ライフサイエンスコーパス: membrane-spanning

1 spirin belonged to arachidonic acid pathway, membrane-spanning 4A gene family, histamine production p

2 nsmembrane conductance regulator (CFTR) is a membrane-spanning adenosine 5'-triphosphate (ATP)-bindin

3 owed that the TMD of Sso1p is a well-defined membrane spanning alpha-helix.

4 In particular, the peptides assume a membrane-spanning alpha-helical conformation that does n

5 ntation of a designed synthetic hydrophobic, membrane-spanning alpha-helical peptide that is anchored

6 odel membrane protein consisting of a single membrane-spanning alpha-helix with a Green Fluorescent P

7 ading to a Y356C substitution in the seventh membrane-spanning alpha-helix, was observed in a patient

8 putative scaffold domains, which coordinate membrane-spanning amphipathic helices that form the suga

9 Cellular expression studies showed that membrane spanning and C-loop mutations produced a simila

10 ively charged linker sequence that separates membrane-spanning and cytoplasmic (YscUC) domains.

11 peatedly identified near the junction of the membrane-spanning and cytoplasmic domains of band 3, and

12 d exhibit occasional transitions between the membrane-spanning and the surface-bound configurations.

13 s governed by the rate of degradation of its membrane-spanning anti-sigma factor, RseA.

14 ntrolled by regulated degradation of RseA, a membrane-spanning anti-sigma factor.

15 e is initiated by sequential cleavage of the membrane-spanning antisigma factor, RseA.

16 proteins are believed to interact to form a membrane-spanning apparatus through which the toxin is s

17 ng substrate of 220 kDa)/ankyrin repeat-rich membrane spanning (ARMS) acts as a signaling platform at

18 However, designed membrane-spanning assemblies developed to date have been

19 rsin/cofactor AAA ring, forming a composite, membrane-spanning assembly.

20 been shown to be a beta-barrel containing 19 membrane spanning beta-strands and an N-terminal alpha-h

21 Tom40 is predicted to comprise a membrane-spanning beta-barrel domain with conserved alph

22 al for the functions of Toc75, followed by a membrane-spanning beta-barrel domain.

23 om a combinatorial library designed to mimic membrane-spanning beta-hairpins.

24 o 50 site-specific modifications to create a membrane-spanning beta-helical structure.

25 Here we test the hypothesis that membrane-spanning beta-sheets can exhibit structural pla

26 A series of membrane-spanning bolaamphiphiles (molecules with two hy

27 s are an exception to the rule-of-thumb that membrane-spanning bolaamphiphiles are inherently membran

28 e monopolar lipid hydrocarbon chains and the membrane-spanning bolalipid chains.

29 h each protomer contributes two helices to a membrane-spanning bundle.

30 r in the N3 domain that is peripheral to the membrane-spanning C domain in the dodecameric secretin P

31 Unlike the membrane-spanning C-terminal helix from Wza, the GfcC C-

32 The membrane-spanning C-terminal regions in tail-anchored pr

33 t Rab43 regulates the sorting of a subset of membrane-spanning cargo as they progress through the med

34 -1 has three biologically active isoforms: a membrane-spanning cell surface glycoprotein (csCSF-1), a

35 nantly expressed by fibroblasts, whereas the membrane-spanning cell-surface isoform (csCSF-1) is expr

36 A six-lobed membrane spanning cellulose synthesis complex (CSC) cont

37 erivatives have a longer sn-1 diether C32H64 membrane-spanning chain and two ether-linked sn-2 n-hexa

38 mechanism by which low pH is sensed and the membrane-spanning channel is formed.

39 docytosed, such that the PA oligomer forms a membrane-spanning channel that LF and EF translocate thr

40 imately 1.1-megadalton two-chambered, double membrane-spanning channel.

41 dergo a nanomechanical change to open up the membrane-spanning channel.

42 tic-induced conformational changes in the M2 membrane-spanning, channel-lining segment using disulfid

43 nd how Trp residues modulate the function of membrane-spanning channels, we have examined the effects

44 average indole ring orientations within the membrane-spanning channels.

