ライフサイエンスコーパス: membrane-associated protein

1 s and 45.5% cytosol proteins (including 8.6% membrane-associated proteins).

2 ed that the XAP-1 antigen is a photoreceptor membrane-associated protein.

3 retromer complex and Hrs, an early endosomal membrane-associated protein.

4 elongated into a tube encased in a sheath of membrane-associated protein.

5 lla, and demonstrate that Mig-14 is an inner membrane-associated protein.

6 of vaccinia virus was predicted to encode a membrane-associated protein.

7 elivered by Escherichia coli as a lipidated, membrane-associated protein.

8 One PNKD isoform is a membrane-associated protein.

9 rt the partitioning of additional well known membrane associated proteins.

10 OMP component BamA along with several outer membrane associated proteins.

11 ted that EGRs target cytoskeleton and plasma membrane-associated proteins.

12 e processes and as a barrier to diffusion of membrane-associated proteins.

13 ified CT049 and CT050 as potential inclusion membrane-associated proteins.

14 so affected the transport of soluble but not membrane-associated proteins.

15 sinica, as a model for NMR investigations of membrane-associated proteins.

16 he membrane on the structure and dynamics of membrane-associated proteins.

17 he endocytic process, along with a number of membrane-associated proteins.

18 ethodology facilitates the reconstitution of membrane-associated proteins.

19 ted to be outer membrane, inner membrane, or membrane-associated proteins.

20 Slit/Robo, cell-polarity proteins, and other membrane-associated proteins.

21 ne surfaces where it may interact with other membrane-associated proteins.

22 igned as known integral membrane proteins or membrane-associated proteins.

23 and extracts, whereas Alb-23 and Alb-69 were membrane-associated proteins.

24 ll as numerous conserved-hypothetical and/or membrane-associated proteins.

25 s are responsible for ectodomain shedding of membrane-associated proteins.

26 ng factors, RNA-binding proteins, and plasma membrane-associated proteins.

27 density fractions at the buoyant density of membrane-associated proteins.

28 ted with assaying for interactions involving membrane-associated proteins.

29 owed that Erg26p, Erg27p, and Erg28p are all membrane-associated proteins.

30 s linking spectrin-actin complexes to plasma membrane-associated proteins.

31 been identified, including both nuclear and membrane-associated proteins.

32 or that is involved in trafficking of plasma membrane-associated proteins.

33 phages derived from mice deficient for these membrane-associated proteins.

34 found to be homologous to known exported or membrane-associated proteins.

35 s of membrane lipids and integral as well as membrane-associated proteins.

36 the activity of many ion channels and other membrane-associated proteins.

37 e composition, shape and the organization of membrane-associated proteins.

38 s of membrane lipids and integral as well as membrane-associated proteins.

39 ed with a diverse population of integral and membrane-associated proteins.

40 arge that in turn modulate interactions with membrane-associated proteins.

41 ntified, including 379 integral membrane and membrane-associated proteins.

42 ing a role for Arp2/3 in the distribution of membrane-associated proteins.

43 sion studies revealed that CidA and LrgA are membrane-associated proteins.

44 membrane curvature, and its interaction with membrane-associated proteins.

45 ounts of perforin, granzyme B, and lysosomal membrane-associated protein 1 (CD107a) in their cytotoxi

46 ated within single-membrane acidic lysosomal membrane-associated protein 1-positive inclusions, where

47 fs, 12 lipoproteins, 9 secreted proteins, 22 membrane-associated proteins, 1 bacteriophage-associated

48 Integral membrane-associated protein-1 (Itmap1) is a CUB (complem

49 RPE65 is a membrane-associated protein abundantly expressed in the

50 ide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate

51 n is mislocalized in this mutant, as are the membrane-associated proteins, actin and beta-catenin, th

52 ps Cdc42 to undergo the transition between a membrane-associated protein and a soluble (cytosolic) sp

53 that the product of the A9L gene is a viral membrane-associated protein and functions at an early st

54 ClipR-59 is a membrane-associated protein and has been implicated in m

55 rea denaturation process of an alpha-helical membrane-associated protein and its completely unfolded

56 mutant strains were associated only with the membrane-associated protein and not with the cytoplasmic

57 h in yeast with both a selection to identify membrane-associated proteins and a selection to identify

58 y-modulated, processive interactions between membrane-associated proteins and elongating filament end

59 Ezrin provides a linkage between membrane-associated proteins and F-actin, oscillating be

60 nt micelles, methods are outlined for larger membrane-associated proteins and for use of other solubi

61 homology (PH) domains are found in numerous membrane-associated proteins and have been implicated in

62 In contrast, other membrane-associated proteins and non-CME endocytic prote

63 -level-resolution structures and dynamics of membrane-associated proteins and peptides.

