ライフサイエンスコーパス: membrane ruffling

1 KIalpha in PDGF-stimulated cells resulted in membrane ruffling.

2 ways that stimulate actin reorganization and membrane ruffling.

3 ncident with increases in cell spreading and membrane ruffling.

4 nosomes but, surprisingly, did not eliminate membrane ruffling.

5 t-Leu-Phe to induce actin reorganization and membrane ruffling.

6 itic cells but may be required downstream of membrane ruffling.

7 ession systems, also inhibited GH-stimulated membrane ruffling.

8 The small GTPase Rac mediates membrane ruffling.

9 luencing actin cytoskeletal organization and membrane ruffling.

10 from the cytosol to the plasma membrane, and membrane ruffling.

11 esponse to stimuli (e.g., serum) that induce membrane ruffling.

12 m pathways such as PAK, JNK/SAPK kinases and membrane ruffling.

13 as a dominant negative for another pathway, membrane ruffling.

14 effect on the ability of RasVal-12 to induce membrane ruffling.

15 Shc mutant, has no effect on IGF-I-mediated membrane ruffling.

16 resembles the time course of IGF-I-mediated membrane ruffling.

17 wortmannin and LY294002 blocks IGF-I-induced membrane ruffling.

18 ined actin stress fibers and showed enhanced membrane ruffling.

19 mplex may regulate growth cone extension and membrane ruffling.

20 inct pathway that regulates adhesion-induced membrane ruffling.

21 ab5-dependent pinocytosis and Rac1-dependent membrane ruffling.

22 ffect of Ha-Ras(G12V) on pinocytosis but not membrane ruffling.

23 of PDGF-induced mitogenesis, chemotaxis, and membrane ruffling.

24 ion of KCNQ2/3 channel currents, and loss of membrane ruffling.

25 5-P3) also produced actin reorganization and membrane ruffling.

26 yphimurium strains are unable to induce this membrane ruffling.

27 d mutant of Ras, V12Ras, in the induction of membrane ruffling.

28 ttenuating actin polymerization and reducing membrane ruffling.

29 ynthesis, but retained the ability to induce membrane ruffling.

30 ytoskeletal organization, and reduced plasma membrane ruffling.

31 s of active GTP-bound Rac and EGF-stimulated membrane ruffling.

32 supports a functional link between SOCE and membrane ruffling.

33 is most evident in podosomes and regions of membrane ruffling.

34 associated with enhanced cell spreading and membrane ruffling.

35 ells has no additive effect on the amount of membrane ruffling.

36 o promote cell survival, transformation, and membrane ruffling.

37 actin dynamics, lamellipodia protrusion, and membrane ruffling.

38 ion of p50alpha also restored PDGF-dependent membrane ruffling.

39 membrane trafficking, glucose transport, and membrane ruffling.

40 /- p85beta-/-) are defective in PDGF-induced membrane ruffling.

41 gulators of endocytosis, actin dynamics, and membrane ruffling.

42 spholipase D (PLD) homolog, which facilitate membrane ruffling.

43 ated Rac3 causes transformation and leads to membrane ruffling.

44 ium stimulates signaling pathways leading to membrane ruffling, actin cytoskeleton rearrangements, an

45 of PIPKI-alpha causes pronounced defects in membrane ruffling, actin organization, and focal adhesio

46 s a mitogen, cAMP-elevating agents stimulate membrane ruffling, Akt phosphorylation, and p70 ribosoma

47 Rac1 effector binding loop shown to abolish membrane ruffling also abolishes interaction with POR1.

48 d -independent growth assays, cell cycle and membrane ruffling analyses showed that Akt exerts estrog

49 Eklf-deficient EryP exhibit membrane ruffling and a failure to acquire the typical d

50 hat schwannoma-derived Schwann cells exhibit membrane ruffling and aberrant cell spreading when plate

51 e degranulation and is impaired in mediating membrane ruffling and actin assembly.

52 wild-type L. pneumophila, without affecting membrane ruffling and actin polymerization.

53 rin and phosphotyrosine, along with enhanced membrane ruffling and actin stress fiber formation.

