ライフサイエンスコーパス: membrane protein

1 ogical ligand, podoplanin, being an integral membrane protein.

2 that was previously reported to be an outer membrane protein.

3 tudy indicated that it is an integral plasma membrane protein.

4 succinate dehydrogenase complex, an integral membrane protein.

5 ropy, nor does the nature or function of the membrane protein.

6 instructive role in the turnover of synaptic membrane proteins.

7 , a broad-spectrum modulator for a number of membrane proteins.

8 strong determining factor in the function of membrane proteins.

9 in studies of the structure and function of membrane proteins.

10 sensory proteins, including GPCRs and other membrane proteins.

11 ids, particularly in their interactions with membrane proteins.

12 was used to succinylate liver mitochondrial membrane proteins.

13 ed for the insertion of mitochondria-encoded membrane proteins.

14 indispensable experimental tool for studying membrane proteins.

15 be exploited for solid-state NMR studies on membrane proteins.

16 the localization and function of peripheral membrane proteins.

17 e can modulate the structure and function of membrane proteins.

18 nism governing the assembly of dual targeted membrane proteins.

19 hanistic studies in the proteolysis of outer membrane proteins.

20 y-control center for mutant and/or malformed membrane proteins.

21 ance of structural and functional studies of membrane proteins.

22 accessible and lipid accessible residues in membrane proteins.

23 hemagglutinin (HA), NA, and M2, are integral membrane proteins.

24 of pure or mixed detergents in complex with membrane proteins.

25 understand cholesterol-dependent function of membrane proteins.

26 d by colocalization with lysosome-associated membrane protein 1 (LAMP1)-positive and LysoTracker-posi

27 f enlarged perinuclear, lysosomal-associated membrane protein 1 (LAMP1)-positive organelles.

28 stroglycan (alphaDG) and lysosome-associated membrane protein 1 (LAMP1).

29 BNA2 (which hijacks Notch signaling), latent membrane protein 1 (LMP1) (which mimics CD40 signaling),

30 The EBV oncoprotein latent membrane protein 1 (LMP1) functions to constitutively ac

31 Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV)

32 EBV latent membrane protein 1 (LMP1) is required for the efficient

33 vidence that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation

34 n AgRP neurons to prevent vesicle-associated membrane protein 2-dependent vesicle fusion.

35 pression of the oncogenic protein epithelial membrane protein-2 (EMP2) correlates with endometrial ca

36 During latent infection, EBV encodes latent membrane protein 2A (LMP2A) to promote the survival of B

37 SNARE) called cellubrevin/vesicle-associated membrane protein-3 (VAMP-3) in platelet function.

38 The alphavirus small membrane proteins 6K and TF have been reported to be pal

39 Here, we demonstrate that A. marginale outer membrane protein A (AmOmpA; AM854) contributes to the in

40 Outer membrane protein A (OmpA) is a porin involved in Acineto

41 An anti-outer membrane protein A (OmpA) polyclonal antibody previously

42 VAPA and VAPB) interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (A

43 Here, we identify the PO membrane protein acyl-coenzyme A-binding domain protein

44 determine the structural properties of these membrane proteins after isolation in nanoscale vesicles

45 asites, which lack a parasitophorous vacuole membrane protein and arrest during liver-stage developme

46 Its application to a membrane protein and to myoglobin show that the approach

47 Claudins are a family of integral membrane proteins and are components of tight junctions

48 g traditional methods-to concentrate certain membrane proteins and complexes to values suitable for i

49 ch represent the largest class of both human membrane proteins and drug targets-depends critically on

50 ved effective at both stabilizing a range of membrane proteins and extracting proteins from the membr

51 lesterol, detergents, peptides, and integral membrane proteins and formation of lipid rafts.

52 y to Eugene Kennedy's laboratory, where both membrane proteins and phospholipids were the foci of stu

53 l-surface macromolecules (likely to be outer membrane proteins and pili) which, upon contacting the m

54 t the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK l

55 alent cations, and can be used to solubilize membrane proteins and produce nanodiscs of controlled si

56 resolves the dissociation of detergents from membrane proteins and protein unfolding.

