with identical membrane lipid composition, ionic strength, and nucleoti

133 lencing of PDAT in C. reinhardtii alters the membrane lipid composition, reducing the maximum specifi

134 ogical conformers is dependent solely on the membrane lipid composition, we determined the topologica

135 embrane-bound form in response to changes in membrane lipid composition.

136 particle infectivity involves alterations of membrane lipid composition.

137 cally responsive to post-assembly changes in membrane lipid composition.

138 cause it is difficult to manipulate cellular membrane lipid composition.

139 hanging climate, can be observed in terms of membrane lipid composition.

140 OHOA is associated with important changes in membrane-lipid composition, primarily a recovery of sphi

141 Peptides were added to liposomes with membrane lipid compositions ranging from pure phosphatid

142 wn blocks phospholipid synthesis and changes membrane lipid compositions that ultimately induce the a

143 tional analyses of approximately 5000 plasma membrane lipid constituents of 273 species in the three

144 ometry provided evidence for the presence of membrane lipids containing one or more oxidized acyl cha

145 e levels, promotes cell growth, and elevates membrane lipid content.

146 P mobilization through membrane lipid degradation is mediated mainly by two gly

147 h under favorable culture conditions and for membrane lipid degradation with concomitant production o

148 is only partially the consequence of reduced membrane lipid desaturation, implicating other mdt-15-re

149 The membrane lipid does have a minor role by modulating the

150 essfully monitored rapid encounter events of membrane lipid domains using flow cytometry and fluoresc

151 ly used fluorescence probe for studying cell membrane-lipids due to its affinity toward the acyl chai

152 Membrane lipid dynamics must be precisely regulated for

153 urface and hydrophobic interactions with the membrane lipids enable intracellular delivery or cell ly

154 oteins, or from the difference between their membrane lipid environments.

155 lamellar vesicles (GUVs) made of erythrocyte membrane lipids (erythro-GUVs) when exposed to the deter

156 Experiments using a native membrane lipid extract showed that the SMA copolymer doe

157 the cellular physiological role that plasma membrane lipids, fatty acids and sterols play in various

158 unsaturated fatty acids required to optimize membrane lipid fluidity.

159 iate in the mobilization of fatty acids from membrane lipids for peroxisomal beta-oxidation under pro

160 ronment by altering the composition of their membrane lipids, for example, by modification of the abu

161 We also show that the polar membrane lipid fraction of SL-induced LDs is rich in pla

162 Cooling alters the membrane lipids from the fluid to gel phase, and also ca

163 Our understanding of membranes and membrane lipid function has lagged far behind that of nu

164 Sphingolipids are membrane lipids globally required for eukaryotic life.

165 idase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide into glucose and ceramid

166 ed cells were similar, indicating that outer membrane lipids govern overall hydrophobicity.

167 The release of fatty acids from membrane lipids has been implicated in various metabolic

168 phospholipase A (OmpLA) is involved in outer-membrane lipid homeostasis and bacterial virulence.

169 n via TAG intermediates, thereby maintaining membrane lipid homeostasis in leaves.

170 um (ER) and other membranes help to maintain membrane lipid homeostasis.

171 suggest that unsaturated SM may help to keep membrane lipids in a homogeneous mixture rather than in

172 her determined the roles of cytoskeleton and membrane lipids in DRG neuron mechanics.

173 mpound (QAC) choline is a major component of membrane lipids in eukaryotes and, if available to micro

174 osition and fluxes of 62 nitrogen-containing membrane lipids in human hepatoma HepG2 cells.

175 ton, and fossil forms of archaeal tetraether membrane lipids in sedimentary rocks document their part

176 n seedlings and mature siliques and of major membrane lipids in seedlings and triacylglycerol in matu

177 g, adapted to specifically removing HFA from membrane lipids in seeds.

178 nal region of vIRF-1 interacts directly with membrane lipids, including cardiolipin.

179 Fatty acid desaturation of membrane lipids is a strategy for plants to survive chil

180 ing the viral infection, gB interaction with membrane lipids is still poorly understood.

181 Archaeal membrane lipids known as glycerol dibiphytanyl glycerol

182 nces TAG content at the expense of thylakoid membrane lipids, leading to defects in chloroplast divis

183 ronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and

184 , and markers of the peroxidation process of membrane lipids, MDA, fatty acid hydroperoxides and 7-ke

185 sicle trafficking, defense signaling through membrane lipid metabolism and mucilage production.

186 ivity was expressed, the formation of plasma membrane lipid microdomains and the number of exocytotic

187 Lipid rafts, chemically distinct membrane lipid microdomains that are enriched in GSLs an

188 nal function depends on the integrity of the membrane lipid microenvironment.