54 oteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to st

55 These results indicate that membrane ruffling and activation of MAP kinase represent

56 Protein kinase C (PKC) stimulates membrane ruffling and adhesion [2], but the mechanism by

57 athways and the actin cytoskeleton to induce membrane ruffling and bacterial internalization.

58 that MARCKS and PKC regulate actin-dependent membrane ruffling and cell adhesion, perhaps via a PIP2-

59 These data show that SHEP1 regulates membrane ruffling and cell migration and that binding to

60 221F fails to induce JNK and PAK activation, membrane ruffling and cell migration, suggesting that it

61 ed to function downstream of Arf6 to control membrane ruffling and cell migration, this pathway has n

62 tly, inhibition of Hsp90 activity suppressed membrane ruffling and cell migration, while expression o

63 of interacting with Crk inhibits Bmx-induced membrane ruffling and cell migration.

64 mediates attachment-induced JNK activation, membrane ruffling and cell motility in a Rac-dependent m

65 tion of 14-3-3zeta to increase AngII-induced membrane ruffling and cell motility.

66 th hormone-dependent actin reorganization in membrane ruffling and cell motility.

67 ependent of Rac1 activation, actin-dependent membrane ruffling and cell spreading are Rac1-dependent

68 R-induced Rac1 activation and Rac1-dependent membrane ruffling and cell spreading were restored.

69 This mmLDL activates macrophages inducing membrane ruffling and cell spreading, activation of ERK1

70 anism by which Neisseria gonorrhoeae elicits membrane ruffling and cellular invasion of the cervical

71 onococcal PLD may be necessary to potentiate membrane ruffling and clustering of gonococci on the cer

72 s engaged with extracellular matrix, whereas membrane ruffling and decreased actin stress fibers indu

73 ever, such signaling when persistent induced membrane ruffling and decreased cell motility.

74 s in the actin-binding domain cause aberrant membrane ruffling and defective actin stress fibre forma

75 ed cytoskeletal rearrangements manifested by membrane ruffling and disruption of intercellular juncti

76 f PIP(2) and produced smooth T cells void of membrane ruffling and filopodia.

77 ress fibers and exhibit clear differences in membrane ruffling and filopodial extension when stained

78 A cells and assayed for GH- and PDGF-induced membrane ruffling and fluid phase pinocytosis.

79 ed PAK1 have been reported to either promote membrane ruffling and focal adhesion assembly or cause f

80 with multiple cellular responses, including membrane ruffling and focal complex formation.

81 C, and N43D) retained the ability to promote membrane ruffling and focus formation.

82 beta but not Nckalpha blocks PDGF-stimulated membrane ruffling and formation of lamellipoda.

83 eta but not Nckalpha blocks Rac1-L62-induced membrane ruffling and formation of lamellipodia, suggest

84 ment caused shape changes in the cells, with membrane ruffling and formation/retraction of thin actin

85 ssion of Bmx with Cas results in an enhanced membrane ruffling and haptotactic cell migration.

86 V), an activated Ras mutant, stimulated both membrane ruffling and horseradish peroxidase uptake.

87 erexpression of MAYP decreased CSF-1-induced membrane ruffling and increased filopodia formation, mot

88 MAP kinase, was defective for stimulation of membrane ruffling and induction of DNA synthesis.

89 arrangements encompass increased Rac-induced membrane ruffling and lamellipodia, Cdc42-initiated filo

90 cretion system (T3SS), leading to pronounced membrane ruffling and macropinocytic uptake of attached

91 ity is initially manifested by inhibition of membrane ruffling and macropinocytosis in infected macro

92 ica bead uptake in a process associated with membrane ruffling and macropinocytosis.

93 ulate PAK and JNK activity but still induced membrane ruffling and mediated transformation.

94 mulation of two distinct insulin bioeffects, membrane ruffling and mitogenesis, in 3T3-L1 adipocytes

95 -assisted laser inactivation) blocked plasma-membrane ruffling and motility of Fos-transformed fibrob

96 mation in CV1 cells and blocked PDGF-induced membrane ruffling and nucleated actin assembly.

