ライフサイエンスコーパス: membrane receptor

1 n be subsequently optimized for binding to a membrane receptor.

2 e of vitamin A from RBP4 is facilitated by a membrane receptor.

3 e multivalent effects of ligand binding to a membrane receptor.

4 cid receptor 2 (HCA(2)), a G protein-coupled membrane receptor.

5 ic pathway, consistent with activation via a membrane receptor.

6 osiderophore enterobactin via the BfeA outer membrane receptor.

7 lysosomal trafficking of an activated plasma membrane receptor.

8 ered by the binding of PA4 alone to its cell membrane receptor.

9 sociated with the down-regulation of another membrane receptor.

10 les it to HasRSM, a specific hemophore outer membrane receptor.

11 es the expression of CD44, the major HA cell membrane receptor.

12 rget genes and the increased binding of cell membrane receptor.

13 icable for labeling and performing assays on membrane receptors.

14 ligand-mediated allosteric changes of these membrane receptors.

15 rotein phosphorylation cascades initiated at membrane receptors.

16 ed in the co/posttranslational processing of membrane receptors.

17 ain, have each been proposed to serve as its membrane receptors.

18 ligands in solution can induce clustering of membrane receptors.

19 eceptor family, a group of single-pass trans-membrane receptors.

20 proteins and are generally thought to act as membrane receptors.

21 stabilized variants of many uncharacterized membrane receptors.

22 regulating cell-surface targeting of plasma membrane receptors.

23 gnaling complexes with effector proteins and membrane receptors.

24 e after 'inside-out' signaling through other membrane receptors.

25 immobilization of functionally antagonistic membrane receptors.

26 e retention or rejection, as appropriate, of membrane receptors.

27 e used to probe the expression of endogenous membrane receptors.

28 immune-related pathways transduced by plasma membrane receptors.

29 ated PAK1 through both the ERalpha and GPER1 membrane receptors.

30 ell to fine tune its mechanotransduction via membrane receptors.

31 perspective on the molecular recognition of membrane receptors.

32 and stromal cells to activate corresponding membrane receptors.

33 val and motility by transducing signals from membrane receptors.

34 ge and characterize ligand binding of native membrane receptors.

35 and signalling in single-spanning eukaryotic membrane receptors.

36 rieval, sorting, and retrograde transport of membrane receptors.

37 Thrombomodulin (TM), an endothelial cell membrane receptor, accelerates the conversion of PC to a

38 lectively, this study shows that like plasma membrane receptors, activated nuclear mGlu5 receptors co

39 avenger receptor class B, type I, and plasma membrane receptor activation by HDL cargo molecules.

40 Internalization, a measure of membrane receptor activation, was also increased by estr

41 elical constellations during the seven-trans-membrane receptor activation.

42 hotoactivatable ligands to characterize cell membrane receptors activity, a relevant issue for cancer

43 ssium level, but it also identifies a second membrane receptor, after angiotensin 2 receptor, that di

44 Although an increasing number of membrane receptors also undergo recycling via specific p

45 es within the plasma membrane that segregate membrane receptors and affect membrane curvature and ves

46 n is accompanied by a profound remodeling of membrane receptors and alterations in cAMP-dependent reg

47 They bind to cell membrane receptors and are internalized.

48 tors (GPCRs) represent the largest family of membrane receptors and are responsible for regulating a

49 rs undergo endocytosis upon binding to their membrane receptors and are transported into cellular com

50 tructure determination of several classes of membrane receptors and associated oligomers.

51 e cell entry by connecting viruses to plasma membrane receptors and by catalyzing subsequent virus-ce

52 dozens of other proteins that have roles as membrane receptors and channels, enzymes, signaling inte

53 y cilia detect extracellular signals through membrane receptors and channels.

54 binding of viral glycoprotein spikes to cell membrane receptors and coreceptors.

55 The interactions between membrane receptors and extracellular ligands control cel

56 ion of new BAM complexes by serving as outer membrane receptors and folding factors for nascent BamA

57 genetic predisposition, which involves cell-membrane receptors and genes in second messenger signall

58 ey secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I.

