ライフサイエンスコーパス: membranous

1 Furthermore, comparable membranous abnormalities in cultured HACD1-deficient myo

2 data with that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the puri

3 efining characteristic is the apical complex-membranous and cytoskeletal elements at the apical end o

4 module that facilitates BGIN distribution to membranous and detergent-insoluble fractions.

5 underlying disease process, such as combined membranous and focal or diffuse lupus nephritis.

6 maternal age is correlated with the risk of membranous and muscular VSD in Nkx2-5(+/-) but not wild-

7 se kinase (GSK3) activity and enhancement of membranous beta-catenin and E-cadherin proteins.

8 zed as transformasomes in Haemophilus, these membranous blebs facilitate transfer of DNA among bacter

9 g a crucial requirement for Bmp signaling in membranous bone and cartilage development.

10 res, including ossification delay in several membranous bones and enlargement of the nasal septum or

11 into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into

12 B3 established endoplasmic reticulum-derived membranous caps at PD orifices.

13 Cytoplasmic dynein transports membranous cargoes along microtubules, but the mechanism

14 Thus dynein recruitment to two different membranous cargoes, namely EEs and SVs, requires p25, hi

15 ellular release of molecules encapsulated in membranous carriers, such as polymersomes.

16 In cell culture studies, membranous caveolin-1 and nuclear p53 expression was gre

17 l lines of intercellular crosstalk via these membranous cellular tubes has strong potential as a nove

18 tly described tunneling nanotubes (TNTs) are membranous channels that connect cells together and allo

19 Plasmodesmata (Pd) are membranous channels that serve as a major conduit for ce

20 ajor secretory station composed of stacks of membranous cisternae, is a central yet unsettled issue i

21 dium development occurs inside a specialized membranous compartment termed the parasitophorous vacuol

22 The replicase proteins form membranous compartments in cells to facilitate replicati

23 port properties and the de novo formation of membranous compartments within the erythrocyte cytosol.

24 AV2 particles were transported on MTs within membranous compartments, and surprisingly, the acidifica

25 e iron-phosphorus granules are surrounded by membranous compartments.

26 om the endoplasmic reticulum (ER) to various membranous compartments.

27 cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, an

28 s within clmp1 clusters are held together by membranous connections, including thin isthmi characteri

29 We characterised the membranous/cortical lines (102) throughout stage 5 to 10

30 ally, we categorised the localisation of the membranous/cortical proteins during cytokinesis.

31 tures in rigid cuticles, but not in soft and membranous cuticles.

32 e that hemesbin this cytochrome and in other membranous cytochromesbact as electronic connectors for

33 g5-Atg12/Atg16L1, inhibited formation of the membranous cytoplasmic MNV replication complex, where At

34 terpreted as layers of lipid mineralization (membranous debris also called "lipoprotein-derived debri

35 Retinal pigment epithelium (RPE)-derived membranous debris named blebs, may accumulate and contri

36 1q IgG4 was mainly detected in subepithelial membranous deposits.

37 different anatomy, with only rods containing membranous discs enclosed by the plasma membrane.

38 l anisotropy compared to the ones with extra membranous domains or fusions with soluble proteins.

39 All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintai

40 Mechanical indentation of the membranous duct at high frequencies evokes traveling wav

41 1-mediated dissociation of beta-catenin from membranous E-cadherin, which may promote senescence bypa

42 ing DSBs still correlated with the amount of membranous EGFR (24 h: r(2) = 0.977, P < 0.001; 48 h: r(

43 er was found to correlate with the amount of membranous EGFR (r(2) = 0.877, P = 0.006).

44 ) = 0.989, P < 0.001) and with the amount of membranous EGFR (r(2) = 0.967, P < 0.001).

45 vided the necessary compartmentalization and membranous environment for RNA viruses to flourish, crea

46 dSQR exhibited higher catalytic rates in its membranous environment than in its solubilized state.

47 with a loss of the beta-sheet structure in a membranous environment.

48 r purification and handling outside of their membranous environment.

49 components while they are still within their membranous environment.