64 eased MAP kinase-mediated phosphorylation of membrane-associated proteins and reduced phosphorylation

65 biosynthesis as well as other cell wall and membrane-associated proteins and ROS scavenging enzymes.

66 We determined that HfaB and HfaD are membrane-associated proteins and that HfaB is a lipoprot

67 appears to provide regulated linkage between membrane-associated proteins and the actin cytoskeleton

68 proteins provide a regulated linkage between membrane-associated proteins and the actin cytoskeleton.

69 ly required for thorough characterization of membrane-associated proteins and were facilitated by the

70 resistance to MC, led to the synthesis of a membrane-associated protein, and correlated with reduced

71 ifiable MOMP either in purified form or as a membrane-associated protein, and so facilitate the inves

72 The variants include STEP(61), a membrane-associated protein, and STEP(46), a cytosolic p

73 proteoglycans and the tetraspanin family of membrane-associated proteins appear to act as cofactors

74 Genes coding for putative membrane and membrane-associated proteins are among the largest class

75 cific probes to show that most or all plasma membrane-associated proteins are clustered in cholestero

76 sive properties of the RGM-related family of membrane-associated proteins are compatible with specifi

77 t regulators and conserved rickettsial outer membrane-associated proteins are critical to mediate ser

78 This suggests that membrane-associated proteins are important for the coexi

79 Several membrane-associated proteins are known to modulate the a

80 rans-Golgi lumina were spanned by asymmetric membrane-associated protein arrays that had approximatel

81 Increased expression of the membrane-associated protein At14a-like1 (AFL1) led to in

82 zation-like signal, sequence similarities to membrane-associated proteins, ATP binding properties, an

83 Two membrane-associated proteins, bacteriorhodopsin and ApoA

84 one Sox2-replacing antibody antagonizes the membrane-associated protein Basp1, thereby de-repressing

85 s on a hierarchical process whereby specific membrane-associated proteins become targeted to speciali

86 F-BAR proteins are membrane-associated proteins believed to link the plasma

87 product of a cDNA encoding a multifunctional membrane-associated protein binds the seco-steroid 1,25(

88 51 proteins, including periplasmic and outer membrane-associated proteins, but also many determinants

89 more, TUDCA promoted the degradation of cone membrane-associated proteins by enhancing the ER-associa

90 Removal of membrane-associated proteins by proteases decreases the

91 Expression of a thylakoid membrane-associated protein called IdiA (iron-deficiency

92 mor suppressor gene encodes an intracellular membrane-associated protein, called merlin, which belong

93 Ubiquitination of membrane-associated proteins can direct their proteasome

94 Reciprocally, many membrane-associated proteins can modulate the shape, lip

95 nstrated that the membrane alone, or through membrane-associated proteins, can effect dynamic changes

96 Human ferrochelatase, a mitochondrial membrane-associated protein, catalyzes the terminal step

97 ndent increase in membrane colocalization of membrane-associated protein CD14.

98 Recent reports indicate that three membrane-associated proteins, CD14, CD11b/CD18, and Toll

99 d and colocalized with MAP17, a small 17-kDa membrane-associated protein; cMOAT, an organic anion tra

100 MyoA is part of a membrane-associated protein complex called the glideosom

101 king that intersectin is present in ECs in a membrane-associated protein complex containing dynamin a

102 Sarcoglycan is a membrane-associated protein complex found at the plasma

103 reby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immed

104 EF) activity and characterized it as a large membrane-associated protein complex that localizes to th

105 proteins encoded by the operon form an inner-membrane-associated protein complex that may interact wi

106 The dystrophin complex is a multimolecular membrane-associated protein complex whose defects underl

107 ir main function is to provide scaffolds for membrane-associated protein complexes by binding to the

108 We propose that membrane-associated protein complexes may represent a ge

109 verse range of known and novel cytosolic and membrane-associated protein complexes.