57 We developed a DBS method to enrich for membrane proteins and remove soluble proteins and matrix

58 of capturing transient interactions between membrane proteins and their lipid environment, and a det

59 ibed here exploits the amphiphilic nature of membrane proteins and their natural tendency to partitio

60 represents a novel approach to the study of membrane proteins and, through the use of selective deut

61 enes encoding extracellular matrix, basement membrane proteins, and members of ERK, FGF and PDGF sign

62 uble, peripheral, and integral mitochondrial membrane proteins, and the assignment of 818 proteins in

63 M (Lap2-Emerin-Man1) family of inner nuclear membrane proteins, and the ESCRT-II/ESCRT-III hybrid pro

64 Signals from two different membrane proteins are combined to modulate how strongly

65 Following a wash in a series of buffers, the membrane proteins are digested with trypsin and quantita

66 Membrane proteins are distinguished from soluble protein

67 Many membrane proteins are known to form higher-order oligome

68 Integral membrane proteins are studied with a number of structura

69 Membrane proteins are targets of most available pharmace

70 Membrane proteins are underrepresented in structural dat

71 Finally, we use the purified membrane protein as an antigen to discover native confor

72 Using plate-bound cell membrane proteins as targets, we detected a significantl

73 smonics, light harvesting, model systems for membrane protein assemblies, or analytical devices.

74 in TamA: a structural element implicated in membrane protein assembly.

75 r the resident ER protein vesicle-associated membrane protein-associated protein B (VAPB).

76 Reconstitution of membrane-protein binding in a liposome assay shows that

77 ocon component advances our understanding of membrane protein biogenesis and sheds light on the role

78 undamental understanding of lipid synthesis, membrane protein biosynthesis, phospholipid and membrane

79 by autoantibodies directed against basement membrane protein BP180.

80 backgrounds that allow greater expression of membrane proteins but that differ in efficacy across pro

81 e also show that quality control of integral membrane proteins by ribosome-associated complex-stress-

82 Multispanning ER membrane proteins, called ERAD-M substrates, are retrotr

83 ed in vitro system that phosphorylation of a membrane protein can trigger a change in topological arr

84 l-SELEX, real-time modification of live-cell membrane proteins can be achieved in one step without an

85 Ubiquitinated plasma membrane proteins (cargo) are delivered to endosomes and

86 functional amyloid requires a bespoke outer-membrane protein channel through which unfolded amyloid

87 technologies, even completely detergent-free membrane protein characterization protocols can be desig

88 nclude that the data identify a hierarchy in membrane protein clustering likely being a paradigm for

89 asmic reticulum (ER), where the conserved ER membrane protein complex (EMC) was shown to be essential

90 ediated by a highly conserved heterotrimeric membrane protein complex denoted Sec61 in eukaryotes and

91 tide transhydrogenase (PntAB) is an integral membrane protein complex participating in the regulation

92 creted protein, EMC10 (endoplasmic reticulum membrane protein complex subunit 10), showing activity i

93 aC, ferries lipids between MlaD and an outer membrane protein complex.

94 matrix proteins, the cytoskeleton, or other membrane protein complexes.

95 etergent molecules) of detergent-solubilized membrane protein complexes.

96 er transient protein-protein interactions in membrane protein complexes.

97 extracts ubiquitylated client proteins from membranes, protein complexes, or chromatin and has an es

98 critical for main-tenance of optimal plasma membrane protein composition.

99 ge mass spectrometry (HDX-MS) to investigate membrane protein conformational dynamics within native l

100 f the native lipid composition in modulating membrane protein conformational dynamics.

101 therefore, an ideal test case for exploring membrane protein coupling.

102 in-protein contacts and triggering/promoting membrane protein crystallization, and to visualize the d

103 d biomedical applications, including in meso membrane protein crystallization, as drug and medical co

104 is an adaptor protein that connects the two membrane proteins CusA (inner membrane) and CusC (outer

105 research, as it can be applied to different membrane protein-cytoplasmic protein pairs.

