ライフサイエンスコーパス: memory impairment

1 of the two peptides combined lead to LTP and memory impairment.

2 R2A predicts severity of age-related working memory impairment.

3 ll recent events occurred after the onset of memory impairment.

4 encoding of spatial information and spatial memory impairment.

5 cated in the pathogenesis of obesity-induced memory impairment.

6 or (GluA23Y) before rapamycin prevented this memory impairment.

7 normalities, including decreased anxiety and memory impairment.

8 this plasticity is altered in aged rats with memory impairment.

9 understood, particularly in mouse models of memory impairment.

10 active in specific brain regions involved in memory impairment.

11 n increase with aging, which correlates with memory impairment.

12 early indicator of Alzheimer's disease (AD) memory impairment.

13 l damage has been thought to result in broad memory impairment.

14 d-beta (Abeta) deposition and improvement of memory impairment.

15 d non-memory cognitive domains contribute to memory impairment.

16 often presents with late-onset psychosis or memory impairment.

17 odeoxynucleotide-mediated knockdown leads to memory impairment.

18 Abeta load, regional neuronal function, and memory impairment.

19 the PFC, correlating with selective working memory impairment.

20 the medial temporal lobe and well-documented memory impairment.

21 hanism is responsible for the age-associated memory impairment.

22 pus that was linked to different features of memory impairment.

23 ion in the hilus is coupled with age-related memory impairment.

24 deposition is associated with GM atrophy and memory impairment.

25 induced locomotor hyperactivity and improved memory impairment.

26 ogical and cognitive dysfunction, as well as memory impairment.

27 ctable temporal lobe epilepsy, but can cause memory impairment.

28 episodic-like accuracy and induced a general memory impairment.

29 itiator of synaptic plasticity and long-term memory impairment.

30 as hemiplegia, mood disorders, cognitive and memory impairment.

31 (CB1) receptors abolished the stress-induced memory impairment.

32 etion contributes to learning deficiency and memory impairment.

33 herapeutic interventions for obesity-induced memory impairment.

34 IRT1 could be responsible for obesity-linked memory impairment.

35 vivo, resulting in hyperactivity and spatial memory impairment.

36 including DAI and clinical sequelae such as memory impairment.

37 cipal pathogenic mediator of obesity-induced memory impairment.

38 the dlPFC can prevent stress-induced working memory impairments.

39 eatments to improve TBI-induced learning and memory impairments.

40 tered during this consolidation period cause memory impairments.

41 ork may underlie the majority of age-related memory impairments.

42 for stress-associated molecular changes and memory impairments.

43 ists to treat schizophrenia-spectrum working memory impairments.

44 ghtened susceptibility to persistent working memory impairments.

45 xcitability in pyramidal neurons and working memory impairments.

46 ortant factor underlying cannabinoid induced memory impairments.

47 mpus-dependent tasks and rescues age-related memory impairments.

48 these patient groups have distinct semantic memory impairments.

49 mpus and preventing SE-induced cognitive and memory impairments.

50 d febrile seizures during development reveal memory impairments.

51 l prefrontal cortex (mPFC) result in working memory impairments.

52 ility of DPM neurons can restore age-related memory impairments.

53 do not fully explain ethanol-induced spatial memory impairments.

54 alter dose-dependent ethanol-induced spatial memory impairments.

55 may have therapeutic potential for reversing memory impairments.

56 tion, as well as contextual fear and spatial memory impairments.

57 fications in PL-mPFC and causes long-lasting memory impairments.

58 and evaluation of strategies for alleviating memory impairments.

59 y contributes to apoE4-mediated learning and memory impairments.

60 in the cortex and hippocampus, and improved memory impairment 2 weeks after trauma.

61 traveled to develop an animal model of human memory impairment, a matter that also turned on question

62 men with low testosterone and age-associated memory impairment (AAMI).

63 eimer's disease and that this contributes to memory impairment, abnormal APP processing and tau hyper

64 of post-traumatic amnesia and evidence that memory impairment acutely after traumatic brain injury r

65 ls can expect to show clinically significant memory impairment after 3 years, whereas Abeta(+)varepsi

66 baric oxygen treatment may alleviate delayed memory impairment after acute carbon monoxide poisoning

67 , but the precise role of PERK activation in memory impairment after TBI has not been well elucidated

68 ting induction of AQP4 as well as attenuates memory impairment after TBI in mice.

69 using GSK2656157 would be beneficial against memory impairment after TBI.