110 ctor (NHERF) homologous adaptors 1 and 2 are membrane-associated proteins composed of two amino (N)-t

111 mon mitochondrial lipids, and abundant inner-membrane associated proteins concentrated in the bottom-

112 p12(I) is a conserved, membrane-associated protein containing four SH3-binding

113 How these membrane-associated proteins cope with the hydrophilic c

114 ctron microscopy, using antisera against the membrane-associated protein CTRP and the soluble WARP, s

115 ficking necessarily involves both lipids and membrane-associated proteins, current mechanistic views

116 The adsorption of membrane-associated protein cytochrome c to anionic lipi

117 cific cysteine protease (ESCP) was the first membrane-associated protein described to be part of the

118 identified and shown to encode two potential membrane-associated proteins, designated LrgA and LrgB,

119 There are several examples of membrane-associated protein domains that target curved m

120 rvival in Opn1sw(-/-)Lrat(-) (/-) mice, cone membrane-associated proteins (e.g. Galphat2, GRK1 and GC

121 PSMA1-GFP copurifies with several acrosomal membrane-associated proteins (e.g., lactadherin/milk fat

122 ne-rich repeats and forms a complex with the membrane-associated protein ERBB2IP.

123 our laboratories and applied to the study of membrane-associated proteins, especially GPCRs.

124 ed previously in rat cerebellum, is a plasma membrane-associated protein expressed at the RNA level i

125 Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2

126 Moreover, GacJ, a small membrane-associated protein, formed a complex with GacI

127 hared with mammalian junctophilins and other membrane-associated proteins found within excitable cell

128 ithin the cell as part of the soluble and/or membrane-associated protein fraction.

129 We determined that eight membrane-associated proteins from B. quintana bind hemin

130 The shedding of membrane-associated proteins has been recognized as a re

131 inositol (GPI) linkage found in many natural membrane-associated proteins; however, the synthetic met

132 Notch1 is the first membrane-associated protein identified with either O-lin

133 Out of 1736 soluble proteins and 2187 membrane-associated proteins identified, 288 and 56, res

134 his study, we report the identification of a membrane-associated protein, Ig-like transcript 4 (ILT4)

135 We found that (i) MTMR13 is a predominantly membrane-associated protein; (ii) MTMR2 and MTMR13 cofra

136 However, immunoblots of membrane-associated proteins, immunoelectron microscopy

137 MAL is a detergent-resistant membrane-associated protein implicated in apical sorting

138 Dysferlin is a membrane-associated protein implicated in membrane resea

139 Dysferlin is a membrane-associated protein implicated in muscular dystr

140 Myoferlin is a membrane-associated protein important for muscle develop

141 In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.

142 ptide recognizes an approximately 58-kDa egg membrane-associated protein in eggs of S. purpuratus as

143 tinoid isomerase in this pathway is Rpe65, a membrane-associated protein in the retinal pigment epith

144 ting proteins such as ion channels and other membrane-associated proteins in defined areas of the pla

145 croscopy was used to study redistribution of membrane-associated proteins in naive T cells from young

146 yeast genetics to identify 211 ubiquitinated membrane-associated proteins in Saccharomyces cerevisiae

147 tegral membrane proteins for drug design and membrane-associated proteins in the regulation cellular

148 ated lysosomal hydrolytic enzymes and plasma membrane-associated proteins in the supernatant of Tat-e

149 ubiquitin-modifying enzymes, which act upon membrane-associated proteins in transit.

150 eta-subunit and molecule X, a thiol-reactive membrane-associated protein, in both intact and semiperm

151 roxy acid oxidase/dehydrogenase family, is a membrane-associated protein, in contrast to the more wel

152 R may have primarily a structural role, as a membrane-associated protein, in milk fat droplet secreti

153 The mistrafficking of cone membrane-associated proteins including cone opsins (M- a

154 the phage display of representative types of membrane-associated proteins including plasma, nuclear,

155 After SPB insertion, membrane-associated proteins including the conserved Ndc

156 However, a rapidly growing number of membrane-associated proteins (including cytoskeletal pro

157 mbrane cholesterol regulates the activity of membrane-associated proteins, including BK channels.