45 In Escherichia coli the membrane-spanning chemosensory complexes are polar and n

46 and 2) catalyzes pore formation by forming a membrane-spanning complex that increases curvature stres

47 oupling, which can operate directly, through membrane-spanning complexes, or indirectly, through diff

48 B7, 9 and 10 assemble into a 1.07 MegaDalton membrane-spanning core complex (CC), around which all ot

49 shed from MIN6 cells and that the remaining membrane spanning cytoplasmic domain is processed by gam

50 s unique to the pore helix (F137) and second membrane-spanning (D173) domain of GIRK1 were identified

51 rps near the C terminus of each subunit in a membrane-spanning dimer.

52 in modulating the conformation of the first membrane spanning domain (Aleksandrov et al., 2012; Ren

53 , even though both proteins lack any obvious membrane spanning domain.

54 domain (residues approximately 1-395) and a membrane-spanning domain (MSD) (residues approximately 3

55 on of one amino acid (+1 leucine) within the membrane-spanning domain (MSD) abolished protein functio

56 larly W127 and W137, and the residues in the membrane-spanning domain (MSD) and also immediately flan

57 s with one nucleotide-binding domain and one membrane-spanning domain (MSD) likely work as dimers, wh

58 The membrane-spanning domain (MSD) of the envelope (Env) gly

59 The 27-residue membrane-spanning domain (MSD) of the HIV-1 glycoprotein

60 The membrane-spanning domain (MSD) of the human immunodefici

61 ution of the hydrophobicity of the F-MLV Env membrane-spanning domain (MSD) to its incorporation into

62 leotide-binding domain (NBD) followed by one membrane-spanning domain (MSD).

63 er ABC transporters, ABCC1 has an additional membrane-spanning domain (MSD0) with a putative extracel

64 d a cytoplasmic loop (CL4) in the C-terminal membrane-spanning domain (MSD2).

65 els, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containi

66 t Hrd1p interacts with substrate through its membrane-spanning domain and discriminates misfolded fro

67 type Ia transmembrane protein with a single membrane-spanning domain and without any extracellular l

68 e Golgi, the leucine heptad within the first membrane-spanning domain contributes to its trafficking,

69 However, some point mutations in AE1 membrane-spanning domain convert the electroneutral anio

70 fused to GFP demonstrate that the N-terminal membrane-spanning domain flanked by a few positively cha

71 y as a spacer between the IgV domain and the membrane-spanning domain for efficient Tvc receptor acti

72 D2 appears to be anchored with an N-terminal membrane-spanning domain into the inner envelope membran

73 Because the membrane-spanning domain is present, the full-length hHO

74 A structural model of AE1 membrane-spanning domain is proposed, and this model is

75 orylation-induced binding of cdb3-PO4 to the membrane-spanning domain of band 3 in intact cells cause

76 served at three hydrophobic positions in the membrane-spanning domain of G2 (F427, W428, and F438).

77 ded insights into the function of the single membrane-spanning domain of LRAT.

78 focused on a leucine heptad in LMP1's first membrane-spanning domain that was shown to be necessary

79 Ig-like extracellular domains (D1 and D2), a membrane-spanning domain, and a short cytoplasmic tail.

80 located in the cytoplasmic loops (C loops), membrane-spanning domain, C/N terminus, and nonmissense

81 esolutive three-dimensional structure of AE1 membrane-spanning domain, in silico modeling combined wi

82 , the first cytoplasmic domain and the first membrane-spanning domain, respectively.

83 A Vpu mutant containing a scrambled membrane-spanning domain, Vpu(RD), was still able to res

84 he C-terminal cytoplasmic loop of the second membrane-spanning domain, which forms an interface with

85 efect depends on the interaction between the membrane-spanning domain-2 ICLs and the NBDs.

86 ed maturation defect, and substituting mouse membrane-spanning domain-2 or its intracellular loops (I

87 SIV) or 59-70 (HIV-1) residues from the gp41 membrane-spanning domain.

88 op is tempered by residue F162 in the second membrane-spanning domain.

89 lope glycoprotein topology includes a single membrane-spanning domain.

90 are anchored to a lipid surface by their own membrane-spanning domain.

91 PSS1 contains a predicted single membrane-spanning domain.

92 tions as a Cl(-) channel and consists of two membrane spanning domains (MSDs), two cytosolic nucleoti

93 otional freedom for all tryptophans in these membrane spanning domains that exceed the dynamics for t

94 Although RPE65 has no predicted membrane spanning domains, this protein predominantly as

95 ce on calnexin for proper assembly of CFTR's membrane spanning domains.

