ライフサイエンスコーパス: menadione

1 the presence of 2-methyl-1,4-naphthoquinone (menadione).

2 d with the reduction-oxidation cycling agent menadione.

3 y directly sense oxidative stresses, such as menadione.

4 y active PKD prevented death from Ro-31-8425/menadione.

5 de I sensitized this cell line to death from menadione.

6 nus kinase 3 (JAK3) by the vitamin K3 analog menadione.

7 oxidant stress from the superoxide generator menadione.

8 stream substrate for JNK, blocked death from menadione.

9 uring oxidant-induced hepatocyte injury from menadione.

10 methyl group and the adjacent ring carbon in menadione.

11 scued by addition of small concentrations of menadione.

12 This was also the case after exposure to menadione.

13 t sensitive to the oxidizing agents H2O2 and menadione.

14 none, 2,3-dimethoxy-1, 4-naphthoquinone, and menadione.

15 e GSH increase to activation of NF-kappaB by menadione.

16 cytotoxicity produced by preincubation with menadione.

17 NF-kappaB, resulted in increased toxicity by menadione.

18 activated by the superoxide anion generator menadione.

19 iation after exposure to H(2)O(2) but not to menadione.

20 but not to the superoxide radical generator menadione.

21 ied by exposing worms to D-penicillamine and menadione.

22 tabolic activation of toxic quinones such as menadione.

23 exacerbated in the presence of the genotoxin menadione.

24 autophagy (CMA) also mediated resistance to menadione.

25 bility to reduce extracellular plumbagin and menadione.

26 ath from normally nontoxic concentrations of menadione.

27 de was elevated with the redox cycling agent menadione.

28 ificity constants are found with the quinone menadione.

29 trically at 490 nm after addition of XTT and menadione.

30 nder exposure to either hydrogen peroxide or menadione.

31 of mtDNA damage in neurons when treated with menadione.

32 genin, 15-deoxy-Delta12,14-prostaglandin-J2, menadione, 1-Cl-2,4-dinitrobenzene, and biotinylated iod

33 ture (40 degrees C), jasmonic acid (200muM), menadione (120muM) and abscisic acid (3.026mM) treatment

34 enzyme-orotate complex reacted rapidly with menadione (180 s(-1)), demonstrating that the reduced en

35 ge cell line (NR8383) was exposed to H2O2 or menadione (2-methyl-1,4-naphthoquinone (MQ)), a quinone

36 The uptake of menadione (2-methyl-1,4-naphthoquinone), which is toxic

37 idative stress induced in live HeLa cells by menadione (2-methyl-1,4-napthaquinone) was studied in re

38 to 2-methyl-1, 4-naphthoquinone (vitamin K3, menadione, 2MNQ) in the presence of hydrogen peroxide an

39 Menadione (50 muM) produced twice as many lesions in gra

40 epared by coupling vitamin K3, also known as menadione (a quinone redox center), to a boron-dipyrrome

41 lphaE2), 17alpha-ethinylestradiol (alphaEE), menadione, a combination of alphaE2 and alphaEE, or a co

42 The structural similarity between menadione, a para-quinone, and beta-lapachone, an ortho-

43 +) versus ERalpha(-) cells and 4-OHEN versus menadione, a reactive oxygen species (ROS)-generating, b

44 Menadione activated NF-kappaB as determined by electroph

45 ative stress induced by hydrogen peroxide or menadione activates the heat shock transcription factor

46 by N-methyl-N'-nitro-N-nitrosoguanidine and menadione after benzamide withdrawal.

47 f hamsters treated with alphaE2, alphaEE, or menadione alone did not show any gross evidence of tumor

48 ress induced by 0.5 mM H(2)O(2) or 50 microM menadione also caused a greater than 50% reduction in GP

49 SPRR2D, and SPRR2F) were rapidly induced by menadione, an agent that promotes apoptosis through the

50 equivalents from NADH or CH(3)-H(4)folate to menadione, an artificial electron acceptor.

51 e exogenous addition of hydrogen peroxide or menadione, an intracellular generator of superoxide anio

52 t photoirradiation with isotopically labeled menadione and 2,3-dimethyl-1,4-naphthoquinone.

53 ures of GlpD bound with ubiquinone analogues menadione and 2-n-heptyl-4-hydroxyquinoline N-oxide, ide

54 22 s(-1), and an apparent K(m) of 14 muM for menadione and 26 muM for NADPH.