189 tudies indicate that Lpcat3 activity impacts membrane lipid mobility in living cells, suggesting a bi

190 lts show that deliberate stress induction or membrane lipid modification can be employed to significa

191 These membrane lipid modifications were investigated in glucos

192 e findings are relevant to understanding how membrane lipids modulate other "receptor-operated" TRP c

193 Membrane lipids of marine planktonic archaea have provid

194 analysis of both the cell wall and the inner membrane lipids of Mycobacterium smegmatis.

195 h peptidoglycan, such as a hydrophobic outer membrane lipid or lipopolysaccharide.

196 n E by interference with binding to specific membrane lipids or by altering cellular structures such

197 In addition, Golgi membrane lipid order disruption byd-ceramide-C6 causes G

198 afish homologue of human AIBP, regulates the membrane lipid order in embryonic zebrafish vasculature

199 The differences seen in the membrane lipid ordering and in the distributions of the

200 effectors through Abca1-dependent changes in membrane lipid organization that disrupt the recruitment

201 ximately 28 degrees C, suggesting a role for membrane lipid packing.

202 ter-holding capability and reduced levels of membrane lipid peroxidation and electrolyte leakage unde

203 iration rate, ascorbic acid degradation, and membrane lipid peroxidation, which enhanced total phenol

204 nt changes were found in the extent of their membrane lipid peroxidation.

205 tes at 1.0% and 2.0%, possibly via modifying membrane lipid peroxidation.

206 , Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cel

207 via lateral fenestrations connecting to the membrane lipid phase, as well as via an aqueous pathway

208 bon chains following passively, still in the membrane lipid phase.

209 t2 positions the ER and Sac1, an integral ER membrane lipid phosphatase, in discrete ER-PM junctions.

210 The membrane lipid phosphatidic acid, produced by phospholip

211 osperm, even though it is synthesized on the membrane lipid phosphatidylcholine (PC) from an oleoyl e

212 ase C-beta (PLC-beta) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI

213 Here, we show that the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI

214 s non-apoptotic cell surface exposure of the membrane lipid phosphatidylserine (PS).

215 llar vesicle membranes containing the plasma membrane lipid PI(4,5)P(2).

216 uch as increases in the concentration of the membrane lipid PIP(2), or addition of physiological leve

217 r-pore coupling and pore opening require the membrane lipid PIP2 and intracellular ATP, respectively,

218 e is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD

219 also conducted with three negatively charged membrane lipids, POPG (1-palmitoyl-2-oleoyl-sn-glycero-3

220 Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway

221 id droplets (LDs) store metabolic energy and membrane lipid precursors.

222 ncept that the oxidations disrupt corneocyte membrane lipids, promoting release of free omega-hydroxy

223 its polybasic region and negatively charged membrane lipids provided by ATP8B1.

224 ic iNKT cells deficient in ABCG1 had reduced membrane lipid raft content, and showed impaired prolife

225 Membrane lipid raft disruption and inhibition of cholest

226 ncreased hippocampal expression of Cav-1 and membrane/lipid raft localization of postsynaptic density

227 Membrane lipid rafts (MLRs) within the plasma membrane o

228 The distribution of membrane lipid rafts and adhesion receptors were analyze

229 PrP(C)) resides in detergent-resistant outer membrane lipid rafts in which conversion to the pathogen

230 epatica (FhHDM-1) binds to macrophage plasma membrane lipid rafts via selective interaction with phos

231 Mutant Htt colocalized at plasma membrane lipid rafts with gp91-phox, a catalytic subunit

232 We find that apoA1 rapidly disrupts membrane lipid rafts, and as a consequence, dampens the

233 ry to altered cholesterol composition within membrane lipid rafts, and required intact function of th

234 anslocation and clustering within the plasma membrane lipid rafts, dimerization and autophosphorylati

235 ciated with a clustering of CD44 and CD24 in membrane lipid rafts, leading to the activation of Src F

236 ed cellular cholesterol and disrupted plasma membrane lipid rafts, similar to positive control methyl

237 Here we show that soluble klotho binds membrane lipid rafts.

238 Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by c

239 tudies in vitro and in vivo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrow

240 a incorporate extracellular fatty acids into membrane lipids, raising the question of whether pathoge

241 ipts encoding proteins involved in thylakoid membrane lipid recycling suggested more abrupt repartiti

242 ellular spaces of plant tissues, such as for membrane lipid recycling.

243 in the interactions of ceramides with other membrane lipids, reflecting possible functional implicat

244 cement of substrate binding, probably to the membrane lipid regions of the thylakoid.