59 not well understood how estrogen signals via membrane receptors and how these signals impact not only

60 in thought to transduce signals from various membrane receptors and intracellular proteins onto the a

61 et for anesthetics is assumed to be neuronal membrane receptors and ion channels, however new evidenc

62 nociceptors are excited by the activation of membrane receptors and ion channels.

63 rier function is tightly regulated by plasma membrane receptors and is crucial for tissue fluid homeo

64 d receptors constitute the largest family of membrane receptors and modulate almost every physiologic

65 kappaB signaling by providing a link between membrane receptors and NF-kappaB transcriptional subunit

66 viruses recognize host cells by their plasma membrane receptors and often exploit the native transloc

67 onsible for the itinerary and destination of membrane receptors and proteins moving into subcellular

68 Tyrosine phosphorylation of membrane receptors and scaffold proteins followed by rec

69 ransmitters, following the intermediation of membrane receptors and second messengers such as cyclic

70 aminergic GPCRs) belong to the class of cell membrane receptors and share many levels of similarity a

71 that crosslinks actin filaments and anchors membrane receptors and signaling intermediates.

72 ite that can activate G-protein-coupled cell membrane receptors and suggests a functional link betwee

73 Imaging native membrane receptors and testing how they interact with li

74 is require the coordinated interplay between membrane receptors and the actin cytoskeleton.

75 More recent research has focused on membrane receptors and the dynamics of the responses of

76 cellular process by which cells internalize membrane receptors and their extracellular ligands, is a

77 for the trafficking and molecular sorting of membrane receptors and their ligands into intracellular

78 ed by multivalent ligands that first bind to membrane receptors and then promote receptor clustering,

79 aling pathways through its interactions with membrane receptors and transcription factors/repressors.

80 in complexes (i.e., quaternary structure) of membrane receptors and transporters in living cells.

81 f CD11b/CD18 or evidence of another specific membrane receptor, and it is not dependent on post-trans

82 ess, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of mon

83 not well understood how estrogens signal via membrane receptors, and how these signals impact not onl

84 tease-independent action of tPA required its membrane receptor, annexin A2.

85 asmic tail regions, of heptahelical integral membrane receptors are of particular interest in that th

86 Using U87MG cells, we identified the LD22-4 membrane receptor as neuropilin 1 (NRP1).

87 Humans have two forms of TREM-1: a membrane receptor, associated with the adaptor DAP12, an

88 termining affinity and kinetics of drugs for membrane receptors assume the interacting molecules are

89 protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called CD80 and CD86), is a n

90 diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic si

91 hibitors, extracellular matrix proteins, and membrane receptors, bind heparin.

92 alphavbeta3 integrin, a plasma membrane receptor, binds thyroid hormones (L-thyroxine,

93 tropin was stimulated by ligands of aberrant membrane receptors but not by corticotropin-releasing ho

94 embers of the LRRC8 family act not as plasma membrane receptors, but rather as channels that mediate

95 in multicellular organisms are maintained by membrane receptors called cell adhesion molecules (CAMs)

96 2 domain-containing phosphatase 1 (SHP1) or membrane receptors CD22 and/or Siglec-G, result in enhan

97 t's view of the podocyte, examining the many membrane receptors, channels, and other signaling molecu

98 ing organisms use a sophisticated arsenal of membrane receptors, channels, and pumps to control signa

99 mponent signal transduction system through a membrane receptor, ComD.

100 secreted from the ileum; binds to a hepatic membrane receptor complex, FGF19 receptor 4 and corecept

101 Because the determinants of membrane receptor conformational stability are still poo

102 es a focal point for fine-tuning seven trans-membrane receptor conformations activating different sig

103 optosis-inducing ligand (TRAIL) and its cell membrane receptors constitute an elaborate signaling sys

104 genes for extracellular matrix constituents, membrane receptors, contractile proteins, and associated

105 bFGF induced membrane receptor cooperation between integrin beta(3) a

106 ex cellular signaling cascade, in which cell membrane receptors could serve as the upstream triggers

107 dramatic enhancement of binding of two model membrane receptors, dendritic cell-specific intercellula

108 cell-matrix mechanical interactions through membrane receptors direct a wide range of cellular funct

109 prostaglandin E2 (PGE2) that activates four membrane receptors, EP1-EP4.

