ライフサイエンスコーパス: membrane transporter

1 e.g., angiogenesis) or uptake (e.g., amplify membrane transporters).

2 ubiquitous Na(+),K(+)-ATPase, a major plasma membrane transporter.

3 homologue that delivers glycans to the outer membrane transporter.

4 sis suggested that PEG344 serves as an inner membrane transporter.

5 recovery of ligand binding for a multidomain membrane transporter.

6 ins and must homodimerize to form the active membrane transporter.

7 folding of the energy coupling motif of this membrane transporter.

8 couples the proton-motive force to the outer membrane transporter.

9 cific lysosomal transporter but not a plasma membrane transporter.

10 e studies on the functional dynamics of this membrane transporter.

11 CusA/CusB/CusC to form the CusCBA periplasm membrane transporter.

12 th a GT-B fold, and EpsK is an alpha-helical membrane transporter.

13 lecular mechanism of water transport through membrane transporters.

14 nsmit the proton motive force (PMF) to outer membrane transporters.

15 on/cytoskeletal proteins, scaffold proteins, membrane transporters.

16 target genes encoding metabolic enzymes and membrane transporters.

17 ong acid in collaboration with several other membrane transporters.

18 ptake in prokaryotes, are a unique family of membrane transporters.

19 rive active transport by high-affinity outer membrane transporters.

20 C complexes and structural features of inner membrane transporters.

21 use of the structural diversity of the inner membrane transporters.

22 ing factor transporters for the new class of membrane transporters.

23 ole as a regulator of structurally unrelated membrane transporters.

24 s may play distinct roles in the function of membrane transporters.

25 ient uptake before the evolution of advanced membrane transporters.

26 pace primarily through the actions of plasma membrane transporters.

27 e a large and functionally diverse family of membrane transporters.

28 major regulated renal proximal tubule apical membrane transporters.

29 re maintained by a specific system of plasma membrane transporters.

30 and bilayer lipid composition in studies of membrane transporters.

31 rmationally stored potential energy to outer membrane transporters.

32 ored potential energy to ligand-loaded outer membrane transporters.

33 apical pools of BSEP as well as other apical membrane transporters.

34 proteins and the thermodynamic properties of membrane transporters.

35 rage form of pABA as well as a substrate for membrane transporters.

36 d on the crystal structures of two bacterial membrane transporters.

37 g that this collection is highly enriched in membrane transporters.

38 s suggest that U does not exclusively use Ca membrane transporters.

39 e efficiently than selenate due to different membrane transporters.

40 solute carrier 24 (SLC24A1-5) gene family of membrane transporters.

41 nts for use as cofactors requires control of membrane transporters.

42 induced control of ligand affinity to active membrane transporters.

43 primarily via widely expressed facilitative membrane transporters.

44 axon cartridges immunoreactive for the GABA membrane transporter 1 (GAT1) or the calcium-binding pro

45 detectable by gamma-aminobutyric acid (GABA) membrane transporter 1 immunoreactivity is lower, wherea

46 es and the degree of gamma-aminobutyric acid membrane transporter 1 innervation in each axo-axonic sy

47 1) gamma-Aminobutyric acid membrane transporter 1-positive varicosities, whose appe

48 d decarboxylase (GAD) 65 and 67; GABA plasma membrane transporter-1 (GAT-1); GABA type A (GABA(A)) re

49 of the bacterium via an alpha-helical, inner membrane transporter; a periplasmic membrane fusion prot

50 The membrane transporter ABCA1 is a key player in cholestero

51 Extracellularly, in a reaction dependent on membrane transporter ABCA1, prealpha-migrating 2.6 nm ap

52 Here we report genetic mapping of a membrane transporter (ABCC2) to a locus controlling Bt C

53 es a functional connection between the inner membrane transporter AcrB of the RND superfamily and the

54 Membrane transporters actively translocate their substra

55 rs, termed AmTrac and MepTrac, which monitor membrane transporter activity in vivo.