50 efined luminal diameter and stoichiometry in membranous environments and that such channels mediated

51 revealed that coexistence of GD3 with Yes in membranous environments enhances the kinase activity of

52 ion molecule (EpCAM(+)) SHPC clusters showed membranous EpCAM(+)/HNF-4alpha(+) (hepatocyte nuclear fa

53 ion stabilized in mature myelin, but overall membranous expression diminished.

54 We show membranous expression of PD-L1 in the tonsillar crypts,

55 denocarcinomas and squamous cell carcinomas, membranous expression of PD-L1 was significantly associa

56 The slow diffusion of membranous ezrin and its interaction partners relative t

57 enetrans and M. iowae showed the presence of membranous filaments connecting pairs of dividing cells.

58 at large fluorescent signals correlated with membranous Gag-containing structures with unknown pathol

59 sed the earliest manifestations of recurrent membranous glomerulonephritis (MGN) in renal allografts.

60 us pseudotumor, sclerosing mesenteritis, and membranous glomerulonephritis should all be added to the

61 pathies, including minimal change nephrosis, membranous glomerulonephritis, and IgA nephropathy.

62 = 3; psoriasis, n = 2; Graves disease, n 1; membranous glomerulonephritis, n = 2; rheumatoid arthrit

63 Membranous glomerulopathy (MG) is one of the most common

64 e showed mild proteinuria at 18-24 wk due to membranous glomerulopathy.

65 t wound healing, we investigated the role of membranous glucocorticoid receptor (mbGR) by using cell-

66 Additional GI accelerated membranous GLUT1 translocation, elevating glucose uptake

67 n HIV-1 patients, immune complex GNs such as membranous GN and membranoproliferative GN are particula

68 t SCD-1 inhibition disrupts the integrity of membranous HCV replication complexes and renders HCV RNA

69 In contrast, EBP50 was primarily membranous in confluent cell lines.

70 ediate filament vimentin as an extracellular membranous interaction partner of C3.

71 ardial cushions, resulting in the failure of membranous interventricular septum formation.

72 We report a case of membranous IVC obstruction at the junction of hepatic an

73 d in HEK cells coexpressing TRPV5 and sKL or membranous Klotho (mKL).

74 ition of soluble Klotho or overexpression of membranous Klotho in tissue culture suppressed NF-kappaB

75 ology, dynamics of the inner ear fluids, and membranous labyrinth deformability.

76 ted with an accumulation of endolymph in the membranous labyrinth in the inner ear.

77 y chamber, which collectively constitute the membranous labyrinth of the inner ear.

78 of a complex organ rudiment, the developing membranous labyrinth, is initiated.

79 sensory and nonsensory elements of the adult membranous labyrinth.

80 to a decreased size and malformation of the membranous labyrinth.

81 rance plus C4 was a good diagnostic test for membranous LN (AUC 0.75).

82 activity, LN chronicity, and the presence of membranous LN.

83 lated to predict LN activity, chronicity, or membranous LN.

84 face of two alpha-helices to be critical for membranous localization.

85 Membranous location was confirmed by flow cytometry of v

86 ochemical features, such as N-glycosylation, membranous location, and reactivity with serum only unde

87 induction therapy of both proliferative and membranous lupus nephritis.

88 Here we show that membranous material for cell-plate formation initially a

89 p-viral RNA interaction, suggesting that the membranous microdomain surrounding the RdRp greatly affe

90 ine shapes, similar to multiply spin-labeled membranous Na,K-ATPase below 200 K.

91 ional motion of spin-labeled lipid chains in membranous Na,K-ATPase is investigated by spin-echo elec

92 In multiply spin-labeled membranous Na,K-ATPase, this heterogeneous population of

93 Bloodstream African trypanosomes produce membranous nanotubes that originate from the flagellar m

94 ost's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorou

95 Exosomes, which are membranous nanovesicles, are actively released by cells

96 Heymann nephritis (HN), a rat model of human membranous nephritis, to study the effects of TCV on aut

97 rulosclerosis (HR, 0.80; 95% CI, 0.77-0.82), membranous nephropathy (HR, 0.88; 95% CI, 0.83-0.93), me

98 nephropathy (HRa, 0.74; 95% CI, 0.59-0.92), membranous nephropathy (HRa, 0.47; 95% CI, 0.29-0.75), a

99 Most patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies ag

100 1) is the major target antigen in idiopathic membranous nephropathy (iMN).