70 dicate a causal role of the dlPFC in working memory impairments after acute stress and point to anoda

71 of corticosterone and CRH underlie enduring memory impairments after concurrent acute stresses, whic

72 one and CRH at hippocampal synapses underlie memory impairments after concurrent and perhaps also sin

73 eliorate the gliovascular damage and working memory impairments after hypoperfusion possibly via endo

74 trate of working memory, may prevent working memory impairments after stress.

75 d with vehicle displayed significant working memory impairment and a concomitant 44% increase in pres

76 Her medical history included memory impairment and a left posterior cerebral artery t

77 mouse cerebral cortex results in progressive memory impairment and age-dependent neurodegeneration, r

78 s disease, and loss of PS causes progressive memory impairment and age-related neurodegeneration in t

79 we evaluated mouse models of age-associated memory impairment and amyloid deposition to study transc

80 ermore, injection of a PKR inhibitor rescued memory impairment and attenuated ATF4 mRNA increased exp

81 of low-intensity pulsed (LIP) ultrasound on memory impairment and central nervous system injury in a

82 ing the function of mAChRs are used to treat memory impairment and decline.

83 SCI caused spatial and retention memory impairment and depressive-like behavior, as evide

84 egions consistent with their greater working memory impairment and development of behavioral symptoms

85 sults in the formation of NFTs, learning and memory impairment and massive neuronal death.

86 the cortex and hippocampus, concomitant with memory impairment and neurodegeneration, in adult mice.

87 postnatal mouse brains causes age-dependent memory impairment and neurodegeneration.

88 eptor Ca(2+) release, reverses aging-induced memory impairment and neuronal Ca(2+) dysregulation.

89 attenuation of protein synthesis, leading to memory impairment and neuronal loss.

90 role of CB1 cannabinoid receptors (CB1Rs) in memory impairment and spine density changes induced by n

91 n chronic seizure development and associated memory impairment and suggest that targeting aberrant hi

92 ice, an animal model of FXS, exhibit spatial memory impairment and synapse malfunctioning in the hipp

93 LAE Type 2; n = 13) did not show declarative memory impairment and were indistinguishable from patien

94 tion as a therapeutic strategy to ameliorate memory impairments and brain structural defects in the D

95 uman apoE4 causes age-dependent learning and memory impairments and degeneration of GABAergic interne

96 both male and female) displayed mild spatial memory impairments and disrupted cingulate network conne

97 memory rehearsal may paradoxically increase memory impairments and distraction alleviates these memo

98 eurin dyshomeostasis underlies age-dependent memory impairments and further imply that chronic Nebula

99 Memory impairments and hippocampal demyelination are com

100 Since semantic memory impairments and psychosis are also found in bipol

101 atures were headache, a cerebellar syndrome, memory impairment, and altered consciousness.

102 A positive family history, memory impairment, and clinical abnormalities at present

103 es a new murine model of WNV-induced spatial memory impairment, and identifies a potential mechanism

104 hyperactivity, some defects in motor skills, memory impairment, and reduced anxiety, but in the absen

105 in the brain, progressive and age-dependent memory impairment, and shortened lifespan.

106 namely prepulse inhibition decrease, working memory impairment, and social memory deficits, as well a

107 5 expression critically drives Abeta-induced memory impairment, and strategies aimed at reducing Ephe

108 ently improved, but one patient had residual memory impairment, and the other patient had a residual

109 he hypothesis that sleep restriction worsens memory impairments, and amyloid beta-peptide (Abeta) and

110 wild-type littermates, exhibit learning and memory impairments, and autistic-like behaviors (increas

111 re largely responsible for the synapticloss, memory impairments, and neurotoxicity that underlie Alzh

112 prevent Abeta oligomers-induced synaptic and memory impairments, and offered a strong support for the

113 ypes, including motor coordination, episodic memory impairments, and synaptic plasticity deficits.

114 ction in PD patients, cognitive deficits and memory impairment are also an important part of the diso

115 for recent events and patients with existing memory impairment are particularly vulnerable to distrac

116 In conclusion, working memory impairments are common and significantly impact t

117 Learning and memory impairments are common in traumatic brain injury

118 Working memory impairments are commonly found in attention-defic

119 of age-related sleep disruption, focusing on memory impairment as an exemplar.

120 ly reversed the long-term spatial and visual memory impairment as well as the motor coordination defi

121 aspects of AD pathophysiology which includes memory impairments as well as synaptic integrity.

122 at it is possible to detect the signature of memory impairment associated with Parkinson's disease in

123 interleukin-1beta (IL-1beta) plays a role in memory impairment associated with various neurological d

124 for treatment of both seizures and comorbid memory impairments associated with epilepsy.

125 ear which cell types are responsible for the memory impairments associated with sleep deprivation.