56 Membrane transporters, among them the calmodulin (CaM)-a

57 coelicolor to stimulate the production of a membrane transporter and proteins with homology to actin

58 onents of each transport system are an outer membrane transporter and the energy-coupling protein Ton

59 lux pump, specifically in coupling the inner membrane transporter and the outer membrane exit duct.

60 Membrane transporters and channels (collectively the tra

61 , and plants tend to readjust it, regulating membrane transporters and channels.

62 Numerous membrane transporters and enzymes couple their mechanism

63 f these sequences revealed a large number of membrane transporters and enzymes of carbohydrate metabo

64 nd H(+)-coupled systems in other families of membrane transporters and enzymes.

65 Many Gram-negative outer-membrane transporters and Gram-positive lipoprotein side

66 s well as sex differences in the activity of membrane transporters and in recently discovered myocard

67 s different from those of glucose for plasma membrane transporters and intracellular enzymes; the lum

68 ed targeting and/or retaining of canalicular membrane transporters and is a critical determinant of t

69 stood mechanisms involving a large number of membrane transporters and metal binding proteins with ov

70 abase resource of information on cytoplasmic membrane transporters and outer membrane channels in org

71 on by creating a physical link between inner membrane transporters and outer membrane channels.

72 racterized, and the binding ability of outer-membrane transporters and siderophore-binding proteins f

73 ing five different databases; genes encoding membrane transporters and their regulators were enriched

74 tch is characterized by a down-regulation of membrane transporters and up-regulation of immune access

75 proteins, cytoskeleton-associated proteins, membrane transporters, and enzymes, suggesting the scope

76 esents the largest group of secondary active membrane transporters, and its members transport a diver

77 n orphan gene in the SLC22 family of organic membrane transporters, and its single-nucleotide polymor

78 ations with different activities of enzymes, membrane transporters, and other functional units which

79 The biologically and clinically important membrane transporters are challenging proteins to study

80 Some membrane transporters are dual-topology dimers in which

81 Most plant membrane transporters are encoded by multigene families

82 Variations in intestinal antioxidant membrane transporters are implicated in the initiation a

83 K+ channels and K+-coupled membrane transporters are important targets for drug dis

84 In Enterobacteriaceae, several membrane transporters are involved in zinc homeostasis a

85 Membrane transporters are key determinants of therapeuti

86 Plasma membrane transporters are often downregulated by their s

87 not only ABC transporters but other types of membrane transporters as well.

88 pH environment in bark, they seem to employ membrane transporters associated with nitrogen uptake an

89 ffusion and transport facilitated by various membrane transporters, association with serum albumin in

90 s transmembrane conductance regulator (CFTR) membrane transporter at its original plasma membrane loc

91 xamining the functional expression of plasma membrane transporters at presynaptic terminals, we aim t

92 nce that anti-HAT drugs are interacting with membrane transporters at the human BBB and suggest that

93 r Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the

94 ltured cells by a pathway requiring the cell membrane transporter ATP-binding cassette transporter A1

95 -RLKs) and RLK superfamily members, integral membrane transporters, ATPases, soluble N-ethylmaleimide

96 endocytosis is a common control mechanism of membrane transporters avoiding excess uptake of external

97 nB, an inner membrane protein, with an outer membrane transporter based upon a recent crystal structu

98 Gram-negative bacteria that contain an inner membrane transporter belonging to the resistance nodulat

99 They are composed of the inner membrane transporters belonging to one of three superfam

100 Membrane transporters belonging to the multidrug and tox

101 st, FXR expression and several FXR-dependent membrane transporters (bile salt export pump [BSEP], mul

102 Gram-negative bacteria, TonB-dependent outer-membrane transporters bind large, scarce organometallic

103 not previously recognized, including a major membrane transporter (Brittle-1 or ADP-glucose transport

104 In Escherichiacoli, the TonB-dependent outer membrane transporter BtuB carries out active transport o

105 to determine the affinity of TonB for outer membrane transporters BtuB, FecA, and FhuA.

106 Transcriptional regulation of plasma membrane transporters by internal nutrient concentration

107 rystal structures of a Yersinia pestis outer membrane transporter called FyuA and a bacterial toxin c

108 rge amounts of calcium (Ca(2+)) via an inner membrane transporter called the uniporter.