101 the autoimmune glomerular disease idiopathic membranous nephropathy (IMN).

102 ed as a surrogate for long-term prognosis in membranous nephropathy (MGN), variability in proteinuria

103 D7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen

104 Absent a remission of proteinuria, primary membranous nephropathy (MN) can lead to ESRD over many y

105 Membranous nephropathy (MN) can recur in kidney allograf

106 fies a new antigen responsible for secondary membranous nephropathy (MN) in a patient with mucopolysa

107 Membranous nephropathy (MN) is a common cause of nephrot

108 Membranous nephropathy (MN) is a leading cause of nephro

109 Primary membranous nephropathy (MN) is an autoimmune disease mai

110 Membranous nephropathy (MN) is the most common cause of

111 Membranous nephropathy (MN) is the most common cause of

112 As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause o

113 A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular su

114 ssion in two-thirds of patients with primary membranous nephropathy (MN), even after other treatments

115 s a target for autoimmunity in patients with membranous nephropathy (MN).

116 In a rat model of experimental membranous nephropathy (passive Heymann nephritis (PHN))

117 Randomized trials of rituximab in primary membranous nephropathy (PMN) have not been conducted.

118 t ( approximately 70%) patients with primary membranous nephropathy (pMN).

119 Here, we describe a patient with recurrent membranous nephropathy 13 days after kidney transplantat

120 g a large cohort of patients with idiopathic membranous nephropathy according to a restrictive treatm

121 However, in some patients with membranous nephropathy and crescents, the crescentic les

122 For the subset of patients with idiopathic membranous nephropathy and deteriorating excretory renal

123 In nephrotic diseases, such as membranous nephropathy and FSGS, persistent injury often

124 pressive therapy in patients with idiopathic membranous nephropathy and nephrotic syndrome.

125 rt of 117 Caucasian patients with idiopathic membranous nephropathy and nephrotic-range proteinuria u

126 Crescents are rare in primary membranous nephropathy and thus suggest another underlyi

127 (St-Cp) therapy for patients with idiopathic membranous nephropathy at high risk of progression to ES

128 Human membranous nephropathy biopsy samples showed podocyte st

129 r cohort, 15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to

130 Up to 80% of patients with idiopathic membranous nephropathy have non-complement-fixing IgG4 a

131 In summary, this case of recurrent membranous nephropathy in a graft suggests that circulat

132 phritis is an experimental model that mimics membranous nephropathy in humans, wherein the glomerular

133 al of 35 patients treated with rituximab for membranous nephropathy in two distinct cohorts.

134 Membranous nephropathy is a common cause of adult nephro

135 Membranous nephropathy is a common cause of nephrotic sy

136 Membranous nephropathy is a disease that affects the fil

137 Idiopathic membranous nephropathy is an autoimmune disease.

138 pports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.

139 Membranous nephropathy leads to end-stage renal disease

140 d decline in renal function in patients with membranous nephropathy may be due to renal vein thrombos

141 vs IgAN, ranged from 0.49 for DN to 0.92 for membranous nephropathy or ADPKD) than by lower rates of

142 and nephrotic syndrome caused by idiopathic membranous nephropathy or focal segmental glomeruloscler

143 cohort with anti-PLA2R1-negative idiopathic membranous nephropathy recognized a glomerular protein t

144 Membranous nephropathy recurs in 48% of cases threatenin

145 Membranous nephropathy recurs in approximately 40% of pa

146 use of immunosuppressive drugs in idiopathic membranous nephropathy to patients at the highest risk o

147 of immune deposit formation in experimental membranous nephropathy to the role of a microRNA in FSGS

148 We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant

149 samples from the 74 patients with idiopathic membranous nephropathy who were seropositive for anti-PL

150 pholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipa

151 s renal function in patients with idiopathic membranous nephropathy with declining renal function.

