ライフサイエンスコーパス: membrane permeability

1 s engulfed prior to changes in chromatin and membrane permeability.

2 subunits significantly reduced ATP-activated membrane permeability.

3 in the low micromolar range and significant membrane permeability.

4 ng protocell constructs with self-controlled membrane permeability.

5 ack cellular activity conceivably due to low membrane permeability.

6 and hydrocortisone-covering a wide range of membrane permeability.

7 ber 2, channels had no significant effect on membrane permeability.

8 utrient-poor conditions without compromising membrane permeability.

9 tors reported to date, and 10 shows improved membrane permeability.

10 holine, and cholesterol) was used to measure membrane permeability.

11 s membrane blebbing and decreases changes in membrane permeability.

12 nduces both membrane blebbing and changes in membrane permeability.

13 rial potential depolarization, and plasmatic membrane permeability.

14 rythrocytes, with some contribution of a low membrane permeability.

15 ell microparticles, we find a major role for membrane permeability.

16 t have trypanocidal activity due to its poor membrane permeability.

17 e with decreased fibrosis, calcification and membrane permeability.

18 were found for cell wall neutral sugars and membrane permeability.

19 oechst staining assay assess only late stage membrane permeability.

20 tides (AMPs) induce cytotoxicity by altering membrane permeability.

21 t ganglion (DRG) exposure attributed to poor membrane permeability.

22 i GC 4560 imp, a strain with increased outer membrane permeability.

23 hia coli imp mutant that has increased outer membrane permeability.

24 ell wall by OligoG CF-5/20 and its effect on membrane permeability.

25 were associated with increased mitochondrial membrane permeability.

26 AMP concentrations to the same steady-state membrane permeability.

27 itin insusceptibility, such as reduced outer membrane permeability.

28 cent dyes point to a generalized increase in membrane permeability.

29 s some Gram-negative organisms by increasing membrane permeability.

30 functions including protein trafficking and membrane permeability.

31 rane potential preceded the increase in cell membrane permeability.

32 phobic domain that is essential for altering membrane permeability.

33 membrane and that this interaction increases membrane permeability.

34 er their size, shape, surface chemistry, and membrane permeability.

35 control as a function of applied voltage and membrane permeability.

36 OS levels and the resulting increase in cell membrane permeability.

37 al levels of susceptibility to SP-A-mediated membrane permeability.

38 ally similar probes that differ in color and membrane permeability.

39 ich are metabolically unstable and have poor membrane permeability.

40 event complete pore closure and lead to high membrane permeability.

41 spectral overlaps and temperature effects on membrane permeability.

42 active oxygen species formation or lysosomal membrane permeability.

43 hibited a low T1-weighted signal, due to low membrane permeability.

44 hers and its importance in maintaining outer-membrane permeability.

45 chanical forces to transiently increase cell membrane permeability.

46 fluorescent dye, indicating that SH affects membrane permeability.

47 for cell-based studies because of their poor membrane permeability.

48 structures consistent with a pore and alters membrane permeability.

49 tramolecular hydrogen bonding with increased membrane permeability.

50 o modulate the transport of solutes with low membrane permeabilities.

51 ads and cyclic hydroxylamines with differing membrane permeabilities.

52 substituents have, in correlation with their membrane permeability, a more pronounced antiviral activ

53 erms of loss of tissue volume and/or altered membrane permeability, agreeing with both hypotheses of

54 on, and caused Bnip3-dependent mitochondrial membrane permeability, AIF translocation, and neuron dea

55 proteins; those complexes then induce plasma membrane permeability alterations in host intestinal epi

56 e is associated with increased mitochondrial membrane permeability, alterations in glutamine/glutamat

57 Loss of CtaP increased membrane permeability and acid sensitivity, and reduced

58 is required for loss of mitochondrial outer membrane permeability and apoptosis in cells treated wit

59 -methylation, and side chain size to passive membrane permeability and aqueous solubility.

60 e lipids, which in turn results in increased membrane permeability and bacterial lysis.