96 (NBD) and the cytoplasmic loops (CL) of the membrane-spanning domains (MSD).

97 These transporters are assembled from two membrane-spanning domains (MSDs) and two nucleotide-bind

98 membrane-proximal external region (MPER) and membrane-spanning domains (MSDs) of viral glycoproteins

99 CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding

100 of NBD1 and disruption of its interface with membrane-spanning domains (MSDs).

101 The b subunit has two membrane-spanning domains and a large hydrophilic domain

102 vely, we demonstrate that VirB3 contains two membrane-spanning domains and that both the N and C term

103 f a truncated RocA derivative, harboring the membrane-spanning domains but not the dimerization or HA

104 eas the exchange of amino acids in predicted membrane-spanning domains caused loss of function or sho

105 While the third and fourth membrane-spanning domains of LMP1 foster its trafficking

106 of a triangular cleft lined by the M1 and M2 membrane-spanning domains of one subunit and the M2 doma

107 Steroids interact with the membrane-spanning domains of the alpha subunits of the r

108 The membrane-spanning domains of the paradigm neurotransmitt

109 ed that the first intracellular loop between membrane-spanning domains one and two and the second ext

110 wo and the second extracellular loop between membrane-spanning domains three and four of NKCC1 are ne

111 3p reside in the cytoplasm, and six putative membrane-spanning domains were identified by insertion o

112 el has been proposed which features multiple membrane-spanning domains.

113 ature virions, consistent with two potential membrane-spanning domains.

114 uding the conserved hydrophilic and terminal membrane-spanning domains.

115 surface exposed, despite a lack of classical membrane-spanning domains.

116 all missense mutations were in the putative membrane-spanning domains.

117 bility of the interface between NBD1 and the membrane-spanning domains.

118 n the 114-residue loop between the M3 and M4 membrane-spanning domains.

119 the outer membrane and most probably enables membrane spanning electron transfer.

120 The 12 membrane-spanning endoplasmic reticulum-resident protein

121 Membrane-spanning epidermal growth factor receptor ErbB2

122 Our results indicate that both luminal and membrane-spanning ER proteins can be fully dislocated fr

123 irB1-11 and VirD4 that assemble into a large membrane-spanning exporting machine.

124 o indicates that TM1 does not integrate in a membrane-spanning fashion, but that TM12, TM123, and TM1

125 tein stress, our analysis shows that generic membrane-spanning features of the TMD are sufficient for

126 ort here an approach to producing an active, membrane-spanning form of EGFR of suitable purity, homog

127 Here, we report the design of a membrane-spanning, four-helical bundle that transports f

128 95-kDa ectodomain shed product and a 65-kDa membrane-spanning fragment, the latter of which localize

129 tion of transmembrane helices constituting a membrane-spanning furrow that provides a path for lipids

130 cterization, and structural determination of membrane-spanning G-protein-coupled receptors (GPCRs) ar

131 ead-to-head dimers that form the conducting, membrane-spanning gA channels, these sequence positions

132 Double-membrane-spanning gap junction (GJ) channels cluster int

133 is largely enthalpic in nature, whereas the membrane-spanning global minimum is favored by entropy.

134 hesis depends on the biochemical activity of membrane spanning glucan synthases encoded by the CSLH a

135 strains are generally similar and consist of membrane-spanning, glycerol dibiphytanyl glycerol tetrae

136 expressed CD133, an unusual surface-exposed membrane-spanning glycoprotein associated with CSC.

137 lin-like growth factor receptor (IGF1R) is a membrane-spanning glycoprotein of the insulin receptor f

138 Trp --> 1-methyl-tryptophan substitutions in membrane-spanning gramicidin A channels.

139 heme channel (i.e., heme binding site within membrane spanning helices) is not present in CcmC, in co

140 red a SH2 signature motif positioned between membrane-spanning helices 4 and 5.

141 NPC1 contains 1278 amino acids that form 13 membrane-spanning helices and three large loops that pro

142 cytoplasmic tail, adding back the C-terminal membrane-spanning helices one at a time.

143 l isomerization are coupled to the motion of membrane-spanning helices to create a G protein binding

144 LAMP-2A exists as a homotrimer in which the membrane-spanning helices wrap around each other to form

145 RNF170 is predicted to have three membrane-spanning helices, is localized to the ER membra

146 submerged in the membrane and surrounded by membrane-spanning helices.

