ライフサイエンスコーパス: membrane traffic

1 MDs and support the central role of rafts in membrane traffic.

2 inositides that regulate endosomal-lysosomal membrane traffic.

3 irect effects of acute TRP-ML1 deficiency on membrane traffic.

4 ns, including acidification, morphology, and membrane traffic.

5 ryotic cell pathways such as those mediating membrane traffic.

6 f GTPases, which are key players in cellular membrane traffic.

7 bypasses the usual route for Golgi-dependent membrane traffic.

8 uitous clathrin-coated vesicles that mediate membrane traffic.

9 Arf family and Ras superfamily that regulate membrane traffic.

10 Small GTPases play a critical role in membrane traffic.

11 TPase is an important regulator of endocytic membrane traffic.

12 slocated into the host cell where they alter membrane traffic.

13 mic locus of cytoskeletal reorganization and membrane traffic.

14 stored lamellipodial dynamics independent of membrane traffic.

15 e elucidation of the function of proteins in membrane traffic.

16 and ARF-dependent pathways in TGN to plasma membrane traffic.

17 ation is due to nonspecific perturbations in membrane traffic.

18 PITP) function in signal transduction and in membrane traffic.

19 es that can interfere with specific steps in membrane traffic.

20 ns to our understanding of the mechanisms of membrane traffic.

21 lay an important regulatory role in synaptic membrane traffic.

22 l integration point of insulin signaling and membrane traffic.

23 ction with Yip1p to mediate a common step in membrane traffic.

24 n of internal cell membranes, and a block in membrane traffic.

25 s factors potentially involved in regulating membrane traffic.

26 ted endocytosis and receptor tyrosine kinase membrane traffic.

27 ole in regulation of signal transduction and membrane traffic.

28 r independently of COPI- and COPII-dependent membrane traffic.

29 addition to its previously described role in membrane traffic.

30 rve as a paradigm for how CK1 kinases act in membrane traffic.

31 of neuronal proteins thought to function in membrane traffic.

32 in all cells suggests a fundamental role in membrane traffic.

33 eria monocytogenes (LM) modulates phagocytic membrane traffic.

34 me proteins that are important for lysosomal membrane traffic.

35 phosphoinositides play an important role in membrane traffic.

36 usually associated with trans-Golgi network membrane traffic.

37 ulation of actin cytoskeleton remodeling and membrane traffic.

38 additional proteins to ensure specificity in membrane traffic.

39 ons between the microtubule cytoskeleton and membrane traffic.

40 SNAREs were thought to ensure specificity in membrane traffic.

41 hich was shown previously to be required for membrane traffic.

42 a role in providing specificity to polarized membrane traffic.

43 n tyrosine phosphorylation via pp60c-src and membrane traffic.

44 central functions in signal transduction and membrane traffic.

45 1 (ARF1) is a key regulator of intracellular membrane traffic.

46 st homologue Uso1p have an essential role in membrane traffic.

47 lle engaged in both secretory and retrograde membrane traffic.

48 ulators of virtually every step of vesicular membrane traffic.

49 ns in the production of vesicles involved in membrane traffic.

50 nctioned normally in the regulation of other membrane traffic.

51 gnate t-SNARE may mediate the specificity of membrane traffic.

52 le for this enzyme activity in intracellular membrane traffic.

53 esicles and contribute to the specificity of membrane traffic.

54 issect the role of clathrin in intracellular membrane traffic.

55 mbers that have been implicated in endocytic membrane traffic.

56 3,5)P2, lipids which regulate endo-lysosomal membrane traffic.

57 topic activation in vivo and thereby disrupt membrane traffic.

58 vel models for cargo-dependent regulation of membrane traffic.

59 rates play essential roles in endo-lysosomal membrane traffic.

60 s and thus appears to play a broader role in membrane traffic.

61 roteins required for signal transduction and membrane traffic.