109 c drug resistance network, expression of the membrane transporters can be regulated by Plc1p, a compo

110 Recent advances show that specialized plant membrane transporters can be used to enhance yields of s

111 as an oligopeptide transporter, is a plasma membrane transporter capable of transporting transition

112 ne operon that also encodes a putative outer membrane transporter, CdrB.

113 r of the ATP-binding cassette superfamily of membrane transporters, CFTR contains two transmembrane d

114 inactivation of the gene (mtrD) encoding the membrane transporter component of the Mtr efflux pump in

115 suggest that a putative endocannabinoid cell membrane transporter controls the cellular AEA and 2-AG

116 CPn1032 or aaxB), and a putative cytoplasmic membrane transporter (CPn1031 or aaxC).

117 TbpA is a TonB-dependent, outer membrane transporter critical for iron acquisition, whil

118 ted the crystal structures of both the inner-membrane transporter CusA and membrane fusion protein Cu

119 bed the crystal structures of both the inner membrane transporter CusA and the membrane fusion protei

120 describe the crystal structures of the inner-membrane transporter CusA in the absence and presence of

121 the cation/proton antiporter 3 family of the Membrane Transporter Database are widely distributed in

122 nsporter type 2 (VMAT2), and dopamine plasma membrane transporters (DATs) were all expressed in cereb

123 the TonB(33-239) dimer is bound to the outer membrane transporter, DEER shows that the TonB(33-239) d

124 Multidrug membrane transporters (efflux pumps) in both prokaryotes

125 There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, wh

126 er, our results support a model in which (i) membrane transporters, encoded by Pdr1 target genes act

127 le to that of other bacteria involving outer membrane transporters energized by TonB as well as plasm

128 mitochondrial outer (cPT1) and inner (cPT2) membrane transporter enzymes are specialized in acylatio

129 P-glycoprotein (P-gp) is a well-known membrane transporter expressed in a number of strategic

130 ndicated that NRT1.11 and NRT1.12 are plasma membrane transporters expressed in the companion cells o

131 NASH is known to alter hepatic membrane transporter expression and drug disposition sim

132 main proteins and one of the most widespread membrane transporter families, the major facilitator sup

133 sporters constitute one of the most abundant membrane transporter families.

134 lated by ferric citrate binding to the outer membrane transporter FecA.

135 otein toxin that uses the TonB system (outer membrane transporter, FepA, and three cytoplasmic membra

136 cytotoxic protein that recognizes the outer membrane transporter, FepA, as a receptor and, after gai

137 We confirmed that the outer membrane transporter FetA allows gonococcal strain FA109

138 In this study, we identified a novel plasma membrane transporter for cGMP.

139 Reduced folate carrier (RFC) is the major membrane transporter for folates and antifolates in mamm

140 MsbA, the inner membrane transporter for nascent lipopolysaccharide, pre

141 ysis, we conclude that MATE1 is an essential membrane transporter for proanthocyanidin biosynthesis i

142 e receptor for the ecotropic retrovirus as a membrane transporter for the essential amino acids lysin

143 rium within BtuB, the Escherichia coli outer membrane transporter for vitamin B(12).

144 BtuB is a TonB-dependent outer-membrane transporter for vitamin B12 (or cyanocobalamin,

145 Taste buds also robustly express plasma membrane transporters for 5-HT and NE.

146 rane proton motive force to TonB-gated outer membrane transporters for active transport of nutrients

147 ECF transporters are a family of active membrane transporters for essential micronutrients, such

148 protein does not resemble that of polytopic membrane transporters for other substrates.