61 reactivity in vitro but also decreases cell-membrane permeability and biological activity, (b) the a

62 ernal hydrogen bonds is critical for passive membrane permeability and can be the distinguishing fact

63 f cells with nystatin, a drug that increases membrane permeability and causes cell shrinkage, reduced

64 At these doses, NaN3 alters mitochondrial membrane permeability and causes mitochondrial swelling

65 itochondrial blockers induced loss of plasma membrane permeability and cell death.

66 Loss of Bax/Bak reduced outer mitochondrial membrane permeability and conductance without altering i

67 Membrane permeability and consequent disruption of calci

68 led trial to investigate the effects of both membrane permeability and dialysate purity on cardiovasc

69 +) C. sakazakii/DC culture markedly enhanced membrane permeability and enterocyte apoptosis, whereas

70 ck out mutants induced disruption of surface-membrane permeability and expression of features of apop

71 ansport mechanisms, such as the interplay of membrane permeability and extrusion machinery, leading t

72 n gene mutations produce regional defects in membrane permeability and focal degeneration, and it was

73 that the HMPV SH protein could regulate both membrane permeability and fusion protein function during

74 lipids in control of the mitochondrial outer membrane permeability and hence mitochondrial respiratio

75 Active caspase-1 increased cellular membrane permeability and intracellular calcium levels,

76 ture of the cell envelope and alterations in membrane permeability and membrane potential.

77 any component processes, such as signalling, membrane permeability and metabolic activity.

78 the mechanism of toxicity may include plasma membrane permeability and mitochondrial poisoning that l

79 gical features of muscular dystrophy, muscle membrane permeability and muscle fibrosis.

80 ules in optically trapped DMPC vesicles, the membrane permeability and partitioning of the drugs coul

81 ellular calcium concentration and changes in membrane permeability and phosphatidylserine asymmetry.

82 Membrane permeability and polarization were measured usi

83 udy, we directly measure real-time change of membrane permeability and pore sizes of P. aeruginosa at

84 s, suggesting that chloramphenicol increases membrane permeability and porosity.

85 The results show that plasma membrane permeability and potential are key factors invo

86 n hybrid core structure which enhances outer membrane permeability and reduces efflux by dissipating

87 e apoptosis through control of mitochondrial membrane permeability and release of cytochrome c.

88 les, can temporarily change vascular or cell membrane permeability and release or activate various co

89 m of Bax is sufficient to increase lysosomal membrane permeability and restore autophagic cell death

90 The membrane permeability and selective uptake of the peptid

91 ysterols are known to have direct effects on membrane permeability and structure, effects that are st

92 analysing the relation between the effective membrane permeability and the applied stress, both the i

93 eases in mitochondrial superoxide levels and membrane permeability and the decrease in complex III ac

94 that AZT induces the sized transformation of membrane permeability and the disruption of the cell wal

95 chanism involves the induction of changes in membrane permeability and the intrinsic pump machinery.

96 , deletion of both genes did not change cell membrane permeability and the oxidative and heat stress

97 at the mitochondrial outer membrane controls membrane permeability and thereby the apoptotic program.

98 positively charged ceramides increased inner membrane permeability and triggered release of mitochond

99 y and the applied stress, both the intrinsic membrane permeability and UWL thickness can be determine

100 tein, VP4, is required for rotavirus-induced membrane permeability and viral entry into cells.

101 utant and demonstrated that it had increased membrane permeability and was unable to form colonies on

102 net Hg(II) accumulation by decreasing outer membrane permeability and, therefore, the passive diffus

103 gical activity may be limited by inefficient membrane permeability and/or endosomal escape.

104 The unique combination of ROS selectivity, membrane permeability, and a range of available excitati

105 clear degradation, mitochondrial disruption, membrane permeability, and caspase activation, indicatin

106 n culture supernatants, alterations in outer membrane permeability, and changes in surface ultrastruc

107 The stability, neutral charge, cell membrane permeability, and favorable relative influences

108 nteractions with targets, improving cellular membrane permeability, and increasing robustness towards

109 ease BCL2 expression, increase mitochondrial membrane permeability, and induce a caspase-dependent ap

110 Nuclear condensation, membrane permeability, and interleukin-1beta secretion w

111 wed nanomolar IC50 values for both proteins, membrane permeability, and no interference with estrogen

112 iomarkers for mitochondrial activity, plasma membrane permeability, and nuclear morphology.