152 a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localizatio

153 y in this cohort of patients with idiopathic membranous nephropathy yielded favorable outcomes while

154 (18-75 years) with biopsy-proven idiopathic membranous nephropathy, a plasma creatinine concentratio

155 and nephrotic syndrome (minimal change/FSGS, membranous nephropathy, and C3 glomerulopathies).

156 and fibrosis, IgA nephropathy and idiopathic membranous nephropathy, and kidney transplantation.

157 been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this dis

158 - was induced in minimal change disease and membranous nephropathy, but not focal segmental glomerul

159 A2R is the target of the autoimmune disease, membranous nephropathy, characterised by production of a

160 In experimental membranous nephropathy, complement C5b-9-induces glomeru

161 ase were primary FSGS, diabetic nephropathy, membranous nephropathy, immunoglobulin A nephropathy, an

162 peutic advances for patients with idiopathic membranous nephropathy, including antibody inhibition th

163 actors, compared with IgAN (referent), FSGS, membranous nephropathy, membranoproliferative GN, lupus

164 serum samples from patients with idiopathic membranous nephropathy, patients with other glomerular d

165 correlate with the immunological activity of membranous nephropathy, potentially exhibiting a more ra

166 lomerulopathies minimal-change nephrosis and membranous nephropathy, there is an increase in Shp2 pho

167 y showed phospholipase A 2 receptor-negative membranous nephropathy.

168 he UPS depended on oxidative modification in membranous nephropathy.

169 imal-change disease and a low correlation in membranous nephropathy.

170 d human glomerular diseases, particularly in membranous nephropathy.

171 rtant advances regarding the pathogenesis of membranous nephropathy.

172 R) is the major target antigen in idiopathic membranous nephropathy.

173 R) are sensitive and specific for idiopathic membranous nephropathy.

174 dict response to treatment with rituximab in membranous nephropathy.

175 peutic intervention in patients with primary membranous nephropathy.

176 (PLA2R1) is the major autoantigen in primary membranous nephropathy.

177 A2R1) is the major autoantigen in idiopathic membranous nephropathy.

178 toantigen in 70% of patients with idiopathic membranous nephropathy.

179 the inferior vena cava (IVC) is infrequent, membranous obstruction of the IVC (MOIVC) being one of i

180 hough traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, sc

181 h a large and otherwise poorly characterized membranous organelle system of the presynaptic terminal,

182 In Caenorhabditis elegans, secretory membranous organelles (MO) fuse with the plasma membrane

183 of both of these proteins is confined to the membranous organelles (MOs) in undifferentiated spermati

184 other regulated Ago1 complex associates with membranous organelles and is likely an intermediate in m

185 The timely delivery of membranous organelles and macromolecules to specific loc

186 apart from each other, with microtubules and membranous organelles clustered centrally and neurofilam

187 ed cargoes and debris derived from different membranous organelles inside the cell.

188 d by enzymes associated with the cytosol and membranous organelles, including endoplasmic reticulum,

189 physical contacts with all other classes of membranous organelles, including the plasma membrane (PM

190 Like membranous organelles, large-scale coassembly of macromo

191 eleased during the autophagic degradation of membranous organelles, reducing lipotoxicity.

192 protruding spikes, and precocious fusion of membranous organelles.

193 L160 and Atp1 facilitate the assembly of the membranous part of the cpATPase in their hosts, but loss

194 r septum is a rare entity as compared to the membranous part.

195 cells release distinct types of subcellular membranous particles (scMP) derived from the endoplasmic

196 nown as microvesicles (EMVs), are nano-sized membranous particles secreted from nearly all mammalian

197 entage of neoplastic cells with staining for membranous PD-L1 (proportion score).

198 Membranous PD-L1 expression in tumor and tumor-associate

199 Destructive membranous periodontal disease, or ligneous gingivitis,

200 cyclooxygenase (COX)-2, was coincident with membranous PGE(2) synthase, and was not significantly al

201 separated from the adjacent compartments by membranous processes from ensheathing glia.