158 ative protein targets of the acetogenins are membrane-associated proteins, including complex I.

159 eria and causes mislocalization of essential membrane-associated proteins, including MinD and FtsA.

160 r examine the interaction of PorB with outer membrane-associated proteins, including PorA and RmpM.

161 Several cytosolic and membrane-associated proteins, including the Rab family m

162 Recent studies have implicated a number of membrane-associated proteins, including the signaling pa

163 The membrane-associated proteins initiate signaling that act

164 ion, CEP-290 prevents inappropriate entry of membrane-associated proteins into cilia and keeps ARL-13

165 Dysferlin is a membrane associated protein involved in vesicle traffick

166 member of a newly recognized superfamily of membrane-associated proteins involved in eicosanoid and

167 her structures of proteins within the MAPEG (Membrane-Associated Proteins involved in Eicosanoid and

168 Caveolin-1 (CAV1), a highly conserved membrane-associated protein, is a putative regulator of

169 omal prostaglandin E synthase-1 (mPGES-1), a membrane-associated protein, is critically involved in t

170 CTRP5, a secretory and membrane-associated protein, is localized to the lateral

171 immune response of mice and Lyme patients to membrane-associated proteins isolated from Borrelia burg

172 Three membrane-associated proteins, Kibra, Merlin, and Expande

173 Sulfolobus solfataricus contains a membrane-associated protein kinase activity that display

174 c archaeon Sulfolobus solfataricus harbors a membrane-associated protein kinase activity.

175 The activity of membrane-associated protein kinase C (PKC) is tightly co

176 that the glucose sensors are coupled to the membrane-associated protein kinase casein kinase I (Yck1

177 A novel murine membrane-associated protein kinase, PKK (protein kinase

178 Two paralogous plasma membrane-associated protein kinases, Pkh1 and Pkh2 (orth

179 Additionally, the nuclear-membrane-associated proteins, lamin A/C and emerin, were

180 By contrast, alpha-helical membrane-associated proteins largely evade such approach

181 PHB2 binds the autophagosomal membrane-associated protein LC3 through an LC3-interacti

182 Mutations that alter the expression of these membrane-associated proteins lead to muscular dystrophy

183 Transcription of membrane-associated proteins leads to localized hypersup

184 n-glycoprotein complex is a large complex of membrane-associated proteins linking the cytoskeleton to

185 lize to the cell midpoint, assembling into a membrane-associated protein machine that forms the divis

186 , we identified an accessory protein, 17 kDa membrane-associated protein (MAP17), that increased SGLT

187 t the proportions of proteomes consisting of membrane-associated proteins may be currently underestim

188 structure and dynamics of the alpha-helical membrane-associated protein Mistic as well as its intera

189 lts have been reported as to whether the two membrane-associated proteins MreC and MreD are essential

190 We show that a gut-membrane-associated protein, named Mesh, plays an import

191 ay facilitate the identification of cellular membrane-associated proteins necessary for induction of

192 scribed role of SGK-1 in phosphorylating the membrane-associated protein Nedd4-2 and the integral mem

193 and peripheral nervous system (PNS), where a membrane-associated protein, Numb, is asymmetrically loc

194 The IM30 (inner membrane-associated protein of 30 kDa), also known as th

195 photoaffinity analog specifically labeled a membrane-associated protein of approximately 170 kDa.

196 We conclude that FAM65B is a plasma membrane-associated protein of hair cell stereocilia tha

197 furthermore demonstrate that RPE65, a major membrane-associated protein of the RPE, is a RBP.

198 tein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hai

199 e it readily applicable to the study of many membrane-associated proteins of biochemical and pharmaco

200 tospiral proteins in Escherichia coli as the membrane-associated proteins OmpL1-M and LipL41-M.

201 e made of their capacities to ADP-ribosylate membrane-associated proteins on the surface of V79 cells

202 rotocol was found to detect ~65% more unique membrane-associated protein (p < 0.001, n = 6) based on

203 eta(2) by lipid rafts and by the presence of membrane-associated protein partners.