113 ar morphology, flow cytometry, mitochondrial membrane permeability, and pharmacological caspase inhib

114 ides with increased conformational rigidity, membrane permeability, and protease resistance.

115 physiology and function such as cell shape, membrane permeability, and protein synthesis.

116 , extracellular calcium entry, mitochondrial membrane permeability, and release of apoptosis-inducing

117 ensitivity, antiphagocytosis activity, outer membrane permeability, and sensitivity to anionic deterg

118 Moreover, BV supply is limited by membrane permeability, and smURFPs (but not BPH FPs) can

119 to intense noise caused a rapid increase in membrane permeability, and the onset of membrane leakage

120 Changes in HeLa cell morphology, membrane permeability, and viability caused by the prese

121 e regulation of epithelial barrier function, membrane permeability, and water homeostasis in the resp

122 of various proteases, inhibition mechanisms, membrane permeability, antiviral activity, and cytotoxic

123 ve stress and altered mitochondrial and cell membrane permeability appear to be critical factors in i

124 Nontoxic nature and cell membrane permeability are key features of this probe and

125 cate a p38-dependent change in mitochondrial membrane permeability as a downstream effector of apopto

126 ells with tachyplesin and serum increased in membrane permeability as indicated by the ability of FIT

127 In holin-induced cells, membrane permeability as measured using propidium iodide

128 ndrial membranes, followed by an increase in membrane permeability, as an intermediate step in cerami

129 d experimentally using a parallel artificial membrane permeability assay (PAMPA) and showed a linear

130 ) were studied using the parallel artificial membrane permeability assay (PAMPA) at pH 6.5.

131 eability was assessed by parallel artificial membrane permeability assay and Caco-2 assay.

132 stereoisomers using the parallel artificial membrane permeability assay and looked at differences in

133 as well as a customized parallel artificial membrane permeability assay indicated good skin permeati

134 urements determined by a parallel artificial membrane permeability assay was drawn.

135 However, through a combination of membrane permeability assays and imaging techniques we f

136 Artificial and cell-based membrane permeability assays provided evidence that the

137 , a rhodamine 123 retention assay, lysosomal membrane permeability assessment, and DCF (2',7'-dichlor

138 there is a significant change in spore inner membrane permeability at commitment.

139 yclic peptides displayed a steep drop-off in membrane permeability at molecular weights above 1000 Da

140 potential utility due to its exceedingly low membrane permeability at physiological pH.

141 of sized transformation of the cell wall and membrane permeability at the nanometer scale.

142 and phagocytosis; perturbation to the outer membrane permeability barrier and hypersensitivity to bi

143 mportant roles in the integrity of the outer-membrane permeability barrier and participate extensivel

144 early 1990s, it became clear that the outer membrane permeability barrier and the activity of peripl

145 deliver antibacterial cargo across the outer membrane permeability barrier of Gram-negative pathogens

146 als the contribution of the formidable outer-membrane permeability barrier that reduces the compounds

147 a means to overcome the Gram-negative outer membrane permeability barrier.

148 causing a profound defect in the cytoplasmic membrane permeability barrier.

149 ations to study the effect of cholesterol on membrane permeability, because cholesterol is abundant i

150 trogen atom at physiological pH to allow for membrane permeability, but which can become protonated w

151 Aldosterone acts to increase apical membrane permeability by activation of epithelial Na(+)

152 and causes an order-of-magnitude increase in membrane permeability by facilitating the formation of l

153 hile archaeal organisms overcome problems of membrane permeability by producing lipids with structura

154 cillation physics and the resulting cellular membrane permeability by simultaneous microscopy of thes

155 tely 200-kDa complexes coincides with plasma membrane permeability changes in eukaryotic cells, causi