126 E.P. developed profound memory impairment at age 70 y and then was studied for 1

127 h similar cognitive performance and episodic memory impairment but who did not show progression of sy

128 in designing new therapies to treat working memory impairments by enhancing the function of NR2A-con

129 neuronal oxidative stress and the transient memory impairment caused by HMW oligomers, but did not p

130 Episodic memory impairment caused by lesions of the mammillary bo

131 negative dynamin transgenes ameliorated the memory impairment caused by PTX, indicating that the dis

132 n vivo, leading to a selective abrogation of memory impairments caused by exposure to THC.

133 imer's disease, may be less able to adapt to memory impairments caused by structural neuronal damage

134 s and predicts both entorhinal pathology and memory impairment, challenging the widely held belief th

135 this study, we evaluated whether the working-memory impairment characteristic of animal models of chr

136 s a cellular mechanism for the attention and memory impairments comorbid with chronic pain.

137 th LOC were more likely to report subjective memory impairment compared to those without TBI even aft

138 cture and function contribute to age-related memory impairment, complementing findings in the rodent

139 Pups of FASD mothers displayed short-term memory impairment, decreased hippocampal size and decrea

140 l features of schizophrenia, such as working memory impairments, depend on distributed neural circuit

141 (NMDAR) encephalitis suffer from persistent memory impairment despite unremarkable routine clinical

142 resentation in humans for both patients with memory impairment due to bilateral hippocampal lesions a

143 e has shown that the British mutation causes memory impairments due to loss of Bri2 function.

144 Memory impairment during nicotine withdrawal was blocked

145 s are characterised by executive and working-memory impairments, extending to changes in language and

146 We then examined if differences in memory impairment following these two stress types might

147 ative brain circuits permits compensation of memory impairments following damage to brain regions spe

148 is consistent with navigational and episodic memory impairments following damage to this region in hu

149 hese processes might contribute to amplified memory impairments following short, multimodal stress.

150 e disease was first described, their role in memory impairment has been poorly understood.

151 ognitive deficits, and hippocampal-dependent memory impairment has been reported in >30% of these pat

152 Age-related memory impairments have been associated with structural

153 Similar working memory impairments have been observed in healthy individ

154 nterneuron network integrity and age-related memory impairment, however, has not been tested directly

155 lucose intolerance, brain soluble Abeta, and memory impairment in 3xTg-AD mice.

156 nd reverted the neurodegeneration-associated memory impairment in a passive avoidance paradigm.

157 Verbal episodic memory impairment in AD is associated with altered audit

158 ure caffeine for 2months partially prevented memory impairment in AD mice, with CC having greater eff

159 ht to cause severe clinical symptoms such as memory impairment in AD patients.

160 s aimed to resolve the cognitive decline and memory impairment in AD using DBS of hippocampal afferen

161 ultimately leading to neurodegeneration and memory impairment in AD.

162 effective therapeutic strategy for treating memory impairment in AD.

163 lactic agents against the cell death and the memory impairment in AD.

164 of patients and are thought to contribute to memory impairment in AD.

165 asks may be useful in detecting the earliest memory impairment in AD.

166 loid fibrils, cause neuronal dysfunction and memory impairment in AD.

167 associates with naturally occurring working memory impairment in aged rats.

168 ng FKBP1b reversed calcium dysregulation and memory impairment in aging rats, allowing them to perfor

169 s a novel target for therapeutics to improve memory impairment in Alzheimer disease patients.Molecula

170 Memory impairment in Alzheimer's disease is a manifestat

171 We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice.

172 led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy.

173 Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfi

174 physiologic determinant of cytokine-induced memory impairment in brain.

175 n, neuroinflammation, synaptic pathology and memory impairment in control mice, but not in mice lacki

176 e anatomic and neuropathologic correlates of memory impairment in dementia with Lewy bodies (DLB) rem

177 tionally relevant than CA2 in the context of memory impairment in DLB.

178 t that inhibition of PKR is a way to restore memory impairment in early stages of sporadic AD.

179 is a way to restore ATF4 overexpression and memory impairment in early stages of sporadic AD.

180 which suggests a target for the treatment of memory impairment in epilepsy.

181 he stress-induced glutamatergic deficits and memory impairment in females, and the level of aromatase

182 712 may be effective to treat age-associated memory impairment in humans.

183 While memory impairment in LMW oligomer-injected mice was asso

184 nce for neurodegeneration or of learning and memory impairment in mice aged up to 18 months.

185 evented hippocampal dendritic spine loss and memory impairment in mice that received an intracerebrov

186 reduced hippocampal dendritic spine loss and memory impairment in mice that received intracerebrovent

187 against beta-amyloid (1-40)-induced spatial memory impairment in mice.