62 dosomal PI(4,5)P2, a key phosphoinositide in membrane traffic.

63 re the largest family of proteins regulating membrane traffic.

64 act to modify phosphoinositides and regulate membrane traffic.

65 utations of the surface result in defects in membrane traffic.

66 sion, a new role of tethering factors during membrane traffic.

67 sponsible for regulating the choreography of membrane traffic.

68 ciates with TJs but has no known function in membrane traffic.

69 suited for a multifunctional GEF involved in membrane traffic.

70 oskeleton; Rab GTPases are key regulators of membrane traffic.

71 rst time the role that this complex plays in membrane traffic.

72 Because membrane traffic aberrations may be secondary to lipid b

73 tion of Sec15p relies on functional upstream membrane traffic, activated rab protein Sec4p, and its g

74 n that seems to resemble the polarization of membrane traffic after their activation.

75 Membrane traffic along the endocytic and exocytic pathwa

76 Our results suggest that RabD regulates membrane traffic along the endosomal pathway, and that t

77 ition, the function of Vam3p is required for membrane traffic along the VPS-independent pathway.

78 Membrane traffic and actin cytoskeleton dynamics are int

79 elationships between Avl9p and regulators of membrane traffic and actin function.

80 ons at a number of cellular sites to control membrane traffic and actin remodeling.

81 thod is of general interest for the study of membrane traffic and aging.

82 Signaling via this pathway is dependent on membrane traffic and appears to increase gradually durin

83 with a role for COPII vesicles and Hrr25 in membrane traffic and autophagosome biogenesis, hrr25 mut

84 RISAP overexpression interferes with apical membrane traffic and blocks tip growth.

85 may be a bifunctional protein with roles in membrane traffic and cortical ER inheritance.

86 nversions appear to confer directionality to membrane traffic and couple each stage of traffic with t

87 Myosin VI is involved in membrane traffic and dynamics and is the only myosin kno

88 the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in ooc

89 characterized for its role in intracellular membrane traffic and endocytosis from the plasma membran

90 for forward and reverse genetic analysis of membrane traffic and endomembrane organisation in Arabid

91 Sec7p, a Golgi protein required for general membrane traffic and functioning as a nucleotide exchang

92 sustained membrane remodeling that underlies membrane traffic and Golgi biogenesis.

93 any proteins that are involved in regulating membrane traffic and have been shown to bind specificall

94 Abscission requires membrane traffic and microtubule disassembly at a specif

95 Membrane traffic and organelle integrity in the plant se

96 naling pathways, including the regulation of membrane traffic and organelle morphology.

97 cal properties of membranes are critical for membrane traffic and organelle morphology.

98 f family of small G proteins are involved in membrane traffic and organelle structure.

99 ase has a dual function in cells, regulating membrane traffic and organizing cortical actin.

100 ctive organelle that is directly involved in membrane traffic and possibly phospholipid recycling.

101 Rab GTPases control membrane traffic and receptor-mediated endocytosis.

102 vesicular trafficking, thus remodeling Golgi membrane traffic and redirecting Golgi-derived vesicles

103 lation factor-6 (ARF6), which is involved in membrane traffic and regulation of the cortical actin cy

104 articularly abundant in proteins involved in membrane traffic and signal transduction.

105 de exchange factors (GEFs) play key roles in membrane traffic and signaling.

106 , motility, cell size, protein synthesis and membrane traffic and signaling.

107 d by post-Golgi compartments that coordinate membrane traffic and sorting of materials to the vacuole

108 light a novel role for lysosomes in cellular membrane traffic and suggest that fusion of lysosomes wi

109 ly of GTP-binding proteins are regulators of membrane traffic and the actin cytoskeleton.

110 To examine the roles of Rac1 in membrane traffic and the formation of this aggregate, we

111 e with those of other types of intracellular membrane traffic and, in turn, support a role for tether

112 myosin teams up to drive muscle contraction, membrane traffic, and cell division in biological cells.