156 s biotransformation (sulfamethoxazole), poor membrane permeability (cimetidine, colchicine) and also

157 e fitted to a membrane kinetic model to find membrane permeability coefficients of short-chain alcoho

158 of LIGA 20 was correlated with its enhanced membrane permeability (compared with GM1), as seen in th

159 While membrane permeability could also be induced by cationic

160 deletion of pe19, suggesting that increased membrane permeability due to PE19 overexpression sensiti

161 ease of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechan

162 asmodium falciparum increases red blood cell membrane permeability during infection to allow for impo

163 Owing to changes in membrane permeability, early apoptotic cells show an inc

164 gent alpha-hemolysin, we have controlled the membrane permeability, enabling targeted delivery of the

165 Stress sensors monitor outer membrane permeability, envelope protein folding, and ene

166 oid oligomers and protofibrils increase cell membrane permeability, eventually leading to cell death.

167 ol element also contributes to the increased membrane permeability exhibited by multicomponent-derive

168 ly amplifying advantage to proton pumping as membrane permeability falls, for the first time favoring

169 tive heteromeric hemichannels increases cell membrane permeability, favoring ATP release and Ca(2+) o

170 an cell membranes and is required for proper membrane permeability, fluidity, organelle identity, and

171 eated with the chemokine developed increased membrane permeability followed by apoptosis via activati

172 ocalize at the mitochondria, where it alters membrane permeability following genotoxic stress.

173 ith mitochondrial tubular assembly and outer membrane permeability for adenine nucleotides leading to

174 destroy diseased cells and/or increase cell membrane permeability for drug delivery.

175 Based on a simulation model, the membrane permeability for ferrocyanide molecules passing

176 sonoporation that transiently increases cell membrane permeability for localized delivery of DNA.

177 In particular, insufficient membrane permeability frequently limits the accumulation

178 together with additional measurements on CO2 membrane permeability from Fragilariopsis cylindrus labo

179 The ion channel-like protofibrils and their membrane permeability have also been found in other amyl

180 nd stereoselective mechanism of action, high membrane permeability, high brain penetration evaluated

181 eus, and group B streptococcus by increasing membrane permeability; however, SP-B also lysed RBC, ind

182 AMPs induce membrane permeability in E. coli spheroplasts or giant u

183 ing showed that Vp1659 is required to induce membrane permeability in HeLa cells.

184 Connexons regulate membrane permeability in individual cells or couple betw

185 he sphingosine salvage pathway in regulating membrane permeability in the execution phase of programm

186 oton or ion channels, and in general enhance membrane permeability in the host.

187 electron transport complexes I and III, and membrane permeability in the isolated mitochondria prepa

188 is, diffusion of the NO to the membrane) and membrane permeability, in addition to intracellular diff

189 These observations suggest that the inner membrane permeability increase is due to activation of s

190 Field exposure is associated with a membrane permeability increase usually ascribed to elect

191 age must undergo late reversal, requiring a membrane permeability increase with net NaCl gain exceed

192 Yet, mitochondrial size and membrane permeability increased significantly during, bu

193 ayed both Ca(2+) deregulation and the plasma membrane permeability increases, indicating that Zn(2+)

194 lopascals, beyond which endothelial cellular membrane permeability increases.

195 rons underwent a terminal increase in plasma membrane permeability, indicated by loss of AlexaFluor-4

196 Indeed the steady-state membrane permeability induced by AMPs is quantitatively

197 The addition of TAM enhances membrane permeability, inducing calcein to translocate f

198 Once formed, membrane permeability (integrity) was unaffected by mine

199 In addition, reduced membrane permeability is a leading cause of antibiotic r

200 potoxicity, we show that outer mitochondrial membrane permeability is altered and identified a posttr

201 equent temporal propagation of mitochondrial membrane permeability is calcium-dependent.

202 Control of membrane permeability is especially important for proces

203 The altered membrane permeability is reversible, and the cells under

204 structural basis for cholesterol effects on membrane permeability is still unclear.

205 olvent, a cryoprotectant, and an enhancer of membrane permeability, leading to the general assumption

206 from lysosomes, an event known as lysosomal membrane permeability (LMP).