188 significantly increased risk for subjective memory impairment in models adjusted for demographics an

189 ve previously shown that a moderate episodic memory impairment in monkeys with transection of the for

190 mory deficits in rats and attenuated working memory impairment in NMDA Nr1(neo-/-) mice.

191 ethyl metabolism, embryonic growth delay and memory impairment in offspring.

192 pid eye movement (NREM) sleep disruption and memory impairment in older adults.

193 k and the medial temporal lobe contribute to memory impairment in PD.

194 dysfunction in these regions contributes to memory impairment in PD.

195 t increased anxiety-like behavior and caused memory impairment in rats (P<0.05).

196 ety-depression-like behaviors and as well as memory impairment in rats.

197 suggested that the mechanisms underlying the memory impairment in schizophrenia are fully attributabl

198 we summarize the neuronal basis for working memory impairment in schizophrenia, including dysfunctio

199 relevant in an effective therapy for working memory impairment in schizophrenia.

200 synaptic and neuronal mechanisms of working memory impairment in the context of psychiatric disorder

201 eus and hippocampus associated with episodic memory impairment in the NC PiB-positive (NC+) group whe

202 50 (BAY) affected Abeta-induced learning and memory impairment in two classic rodent models.

203 se of the central nervous system, leading to memory impairment in up to 65% of patients.

204 glia contribute to neuronal loss, as well as memory impairments in 5xfAD mice, but do not mediate or

205 can prevent developmental delay and AD-like memory impairments in a DS mouse model.

206 T mice and can offset synaptic signaling and memory impairments in a model of congenital intellectual

207 medial temporal lobe (MTL) underlie episodic-memory impairments in AD dementia.

208 upregulation may contribute to age-dependent memory impairments in AD in DS.

209 ay in pups and AD-like hippocampus-dependent memory impairments in adult life in Ts65Dn mice.

210 elucidating the neural mechanisms underlying memory impairments in aging and dementia.

211 NMDAR loss in PFC may account for working memory impairments in aging and psychiatric disease.

212 beta)-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice, a w

213 aling is involved in synaptic plasticity and memory impairments in AS model mice, suggesting that Erb

214 We rescued memory impairments in BAF53b mutant mice by reintroducin

215 ut the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzhe

216 ogical mechanisms that underlie learning and memory impairments in DS.

217 olves multiple events, and notably, episodic memory impairments in human diseases are not limited to

218 o methamphetamine (meth) can produce lasting memory impairments in humans and rodents.

219 ed by clinical reports of long-term episodic memory impairments in psychiatric conditions with dissoc

220 reases with age and has been associated with memory impairments in rats.

221 l features that accompany comparable working memory impairments in schizophrenia and healthy aging.

222 he cortical oscillation deficits and working memory impairments in schizophrenia.

223 een brain regions as a mechanism for working memory impairments in the disorder.

224 ese effects were shown to be correlated with memory impairments in the working memory task.

225 us system where it modulates amyloidosis and memory impairments in transgenic mouse models of Alzheim

226 rexidine (DAR-0100A) could attenuate working memory impairments in unmedicated patients with schizoty

227 lder adults and alleviate age-related source memory impairments, in part, by reducing demands on post

228 hibitor that also inhibits mTOR, reduced the memory impairment induced by Abeta.

229 lpha and anti-NL1 antibodies further blocked memory impairment induced by AbetaOs in mice.

230 d hippocampus-dependent spatial learning and memory impairments induced by cranial irradiation.

231 beta/beta-catenin signaling may underlie the memory impairments induced by Dkk-1.

232 JH-deficit-induced memory impairment involves rapid decay rather than failu

233 Episodic memory impairment is a common but poorly-understood phen

234 Episodic memory impairment is a hallmark for early diagnosis of A

235 This threat memory impairment is also reflected in increased behavio

236 Associative memory impairment is an early clinical feature of dement

237 Among these deficits, working memory impairment is considered a central cognitive impa

238 ith age, but the cause of this age-dependent memory impairment is not well understood.

239 Memory impairment is often associated with disrupted reg

240 Memory impairment is the cardinal early feature of Alzhe

241 In Alzheimer's disease (AD), memory impairment is the most prominent feature that aff

242 is altered during aging to cause age-related memory impairments is unknown.