113 conclude that Sec5 is required for directed membrane traffic, and consequently for the establishment

114 to clathrin adaptors, function in post Golgi membrane traffic, and have been implicated in glioblasto

115 cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process t

116 inases (SFK) to perturb cellular morphology, membrane traffic, and organellar dynamics and to trigger

117 n functions as diverse as lipid homeostasis, membrane traffic, and signaling.

118 , intracellular [Ca(2+)] and pH, endocytosed membrane traffic, and the transport of other solutes.

119 Nevertheless, biosynthetic membrane traffic appears to follow different routes in v

120 ng recognition that defects in intracellular membrane traffic are a significant cause of motor neuron

121 id-directed protein-protein interactions for membrane traffic are discussed.

122 crotubule association and the role of p22 in membrane traffic are functionally related, because N-myr

123 large multimeric assemblies that function in membrane traffic, are guanine nucleotide exchange factor

124 deficiency virus (SIV) subvert intracellular membrane traffic as part of their replication cycle.

125 ecific interactions with known components of membrane traffic as well as with diverse proteins not pr

126 tes that Src may play a more general role in membrane traffic as well.

127 ransporters) that mediate a variety of trans-membrane traffic, as well as a segment, DIxxN, that rese

128 11, revealed that Vti1p also plays a role in membrane traffic at a cis-Golgi stage.

129 athrin is a ubiquitous protein that mediates membrane traffic at many locations.

130 ol 4-phosphate (PI4P) regulates biosynthetic membrane traffic at multiple steps and differentially af

131 in yeast) has been implicated in regulating membrane traffic at postinternalization steps along the

132 Golgi complex executed via Rab6 and neuronal membrane traffic at the active zone executed via RIMs.

133 a major contribution to the organization of membrane traffic at the Golgi apparatus.

134 er of the family that has a critical role in membrane traffic at the Golgi apparatus.

135 g unexpected connections between nonneuronal membrane traffic at the Golgi complex executed via Rab6

136 n factor (Arf) GTPases are key regulators of membrane traffic at the Golgi complex.

137 d to Rab6, a GTP-binding protein involved in membrane traffic at the Golgi complex.

138 osphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome format

139 activity prior to glucose starvation primes membrane traffic at the TGN and endosomes in response to

140 N, endosomes, and the cell surface regulates membrane traffic at the TGN/endosomal interface.

141 the small GTP-binding protein that regulates membrane traffic at this stage of the secretory pathway,

142 , sorting endosomes are a major crossroad of membrane traffic, at the intersection of the endocytic a

143 Membrane traffic between the endoplasmic reticulum (ER)

144 in this mutant are indicative of a block in membrane traffic between the ER and Golgi apparatus.

145 COPI-coated vesicles, which are involved in membrane traffic between the ER and Golgi complex.

146 mily not only regulate target recognition in membrane traffic but also control other cellular functio

147 Rab3 is not in itself essential for synaptic membrane traffic but functions to modulate the basic rel

148 eins are best characterized as regulators of membrane traffic, but recent studies indicate an additio

149 rturbs several cellular processes, including membrane traffic, but the underlying mechanisms remain p

150 also find that inhibition of COPII-dependent membrane traffic by a dominant negative SAR1 mutant fail

151 osine triphosphatases regulate intracellular membrane traffic by binding specific effector proteins.

152 otein structural element that contributes to membrane traffic by either inducing or sensing membrane

153 Ps are multidomain proteins that function in membrane traffic by inactivating the GTP binding protein

154 ly and suggest a mechanism for regulation of membrane traffic by lipid products of phosphoinositide 3

155 recent work suggests that this regulation of membrane traffic by phosphorylation also occurs postsyna

156 Reduced membrane traffic caused by loss of Jagunal affects oocyt

157 In this paper, we report that blocking membrane traffic causes a mitotic checkpoint arrest via

158 y of essential cellular processes, including membrane traffic, cell division, and energy metabolism;

159 t VacA-induced alterations in late endocytic membrane traffic contribute to the capacity of H. pylori

160 imental findings suggest that actin-directed membrane traffic contributes to wandering by diluting lo

161 Membrane traffic critically regulates most aspects of ne

162 ring migrated away from the cell middle in a membrane traffic-dependent manner, resulting in asymmetr

163 ically alters postendocytic and biosynthetic membrane traffic directed to the apical, but not the bas

164 lls, therefore coordinating cytoskeleton and membrane traffic during cell migration.