202 ons, enabling templated RNA synthesis within membranous protocells.

203 This procilium consists of a membranous protrusion extending from the basal body but

204 cells toward apposing cells on actin-filled membranous protrusions or actin tails.

205 enveloped poxvirus virions form actin-filled membranous protrusions, called tails, beneath themselves

206 ions support BGIN-mediated inactivation of a membranous Rac1 population, which consequently inactivat

207 amino acid compositional fluxuation in extra-membranous regions that correspond with episodes of terr

208 Positive-strand RNA viruses build extensive membranous replication compartments to support replicati

209 k the cellular machinery to form and operate membranous replication complexes.

210 us web, but had little effect on established membranous replication factories.

211 for genome replication, and the formation of membranous replication organelles with similar architect

212 bles many host cellular proteins into unique membranous replication structures as a prerequisite for

213 nrichment of ADP-ribosylated proteins in non-membranous RNA granules.

214 nt PD, each pore containing a desmotubule, a membranous rod derived from the cortical ER.

215 inion, we argue that neurosteroids require a membranous route of access to transmembrane-domain bindi

216 d left-sided posterolateral CDH covered by a membranous sac who had no features suggestive of BNAR or

217 diaphragmatic hernias which are covered by a membranous sac.

218 Exosomes and microvesicles (MV) are cell membranous sacs originating from multivesicular bodies a

219 Small membranous secretions from tumor cells, termed exosomes,

220 gth, and transport of two different cargoes (membranous serotonin receptor 6-green fluorescent protei

221 ing several human pathogens, is encased in a membranous sheath of unknown function.

222 greatly increased by myelin, a multilayered membranous sheath surrounding axons.

223 tly identified a creased and distinct glassy membranous sheet enveloping the posterior vitreous surfa

224 ent to trigger spindle assembly from ectopic membranous sites.

225 , a potent vasoconstrictor that inhibits the membranous sodium-potassium ATPase pump across cell type

226 ded RNA (dsRNA) revealed that the ER-derived membranous spherules provide the site for BBSV replicati

227 Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; howeve

228 Lamin B is a component of the membranous spindle matrix isolated from Xenopus egg extr

229 This membranous "spindle envelope" confined spindle assembly,

230 ry and immunofluorescence stainings revealed membranous ST2L expression on specific trophoblast popul

231 The membranous "stacked pancake" architecture of this organe

232 blinded to clinical outcome; a score >/= 2 (membranous staining in >/= 1% of cells) was considered p

233 hout early ureteric ducts as cytoplasmic/sub-membranous staining; with nuclear localization seen in d

234 to the plasma membrane or to each other by a membranous stalk, suggesting membrane fission impairment

235 ocal micrographs demonstrated the enveloping membranous structure identified on phase-contrast micros

236 Because this membranous structure is observed only after posterior vi

237 At this stage, a continuous membranous structure may have double- and single-walled

238 ive agents of malaria, possess a distinctive membranous structure of flattened alveolar vesicles supp

239 in TgCRND8 brain where lipids accumulate as membranous structures and lipid droplets within giant ne

240 FA0210c plays a role in the formation of the membranous structures and nutrient phospholipid transfer

241 often found to associate with other cellular membranous structures and vary in size in a given cell,

242 Plant virus-induced membranous structures are motile, and this intracellular

243 e p62, accumulation of abnormal intra-axonal membranous structures bearing the autophagy protein LC3,

244 nutrients and macromolecules through tubular membranous structures called nanotubes.