110 Complement receptor type 1 (CR1) is a membrane receptor expressed on a wide range of cells.

111 creased LTB4 production, and associated BLT1 membrane receptor expression.

112 diated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and

113 nterobactin and salmochelin across the outer membrane receptors, fepA and iroN, are needed for coloni

114 gh it is known that AtRALF1 binds the plasma membrane receptor FERONIA and conveys its signals via ph

115 We have previously established that the membrane receptor FGFR2 drives LUAD progression through

116 The plasma membrane receptor flagellin sensing2 (FLS2) confers immu

117 multifunctional protein hypothesized to be a membrane receptor for 1,25(OH)(2)D(3).

118 hese results identify a cell-cycle-regulated membrane receptor for a molecular motor and suggest a me

119 owed us to identify BamA (YaeT) as the outer membrane receptor for CDI and AcrB as a potential downst

120 y of innate immune receptors, as the surface membrane receptor for CGN in human colonic epithelial ce

121 fission factor (MFF), a mitochondrial outer-membrane receptor for DRP1, the cytoplasmic guanosine tr

122 lic targeting factors that deliver them to a membrane receptor for insertion.

123 this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipopro

124 STRA6 is a high-affinity membrane receptor for RBP and mediates vitamin A uptake

125 is a component of the heterotrimeric plasma membrane receptor for the pleiotropic cytokine IL-15.

126 However, the platelet membrane receptor for these adhesins has been unknown.

127 This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several

128 , the pyoR gene (blr3555) encoding the outer membrane receptor for transport of a ferric pyoverdine.

129 Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-alphabetaR(

130 a cytokine, IFN-gamma, and G protein-coupled membrane receptors for a chemokine, eotaxin, and that th

131 w that granules of human eosinophils express membrane receptors for a cytokine, IFN-gamma, and G prot

132 pressible proteins including the known outer membrane receptors for alcaligin, enterobactin and haem,

133 Cell membrane receptors for SDF1, bFGF, and BMP7 were up-regu

134 n that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL1 domain i

135 on corresponding to changes in the levels of membrane receptors for spore germinants and a protein ch

136 , the N-terminal domains bind specific inner-membrane receptors for subsequent translocation into the

137 d, while Class II receptors are nonclassical membrane receptors for the steroid hormone progesterone.

138 domain to transduce the Wnt signals from the membrane receptor Frizzled to downstream components.

139 se findings, combined with considerations of membrane receptor geometry, are consistent with the idea

140 n this study the association of ILY with its membrane receptor has been examined throughout the assem

141 s a carrier of the metal cofactor toward the membrane receptor HasR, and the heme-free apoprotein fis

142 The cytoplasmic domains of these membrane receptors have been shown to bind to various fi

143 esolution analytical methods, these integral membrane receptors have to be expressed in large quantit

144 tial for analyzing the function of any other membrane receptor if a potent fluorescent ligand is avai

145 ating signaling pathways activated by a cell membrane receptor in animal models of CNS disorders prom

146 s) are the largest and most diverse group of membrane receptors in eukaryotes and detect a wide array

147 ors (GPCRs) constitute the largest family of membrane receptors in eukaryotes.

148 the functional consequence of E2 binding to membrane receptors in individual neurons.

149 understanding of the molecular mechanisms of membrane receptors in signal transduction make use of ra

150 ential model system for the study of ciliary membrane receptors, including their transport.