106 f the sorting machinery required for vacuole membrane protein degradation.

107 ought exocyst receptor required for targeted membrane-protein delivery.

108 Both structure and function of membrane proteins depend on the magnitudes of side-chain

109 ncreasing concentration gradient of the free membrane proteins develops between the opposing surfaces

110 ing this line, we show here that crystals of membrane proteins display systematically higher diffract

111 It was observed that membrane proteins distributed among different solvents,

112 ional folding of two bacterial alpha-helical membrane proteins, DsbB and GlpG.

113 d turnover of a subset of endocytosed plasma membrane proteins due to deficient sorting into a retrom

114 important in the further development of new membrane protein electrochemical sensors and enzyme elec

115 A comparison with other peripheral membrane proteins elucidates common and specific feature

116 The connexin family of membrane proteins enable gap junction formation and home

117 ified myomaker (Tmem8c) as a muscle-specific membrane protein essential for fusion.

118 ce, we show that myomaker, a muscle specific membrane protein essential for myoblast fusion, is activ

119 It is also believed that CPR is an integral membrane protein exclusively.

120 d, protease-activated receptor 1 (PAR1) is a membrane protein expressed in astrocytes.

121 hia coli mutants that demonstrated increased membrane protein expression relative to that in wild typ

122 em for study of wild-type and variant PIEZO1 membrane protein expression, trafficking, and electrophy

123 sess genome-wide impact of gene deletions on membrane protein expression.

124 This heterogeneity does not allow a total membrane protein extraction by a unique method or even c

125 The process by which membrane proteins fold involves the burial of side chain

126 ems, one of the main technical challenges of membrane protein folding studies.

127 dhesion, conjugation, sporulation, and outer membrane protein folding.

128 t sorting mechanisms target aggregated Golgi membrane proteins for lysosomal degradation.

129 operon partner ToxS, a periplasmic integral membrane protein, for full activity.

130 Membrane proteins frequently assemble into higher order

131 Ac, Cry2Aa and Cry1Ca to midgut brush border membrane proteins from BPH and PWS.

132 bacterium Rubrivivax gelatinosus Analyses of membrane proteins from different mutants revealed the pr

133 Membrane proteins fully embedded within the membrane dis

134 Membrane protein function can be affected by the physica

135 Integral membrane protein function can be modulated by the host b

136 tunities for applications built upon diverse membrane protein functions, or involved with drug target

137 The HSV membrane proteins gE/gI and US9 initiate the process of

138 Biophysical investigation of membrane proteins generally requires their extraction fr

139 o unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor comp

140 cholesterol with M2, as with most eukaryotic membrane proteins, has long been elusive.

141 Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology.

142 An important subset of membrane proteins have globular, cofactor-containing ext

143 ts to the human proteome reveals that plasma membrane proteins have higher raft affinity than those o

144 ber of high-resolution structural studies of membrane proteins have successfully manifested an in-dep

145 we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in ana

146 ecent studies have implicated the peripheral membrane protein HID-1 in neuropeptide sorting and insul

147 e lipid bilayer influence their neighbouring membrane proteins, however it is unknown whether differe

148 Mitofusin 2 (Mfn2), a membrane protein implicated in ER-mitochondria tethering

149 Astrotactins are vertebrate-specific membrane proteins implicated in neuron-glia interactions

150 o this belief, CPR can exist as a peripheral membrane protein in the absence of NADPH and will transi

151 previously shown that Myrf is generated as a membrane protein in the endoplasmic reticulum (ER), and

152 of NADPH and will transition to an integral membrane protein in the presence of stoichiometric amoun

153 rs to determine the oligomerization state of membrane proteins in a static quenching FRET experiment:

154 ntify a new route for the targeting of inner membrane proteins in bacteria and highlight the diversit

155 The role of membrane proteins in cellular mechanism strongly depends

156 owever, pathways that target and concentrate membrane proteins in cilia are not well understood.