147 ues in exofacial loop regions, as well as in membrane-spanning helices.

148 remain membrane bound owing to their single membrane-spanning helices.

149 s thaliana ETR1 receptor is modeled as three membrane-spanning helices.

150 Cleavage by S2P, within the first membrane-spanning helix of SREBP, releases the transcrip

151 reaction with regard to residues in the M3, membrane-spanning helix of the muscle acetylcholine rece

152 gral bitopic membrane proteins with a single membrane-spanning helix play a plethora of vital roles i

153 e-2 protease (S2P), which cleaves within its membrane-spanning helix to release the transcription fac

154 ys149, at the junction of IC2 and the fourth membrane-spanning helix, has intramolecular interactions

155 multiple C2 domains and a single C-terminal membrane-spanning helix.

156 It is composed of a membrane-spanning heterodimer, MalF-MalG; a homodimeric

157 e chain or single amino acid deletion in the membrane-spanning hphi2 region significantly diminishes

158 The 58-amino-acid residue SSP comprises two membrane-spanning hydrophobic regions separated by a sho

159 to NSm, rendering the NSm topology as a two-membrane-spanning integral membrane protein.

160 The membrane-spanning ion translocator (DeltaehbF) and the l

161 with subsequent calpain activity cleaved the membrane-spanning junctional proteins occludin and E-cad

162 ing substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) is a conserved membra

163 eptor tyrosine kinases that are activated by membrane-spanning ligands called ephrins.

164 E1 isoform have implicated several predicted membrane-spanning (M) helices, most notably M4, M9, and

165 acromolecules that regulate docking, and the membrane spanning macromolecules linked to these nubs ar

166 A transbilayer mechanism and membrane-spanning may be essential for the cellular upta

167 sonance was used to study the tryptophans in membrane-spanning model peptides from the WALP family (a

168 Prestin is a voltage-dependent membrane-spanning motor protein that confers electromoti

169 n which the periciliary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely

170 he Pal/Tol system which forms a five-member, membrane-spanning, multiprotein complex that is conserve

171 TRPC consists of a family of seven membrane-spanning nonselective cation channels that have

172 46's transmembrane hydrophobic core prevents membrane spanning, obscures the N-terminal ectodomain, a

173 Few membrane-spanning OMPs of B. burgdorferi have been defin

174 The most potent variants reside in a membrane-spanning orientation, in contrast to the parent

175 e was mapped by cross-linking and EPR to the membrane-spanning part of the transmembrane domain (TMD)

176 Both the structure and the function of the membrane-spanning part of this pathway are well defined.

177 and skeletal muscle where dystrophin and its membrane-spanning partner dystroglycan distribute intrac

178 ing synthetic peptides, corresponding to the membrane-spanning parts of functional and nonfunctional

179 7 emerges as a central component in a triple membrane-spanning pathway between FGFR2b or VEGFR2 and E

180 ly the geometry but also the dynamics of the membrane-spanning peptide.

181 The dynamics of membrane-spanning peptides have a strong affect on the s

182 An explanation is given as to why membrane-spanning peptides must have been the first "inf

183 e successfully applied this method to design membrane-spanning peptides targeting the transmembrane d

184 A membrane-spanning peptidoglycan recognition protein, PGR

185 A membrane-spanning peptidoglycan recognition protein, PGR

186 single pore located at the interface between membrane-spanning pore domains from each of four subunit

187 imer, and each subunit contains a continuous membrane-spanning pore formed by the two homologous halv

188 phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory part

189 gomerizes and potentially forms the putative membrane-spanning pore to which the remainder of the PTE

190 sed ends of alpha-helices shaping the narrow membrane-spanning pore.

191 sxA inserted into the membranes and formed a membrane-spanning pore.

192 igomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and

193 e peptides disrupt cell integrity by forming membrane-spanning pores that ultimately lead to their de

194 in function and designated as a 28-kDa outer membrane-spanning porin (Oms28).