151 Thus, activation of plasma membrane receptors increased the ambit of inflammatory r

152 and-induced conformational changes of plasma membrane receptors initiate signals that enable cells to

153 Activation of plasma membrane receptors initiates compartmentalized second me

154 Although this process involves cellular membrane receptor integrins, the role of integrins in my

155 studies may help in the design of assays for membrane receptor interactions with soluble ligands, and

156 for cytoplasmic adaptor proteins to organize membrane receptors into micrometer-scale signaling zones

157 Neuropilins (NRPs) are trans-membrane receptors involved in axon guidance and vascula

158 nilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation.

159 CRs), form the largest class of cell surface membrane receptors, involving several hundred members in

160 host are revealed, and the identification of membrane receptors, ion channels and more than 300 prote

161 es, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented.

162 (PC1) and polycystin-2 (PC2), form a plasma membrane receptor-ion channel complex.

163 rticular, the spatiotemporal distribution of membrane receptors is an active field of study due to it

164 Dimerization of single-pass membrane receptors is essential for activation.

165 Kinase recruitment to membrane receptors is essential for signal transduction.

166 The membrane receptor isoform acts synergistically with the

167 that the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protei

168 ished that ligand stimulation of many plasma membrane receptors leads to their internalization.

169 llosteric modulators are over-represented in membrane receptors, ligand-gated ion channels and nuclea

170 essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of hea

171 ent, defense, and homeostasis rely on plasma membrane receptor-like kinases to perceive endogenous an

172 0305 interacted with lipocalin-1 interacting membrane receptor (LIMR), enhanced the interaction of LI

173 rane protein-1 (LMBR1)/lipocalin-interacting membrane receptor (LIMR)-type proteins are putative nine

174 of alga, sensory input is first detected by membrane receptors located in the cell body and then tra

175 CD48 is a membrane receptor (mCD48) on eosinophils and mast cells

176 demonstrate, at a single cell level, that E2 membrane receptors mediate the rapid signaling cascades

177 ating Vg uptake and is a promising candidate membrane receptor mediating JH regulation of patency in

178 ors (GPCRs) belong to a large superfamily of membrane receptors mediating a variety of physiological

179 Previous studies suggested that a membrane receptor might be involved in mediating vitello

180 acts with the previously determined N4 outer membrane receptor, NfrA.

181 anchored glycoprotein Juno as the egg plasma membrane receptor of sperm Izumo1 [1,2].

182 recipitation and LC-MS/MS to screen putative membrane receptors of Dkk3a, and Integrin alpha6b (Itgal

183 KEY MESSAGE: Cytokinin membrane receptors of the Arabidopsis thaliana AHK2 and

184 of some ECM noncellular components and trans-membrane receptors of the microenvironment in PTC in ord

185 and activation of all the pertinent cognate membrane receptors of the rest of the GFs.

186 glycoprotein gp120 was being recognized by a membrane receptor on genital epithelial cells, leading t

187 The classical technique of probing membrane receptors on a millisecond scale involves placi

188 g process between multi-specific ligands and membrane receptors on cell surfaces.

189 Here, we show a way to immobilize membrane receptors on nanomechanical cantilevers so that

190 may interact with signaling molecules and/or membrane receptors on the cell surface, or even the enzy

191 ell begins with odorant molecules binding to membrane receptors on the cilia of olfactory receptor ne

192 n and cell death inhibitors on one hand, and membrane receptors on the other.

193 be extended to other dye families and other membrane receptors, opening the route to new ultrabright

194 Binding of a neurotransmitter to its membrane receptor opens an integral ion conducting pore.

195 [eNAD(P)] can either directly bind to plasma membrane receptors or be metabolized by ecto-enzymes to

196 Knowledge of membrane receptor organization is essential for understa

197 or full-length, posttranslationally modified membrane receptors, our approach offers new means to str

198 binds specifically to the G-protein-coupled membrane receptors P2Y1 and P2Y12, stimulating intracell

199 They function downstream from the membrane receptors, Patched and Smoothened, and the prim

200 se and activating the extrinsic Fas-mediated membrane receptor pathway to induce apoptosis, which is

201 nding father of a broad family of pentameric membrane receptors, paving the way for their identificat