157 The heterologous overexpression of integral membrane proteins in Escherichia coli often yields insuf

158 rmination and positioning of isotope-labeled membrane proteins in nanodiscs using nuclear Overhauser

159 gene turnover and faster evolution of trans-membrane proteins in NK cells compared with other immune

160 confirmed the higher gene turnover of trans-membrane proteins in NK cells compared with T cells in f

161 The abundance of integral membrane proteins in the plasma membrane is determined b

162 oligomeric state characterization of various membrane proteins including ion channels, transporters a

163 brane channels known to date are beta-barrel membrane proteins, including the abundant voltage-depend

164 third of ARMMs-enriched proteins are plasma membrane proteins, including the NOTCH2 receptor.

165 minantly tubular carriers shared with plasma membrane proteins, independently of signal-adaptor inter

166 ly factor that belongs to the Oxa1 family of membrane protein insertases.

167 produces experimentally observed features of membrane protein integration, including the efficiency w

168 theoretical model for membrane mechanics and membrane protein interaction, we have systematically inv

169 ytical method is broadly applicable to study membrane protein interactions in the intact plasma membr

170 ational changes, lipid membrane fabrication, membrane-protein interactions, exosome and virus detecti

171 complex assembles a great diversity of outer membrane proteins into a membrane without an obvious ene

172 Cotranslational insertion of membrane proteins into defined nanoparticle membranes ha

173 logous to processes that cluster soluble and membrane proteins into phase-separated droplets.

174 ale lipid bilayer environment for delivering membrane proteins into the gas phase.

175 ytoplasmic membrane or insertion of integral membrane proteins into the phospholipid bilayer.

176 be adapted to direct the insertion of other membrane proteins into vesicles.

177 structure of the p7 viroporin, an oligomeric membrane protein ion channel involved in the assembly an

178 Notably, clustered patterning of membrane proteins is a commonly conserved feature across

179 ium is the site where a subset of the cell's membrane proteins is enriched.

180 owever, achievement of the overexpression of membrane proteins is not necessarily straightforward, an

181 We hypothesized that for any membrane protein, it may be possible to identify a modif

182 The lysosome-associated membrane protein (LAMP) family includes the dendritic ce

183 export from LEs, and the lysosome-associated membrane proteins (LAMP) 1 and 2 are important for robus

184 The mycobacterial membrane protein large (MmpL) proteins are cell wall lip

185 Mycobacterial membrane protein Large 3 (MmpL3), an essential inner mem

186 on water-soluble proteins, however, leaving membrane proteins largely wandering in the wilderness.

187 No significant difference in the membrane proteins levels Pdr5p and Can1p was found.

188 For membrane proteins, lipids are incorporated into the surr

189 nternalization kinetics, and we identify the membrane protein LMBRD2 as a potential regulator of beta

190 The membrane protein melittin's interaction with the DDA ind

191 The outer mitochondrial membrane protein mitochondrial Rho GTPase 1 (Miro1) is a

192 A range of membrane protein modeling tools has been developed in th

193 plemented RosettaMP, a general framework for membrane protein modeling.

194 Integral membrane proteins (MPs) are key engineering targets due

195 e-mimetic system for solution NMR studies of membrane proteins (MPs) under close-to-native conditions

196 erent proteins, including the three integral membrane proteins Mps3, Ndc1, and Mps2.

197 on through modulation of the expression of a membrane protein, Mr-OPY2.

198 le protein serum albumin and to the integral membrane protein NapA shows that soluble proteins acquir

199 ive biophysical and topological diversity of membrane proteins necessitates multiple insertion pathwa

200 port pathway regulated by the late endosomal membrane protein Niemann-Pick disease type C protein 1 (

201 three peptides AHC (ApoB100, HSP60 and outer membrane protein of chlamydia pneumonia) in stabilizing

202 ents showed that I2 colocalized with a major membrane protein of immature and mature virions.