165 inct functions of CHC22 relative to CHC17 in membrane traffic during muscle development, repair, and

166 AC/ROP GTPases coordinate actin dynamics and membrane traffic during polar plant cell expansion.

167 that disruption of the TGN by ASFV can slow membrane traffic during viral infection.

168 point to a role for spastin in intracellular membrane traffic events and provide further evidence to

169 Other membrane traffic events remained unaffected by the drug,

170 No single Arf was required for any step of membrane traffic examined in HeLa cells.

171 ted prominent actin cytoskeleton and receive membrane traffic from cognate apical or basolateral path

172 hich new tER sites are created by retrograde membrane traffic from the Golgi.

173 the yeast Saccharomyces cerevisiae receives membrane traffic from the secretory pathway as well as r

174 sults indicate that PKD-mediated anterograde membrane traffic from the TGN to the PM is required for

175 cells occurs via stimulation of constitutive membrane traffic from the trans-Golgi network (TGN) to t

176 A role for negatively charged lipids in membrane traffic has been postulated to involve the acti

177 tated in CMT, a role for SH3TC2 in endocytic membrane traffic has been previously proposed.

178 s and protein families generally involved in membrane traffic has been reported, despite the essentia

179 However, the role of ArfGAPs in post-Golgi membrane traffic has not been defined.

180 The link between Fas signaling and membrane traffic has remained unclear, in part because i

181 nct models for the regulation of Arf GAP1 in membrane traffic have been proposed.

182 e most important discoveries in the field of membrane traffic have come from studies of Rab GTPases b

183 Transcriptional regulation and membrane traffic have traditionally been quite separate

184 Rab11, a small GTPase implicated in membrane traffic, immunolocalizes to the trans-Golgi net

185 cument an essential role for ARF6- regulated membrane traffic in AJ disassembly and epithelial cell m

186 are 21-kDa GTPases that regulate aspects of membrane traffic in all eukaryotic cells.

187 secGFP) in a non-invasive live cell assay of membrane traffic in Arabidopsis thaliana.

188 coordinate actin cytoskeleton mechanics and membrane traffic in cell migration via integrin beta1 ac

189 Arf and Rab family GTPases regulate membrane traffic in cells, yet little is known about how

190 in-coated vesicles are important vehicles of membrane traffic in cells.

191 s suggest that C9ORF72 is likely to regulate membrane traffic in conjunction with Rab-GTPase switches

192 Here we have examined membrane traffic in cytokinesis and describe several nov

193 , revealing a novel specialization for local membrane traffic in dendritic spines.

194 plex that may tune CFTR activity to rates of membrane traffic in epithelial cells.

195 Membrane traffic in eukaryotic cells relies on recogniti

196 Membrane traffic in eukaryotic cells requires that speci

197 Membrane traffic in eukaryotic cells requires the intera

198 t-SNAREs on target membranes is required for membrane traffic in eukaryotic cells.

199 plays an important role in the regulation of membrane traffic in eukaryotic cells.

200 get particular host factors to short-circuit membrane traffic in macrophages.

201 Our understanding of both membrane traffic in mammalian cells and the cell biology

202 mall synaptic vesicles, the major pathway of membrane traffic in nerve terminals.

203 ly of membrane proteins proposed to regulate membrane traffic in neuronal and nonneuronal cells.