202 cuA, PcuC, and PcuD), a TonB-dependent outer membrane receptor (PcuB), and a cytoplasmic membrane-int

203 seudomonas aeruginosa PAO1 encodes two outer membrane receptors, PhuR (Pseudomonas heme uptake) and H

204 ) show that these highly homologous integral membrane receptors play an essential and partially redun

205 l mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic recep

206 of factors including availability of active membrane receptor pools, the composition of the 5-HT2CR

207 ochlea's base and submillisecond encoding of membrane receptor potential fluctuations in the apex for

208 le amounts of the ferric acinetobactin outer membrane receptor protein BauA while not affecting the p

209 or the production of the acinetobactin outer membrane receptor protein BauA.

210 receptor (GPCR) family is one of the largest membrane receptor protein families and controls many key

211 the interaction of colicin N with its outer membrane receptor protein OmpF.

212 or, class B type 1 (SR-B1), is a multiligand membrane receptor protein that functions as a physiologi

213 sma membrane and intracellular ion channels, membrane receptors, protein kinases, protein phosphatase

214 tors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets o

215 ays involving the BfrA, BfrD, and BfrE outer membrane receptor proteins, and although Bordetella pert

216 Structures of integral membrane receptors provide valuable models for drug-rece

217 le to a wide variety of cell types and their membrane receptors, providing a novel method to determin

218 However, the outer membrane receptor Psn and TonB as well as the inner memb

219 The results demonstrated that activation of membrane receptors related to NE or Ang II caused an ini

220 rotein associations regulate the function of membrane receptors remains poorly understood.

221 s covalently linked to their bacterial outer membrane receptors represent a credible target for vacci

222 was found to activate temperature-sensitive membrane receptors, resulting in an influx of calcium.

223 subcellular localization and distribution of membrane receptors, scaffolds, and signaling proteins re

224 Membrane receptor-sensed input signals affect and modula

225 d products (RAGE) is a highly expressed cell membrane receptor serving to anchor lung epithelia to ma

226 The TRPV1 is the first membrane receptor shown to have a tumor-suppressing effe

227 A wide range of membrane receptors signal through conformational changes

228 molecules that activate multiple nuclear and membrane receptor signaling pathways to control fed-stat

229 Hedgehog signaling through the plasma membrane receptor Smoothened (Smo) is an important proce

230 RBP4 are independent of retinol and the RBP4 membrane receptor STRA6 and occur in part via activation

231 The integral membrane receptor STRA6 mediates cellular uptake of vita

232 n can control the abundance and signaling of membrane receptors such as EGFR.

233 ect in clathrin-mediated endocytosis, plasma membrane receptors such as the transferrin receptor (TfR

234 rates downstream effector proteins with cell membrane receptors, such as the epidermal growth factor

235 YKL-40 induced coordination of membrane receptor syndecan-1 and integrin alphavbeta5, a

236 The membrane receptor TCblR/CD320 binds transcobalamin (TC)

237 The membrane receptor (TCblR/CD320) for transcobalamin (TC)-

238 tissues, holo-RBP is recognized by a plasma membrane receptor termed STRA6, which serves a dual role

239 the microclustering of a ubiquitous class of membrane receptors, termed integrins.

240 esoid X receptor (FXR) and G protein-coupled membrane receptor TGR5 that demonstrated beneficial effe

241 TLR4, a membrane receptor that functions in complex with its acc

242 However, the membrane receptor that interacts with ligand Dkk3a to co

243 ted receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its

244 Dystroglycan is a membrane receptor that mediates interactions between cel

245 Dystroglycan is a cell membrane receptor that organizes the basement membrane b

246 oprotein related receptor 1 (LRP1), a plasma membrane receptor that regulates lipid metabolism, is el

247 buds respond to these diverse compounds via membrane receptors that bind the umami tastants.

248 measurements of this effect, by identifying membrane receptors that do not associate in mammalian me

249 mportant drug target that includes over 1000 membrane receptors that functionally couple extracellula

250 ed receptors represent the largest family of membrane receptors that instigate signalling through nuc

251 and PLL1 in proximity of the upstream plasma membrane receptors that regulate their activity.