203 N gene of B. multivorans encodes an integral membrane protein of the HpnN family of transporters, whi

204 icable to both alpha-helical and beta-barrel membrane proteins of diverse architectures with or witho

205 Expression of membrane proteins often leads to growth inhibition and p

206 ides excellent synergies for the analysis of membrane protein oligomerization within defined membrane

207 ly identified the Borrelia burgdorferi outer membrane protein (OMP) BB0406 and found that the gene en

208 Typhimurium porins including outer membrane protein OmpD, which induce both IgG1 and IgG2a

209 immunizations with antisera targeting outer membrane proteins (OMPs) have shown encouraging results

210 The biogenesis of outer-membrane proteins (OMPs) in gram-negative bacteria invol

211 ible for the biogenesis of beta-barrel outer membrane proteins (OMPs) in Gram-negative bacteria.

212 In the case of outer-membrane proteins (OMPs), unfolded-state properties are

213 nges associated with the characterization of membrane proteins, only a few have known biological func

214 dies will potentially accelerate research in membrane proteins pertaining to their extraction, solubi

215 tiation by engaging the poorly characterized membrane protein PGRMC2.

216 R) in the heart and interacts with the small membrane protein phospholamban (PLN), inhibiting the car

217 These membrane proteins play an essential role in the insertio

218 ntitative mass spectrometry of SIRT5-treated membrane proteins pointed to the electron transport chai

219 OmpA is an outer membrane protein present in the R. rickettsia, the etiol

220 Here, we identify the inner mitochondrial membrane protein, prohibitin 2 (PHB2), as a crucial mito

221 ins, however it is unknown whether different membrane protein properties have the same dependence on

222 terminus regulating trafficking to the cell membrane, protein-protein interactions, and post-transla

223 terial ATP-binding cassette transporter as a membrane protein prototype, we show that the protein can

224 including nanodiscs and liposomes containing membrane protein receptors.

225 find application in situations that require membrane protein reconstitution in a lipid bilayer at hi

226 microcrystalline states, its applications to membrane proteins remain limited.

227 and PEX6 ATPases and the PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the per

228 by Mymk (Tmem8c), is a well-conserved plasma membrane protein required for myoblast fusion to form mu

229 that we introduce can have broad utility in membrane protein research, as it can be applied to diffe

230 indicate that these agents have potential in membrane protein research.

231 ipid vesicles and monitor in real time how a membrane protein responds to structural changes in the m

232 mitter:sodium symporters (NSSs) are integral membrane proteins responsible for the sodium-dependent r

233 ommon assumption (derived from the fact that membrane proteins retain activity in detergent extracts)

234 The membrane protein RFT1 is essential for normal protein N-

235 atic responses induced by the early region 3 membrane protein RIDalpha via its direct interaction wit

236 s of individual proteins, protein complexes, membrane proteins, RNA and DNA, using a variety of enhan

237 lly recognizes the nascent chain of an inner membrane protein, RodZ, with high affinity and specifici

238 proteins have emerged as a powerful tool for membrane protein solubilization and analysis.

239 erior to detergent micelles or liposomes for membrane protein solubilization.

240 However, many eukaryotic membrane proteins solubilized in conventional detergents

241 striction in mouse erythroblasts, nor at the membrane protein-sorting boundary in human erythroblasts

242 proteins play important roles in regulating membrane protein structure and function.

243 High-resolution membrane protein structures are essential for understand

244 rast to the typical type I packing seen from membrane protein structures crystallized in LCP.

245 Most membrane proteins studies require the use of detergents,

246 Membrane proteins, such as ion channels, interact dynami

247 urrence of Ser or Thr based helical kinks in membrane proteins suggests that a similar mechanism coul

248 ikingly, we also find that the inner nuclear membrane protein Sun1 antagonizes Sun2 LINC complexes an

249 INC complexes that contain the inner nuclear membrane protein Sun2 promote focal adhesion assembly by

250 ents and mass spectrometry, we identified 43 membrane proteins targeted by these antibodies.

251 ystallization to a broader range of integral membrane protein targets, the cubicon method should find

252 es with the concerted action of mostly three membrane proteins: TatA, TatB, and TatC.