207 P-C bond of methylphosphonates with the high membrane permeability, low toxicity, and improved gene s

208 enon can cause significant underestimates in membrane permeability measurements which in turn limits

209 luence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacok

210 transduced with MBP-1 displayed early plasma membrane permeability, mitochondrial damage without cyto

211 t-binding proteins of SP-A+/+ mice increased membrane permeability more than those from SP-A-/- mice

212 ebbing of the outer membrane and increase in membrane permeability occurred in association with the c

213 The passive membrane permeabilities of 11 cyclic peptides were obtai

214 icantly improved the metabolic stability and membrane permeability of 2 while retaining mu-opioid rec

215 Thus, the membrane permeability of 8-pCPT-2'-O-Me-cAMP in insulin-

216 an atomistic physical model for the passive membrane permeability of cyclic peptides.

217 transport machinery to overcome the reduced membrane permeability of diacyl lipid membranes.

218 as also important for the 'selective' plasma membrane permeability of early apoptotic cells to specif

219 The high membrane permeability of H2S was studied using polarizab

220 Shigella caused a rapid increase in the cell membrane permeability of infected human monocyte-derived

221 as found that the peptide increased the cell membrane permeability of M. arachidicola, S. cerevisiae

222 luate experimentally and computationally the membrane permeability of matched sets of peptidic small

223 rived macrophages (HMDM) but not in the cell membrane permeability of monocytes, as demonstrated by t

224 orms of cell death through direct effects on membrane permeability of multiple intracellular organell

225 rmaldehyde in addition to markedly augmented membrane permeability of oocytes.

226 yses revealed that AA1 binding increases the membrane permeability of POPC/POPG liposomes, which mimi

227 of the possible avenues to overcome the poor membrane permeability of PTP1B inhibitors.

228 , adherent cells to increase transiently the membrane permeability of the cell.

229 nt necrotic cell death by facilitating outer membrane permeability of the MPTP.

230 tically driven water influx, we find the H2O membrane permeability of the rod OS to be (2.6 +/- 0.4)

231 the high abundance of CSQ in SR and the high membrane permeability of those drugs led us to the speci

232 The K(+)-uptake ability (membrane permeability) of the sos mutant root cells meas

233 on the physical properties, particularly the membrane permeability, of the radical precursors.

234 ids give rise to a bell-shaped dependence of membrane permeability on [Chol] for very hydrophobic sol

235 l cycle arrest was not due to increased cell membrane permeability or DNA damage.

236 t initiated by increased outer mitochondrial membrane permeability or translocation of apoptosis-indu

237 tly, the Caco-2 assay also revealed improved membrane permeability over previous compounds.

238 tauri, we examined the relationship between membrane permeability, oxidative stress and chlorophyll

239 port barriers by analyzing the effect of RBC membrane permeability (P(m)), hematocrit (Hct) and NO-Hb

240 orm apoptotic pores, but still enhance outer membrane permeability, permitted MPTP-dependent mitochon

241 d in lysosomes where its depletion increased membrane permeability, pH, cathepsin release, and cellul

242 of p53, leading to changes in mitochondrial membrane permeability pore transition (MPT) and conseque

243 part desirable properties such as acceptable membrane permeability, potent whole blood activity, and

244 g the IncuCyte ZOOM imaging platform and the membrane-permeability properties of two DNA dyes.

245 cus may be attributed to the changes in cell membrane permeability, protein synthesis activity, and a

246 ets mycobacterial membranes and that reduced membrane permeability provides mycobacteria intrinsic re

247 Their many advantages include membrane permeability, relatively small size, stoichiome

248 Two analogs with improved membrane permeability showed much increased DRG concentr

249 id forms of cathelicidin and correlated with membrane permeability, suggesting that highly structure-

250 the TP0453 polypeptide was found to increase membrane permeability, suggesting the molecule functions

251 ximately 20%, and it increased mitochondrial membrane permeability (swelling) by more than twofold; h