195 omains and critical structural motifs of the membrane-spanning portions of Kv2.1 with corresponding r

196 afficking of falcipains, which include large membrane-spanning prodomains, we utilized chimeras with

197 est that elasticity is critical for some two-membrane spanning protein complexes to cope with variati

198 Here we show that ARMS (ankyrin repeat-rich membrane spanning protein)/Kidins220, a transmembrane sc

199 e of 220 kDa (Kidins220)/ankyrin repeat-rich membrane spanning protein, mammalian target of rapamycin

200 YIPF4 is also a poorly characterized membrane spanning protein.

201 te of 220 kD (Kidins220)/ankyrin repeat-rich membrane-spanning protein (ARMS) as a novel interaction

202 Because Thy1 is not a membrane-spanning protein and, instead, complexes with s

203 is a multiprotein complex and consists of a membrane-spanning protein channel (comprising subunit ty

204 n sorting, during enucleation, creates these membrane-spanning protein deficiencies.

205 nit of the twin arginine translocase, is a 6-membrane-spanning protein exposing three periplasmic loo

206 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes

207 Here we show that BB0405, a conserved membrane-spanning protein of unknown function, fails to

208 The membrane-spanning protein TGBp3 is one of the three move

209 ense allele of Unc93b1, which encodes the 12-membrane-spanning protein UNC-93B, a highly conserved mo

210 ribed as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subs

211 activity, and MsrQ, an integral b-type heme membrane-spanning protein, which acts as the specific el

212 emarkably, these predominantly alpha-helical membrane spanning proteins are unusually highly stable a

213 ature that renders this ubiquitous family of membrane-spanning proteins a prime target for toxins fou

214 In biology, membrane-spanning proteins are responsible for the trans

215 rough plasmodesmata, while TGB2 and TGB3 are membrane-spanning proteins associated with endoplasmic r

216 The membrane-spanning proteins DivIB and its orthologue FtsQ

217 evaluate the role of cytoplasmic domains of membrane-spanning proteins in directing trafficking thro

218 Mapping the interaction sites between membrane-spanning proteins is a key challenge in structu

219 Membrane-spanning proteins may interact with a variety o

220 ith YXXPhi elements from other cell or virus membrane-spanning proteins resulted in alterations in En

221 Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channe

222 r membrane (OM) contains single and multiple membrane-spanning proteins that need to contain signals

223 und at the lipid-aqueous interface region of membrane-spanning proteins, including ion channels, wher

224 Like many other membrane-spanning proteins, this trimeric protein comple

225 e shedding of many type I and type II single membrane-spanning proteins.

226 RAGE is a single membrane spanning receptor containing a very small appro

227 of novel photolabile compounds targeting the membrane-spanning receptor domain to probe the binding s

228 ng pathogen-associated molecular patterns, a membrane spanning region and an intracellular Toll/Inter

229 EFECTIVE KERNEL1 (DEK1), which consists of a membrane-spanning region (DEK1-MEM) and a calpain-like C

230 t a conserved glutamine residue in the first membrane-spanning region (TM1 region) of the alpha subun

231 al domains: an N-terminal protease, a middle membrane-spanning region and a soluble C-terminal region

232 d that both the signal peptide and the first membrane-spanning region are required for insertion of t

233 antagonist probe deep within the receptor's membrane-spanning region at Leu(88), a residue within tr

234 well-defined active site cavities within the membrane-spanning region in each monomer interface of th

235 introduced at selected positions within the membrane-spanning region of acetyl-GGALW(5)LALALAL(12)AL

236 The membrane-spanning region of pro-Monalysin is fully burie

237 beta-sheet was also identified close to the membrane-spanning region that resembles the cytoplasmic

238 y extending from the cytosolic side into the membrane-spanning region.

239 f ion flux have been identified flanking the membrane-spanning region.

240 d form and of an inactive mutant lacking the membrane-spanning region.

241 of NarK2 structure is proposed containing 12 membrane spanning regions consistent with other members

242 nt migration entails a net shift from apolar membrane spanning regions to more polar regions of the p

243 s embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C

244 embrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices.

245 drial intermembrane-facing surface, with six membrane-spanning regions interspersed by two intermembr

246 e pathway that connects the cytoplasm to the membrane-spanning regions is unknown, and functional rol

247 , thus leading to efficient labelling of the membrane-spanning regions of the protein upon irradiatio

248 In the absence of the membrane-spanning regions, lipid allostery is propagated

249 p42, gH, and gL were expressed that lack the membrane-spanning regions.