97 triking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions,

98 d areas 5-7-fold greater than NHSC, aberrant membrane ruffling and numerous, frequently disorganized

99 sion under these conditions causes extensive membrane ruffling and overrides the block in membrane fu

100 Arf6 and its GEFs facilitated membrane ruffling and pathogen invasion via ARNO, and tr

101 coupled events, our study demonstrates that membrane ruffling and pinocytosis are regulated by disti

102 h lacking a functional SH2 domain, inhibited membrane ruffling and pinocytosis induced by GH and PDGF

103 g three Rac-dependent readouts: induction of membrane ruffling and pinocytosis, stimulation of cell m

104 Activation of Ras stimulates cell surface membrane ruffling and pinocytosis.

105 AYP is a negative regulator of CSF-1-induced membrane ruffling and positively regulates formation of

106 tween the intracellular pathways that induce membrane ruffling and promote cell survival.

107 to wounding was characterized by (1) plasma membrane ruffling and protrusion into the wound, (2) lam

108 Membrane ruffling and pseudopod extension via the BLTR w

109 monella typhimurium into host cells requires membrane ruffling and rearrangement of the actin cytoske

110 Rac allele was able to rescue the defect in membrane ruffling and restore the localization of a fluo

111 Membrane ruffling and reversible cell-substratum interac

112 Rac1 and RhoA regulate membrane ruffling and stress fiber formation.

113 ts estrogen-like activity on cell growth and membrane ruffling and that a selective ErbB2 inhibitor,

114 aldesmon may be a key protein that modulates membrane ruffling and that this may involve changes in c

115 cation to the membrane, which in turn causes membrane ruffling and the formation of cellular protrusi

116 Our experiments show that activation of membrane ruffling and transcriptional activation of c-ju

117 to the transcription factor c-Jun and cause membrane ruffling and transformation, indicating that sw

118 JNK activation but was defective in inducing membrane ruffling and transformation.

119 infected cells with 2-10 muM P27 caused cell membrane ruffling and uptake of virus and polymerized fo

120 ine, and filamentous actin filament into the membrane rufflings and uropods of human neutrophils.

121 reatment with GGTIs led to the inhibition of membrane-ruffling and transforming activities of both ac

122 SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal g

123 Gas6 stimulated lamellipodial extension, membrane ruffling, and chemotaxis of immortalized NLT Gn

124 was rapid, involved extensive cholangiocyte membrane ruffling, and culminated in parasite penetratio

125 d GLUT4 translocation, growth factor-induced membrane ruffling, and DNA synthesis, indicating that Pt

126 esion to fibronectin, secretory enhancement, membrane ruffling, and filamentous actin assembly.

127 plasma membrane and stimulates GTP loading, membrane ruffling, and filopodia formation.

128 is required for growth hormone (GH)-induced membrane ruffling, and increases mitogenesis stimulated

129 olocalization with cortical actin filaments, membrane ruffling, and lamellipodia formation, compared

130 luence growth factor-mediated proliferation, membrane ruffling, and migration.

131 o1c promoted G-actin accumulation and plasma membrane ruffling, and Myo1c knockdown confirmed its con

132 FO showed hepatocyte autophagosomes, nuclear membrane ruffling, and porphyrin-containing vacuoles wit

133 eas Rac regulates lamellipodia formation and membrane ruffling, and RhoA regulates the formation of s

134 vated by MLCK at the cell periphery controls membrane ruffling, and that the spatial regulation of ML

135 threonine kinase, to induce lamellipodia and membrane ruffling, and to activate the c-Jun NH2-termina

136 mice failed to become polarized, to undergo membrane ruffling, and to migrate in response to chemoki

137 k results in localized actin polymerization, membrane ruffling, and, ultimately, pathogen entry.

138 Pinocytosis and membrane ruffling are among the earliest and most dramat

139 e is provided that actin-myosin assembly and membrane ruffling are regulated by distinct signaling pa

140 abnormal proliferation, cell morphology, and membrane ruffling are suppressed by the TRQQKRP motif de

141 n (CTTN), a regulator of the cytoskeleton at membrane ruffling areas.