55 ation of 50 microM in presence of 500 microM menadione and 50 microM MK571.

56 ys of hamsters treated with a combination of menadione and alphaEE showed foci of tumor with congeste

57 ys of hamsters treated with a combination of menadione and alphaEE showed increased 8-iso-PGF(2alpha)

58 omplex III and who responded to therapy with menadione and ascorbate.

59 ng compounds, e.g., the environmental toxins menadione and beta-lapachone (in vivo IC(50) = 0.45 muM)

60 hypersensitivity to the DNA-damaging agents menadione and bleomycin, consistent with a role for AtKu

61 chemical microscopy by exposing the cells to menadione and detecting the menadione-S-glutathione conj

62 sensitive to H(2)O(2) and more sensitive to menadione and diamide than wild-type cells.

63 under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or

64 progression of the in vitro reaction between menadione and glutathione was monitored electrochemicall

65 Using menadione and H2O2 as positive controls, just 100 mug/mL

66 ated via mutations in menD or hemB, yielding menadione and hemin auxotrophs, respectively, and studie

67 eterminations of the midpoint potentials for menadione and menadione bisulfite indicated that the lat

68 cell population to the redox-cycling agents, menadione and paraquat; this reduced survival was accomp

69 er, when exposed to naphthoquinones, such as menadione and plumbagin, which cause indirect oxidative

70 t diamide and to the redox cycling compounds menadione and plumbagin.

71 naling reversed CYP2E1-induced resistance to menadione and sensitization to AA toxicity.

72 ap1 cells to the oxidants H(2)O(2), diamide, menadione and tert-butyl hydroperoxide.

73 also more resistant to apoptosis induced by menadione and thapsigargin.

74 gested the rate was limited by the uptake of menadione and that the efflux through the glutathione-co

75 , Atg5-/- cells were resistant to death from menadione and UV light.

76 eased susceptibility to oxidative (H2 O2 and menadione) and UV stress as compared to wild-type and co

77 an oxidant (H2O2), to a redox-cycling agent (menadione), and to an osmotic challenge with 2.5 M NaCl.

78 ,10-phenanthrenequinone, 1,4-naphthoquinone, menadione, and 2,3-dimethyl-1,4-naphthoquinone.

79 tive to oxidative stress as induced by H2O2, menadione, and diamide treatment.

80 ssive elevations of ROS induced by paraquat, menadione, and light stress and prevent cell death induc

81 dative stress (e.g. H(2)O(2), peroxynitrite, menadione, and paraquat) through transient alterations i

82 highly sensitive to the redox cycling agent menadione, and showed fragmentation of the large vacuole

83 treatment with oxidants (hydrogen peroxide, menadione, and t-butyl hydroperoxide) were investigated

84 etylpyridine adenine dinucleotide phosphate, menadione, and the anticancer drug doxorubicin.

85 ate prevented the activation of NF-kappaB by menadione, and under these conditions, salicylate potent

86 the sensitivity to added prooxidants such as menadione, antimycin A, H(2)O(2), and 4-hydroxynonenal w

87 eractivation of JNK and c-Jun in response to menadione as determined by in vitro kinase assay and imm

88 With NADH as the electron donor and menadione as the electron acceptor, the k(cat) values fo

89 ain neurons leads to enhanced sensitivity to menadione, as indicated by increased levels of DNA stran

90 the XTT method (100 microg/ml XTT, 25 microM menadione) at 6, 8, or 12 h after inoculation and the CL

91 1 (Deltapsi -100 mV; a respiration-deficient menadione auxotroph of 6850) were used to assess the inf

92 ions in three genes encoding proteins in the menadione biosynthesis pathway.

93 ctron transport due to mutations in hemin or menadione biosynthesis.

94 in response to heat shock or treatment with menadione bisulfate.

95 of the midpoint potentials for menadione and menadione bisulfite indicated that the latter compound w

96 the structure of reduced PutA complexed with menadione bisulfite reveals the elusive quinone-binding

97 When another cell line was assayed utilizing menadione bisulfite, an apparent activity of about three

98 When menadione was used in place of menadione bisulfite, an artifactual DT-diaphorase activi

99 d, but was about one-half that obtained with menadione bisulfite.