253 mutations in Nramp1 (SLC11A1), a phagosomal membrane protein that controls iron export from vacuoles

254 Scap is a polytopic membrane protein that functions as a molecular machine t

255 F) is highly conserved and is the only viral membrane protein that is essential for infection.

256 21 (IgSF21) as a neurexin2alpha-interacting membrane protein that selectively induces inhibitory pre

257 a down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi tra

258 ATP synthase is a rotating membrane protein that synthesizes ATP through proton-pum

259 transmitter:sodium symporter (NSS) family of membrane proteins that are responsible for reuptake of n

260 ) are a poorly understood family of integral membrane proteins that can function in iron homeostasis

261 1 and Boi2 (Boi1/2) are budding yeast plasma membrane proteins that function in polarized growth, and

262 Insig-2 is one of two endoplasmic reticulum membrane proteins that inhibit cholesterol synthesis by

263 ignaling is in part achieved by secreted and membrane proteins that negatively control activity of th

264 s of receptor-associated and resident plasma membrane proteins that were not readily observed in the

265 he use of mixed belt nanodiscs with embedded membrane proteins to confirm the dissociation of MSP pri

266 Targeting of most integral membrane proteins to the endoplasmic reticulum is contro

267 ination, a modification well known to target membrane proteins to the lysosome or vacuole for degrada

268 and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determ

269 Membrane protein topology and folding are governed by st

270 The results provide further evidence that membrane protein topology is dynamic, integrating for th

271 ion, indicating an unforeseen selectivity of membrane proteins toward the chemistry of lipid tails.

272 along which newly synthesized secretory and membrane proteins traffic through the cell was revealed

273 brane protein biosynthesis, phospholipid and membrane protein trafficking, and the cellular roles of

274 perform quality control of both soluble and membrane proteins transiting the NPC.

275 Correctly folded membrane proteins underlie a plethora of cellular proces

276 ) alone or include the ZENV precursor to the membrane protein upstream of the envelope protein, and o

277 T/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site

278 acinar cells express two vesicle-associated membrane proteins (VAMP), VAMP2 and -8, each controlling

279 The endoplasmic reticulum (ER) integral membrane protein VAP is a common component of MCS involv

280 Cytochrome b 5 (cytb 5) is a membrane protein vital for the regulation of cytochrome

281 aling, and interactions of vIL-6 with the ER membrane protein vitamin K epoxide reductase complex sub

282 duction and interaction of vIL-6 with the ER membrane protein VKORC1v2.

283 the Rosetta biomolecular modeling suite for membrane proteins, we recently implemented RosettaMP, a

284 before releasing efferent molecules, vacuole membrane proteins were purified and binding to the surfa

285 By day 28, basement membrane proteins were reduced in drug-eluting stents in

286 er of the FRD superfamily of heme-containing membrane proteins, which include the NADPH oxidase prote

287 ients in the viral Envelope and pre-Membrane/Membrane proteins, which together form the virion surfac

288 ource of the need for a specific handling of membrane proteins, which transpired in the creation of n

289 24 is an endoplasmic reticulum (ER)-anchored membrane protein whose reversible localization to ER-pla

290 Aquaporins (AQPs) are integral membrane proteins whose function is to regulate intracel

291 the ubiquitin ligase Hrd1, a multi-spanning membrane protein with a cytosolic RING finger domain.

292 is Pigmentosa Type 2-Clathrin Light Chain, a membrane protein with a novel domain architecture.

293 uires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporter

294 tein-ligand interactions of integral bitopic membrane proteins with a single membrane-spanning helix

295 n the conformational dynamics of near-native membrane proteins with disease relevance remains unknown

296 ional integration and for the engineering of membrane proteins with enhanced membrane integration eff

297 ays fail to effectively engage tail-anchored membrane proteins with moderately hydrophobic transmembr

298 s of various sizes for structural studies of membrane proteins with solution-state NMR spectroscopy.

299 nd oligomer assembly and its connection with membrane proteins within the intercalated disc.

300 nce, distribution and repertoire of integral membrane proteins within their immense, architecturally