252 ll-like receptors (TLRs) provided a class of membrane receptors that sense extracellular microbes and

253 TLRs are membrane receptors that survey the extracellular environ

254 The interaction of IFN with specific membrane receptors that transduce death-inducing signals

255 nt of its protease activity but required its membrane receptor, the LDL receptor-related protein 1 (L

256 this approach to track the motion of single membrane receptors, the Clostridium perfringens epsilon-

257 ar toxicity, even without the involvement of membrane receptors through Abeta peptide-plasma membrane

258 rol controls the activity of a wide range of membrane receptors through specific interactions and ide

259 ty of lipids to regulate the conformation of membrane receptors through specific interactions.

260 he application of single-molecule imaging to membrane receptors through the use of vesicles derived f

261 olarity information can be transduced from a membrane receptor to a key actin regulator to control co

262 ising adaptability of this G protein-coupled membrane receptor to properties of the lipid matrix.

263 nown about the molecular mechanisms coupling membrane receptors to active zone molecules during devel

264 Scaffolding proteins interact with membrane receptors to control signaling pathways and cel

265 spanins and L6 domain proteins recruit other membrane receptors to form active signaling centers that

266 gative bacteria utilize TonB-dependent outer membrane receptors to obtain iron during infection.

267 -phase endocytosis and trafficking of plasma membrane receptors to the early endosomes as well as inh

268 The actin-binding protein filamin links membrane receptors to the underlying cytoskeleton.

269 signaling molecules appear to act on plasma membrane receptors to trigger calcium spike activity, ot

270 oat protein named pIII and a bacterial inner-membrane receptor, TolA, which is part of the conserved

271 s effects are mediated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

272 function to prepare the mitochondrial outer membrane receptor Tom71 for preprotein loading.

273 st-translational modification that regulates membrane receptor trafficking and function.

274 ave direct implications on the regulation of membrane receptor trafficking and signaling.

275 urons, the endosomal system is essential for membrane receptor trafficking to dendrites and axons and

276 Membrane receptors, transporters, and enzymes communicat

277 h is applicable to other cells with constant membrane receptor turnover.

278 We hypothesized that a plasma membrane receptor-type protein would sense the presence

279 ectories from chromosomes, kinetochores, and membrane receptors undergoing a variety of complex motio

280 s that sensing of NHDC by a bacterial plasma membrane receptor underlies sweetener-induced growth of

281 ron encodes a predicted TonB-dependent outer membrane receptor, VciA, and a putative inner membrane p

282 Gain of function of membrane receptor was a good strategy exploited by cance

283 However, little or none of the other membrane receptor was found to be useful as a potential

284 Because NKp46, a glycosylated membrane receptor, was necessary for dose-dependent SP-D

285 For oligomeric membrane receptors, we distinguish between a), the Leffl

286 CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that suppor

287 chanism of action, especially in the case of membrane receptors where just part of the structure has

288 t cytolysins (CDCs) utilize cholesterol as a membrane receptor, whereas a small number are restricted

289 pha (NRXN1alpha) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the

290 paired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pa

291 by a switch in selectivity toward additional membrane receptors, which are specifically expressed by

292 s can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the

293 ered by activation of multiple types of cell membrane receptors, which include adenosine A(1) and bra

294 challenge in life sciences is to image cell membrane receptors while characterizing their specific i

295 d nanovesicles allowed us to separate single membrane receptors while maintaining them in their physi

296 in receptor 1 (TfR1) is a ubiquitous type II membrane receptor with 61 amino acids in the N-terminal

297 FLT3 is a trans-membrane receptor with a tyrosine kinase domain which, w

298 te to synthetic molecules that bind integral membrane receptors with affinities and specificities sim

299 s that depends on the activities of specific membrane receptors with yet unknown regulatory mechanism

300 ent receptor type 2 (CR2 and CD21) is a cell membrane receptor, with 15 or 16 extracellular short con