142 In fibroblasts PAK1 localizes to areas of membrane ruffling, as well as to amiloride-sensitive pin

143 d MLC phosphorylation and blocked peripheral membrane ruffling, as well as turnover of focal adhesion

144 Knockdown of RalA or Sec5 results in reduced membrane ruffling at sites of attachment and impairs bac

145 oad lamellipodium, a response accompanied by membrane ruffling at the cell margin.

146 ese results demonstrated that SOCE regulates membrane ruffling at the leading edge of cells.

147 ccumulation of the PI(4,5)P(2) biosensor and membrane ruffling at the opposite side of the cells.

148 activated Ras(V12) mutant induces prominent membrane ruffling, branching morphogenesis on three-dime

149 d and platelet-derived growth factor-induced membrane ruffling but not Bradykinin-induced filopodia f

150 king Tyr-439 and Tyr-494 inhibits GH-induced membrane ruffling but still activates JAK2.

151 ealed that the DN construct had no effect on membrane ruffling, but dramatically inhibited stress fib

152 In contrast, membrane ruffling, but not cell contraction, requires Ra

153 POR1, a Rac1-interacting protein involved in membrane ruffling, but not with the dominant-negative mu

154 take by 36%, GLUT4 translocation by 35%, and membrane ruffling by 50%, all of which are phosphatidyli

155 Dominant-negative Akt inhibited membrane ruffling by 54%; however, R25C-Akt did not have

156 ed versions of POR1 inhibit the induction of membrane ruffling by an activated mutant of Rac1, V12Rac

157 rowth factors stimulate actin remodeling and membrane ruffling by integration of signaling pathways t

158 tor (PDGF)-induced chemotaxis was to promote membrane ruffling by regulating phosphatidylinositol 3,4

159 role of STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localize

160 ation during ruffling, and the inhibition of membrane ruffling by the Ca(2+)-channel inhibitor SKF963

161 sulted in distinct linear or circular/dorsal membrane ruffling, c-Abl-null cells demonstrated dramati

162 Since Rac-dependent membrane ruffling can be stimulated by PI 3-kinase, it a

163 Lamellipodia formation and membrane ruffling caused by active PAK1 expression, howe

164 ator of diverse cellular functions including membrane ruffling, cell cycle progression, and transform

165 to sustain Rac1 signalling, trigger optimal membrane ruffling, cell migration and invasion.

166 cell spreading, lamellipodia formation, and membrane ruffling, cell morphologies generated by active

167 R), which also induces actin reorganization, membrane ruffling, cell spreading, polarization, and mig

168 t of PI3K, local PI(3,4,5)P(3) synthesis and membrane ruffling could be induced, with corresponding l

169 s typical of FCepsilonRI signaling including membrane ruffling, cytoskeletal rearrangements, and, in

170 roduction of p85alpha or p85beta rescues the membrane ruffling defect.

171 e, we suggest a role of N-WASP in regulating membrane ruffling downstream of phosphatidylinositol 4,5

172 ium that are incapable of inducing host cell membrane ruffling fail to induce apoptosis.

173 This was associated with decreased membrane ruffling, failure to establish cell polarity, a

174 changes in actin-dependent processes such as membrane ruffling, filopodial protrusion, and cell motil

175 e (ERK) activation and the other controlling membrane ruffling formation.

176 a striking increase in spontaneous motility, membrane ruffling, formation of long actin extensions (f

177 Consistent with membrane ruffling, gonococci were found residing within

178 nduced actin cytoskeleton reorganization and membrane ruffling in 3T3-L1 fibroblasts and Rat1 cells t

179 ted transmits signals leading to actin-based membrane ruffling in fibroblasts.

180 R/IR or the CSF1R/IRDelta960 rapidly induced membrane ruffling in Rat1 fibroblasts.

181 and Rhotekin leads to loss of Rho-dependent membrane ruffling in response to epidermal growth factor

182 T4 translocation, c-fos expression, and cell membrane ruffling in single-cell microinjection assay.

183 of the constitutively active RacV12 induces membrane ruffling, increases PI4KIIbeta translocation to

184 , we show that SCH 51344 specifically blocks membrane ruffling induced by activated forms of H-RAS, K

185 ve mutants of SH2-Bbeta are shown to inhibit membrane ruffling induced by constitutively active Rac.