250 ction, we determined the entire inventory of membrane-spanning RING finger E3 ubiquitin ligases local

251 and composition from the other known double membrane-spanning secretion system that has been structu

252 rganize locally to interact closely with the membrane-spanning section of the DNA tube.

253 The N-terminal domain including the first membrane-spanning segment contains sufficient informatio

254 couple and overproduction of the N-terminal membrane-spanning segment of CcmI (CcmI-1) have similar

255 thod (SCAM) to map the residues in the sixth membrane-spanning segment of the CB2 cannabinoid recepto

256 al studies, Leu at the 9'-position in the M2 membrane-spanning segment was replaced with Cys in dupal

257 ting the ligand-binding domain to the fourth membrane-spanning segment, is the principal contact poin

258 smic tail on serine residues adjacent to the membrane-spanning segment, that, when mutated markedly r

259 Each subunit has two putative membrane-spanning segments (M1 and M2), intracellular am

260 of nsp6 transmembrane topology revealed six membrane-spanning segments and a conserved hydrophobic d

261 The membrane-spanning segments of integral membrane proteins

262 however, unlike CsgG, PelC does not possess membrane-spanning segments required for polymer export a

263 d from a HAMP/signaling output domain by two membrane-spanning segments that flank a short (four-amin

264 PlsY has five membrane-spanning segments with the amino terminus and t

265 ly associated with membranes but contains no membrane-spanning segments.

266 l pigment epithelium (RPE) with no predicted membrane-spanning segments.

267 oteins Tim23 and Tim17, each containing four membrane-spanning segments.

268 common catalytic core domain composed of six membrane-spanning segments.

269 and Sema6A exemplify two diverse vertebrate, membrane-spanning semaphorin classes (4 and 6) that are

270 t systems, which are typically composed of a membrane-spanning sensor histidine kinase and a cytoplas

271 an entropic spring to perturb the packing of membrane-spanning sequences that constitute the ion perm

272 ptides that match the composition of helical membrane-spanning sequences, we quantitate anomalous SDS

273 omain, providing little understanding of the membrane-spanning signal transduction domain.

274 , thus providing little understanding of the membrane-spanning signal transduction domain.

275 Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have be

276 gatively charged membranes correlated with a membrane-spanning state of the complex according to MD s

277 partially exposed to water, rather than in a membrane-spanning state.

278 sembled from five distinct subcomplexes, the membrane-spanning (subM) and the luminal (subL) subcompl

279 etrotranslocation of the luminal domain of a membrane-spanning substrate is triggered by autoubiquiti

280 e proteins with catalytic activities against membrane-spanning substrates that require a pair of aspa

281 s constructed for a gene encoding a putative membrane-spanning subunit (ehbO).

282 o-subunit TrkA proteins lack an identifiable membrane-spanning subunit of the Trk K+ transporter.

283 PSII is composed of 17 membrane-spanning subunits and three extrinsic subunits,

284 subset of the helices observed in the larger membrane-spanning subunits of the molybdate (ModBC) and

285 receptor is an assembly of eight single-pass membrane-spanning subunits on the surface of T lymphocyt

286 The uniplex consists of three membrane-spanning subunits--mitochondrial calcium unipor

287 ne by traversing a hydrophilic groove on the membrane-spanning surface of the protein.

288 The HSPG core proteins include the membrane-spanning syndecans (SDCs), the lycosylphosphati

289 The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by

290 n of Fha1, an FHA domain protein, by PpkA, a membrane-spanning threonine kinase.

291 oplasmic reticulum (ER) and assumes a single membrane-spanning topology with an N-terminal cytoplasmi

292 ToxR is a membrane-spanning transcription factor that coordinates

293 ong-sought-after catalytic Phi-clamp and the membrane-spanning translocation channel, and supports th

294 substrate from the binding protein MolA to a membrane-spanning translocation pathway of MolB.

295 e (ABC) transporters comprise a family of 48 membrane-spanning transport proteins, many of which are

296 ne editing, identified the digestive vacuole membrane-spanning transporter PfMDR1 (P. falciparum mult

297 e proteins at the cytosolic interface of the membrane spanning type III secretion 'injectisome'.

298 lular responses to FGFs are mediated through membrane-spanning tyrosine kinase receptors in conjuncti

299 e, the binding site of apicularen within the membrane spanning V(O) complex.

300 e literature, we propose a model for how the membrane-spanning YfgM protein serves as connector betwe