204 are a large family of proteins that regulate membrane traffic in neurons and other cell types.

205 Analysis in this study of KIR3DL1*004 membrane traffic in NK cells shows this allotype is larg

206 mechanism of how mechanical forces regulate membrane traffic in non-excitable cells.

207 tant new information about the correction of membrane traffic in NPC cells by Rab9 overexpression and

208 Efficient postendocytic membrane traffic in polarized epithelial cells is though

209 It has been postulated that membrane traffic in polarized epithelial cells requires

210 ides molecular detail of how the cell alters membrane traffic in response to an external stimulus, in

211 se, is known to govern cellular polarity and membrane traffic in several cell types.

212 a member of the exocyst complex, in directed membrane traffic in the Drosophila oocyte.

213 Sec body formation does not depend on membrane traffic in the early secretory pathway, yet req

214 activating protein receptor (SNARE)-mediated membrane traffic in the transport of MT1-MMP to invadopo

215 lly with two different t-SNAREs in directing membrane traffic in yeast.

216 thrin plays important roles in intracellular membrane traffic including endocytosis of plasma membran

217 any neuronal-specific proteins that regulate membrane traffic, including the poorly understood small

218 r findings suggest that Grp1p may facilitate membrane traffic indirectly, possibly by maintaining Gol

219 vesicle from its parent membrane, can label membrane-traffic intermediates and determine their desti

220 Fas-enhanced membrane traffic invariably produces an accumulation of

221 ogether these results implicate CHC22 in TGN membrane traffic involving the cytoskeleton.

222 Membrane traffic is an essential process that allows pro

223 he accurate assignment of molecular roles in membrane traffic is frequently complicated by the lack o

224 Although membrane traffic is known to play an important role in c

225 pose that the proper regulation of endosomal membrane traffic is necessary for the successful complet

226 ors of cell polarity, but how they influence membrane traffic is not known.

227 complex cellular functions such as polarized membrane traffic is not understood.

228 ere blocked at 14 degrees C, suggesting that membrane traffic is required for both events.

229 nation of actin assembly, AJ remodeling, and membrane traffic is required for the construction of a m

230 Intracellular membrane traffic is thought to be regulated in part by S

231 Intracellular membrane traffic is thought to be regulated in part by s

232 Whether any of this machinery functions in membrane traffic is unknown.

233 ticle (TRAPP), a large complex that mediates membrane traffic, is found in two forms (TRAPPI and -II)

234 hoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of L

235 e homologues in other types of intracellular membrane traffic, likely underlying a universal mechanis

236 tersection of several disciplines, including membrane traffic, lipid organization, synaptic signaling

237 modulating an essential component(s) of the membrane traffic machinery.

238 suggest that dysfunction of Golgi-endosomal membrane traffic may contribute to ANKH-associated patho

239 umophila to manipulate and exploit phagocyte membrane traffic may suggest novel strategies for treati

240 Chloroquine, by inhibiting membrane traffic, may increase association and retention

241 ats, all SCAMPs perform a "core" function in membrane traffic mediated by their TMRs.

242 Proteins involved in membrane traffic must distinguish between different clas

243 ns on gene expression, ion channel function, membrane traffic of ion channels and receptors, and the

244 lts strongly support a role for myosin VI in membrane traffic on secretory and endocytic pathways.

245 in-coated vesicles might regulate retrograde membrane traffic out of the lysosomal compartment.

246 small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediat

247 s can now examine in detail how this ancient membrane traffic pathway contributes to these and other

248 ing key components of this broadly conserved membrane traffic pathway, yeast geneticists generated to

249 Thus, the ARF6 GTP cycle regulates this membrane traffic pathway.

250 sorting events in the transferrin receptor's membrane traffic pathway.

251 chain (CLC) subunits participate in several membrane traffic pathways involving both clathrin and ac

252 Rab GTPases are key regulators of membrane traffic pathways within eukaryotic cells.

253 particular reference to proteins involved in membrane traffic pathways, we discuss recent advances in

254 e small GTPase Arf6, have been used to probe membrane traffic pathways.