100 n enhances sensitivity to UV, gamma rays and menadione, but ectopic expression of RAD9 or NEIL1 resto

101 creased sensitivity to benomyl, diamide, and menadione, but not 4-NQO, cycloheximide, or fluconazole.

102 Exposure to hydrogen peroxide or menadione, but not mercuric chloride, resulted in signif

103 lot analysis showed that SCR1 was induced by menadione, but SCR2 was not.

104 SR and HPLC-EC analysis of the metabolism of menadione by either HepG2 cells or isolated rat hepatocy

105 Menadione caused a dose-dependent thiol oxidation in the

106 Menadione caused apoptosis of pancreatic acinar cells th

107 Both heat and menadione caused parasites to become more resistant to H

108 Menadione causes oxidative stress by generating reactive

109 hibited increased toxicity when administered menadione compared with wild-type mice.

110 l characterizations of the QsrR-DNA and QsrR-menadione complexes further reveal that the covalent ass

111 In contrast, treatment with a toxic menadione concentration induced a prolonged activation o

112 Treatment with a nontoxic menadione concentration resulted in a brief activation o

113 epatocytes to death from previously nontoxic menadione concentrations in association with sustained J

114 and 35 microM upon exposure of the cells to menadione concentrations of 500, 250, and 125 microM, re

115 Maximum protection was found with menadione concentrations of approximately 3 microM and p

116 pe tip current of yeast cells suspended in a menadione-containing solution, the export of the conjuga

117 Menadione cytotoxicity was enhanced when the Hep G2 cell

118 ed NF-kappaB, resulted in protection against menadione cytotoxicity.

119 (astrocytes), and enzyme histochemistry for menadione-dependent a-glycerophosphate dehydrogenase (M-

120 ecombinant HemG was shown to be capable of a menadione-dependent conversion of protoporphyrinogen IX

121 response upon exposure to heat or sublethal menadione, detected by increased levels of HSP70.

122 The hydrophobic molecule menadione diffuses through a living cell membrane where

123 ther reveal that the covalent association of menadione directly leads to the release of QsrR from ope

124 cells with the hOGG1 fusion protein prior to menadione exposure resulted in an increase in the rate o

125 u proteins in neuronal cells are affected by menadione exposure.

126 Chk2 phosphorylation was enhanced following menadione exposure.

127 and alphaEE, or a combination of alphaEE and menadione for 7 months.

128 Menadione generated ROS with a concomitant decrease of N

129 se of DC3000 and provides protection against menadione-generated endogenous H(2)O(2).

130 From the export of the menadione-glutathione conjugate detected at a 1-microm-d

131 including osmotic stress, hydrogen peroxide, menadione, heat shock, and the protein synthesis inhibit

132 tance to death from the superoxide generator menadione in the hepatocyte cell line RALA255-10G is dep

133 menaquinone-4 or whether it is converted to menadione in the intestine followed by delivery of menad

134 2 cells with low, nontoxic concentrations of menadione increased the viability of the cells against t

135 -lapachone and related naphthoquinones, like menadione, induce protein-linked DNA breaks in the prese

136 uction of O2*- by the redox cycling compound menadione induced MEK-1-independent cellular growth and

137 Menadione induced phosphorylation of PKD at Ser-744/748,

138 Menadione-induced apoptosis and the PRC stress program w

139 cts on cellular survival, protecting against menadione-induced apoptosis, but sensitizing to necrotic

140 uced DNA damage in ERalpha(+) cells, whereas menadione-induced damage was not dependent on cellular E

141 ereas ER status had no effect on the rate of menadione-induced damage.

142 species per se but significantly potentiated menadione-induced effects, probably via enhancement of o

143 orylation constitutes a major feature of the menadione-induced oxidative injury in these neuronal cel

144 Hepatocyte resistance to injury from menadione-induced oxidative stress is mediated by distin

145 e hepatocyte injury response, the effects of menadione-induced oxidative stress were examined in the

146 creased mitochondrial distribution following menadione-induced oxidative stress.

147 PKC inhibition blocked menadione-induced phosphorylation of PKD, and expression

148 cells, the cytoskeleton is a prime target of menadione-induced thiol oxidation.

149 licylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-a

150 the strategy can be extended to observe how menadione induces superoxide generation in mitochondria.