149 The membrane transporters for the monoamines serotonin (SERT

150 d of the co-existence of two different outer membrane transporters for the same substrate is discusse

151 FhaC is an outer membrane transporter from Bordetella pertussis belonging

152 Several novel genes that encode membrane transporters from the ALMT and MATE families re

153 It is suggested that Membrane Transporter functionality is based on low energ

154 orm of glutamic acid decarboxylase, the GABA membrane transporter GAT-1, and the alpha 1 and delta su

155 ures labeled with an antibody against a GABA membrane transporter (GAT-1) did not change across devel

156 tiagabine (0.2 mg/kg of body weight), a GABA membrane transporter (GAT1) blocker, in 17 off-medicatio

157 Membrane transporter gene expression in primary human ma

158 ntronic regions for variation in a set of 24 membrane transporter genes (96 kb; 57% coding) in 247 DN

159 ous single-nucleotide polymorphisms in human membrane transporter genes (and their protein products)

160 egulation of a number of stress response and membrane transporter genes, and, as expected, greening i

161 Furthermore, two membrane transporter genes, including vacuole cation/pro

162 We find that the plasma membrane transporter GlyT2 and the intracellular enzyme

163 they mainly do not involve chemical changes, membrane transporters have been a Cinderella subject in

164 Sinusoidal membrane transporters have been shown to participate in

165 rovesicles, and direct efflux through plasma membrane transporters, have been proposed to explain the

166 In Gram-negative bacteria, outer membrane transporters import nutrients by coupling to an

167 e the first to implicate a specific, luminal membrane transporter in the uptake and toxicity of mercu

168 TRAP) transporters are a widespread class of membrane transporters in bacteria and archaea.

169 simulations performed on several classes of membrane transporters in different conformational states

170 n of all protein-altering variants of eleven membrane transporters in heterologous expression systems

171 , we analyzed the gene expression profile of membrane transporters in HNSCC.

172 ters constitute one of the largest family of membrane transporters in nature.

173 size-dependent efflux kinetics of multidrug membrane transporters in single living cells.

174 deiodinases, nuclear thyroid receptors, and membrane transporters in the brain and liver in patterns

175 ly represents the largest group of secondary membrane transporters in the cell.

176 xtracellular transport of other nutrients to membrane transporters in the core.

177 ed sequence tag contigs that encode putative membrane transporters in the economically important red

178 logenesis is not well known, and the role of membrane transporters in tubulogenesis during developmen

179 Membrane transporters, in addition to their major role a

180 ound that nifurtimox appeared to use several membrane transporters, in particular breast-cancer resis

181 rofiling revealed a striking upregulation of membrane transporters, including aquaporin water channel

182 In other tissues, membrane transporters influence profoundly the extracell

183 , we have applied intracellularly anandamide membrane transporter inhibitors to provide novel evidenc

184 ls and the cardiac Na/K-ATPase, a second key membrane transporter involved in the cardiac ischemia re

185 respiration are well characterized, very few membrane transporters involved in photorespiration have

186 To clarify the role of metabolic enzymes and membrane transporters involved in the disposition of bot

187 A new type of synthetic membrane transporter is described and shown to operate i

188 The expression of polyspecific membrane transporters is one important mechanism by whic

189 or studying how the intracellular traffic of membrane transporters is regulated.

190 One of the less well understood aspects of membrane transporters is the dynamic coupling between co

191 zed roles in proteins, but their function in membrane transporters is underappreciated.

192 XK, a putative membrane transporter, is a component of the XK/Kell comp

193 s one of the best structurally characterized membrane transporters, it is still largely unknown how t

194 ia coli, and one most complex and intriguing membrane transporters known to date.

195 D1042A showed a striking reduction in plasma membrane transporter levels.

196 Membrane transporters maintain cellular and organismal h

197 ose-binding protein (MBP) and a multisubunit membrane transporter, MalFGK(2).