204 Receptor-cargo docking occurs at the membrane-associated protein Pex14.

205 ilayers and the membrane-proximal regions of membrane-associated proteins play important roles in reg

206 r results suggest that major cytoplasmic and membrane-associated protein precursors of the presynapti

207 DANGER is a membrane-associated protein predicted to contain a parti

208 RPE65, a membrane-associated protein predominantly expressed in t

209 family, lymphotoxin-alpha (LT-alpha), and a membrane-associated protein referred to as LIGHT.

210 odr-2 encodes a membrane-associated protein related to the Ly-6 superfam

211 Endophilin is a membrane-associated protein required for endocytosis of

212 FTS_1680-encoded protein was identified as a membrane-associated protein required for full cytopathog

213 FLOTILLIN4 (FLOT4), another punctate plasma membrane-associated protein required for infection.

214 A broadly conserved membrane-associated protein required for the functional

215 Spectrins represent a family of membrane-associated proteins responsible for membrane fl

216 he identification of 231 proteins present in membrane-associated protein samples, of which a subset o

217 SIM and the Smad-binding domain (SBD) of the membrane-associated protein SARA (Smad anchor for recept

218 Pkn8 is a membrane-associated protein Ser/Thr kinase (PSTK) of Myx

219 One of the glycoproteins comigrated with the membrane-associated protein-serine/threonine kinase from

220 Membrane associated proteins SNAREs (soluble N-ethylmale

221 udies indicated that a subset of immunogenic membrane-associated proteins (some new and some previous

222 bidopsis (Arabidopsis thaliana), is a plasma membrane-associated protein specifically involved in neg

223 DIAN1 [CIR1], and SPFH/PHB DOMAIN-CONTAINING MEMBRANE-ASSOCIATED PROTEIN [SPFH]) that are mis-spliced

224 81-176 mutants defective in any of the three membrane-associated protein subunits of cytolethal diste

225 ins such as the cannabinoid CB1 receptor and membrane-associated proteins such as FAAH.

226 of the tubulin homolog FtsZ as well as other membrane-associated proteins such as FtsA, a homolog of

227 teractions, we established that heterologous membrane-associated proteins such as MinD can be targete

228 eractions with positively charged regions of membrane-associated proteins such as myristoylated alani

229 plicates trans-synaptic interactions between membrane-associated proteins such as neurexins and neuro

230 ase cascade, in turn, is regulated by apical membrane-associated proteins such as the FERM domain pro

231 N- and C-ERMADs) that mask sites for binding membrane-associated proteins, such as EBP50 and E3KARP,

232 studies show that upon cell contact, various membrane-associated proteins, such as Ras-family protein

233 n the cell surface distribution of polytopic membrane-associated proteins, suggesting that the mutati

234 sts linkage, in astrocytes, between a plasma membrane-associated protein that can act as a receptor f

235 Bacteriophage 29 protein p1 is a membrane-associated protein that forms large protofilame

236 al analyses, we demonstrate that DRAG-1 is a membrane-associated protein that functions at the ligand

237 SNX1 is a membrane-associated protein that functions in lysosomal

238 enuating Notch signaling by inducing Numb, a membrane-associated protein that inhibits Notch signalin

239 Polycystin-1 is a large membrane-associated protein that interacts with polycyst

240 The mouse numb (m-numb) gene encodes a membrane-associated protein that is asymmetrically local

241 We recently identified Vema as a novel membrane-associated protein that is expressed at the ven

242 DAP12 is a cell membrane-associated protein that is expressed in myeloid

243 ow that TG1 is an endoplasmic reticulum (ER) membrane-associated protein that is trafficked through t

244 glo-3 encodes a predicted membrane-associated protein that lacks obvious sequence

245 indicate that BBA74 is a periplasmic, outer membrane-associated protein that lacks properties typica

246 Aer is a membrane-associated protein that mediates aerotactic res

247 Syntabulin is a peripheral membrane-associated protein that targets to mitochondria

248 resulting in the identification of T. cruzi membrane-associated proteins that are potential vaccine

249 t junction is comprised of transmembrane and membrane-associated proteins that are thought to assembl

250 ctionally modulated in part by ectoapyrases, membrane-associated proteins that cleave the gamma- and