151 n contrast, the oxidizing agents diamide and menadione inhibited the development of hillocks triggere

152 se results provide unequivocal evidence that menadione is a catabolic product of oral phylloquinone a

153 vity, to superoxide anion (O(2)()) formed by menadione is attenuated, whereas induction by heme is no

154 yte resistance to oxidant-induced death from menadione is dependent on ERK, whereas cell death is med

155 The vitamin K analog menadione (K3), capable of both redox cycling and arylat

156 s hyperplasia and in metabolic activation of menadione, leading to hepatic toxicity.

157 s low concentrations of H2O2 (0.1-0.2 mM) or menadione (less than = 10 microM) induced myeloid cell a

158 ide (HP) and the superoxide-generating agent menadione (MD).

159 odies in muscle biopsy sections stained with menadione-NBT followed by clinical, histological, ultras

160 es in muscle that exert reducing activity on menadione nitro-blue-tetrazolium (NBT).

161 Sensitization to death from menadione occurred despite up-regulation of other forms

162 ults suggest that acute generation of ROS by menadione occurs via redox cycling, the net effect of wh

163 ifferential effects of hydrogen peroxide and menadione on cell cycle progression.

164 The cytotoxicity of menadione on hepatocytes was studied by using the substr

165 The actions of menadione on ROS production and cell fate were compared

166 The quinone substrate menadione, on the other hand, binds nonspecifically to b

167 Arabidopsis cell culture for 16 h with H2O2, menadione or antimycin A induced an oxidative stress dec

168 ortic endothelial cells after treatment with menadione or antimycin A to induce intracellular reactiv

169 ibited NADPH quinone reductase activity with menadione or benzoquinone and weak activity with cytochr

170 Notably, the superoxide-generating drug menadione or H(2)O(2) was sufficient to trigger differen

171 , salicylate potentiated the cytotoxicity of menadione or H2O2.

172 iability of the cells against toxic doses of menadione or H2O2.

173 ants do not display sensitivity to paraquat, menadione or hydrogen peroxide (H2O2).

174 onstrated decreased toxicity when exposed to menadione or menadione with NRH.

175 ion and loss of c-FLIP(L) protein induced by menadione or paraquat.

176 HEK293T, and HeLa cancer cells treated with menadione or paraquat.

177 ediate doses of nickel, copper, alkaline pH, menadione or paraquat.

178 NONOates plus xanthine oxidase/hypoxanthine, menadione, or mitomycin C) were examined.

179 A Giardia NAD(P)H:menadione oxidoreductase (DT-diaphorase) is known to cat

180 tathione (GSH)-S-transferase family, NAD(P)H menadione oxidoreductase 1, and the ferritin light chain

181 In the NADH-menadione oxidoreductase assay and in the isolated reduc

182 In the NADH-menadione oxidoreductase assay, the mutant demonstrated

183 ayed as either dicumarol-inhibitable NAD(P)H:menadione oxidoreductase or dicumarol-inhibitable NAD(P)

184 In the NADH-menadione oxidoreductase reaction, the reduction of the

185 by CH(3)-H(4)folate in the CH(3)-H(4)folate-menadione oxidoreductase reaction.

186 e sensitive to killing by hydrogen peroxide, menadione, paraquat, and diamide.

187 r PPC-1 cells with the superoxide generators menadione, paraquat, or buthionine sulfoximine down-regu

188 ogen, benzyl viologen, and diquat but not to menadione, plumbagin, pyrogallol, or nitrofurantoin.

189 he results of the current study suggest that menadione pretreatment protects Hep G2 cells from oxidat

190 An increased level of GSH was observed after menadione pretreatment; this increase was blocked by sal

191 n blot technology, we found that exposure to menadione produced detectable mtDNA damage in HeLa cells

192 reatment, and exposure to sodium arsenite or menadione, proved more toxic to those cells expressing t

193 Growth in menadione reconstituted Deltapsi of JB-1 to a level equi

194 e three groups were: CYP2D6, CYP2E1, NAD(P)H-menadione reductase, glutathione transferases M1 and T1,

195 of cytochrome c, 2,6-dichloroindophenol, and menadione reduction is decreased 10-15 fold.

196 recovery of virulence factor expression and menadione resistance, and in restoration of virulence.

197 ing the cells to menadione and detecting the menadione-S-glutathione conjugate (thiodione) that is fo

198 osines from the 2-methyl-1,4-naphthoquinone (menadione)-sensitized 365-nm irradiation of d(CpC).