198 Expression levels of membrane transporters may affect the disposition, and th

199 overexpression of ATP-binding cassette (ABC) membrane transporters, mechanisms behind their up-regula

200 riptions of voltage-gated ionic currents and membrane transporters, mechanisms of calcium-induced cal

201 A highly efficient set of membrane transporters mediates the massive movement of n

202 clude genes for catabolic carbon metabolism, membrane transporters, menaquinone biosynthesis, and com

203 The integral membrane transporter MmpL10 is essential for DAT to reac

204 Membrane transporters move substrates across the membran

205 f V-ATPase activity to Pma1p, another plasma membrane transporter, Mup1p, is not internalized in a vm

206 The family of plant membrane transporters named HKT (for high-affinity K(+)

207 e process of photosynthesis to the number of membrane transporters needed to provide sugars to rapidl

208 Slc11a1 is a membrane transporter of bivalent cations that is express

209 ette transporter superfamily, is the central membrane transporter of the colicin V secretion system i

210 Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in

211 actions such as its ability to block plasma membrane transporters of all monoamines, reduce dopamine

212 et essential organometallic compounds, outer membrane transporters of Gram-negative bacteria work in

213 Membrane transporters of the RND superfamily confer mult

214 ia can detect environmental iron using outer membrane transporters (OMTs), and then regulate certain

215 affect tubular transport by interacting with membrane transporters on the luminal side of tubular epi

216 2+ may be a direct effect of amiodarone on a membrane transporter or may be by a CCE mechanism.

217 d in neuronal tissues and encodes a putative membrane transporter or receptor.

218 ,K(+)-ATPase frequently assembles with other membrane transporters or cellular matrix proteins in spe

219 Localization of the basolateral membrane transporter, organic anion transporting polypep

220 The human multi-drug resistance membrane transporter, P-glycoprotein, or P-gp, has been

221 Cells lacking the genes encoding plasma membrane transporters Pdr5 and Snq2, two targets of Pdr1

222 4A11 has been proposed to be an electrogenic membrane transporter, permeable to Na(+), H(+) (OH(-)),

223 Membrane transporters play a central role in many cellul

224 Membrane transporters play a key role in obtaining suffi

225 cs and substrate specificity, these integral membrane transporters play key roles in metal homeostasi

226 ed esters were examined as modulators of the membrane transporter proteins ABCB1 (P-gp), ABCG2 (BCRP)

227 Membrane transporter proteins are essential for the main

228 stance arising from the activity of integral membrane transporter proteins presents a global public h

229 SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucle

230 ate the endocytosis of Tat2 and likely other membrane transporter proteins.

231 The CmeR-regulated genes encode membrane transporters, proteins involved in C4-dicarboxy

232 e, we establish that the inner mitochondrial membrane transporter, pyrimidine nucleotide carrier, tra

233 member of the Major Facilitator Superfamily, membrane transporters reacting to stimuli from the exter

234 ght to function as a sodium-dependent plasma membrane transporter, recent studies localized the prote

235 enger region, the alpha-domain, and an outer membrane transporter region, the beta-domain.

236 , with IL resistance established by an inner membrane transporter, regulated by an IL-inducible repre

237 Membrane transporters rely on highly coordinated structu

238 physiological role of the several classes of membrane transporters remains unknown.

239 r and antiviral chemotherapies because these membrane transporters remove the chemotherapeutics from

240 ymes responsible for TMAO catabolism and the membrane transporter required for TMAO uptake into micro

241 rstanding of plant phosphoproteins and plant membrane transporters, respectively, from evolutionary r

242 esistant parasites are defective in a plasma membrane transporter responsible for drug uptake.

243 SLC39A8 is a membrane transporter responsible for manganese uptake in

244 TbpA is a TonB-dependent outer membrane transporter responsible for the transport of ir

245 Inactivation of abc3(+), encoding a vacuolar membrane transporter, results in hem1Delta abc3Delta mut

246 brane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented.

247 and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane

248 he rate of serotonin reuptake via its plasma membrane transporter (SERT).