252 s reported by others to show increased outer membrane permeability, temperature-sensitive growth, and

253 and MexXY efflux systems) expression, outer-membrane permeability (tested with 1-N-phenylnaphthylami

254 Membrane permeability tests suggested that the baicalein

255 The results yield membrane permeabilities that are in semiquantitative agr

256 s to establish a theoretical formula for the membrane permeability that is controlled by free ion dif

257 polycationic peptide protamine, to yield the membrane permeability that is lower than the correspondi

258 that M. smegmatis lacking MmpL11 has reduced membrane permeability that results in resistance to host

259 asis it was hypothesized that differences in membrane permeability to aldopentoses provide a mechanis

260 the ability of any compound with significant membrane permeability to be applied intracellularly by w

261 tion field to be directly observed, allowing membrane permeability to be determined easily from the t

262 The increased membrane permeability to Ca2+ cannot be attributed to ac

263 Furthermore, the outer membrane permeability to cephalothin and cephaloridine,

264 ocesses when we change the width of the EUF, membrane permeability to CO(2), native extra- and intrac

265 inhibitors still suffered from too low cell membrane permeability to enter into CNS drug development

266 cretion of ATP that within minutes increases membrane permeability to ethidium (Etd(+)) and Ca(2+) by

267 in tobacco, resulting in tissue collapse and membrane permeability to Evans blue.

268 f proteins termed viroporins, which modulate membrane permeability to facilitate critical steps in a

269 sp null strain and the extent of cytoplasmic membrane permeability to large molecules.

270 viduals in these families had an increase in membrane permeability to Na and K that is particularly m

271 Basolateral membrane permeability to NH(3) was reduced in CDs from R

272 The switch in membrane permeability to OH(-)/HCO(3)(-) can also be rec

273 Pharmacological treatment that alters cell membrane permeability to potassium affected the maintena

274 idylserine exposure, caspase activation, and membrane permeability to propidium iodide in the absence

275 e fusion is accompanied by strongly enhanced membrane permeability to small molecules and a measurabl

276 The high membrane permeability to small monovalent ions is determ

277 Leakage can be predicted by relating membrane permeability to the fraction of peptide translo

278 nd behavioral effects ranging from increased membrane permeability to toxicity, microinjection of DMS

279 tochondrial changes leading to mitochondrial membrane permeability transition and AIF release.

280 member (PP2Cm) that regulates mitochondrial membrane permeability transition pore (MPTP) opening and

281 Inhibition of mitochondrial membrane permeability transition pore opening or caspase

282 and earlier formation of the calcium-induced membrane permeability transition pore.

283 tochrome c in the absence of a mitochondrial membrane permeability transition.

284 fold less lactate dehydrogenase (a marker of membrane permeability) upon infection by invasive S. ent

285 carotenoids, and reactive oxygen species and membrane permeability using fluorescent probes (CM-H2 DC

286 lls preloaded with calcium green (CaGr), and membrane permeability, using FM1-43 dye.

287 Outer-membrane permeability was 3-4.5 times higher in RPMI 164

288 In vitro membrane permeability was assessed by parallel artificia

289 The change in membrane permeability was directly associated with the f

290 A role for cathepsins and lysosomal membrane permeability was excluded.

291 No change in membrane permeability was found at concentrations of 0.1

292 ux of auxin mediated by AUX1, expressed as a membrane permeability, was 1.5 +/- 0.3 mum s(-1) .

293 To understand the reason for the membrane permeability, we investigated the physical prop

294 Because MTX has profound effects on plasma membrane permeability, we used time-lapse videography to

295 ctivities, anti-fIIa activity and artificial membrane permeability were considerably improved by opti

296 analogues exhibiting improved solubility and membrane permeability were shown to have notably enhance

297 amino acid phenylalanine produces increased membrane permeability, which is likely responsible for s

298 proved salt rejection without scarifying the membrane permeability, which provides a new dimension fo

299 ons of new analogues aimed at improving cell membrane permeability while maintaining high in vitro po

300 or-donor pairs in such molecules can improve membrane permeability while retaining or improving other