251 matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces gen

252 nments, placing cPLA2delta into the class of membrane-associated proteins that contain a tandem pair

253 Examining membrane-associated proteins that copurified with GOA-1

254 ing proteins (Csps) are J-domain-containing, membrane-associated proteins that have been functionally

255 analysis enabled the identification of novel membrane-associated proteins that may serve as new diagn

256 genes encode a novel class of extracellular, membrane-associated proteins that notably play an import

257 and characterization of recently identified membrane-associated proteins that regulate replication a

258 (PLSCRs) constitute a family of cytoplasmic membrane-associated proteins that were identified based

259 Dystrophin binds a set of membrane-associated proteins (the dystrophin-glycoprotei

260 n important antiangiogenic vascular basement membrane-associated protein, the 26-kDa NC1 domain of th

261 or normal endosomal recycling of soluble and membrane-associated proteins through the ERC and propose

262 cing the ability of BAX to transition from a membrane-associated protein to a membrane-integral prote

263 r ciliogenesis require it to localize select membrane-associated proteins to the cilium, including Ar

264 , including vacuole biogenesis, targeting of membrane-associated proteins to the vacuole, and secreti

265 that requires A-type lamin, an inner nuclear membrane-associated protein, to accelerated aging observ

266 A thiol-reactive membrane-associated protein (TRAP) binds covalently to t

267 Membrane-associated protein tyrosine kinases and phospha

268 , gK, and gM, the membrane protein UL20, and membrane-associated protein UL11 play important roles in

269 c envelopment, in a protein complex with the membrane-associated protein UL20 (UL20mp).

270 The highly membrane-associated proteins UL20p and glycoprotein K (g

271 it is in close proximity to a thiol-reactive membrane-associated protein under basal and insulin-stim

272 We previously showed that the novel membrane-associated protein Vema is localized to the flo

273 Aberrant localization of these membrane-associated proteins was evident at postnatal da

274 a previously uncharacterized gene encoding a membrane-associated protein, was sensitive to acid and f

275 Membrane associated proteins were extracted from cells w

276 When plasma membrane-associated proteins were applied to these colum

277 utative efflux pump and several hypothetical membrane-associated proteins were identified and predict

278 Moreover, the majority of these immunogenic membrane-associated proteins were recognized by sera fro

279 f X. nematophila and is produced as an outer membrane-associated protein when expressed in Escherichi

280 APC-derived MHC class II molecules and other membrane-associated proteins when cultured with xenogene

281 C2 domains are found in a variety of membrane-associated proteins where they have been implic

282 RP2 is a ubiquitous 350 amino acid plasma membrane-associated protein, which shares homology with

283 n), is a member of the protein 4.1 family of membrane-associated proteins, which also includes ezrin,

284 Both cytoplasmic- and membrane-associated proteins, which are normally restric

285 age-gated calcium channels are extracellular membrane-associated proteins, which are post-translation

286 of changes in sarcomeric, nonsarcomeric, and membrane-associated proteins, which could have important

287 enzyme from C. crescentus is a homodimeric, membrane-associated protein while the enzyme from M. tub

288 es during maturation of cysteine-containing, membrane-associated proteins while ignoring the same cys

289 bly, gCfull was expressed predominantly as a membrane-associated protein, while both gC104 and gC145

290 ionship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fol

291 Each gene encodes a predicted membrane-associated protein with diguanylate cyclase act

292 uscular dystrophy (LGMD) 2B locus, encodes a membrane-associated protein with homology to Caenorhabdi

293 The data suggest DAL-1 is a novel membrane-associated protein with potential to play an im

294 Caveolin 1 (Cav-1) is a plasma membrane-associated protein with the capacity to modulat

295 lic-nucleotide 3'-phosphodiesterase (CNP), a membrane-associated protein with unknown function in mam

296 Although podocin and MEC-2 are membrane-associated proteins with a predicted hairpin-li

297 ochondria and in submitochondrial particles, membrane-associated proteins with apparent molecular mas

298 -dependent colocalization of these and other membrane-associated proteins with crosslinked receptors

299 ifunctional Golgi-endoplasmic reticulum (ER) membrane-associated protein, with roles in enhancing vir

300 ol critical biological processes by cleaving membrane-associated proteins within a transmembrane segm