249 folded protein response by activating the ER membrane transporter SLC33A1/AT-1, which ensures continu

250 Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface recepto

251 a significantly increased mRNA expression of membrane transporters SLCO1A2 and SLCO1B3 and a signific

252 Integral membrane transporters, soluble lipid-binding proteins, a

253 Support for the existence of the putative membrane transporter stems primarily from pharmacologica

254 These efflux pumps consist of an inner membrane transporter such as the AcrB proton antiporter,

255 xpression of some ATP-binding cassette (ABC) membrane transporters such as ABCB1/P-glycoprotein/MDR1

256 of this protein with the inner mitochondrial membrane transporters suggested a domain structure in wh

257 ydrate utilization with TonB-dependent outer membrane transporter system) contains two major xylanase

258 y uncharacterized iron-repressed cytoplasmic membrane transporter system, fbpABC, that is required fo

259 Distinct from many plasma membrane transporters targeted to the vacuole for degrad

260 rmore, expression of the characterized outer membrane transporters TbpA, FetA and LbpA and putative t

261 Plasma membrane transporters terminate the actions of several s

262 YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange acr

263 transporting polypeptide 2B1 (OATP2B1) is a membrane transporter that facilitates the cellular uptak

264 ssette transporter, family 12) is a cellular membrane transporter that facilitates the delivery of gl

265 of multidrug resistance protein 1 (MDR-1), a membrane transporter that functions as an efflux pump fo

266 anger (NHE-1) is a ubiquitous electroneutral membrane transporter that is activated by hypertonicity

267 this study confirm that ZmALMT1 is a plasma membrane transporter that is capable of mediating electi

268 PepT1 is an intestinal epithelial apical membrane transporter that is expressed in the small inte

269 protein MlaD is known to be part of an inner membrane transporter that is important for maintenance o

270 ein, thereby affecting the functions of this membrane transporter that mediates multidrug resistance.

271 FLR1 encodes a plasma membrane transporter that mediates resistance to benomyl

272 Also, NcZNT1 was found to be a plasma membrane transporter that mediates Zn but not Cd, iron (

273 Na(+)/Ca(2+) exchanger (NCX) is a plasma membrane transporter that moves Ca(2+) in or out of the

274 resistance-associated protein-4 (MRP4) is a membrane transporter that regulates the cellular efflux

275 Glyt1 encodes a membrane transporter that regulates the glycine concentr

276 etylation machinery includes AT-1/SLC33A1, a membrane transporter that translocates acetyl-CoA from t

277 Membrane transporters that clear the neurotransmitter gl

278 wth and survival depend upon the activity of membrane transporters that control the movement and dist

279 f cation diffusion facilitators, a family of membrane transporters that play a central role in regula

280 /calcium (Na(+)/Ca(2+)) exchangers (NCX) are membrane transporters that play an essential role in mai

281 rition critically depends on the activity of membrane transporters that translocate minerals from the

282 NCKXs are bi-directional membrane transporters that transport 1 Ca(2+)+K(+) ions

283 Membrane transporters that use energy stored in sodium g

284 cting the symbiotic relationship between two membrane transporters, the Nicotinamide adenine dinucleo

285 Yeast VPS genes play a role in delivery of membrane transporters to the vacuole for degradation, an

286 tein of interest is expressed with its outer membrane transporter (TpsB) protein in a flagellin-minus

287 ession as targets of the AAR pathway include membrane transporters, transcription factors from the ba

288 In these tripartite pumps an inner membrane transporter, typically an ATPase or proton anti

289 ients through high-affinity TonB-gated outer membrane transporters using energy derived from the cyto

290 R controls cytoplasmic chaperones and plasma membrane transporters, whereas CopR/S responds to peripl

291 onformational changes in this class of outer membrane transporters, which involve modest energy diffe

292 s likely represent a universal phenomenon in membrane transporters, which is consistent with their re

293 ke NADA, it was recognized by the anandamide membrane transporter while being a poor substrate for fa

294 the TonB-dependent family of integral outer membrane transporters, while TbpB is lipid modified and

295 SLC22A1 encodes a hepatic plasma membrane transporter whose role in acylcarnitine physiol

296 large-scale conformational changes of other membrane transporters whose computational investigation

297 a(+)/Ca(2+) exchangers (NCXs) are ubiquitous membrane transporters with a key role in Ca(2+) homeosta

298 Two sinusoidal membrane transporters with an established role in hepati

299 ort is mediated by a broad array of specific membrane transporters with overlapping substrate specifi

300 : a secretion pathway comprised of the outer membrane transporter ZirT, and its secreted partner, Zir