245 ed on the endoplasmic reticulum (ER)-derived membranous structures closely juxtaposed to the lipid dr

246 Membranous structures derived from various organelles ar

247 of plus-stranded RNA viruses takes place on membranous structures derived from various organelles in

248 ncer cells, where it interacts with specific membranous structures in a temporally and spatially stab

249 with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replicatio

250 system involves long-known parasite-derived membranous structures in the host cell cytosol, called M

251 been analyzed, foremost because the fragile membranous structures in the inner ear are hard to visua

252 induce the formation of novel intracellular membranous structures that provide an optimum environmen

253 smallest LDs was nearly free of ER and other membranous structures while those with larger LDs contai

254 her viral proteins, induced the formation of membranous structures, some of which were similar to dou

255 f P62(+)/ubiquitin(+) inclusions or abnormal membranous structures, which are observed in mice lackin

256 G) and the activity of DAG kinases (DGKs) in membranous structures.

257 ape, an uneven perinuclear space, and excess membranous structures.

258 todiacylglycerol with carotenoids along with membranous subcellular structures.

259 TPase either are restricted to targeting one membranous subunit of V-ATPase or have poorly understood

260 pse, lung surfactant (LS) develops a complex membranous system at the respiratory surface.

261 This mechanism relies on a membranous system surrounding the mitotic spindle that d

262 es against the constraint of a thin, elastic membranous tissue, the dorsal mesentery.

263 ticulum, secretory proteins traverse several membranous transport compartments before reaching their

264 nalysis of a tumour microarray showed strong membranous TRKB and TRKC staining in cylindromas, as wel

265 Membranous TRKC overexpression was also observed in 70%

266 Further, the presence of membranous tubules transiently connecting PDGs is reveal

267 ents undergoing RTS has shown an increase in membranous urethral length and elevation of the external

268 microscopy revealed the presence of numerous membranous vacuoles containing degrading cellular materi

269 ble zinc accumulation in large lysosomes and membranous vacuoles may contribute to the pathogenesis o

270 phenotype consisting of large lysosomes and membranous vacuoles that accumulate chelatable zinc.

271 V cells develop large hyperacidic lysosomes, membranous vacuoles, mitochondrial fragmentation, and au

272 examination of Ets1(-/-) embryos revealed a membranous ventricular septal defect and an abnormal nod

273 analyses reveal that > or = 2 loci influence membranous ventricular septal defect susceptibility, whe

274 ac defects including hypoplastic myocardium, membranous ventricular septal defect, and double outlet

275 standing cardiac outflow tract alignment and membranous ventricular septal defects.

276 In eukaryotic cells, membranous vesicles and organelles are transported by en

277 The cellular release of membranous vesicles known as extracellular vesicles (EVs

278 Exosomes are small membranous vesicles secreted into body fluids by multipl

279 that nucleate and grow inside intracellular membranous vesicles that originate from invaginations of

280 nus, are released from cells nonlytically in membranous vesicles.

281 t the dsRNA is present in nuclease-resistant membranous VRCs.

282 and 10 that influence the susceptibility to membranous VSDs in Nkx2-5(+/-) animals.

283 o double-membrane structures by extension of membranous walls and/or collapsing of the luminal cavity

284 solic membrane vesicles often clustered in a membranous web (MW).

285 These drugs target de novo formation of the membranous web and RNA replication.

286 oplasmic reticulum modified membranes termed membranous web and utilizes lipid droplets for initiatin

287 block replication of HCV RNA at the stage of membranous web biogenesis-a new paradigm in antiviral th

288 also analyzed the effects of cyclosporine on membranous web formation by electron microscopy.

289 OSBP was required for HCV replication and membranous web integrity.

290 patitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, lik

291 patitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, lik

292 Daclatasvir inhibits the formation of new membranous web structures and, ultimately, of replicatio

293 yclosporine blocked de novo formation of the membranous web, but had little effect on established mem

294 he HCV replication compartment, known as the membranous web, is believed to be cholesterol enriched,

295 evealed that 25HC inhibited formation of the membranous web, the HCV replication factory, independent

296 sitol-4 kinase IIIalpha and induction of the membranous web, which is the site of HCV replication.

297 V replication by preventing formation of the membranous web, which was not linked to an inhibition of

298 , but completely prevented biogenesis of the membranous web.

299 integrity and cholesterol enrichment of the membranous web.

300 OSBP was recruited to membranous webs in a PI 4-kinase-dependent manner, and b