245 Emerging evidence indicates that membrane lipids regulate protein networking by directly

246 sults provide a mechanistic understanding of membrane lipid regulation of Ca(2+) flux and therefore C

247 Membrane lipid regulation of cell function is poorly und

248 ience provides further insights into general membrane lipid remodeling-based stress tolerance mechani

249 trajectories and optogenetic manipulation of membrane lipids revealed that Rac1 membrane translocatio

250 Membrane lipids serve as second messengers and docking s

251 Both, thaumarchaeal quinones and membrane lipids showed similar distributions with maxima

252 enous acetate, with considerable turnover of membrane lipids, so that total lipid rather than TAG is

253 Analysis of the oxidized membrane lipid species and normal-chain phosphatidic aci

254 use the surrogate partition coefficients for membrane lipid, storage lipid, protein, and carbohydrate

255 Further inspection of membrane lipid structures affecting physicochemical prop

256 so reflected through its localization at the membrane, lipid substrate, and overall structure.

257 by inhibitor, recycling receptors and plasma membrane lipids, such as transferrin receptors and sphin

258 f strawberries on plasma antioxidant status, membrane lipid susceptibility to ex vivo-induced oxidati

259 its thioesterase activity proceeds to block membrane lipid synthesis by cleavage of acyl-ACP interme

260 alonyl coenzyme A (malonyl-CoA) required for membrane lipid synthesis is catalyzed by acetyl-CoA carb

261 Chloroplast membrane lipid synthesis relies on the import of glycero

262 crucial for diverting fatty acids (FAs) from membrane lipid synthesis to TAG and thereby protecting a

263 ve acyl-CoAs that can be utilized to restore membrane lipid synthesis.

264 types, consistent with the role in essential membrane lipid synthesis.

265 cate a closer connection between Bazooka and membrane lipids than previously recognized.

266 s involves its ability to protect changes in membrane lipids that are proferroptotic.

267 may be conglomerates of proteins and plasma membrane lipids that modify each other's activities for

268 conformations favor such curvature and host membrane lipids that permit horseshoe conformations are

269 ark salt gland and bilayers of the extracted membrane lipids, the D2O-ESEEM intensities of fully char

270 Besides the function as bulk membrane lipids, they often play a role under phosphate

271 agenesis and did not impair the integrity of membrane lipids, thus seemed safe to bacteria.

272 ement with their proposed role in protecting membrane lipids, TILs have been reported to be associate

273 tional interactions with BinB or microvillar membrane lipids to bind to its intracellular target and

274 reviously unappreciated route for delivering membrane lipids to lysosomes for turnover, a function th

275 ty is that dietary fats can incorporate into membrane lipids to regulate the properties and physiolog

276 ing comparable to the wild type in recycling membrane lipids to TAG but being impaired in additional

277 ipid A, a reaction catalyzed by the integral membrane lipid-to-lipid glycosyltransferase 4-amino-4-de

278 ABC) transporters ABCA1 and ABCG1, which are membrane lipid translocases.

279 class A and class B scavenger receptors, the membrane lipid transporter ABCA1, and its upstream regul

280 ic strains suggest a role for this enzyme in membrane lipid turnover and lipid homeostasis.

281 The data suggest that PDAT-mediated membrane lipid turnover and TAG synthesis is essential f

282 inovosyldiacylglycerol (SQDG), a chloroplast membrane lipid, under nitrogen-limited conditions.

283 embedded in amphipathic environments such as membranes, lipid vesicles, detergent micelles, bicelles,

284 Remodelling membrane lipids, via homeoviscous adaptation (HVA), coun

285 Acyl chain flux into membrane lipids was dominant in the first stage followed

286 In stripped roots, the level of major membrane lipids was not different between N-sufficient a

287 centrations in the target compartment (i.e., membrane lipids) was expected to but did not decrease th

288 effort to improve our understanding of these membrane lipids we examined phenotypes exhibited by the

289 By analyzing membrane lipids, we found that the selected alleles modu

290 Membrane lipids were continually synthesized with associ

291 Membrane lipids were initially postulated to be cytotoxi

292 that phospholipids, sphingolipids, and other membrane lipids were significantly altered in the ctl1 m

293 oph Pelagibacter sp. str. HTCC7211 renovates membrane lipids when phosphate starved by replacing a po

294 tty acids to replace polyunsaturated ones in membrane lipids, which are deposited in lipid bodies; an

295 Ornithine lipids (OLs) are phosphorus-free membrane lipids widespread in bacteria but absent from a

296 Membrane lipids with (2)H-labeled acyl chains or polar h

297 s that utilize aminoacylated tRNAs to modify membrane lipids with amino acids.

298 the subsequent complete extraction of inner membrane lipids with chloroform-methanol-water, revealin

299 FA and acyl chain transfer from pre-stressed membrane lipids with little input from lipid remodeling.

300 Inhibitory ligands were ubiquitous membrane lipids with polar head groups, whereas stimulat