255 egulation of certain signal transduction and membrane traffic pathways.

256 ever, Vti1p also functions in two additional membrane traffic pathways: Vti1p interacts with the t-SN

257 our study supports the notion that polarized membrane traffic regulated by the exocyst is an essentia

258 Organelle-specific marker and membrane traffic-related protein distribution data sugge

259 indings define a novel step in TGN-to-plasma membrane traffic required to export MNK to the cell surf

260 Membrane traffic requires the specific concentration of

261 Membrane traffic requires vesicles to fuse with a specif

262 Quantitative analyses of membrane traffic revealed that PI(4)P is required for la

263 b GTPases known to be involved in regulating membrane traffic; signaling molecules such as p50RhoGAP;

264 v-SNAREs, indicating that, unlike post-Golgi membrane traffic, the active form of the endoplasmic ret

265 n at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and t

266 nal myosin that may play a role in vesicular membrane traffic through actin rich regions of the cytop

267 cognate syntaxin Tlg2, which is required for membrane traffic through the endosomal system.

268 teract with Rab6, a small GTPase involved in membrane traffic through the Golgi apparatus.

269 /Rab family in a signal cascade that directs membrane traffic through the secretory pathway.

270 for ARFs that function in the regulation of membrane traffic through the TGN.

271 s and Sla2p in yeast) link clathrin-mediated membrane traffic to actin cytoskeleton dynamics.

272 -coated vesicle formation is responsible for membrane traffic to and from the endocytic pathway durin

273 omplex architecture of the cell and mediates membrane traffic to control flux through subcellular com

274 xamine the contribution of clathrin-mediated membrane traffic to development in Dictyostelium discoid

275 erting host cell intracellular signaling and membrane traffic to down-regulate cell-surface major his

276 novel adaptor protein that couples endocytic membrane traffic to exocytosis.

277 ctin spinoskeleton and for the regulation of membrane traffic to express functional and structural pl

278 This review highlights underlying themes in membrane traffic to help us refocus and solve many remai

279 as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhi

280 gration of microtubules, microfilaments, and membrane traffic to remove apoptotic cells.

281 chment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polari

282 Little is known about how this actin and membrane traffic to the cleavage furrow.

283 in cell division and provide a new model for membrane traffic to the furrow.

284 that they play a role in the specificity of membrane traffic to the two surfaces.

285 To investigate the role of Ykt6p in membrane traffic to the vacuole we generated temperature

286 ions in YKT6 specifically affects post-Golgi membrane traffic to the vacuole, and the effects of thes

287 gs demonstrate a fundamental shift in plasma membrane traffic toward intracellular compartments while

288 ained via a tightly controlled regulation of membrane traffic using a variety of different signaling

289 to regulate each of the four major steps in membrane traffic: vesicle budding, vesicle delivery, ves

290 d-induced signaling by the pIgR may regulate membrane traffic via well-known second messenger pathway

291 obably connected to the endosomal pathway by membrane traffic) was functionally and morphologically n

292 en independently implicated as regulators of membrane traffic, was examined.

293 addition to the effect of infection on host membrane traffic, we focus on these novel interactions a

294 ility that Src may play a role in regulating membrane traffic, we searched for neuronal proteins that

295 eolae show fundamentally altered patterns of membrane traffic when loaded with excess glycosphingolip

296 suggest that Vti1p plays a role in cis-Golgi membrane traffic, which is essential for yeast viability

297 Inhibition of membrane traffic with 0.4 M sucrose also blocked occludi

298 y-dependent mechanisms precisely synchronize membrane traffic with overall proliferation rates and co

299 agment (NTF) of CD74, which severely impairs membrane traffic within the endocytic system and leads t

300 been implicated in many processes, including membrane traffic, yet its role in cell morphology change