199 ibition induced by oxidative stress (H2O2 or menadione), significantly ameliorated the H2O2-dependent

200 hibitors of quinone reductases, particularly menadione, similarly blocked SAPK activation.

201 Menadione sodium bisulfite (MSB) increased the oxygen co

202 obilized yeast cell aggregates stressed by a menadione solution.

203 Anti-p50 IgG prevented the menadione-stimulated binding of NF-kappaB to the oligonu

204 trations of hydrogen peroxide (H(2)O(2)) and menadione (superoxide generator).

205 Menadione supplementation, which normalized the delta ps

206 cytotoxicities of four oxidative stressors (menadione, tert-butyl hydroperoxide, 4-hydroxynonenal, a

207 Similar to menadione, the polyunsaturated fatty acid (PUFA) arachid

208 In contrast to menadione, the SN-38 induction of the PRC program occurr

209 gen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the d

210 MA inhibition sensitized cells to death from menadione through a mechanism different from that of a l

211 ity of PKC to modulate hepatocyte death from menadione through effects on AP-1 was examined.

212 Elaboration of menadione to a pyranonaphthoquinone has yielded low nano

213 The addition of menadione to Hep G2 cells produced a time- and concentra

214 one in the intestine followed by delivery of menadione to tissues and subsequent conversion to menaqu

215 rthermore, in endothelial cells treated with menadione to trigger cellular superoxide generation, eNO

216 YP2E1-overexpressing cells were resistant to menadione toxicity through an ERK1/2-dependent mechanism

217 NAs, and this protected against H(2)O(2) and menadione toxicity.

218 cells within 5 min, whereas in ERalpha(-) or menadione-treated cells, no selectivity was observed.

219 Despite its effect on thiol oxidation, menadione treatment did not lead to cytoskeletal changes

220 Menadione treatment led to activation of PKCmicro, or pr

221 Cell death from PKC inhibition and menadione treatment resulted from c-Jun activation, sinc

222 ), the Hep G2 cells became more sensitive to menadione treatment.

223 urvival due to increased apoptosis following menadione treatment.

224 f 25 protein spots increased >3-fold in H2O2/menadione treatments, a subset of these increased in ant

225 e 1.6 10(-7) m/s, about 10 times faster than menadione uptake.

226 ts and measurements of phylloquinone-derived menadione using high resolution MS analysis and a bioass

227 QR2 catalyzes the two-electron reduction of menadione via the oxidation of N-alkylated or N-ribosyla

228 ures of QR2: in its native form and bound to menadione (vitamin K(3)), a physiological substrate.

229 Menadione (vitamin K-3,2-methyl-1,4-naphthoquinone), a r

230 uinone but a strong prenylation activity for menadione (vitamin K3), which has long been postulated a

231 Death from menadione was blocked by catalase and ebselen, indicatin

232 l death caused by H(2)O(2), antimycin A, and menadione was considerably suppressed in both the mC5 an

233 Menadione was used as a model quinone substrate to oxidi

234 Menadione was used as a model to induce cellular oxidati

235 water-soluble bisulfite addition product of menadione was used as the electron acceptor, an artifact

236 When menadione was used in place of menadione bisulfite, an a

237 OP2 poisons (e.g. amonafide, batracylin, and menadione) was only slightly (less than 3-fold) affected

238 he hydroquinone, but not the quinone form of menadione, was an intermediate of the conversion.

239 c concentrations of the superoxide generator menadione were established in the RALA255-10G rat hepato

240 nduced by redox cycling agents plumbagin and menadione, whereas an fgd mutant of M. smegmatis used G6

241 d by aminotriazole and to a lesser extent by menadione, whereas ZmMRP2 was expressed at a lower const

242 ts of 37 degrees C "heat shock" or sublethal menadione, which generates superoxide and hydrogen perox

243 tained the binary complex structures with GS-menadione, which in its reduced form, GS-menadiol, is a

244 nhibitors exemplified by the natural product menadione, which is shown in mouse tumor models to have

245 methylenetetrahydrofolate in the presence of menadione, which serves as an electron acceptor.

246 reased toxicity when exposed to menadione or menadione with NRH.

247 the product generated from the incubation of menadione with recombinant UBIAD1 revealed that the hydr