243 h damage to the human fornix also results in memory impairment, it is not known whether there is a pr

244 the loss of dendritic spines and accelerate memory impairments, leading to earlier cognitive decline

245 We examined whether visual short-term memory impairments, long associated with patients with P

246 ing on tangents, suggesting that anterograde memory impairment may have interfered with narrative con

247 Abeta-overproducing mice showed significant memory impairment, memories in GluA3-deficient congenics

248 In addition, we aimed at reversing the memory impairment observed in a mouse model of sporadic

249 the bEKO mice did not have the learning and memory impairment observed in ApoE KO mice.

250 ce with the PKRi before learning rescues the memory impairment of the ApoE4 AD model mice.

251 n treatment effectively rescues the learning/memory impairment of these mice at 3 mo of age, and it s

252 veal a key mechanism underlying learning and memory impairments of PNN-associated neurodevelopmental

253 whether MTL tau pathology also accounts for memory impairments often seen in elderly people and how

254 he strength of this beta echo was related to memory impairment on a between-subjects level.

255 epilepsy at just 5 weeks of age, long before memory impairments or beta-amyloid deposition.

256 cifics, a change that did not involve global memory impairments or increased anxiety.

257 seropositivity was associated with immediate memory impairment (OR, 3.26; 95% CI, 1.68-6.32).

258 participants (P < .001) and athletes without memory impairment (P < .001).

259 e novel arm of the Y maze because of spatial memory impairments (P < .05).

260 n the level of PLXNA4 is sufficient to cause memory impairments, raising the possibility that memory

261 ance deficit more likely indicates a genuine memory impairment rather than a retrieval failure.

262 zygous BDNF Val66Met females exhibit spatial memory impairment, regardless of acute stress.

263 but mechanisms underlying this age-dependent memory impairment remain poorly understood.

264 receptors (D2Rs), on cognitive deficits and memory impairments remains questionable.

265 er it also can ameliorate neural circuit and memory impairments remains unclear.

266 ic interneurons, which prevents learning and memory impairments, rescued SWR-associated slow gamma ac

267 lves long-term cognitive deficits, including memory impairment, resulting in substantial cost to soci

268 lock Drawing Test (k = 7), Mini-Cog (k = 4), Memory Impairment Screen (k = 5), Abbreviated Mental Tes

269 The spatial working memory impairment shown here has the potential to harm b

270 on as an underlying mechanism of age-related memory impairment.SIGNIFICANCE STATEMENT Alterations in

271 ymmetrical effect on memory, inducing strong memory impairment similarly to bilateral inhibition or m

272 evere AD pathology and significantly greater memory impairments than untreated animals.

273 xpression and is a likely contributor to the memory impairment that is found in >40% of individuals w

274 accompanied by cognitive problems, including memory impairments that contribute to poor quality of li

275 use neurotoxicity, synaptic dysfunction, and memory impairments that underlie Alzheimer disease (AD).

276 men with low testosterone and age-associated memory impairment, treatment with testosterone for 1 yea

277 retrograde facilitation and alcohol induced memory impairment using two independent tasks.

278 Working memory impairment was associated with E/E', although imp

279 Memory impairment was associated with the loss of adult-

280 l considerations indicate that E.P.'s severe memory impairment was caused by his medial temporal lesi

281 Moreover, this memory impairment was further associated with persistent

282 ty analyses revealed that risk of subjective memory impairment was increased only among respondents w

283 ive depression, however, risk for subjective memory impairment was no longer significant (RR [95% CI]

284 This stress-induced working memory impairment was prevented by anodal, but not sham

285 Moreover, memory impairment was prevented by the selective mammali

286 Furthermore, the risk of subjective memory impairment was significantly greater among those

287 Remarkably, an improvement of the memory impairments was also observed.

288 nderstand the underlying mechanisms of these memory impairments, we examined hippocampal long-term po

289 Anxiety and agitation and memory impairment were prominent features (between a hal

290 ratory behaviors and subtle spatial learning memory impairments were observed.

291 ying demonstrated the typical stress-related memory impairment, whereas those who learned by retrieva

292 s are increasingly recognized as causing the memory impairments which define Alzheimer's disease (AD)

293 ns, and either altered mental status or mild memory impairment), which are considered more reliable t

294 be epilepsy present with a broad spectrum of memory impairment, which can be assessed during clinical

295 ally diagnosed as unknown or with subjective memory impairment who were later rediagnosed with aMCI/A

296 Subtle memory impairment with a positive beta-amyloid scan iden

297 s with aMCI/AD from patients with subjective memory impairment with a sensitivity of 0.79 and specifi

298 buprofen, and found that ibuprofen prevented memory impairment without producing any measurable chang

299 pathological concomitant of obesity-induced memory impairment, yet a deeper understanding of the bas

300 Of combinations, subtle memory impairment (Z score = -0.5 to -1.5) with a positi