186 an insulin receptor (HIRc-B), SHIP inhibited membrane ruffling induced by insulin and IGF-I by 76 +/-

187 contrast, there was no significant change in membrane ruffling induced by PMA in the cells expressing

188 and size of actin stress fibers and inhibits membrane ruffling induced by Rac.

189 fails to induce ruffling but potently blocks membrane ruffling induced by serum or PDGF.

190 t the tip of the extending growth cone where membrane ruffling is most active.

191 lone A cells inhibited alpha6beta4-dependent membrane ruffling, lamellae formation, and migration.

192 mber of the Rho-family GTPases that promotes membrane ruffling, leading edge extension, and cell spre

193 co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacteriu

194 ll as cell polarity, lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell

195 amma receptor- mediated phagocytosis and for membrane ruffling mediated by structurally distinct rece

196 SV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinas

197 GFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis.

198 Furthermore, Myo1c-induced membrane ruffling of 3T3-L1 adipocytes is also compromis

199 ion, ghrelin led to actin polymerization and membrane ruffling on cells, with the specific co-localiz

200 Although Trk and EGFR each stimulate membrane ruffling, only Trk undergoes both selective and

201 LPS did not induce membrane ruffling or macropinocytosis in enterocytes, ex

202 differ from Rac1 in its ability to stimulate membrane ruffling or to interact with SmgGDS and IQGAP1-

203 ce of granule swelling and fusion, increased membrane ruffling, or exocytosis upon Ag challenge.

204 a on Ser(2152) is required for Pak1-mediated membrane ruffling, our results suggest a novel role for

205 H 51344 inhibits a critical component of the membrane ruffling pathway downstream from RAC and sugges

206 ersely, increasing cytosolic Ca(2+) enhances membrane ruffling, PI3K activity, and F-actin accumulati

207 Kit-mediated filamentous actin assembly and membrane ruffling, secretory enhancement and adhesion to

208 ation stimulated by bradykinin and in dorsal membrane ruffling stimulated by PDGF, whereas the Cdc42G

209 acts as a dominant negative mutant, blocked membrane ruffling, suggesting that PIPKIalpha and PIP2 p

210 he Raji-S1 cells but does inhibit the active membrane ruffling that is necessary for cell polarizatio

211 ing that ARF6 regulates a pathway leading to membrane ruffling that occurs after the activation and m

212 Membrane ruffling then becomes polarized, leading to an

213 Active TRAF4 initiated robust membrane ruffling through Rac1, PAK1, and the oxidase, w

214 Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotype.

215 monella virulence effectors elicit host cell membrane ruffling to facilitate pathogen invasion.

216 Salmonella species trigger host membrane ruffling to force their internalization into no

217 nduces actin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cell

218 ase Rac1, established its ability to promote membrane ruffling, transformation, and activation of c-j

219 for their roles in actin rearrangements and membrane ruffling, translocated effectors also affect ho

220 Both PS and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" up

221 Ras controls membrane ruffling via the small GTPase Rac.

222 Ha-Ras(G12V)-stimulated pinocytosis but not membrane ruffling was abolished by either wortmannin or

223 or-induced cytoskeletal rearrangement, i.e., membrane ruffling, was significantly inhibited (78 +/- 1

224 n and platelet-derived growth factor-induced membrane ruffling, we investigated whether NIH 3T3 cells

225 tial adhesion to fibronectin also stimulates membrane ruffling; we show that this ruffling is indepen

226 domain induce formation of lamellipodia and membrane ruffling, when transiently expressed in fibrobl

227 RhoGAP is rapidly translocated to regions of membrane ruffling, where it colocalizes with polymerized

228 Stimulation through L-selectin induced membrane ruffling, whereas PAF or IL-8 induced bipolar s

229 broblasts induced lamellipodia formation and membrane ruffling, which was unrelated to the substrate

230 actin polymerization-dependent spreading and membrane ruffling while Rac1-independent BCR capping rem

231 asion-deficient mutant (achieved by inducing membrane ruffling with epidermal growth factor) induced

232 ector, resulted in a dramatic stimulation of membrane ruffling without affecting the uptake of horser