ライフサイエンスコーパス: menaquinone

1 they are likely to affect the redox state of menaquinone.

2 gene that is involved in the biosynthesis of menaquinone.

3 ts ability to synthesize both ubiquinone and menaquinone.

4 s in response to the accumulation of reduced menaquinone.

5 formation of the respiratory chain component menaquinone.

6 be complemented by the addition of exogenous menaquinone.

7 low-level maintenance of the mono-saturated menaquinone.

8 MenA, an enzyme involved in the synthesis of menaquinone.

9 t that CMTn-1 was also markedly deficient in menaquinones.

10 h results in the synthesis and absorption of menaquinones.

11 Menaquinone-2 (MK-2), a truncated MK, was synthesized, a

12 vert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissu

13 Here, we show that UBIAD1, a vitamin K2/menaquinone-4 biosynthetic enzyme, functions cell-autono

14 issues in its original form and converted to menaquinone-4 or whether it is converted to menadione in

15 re the novel finding that vitamin K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-me

16 l phylloquinone and a major source of tissue menaquinone-4.

17 into tissues but is not converted further to menaquinone-4.

18 ione to tissues and subsequent conversion to menaquinone-4.

19 metry analysis of the quinone extract showed menaquinone-6 as the major component.

20 shown that the pure enzyme contains 1 eq of menaquinone-7 and that the enzyme stabilizes a mena-semi

21 first time, the cis/trans isomer content of menaquinone-7 in food products has been identified and m

22 trochemistry, it is shown that vesicle-bound menaquinone-7 is not only a substrate for this enzyme bu

23 Dihydrogenated menaquinone-8 [menaquinone-8(H(2))], which probably acts

24 econstituted with excess of ubiquinone-8 and menaquinone-8 analogues.

25 Dihydrogenated menaquinone-8 [menaquinone-8(H(2))], which probably acts as a quencher

26 of the biologically available ubiquinone and menaquinone aid in driving the chemical reaction in one

27 [4Fe-4S] clusters, two heme b groups, and a menaquinone analog.

28 ovide further evidence for the importance of menaquinone and aerobic metabolism for L. monocytogenes

29 urified R48H exhibits very low activity with menaquinone and an apparent Michaelis constant (K(m)) fo

30 tase activity, resulting in net oxidation of menaquinone and inhibition of Cu(II) reduction, response

31 renoid intermediate in the synthesis of both menaquinone and the sesquarterpenoids.

32 e required for the synthesis of both CoQ and menaquinone, and it is the 5' gene in an operon containi

33 ion-translocating electron transfer complex, menaquinone, and membrane-bound Fe-S proteins with assoc

34 er important metabolites, including folates, menaquinone, and siderophores.

35 These results indicate that menaquinones are essential components for the reduction

36 to Mtb drug treatment shifted the menaquinol/menaquinone balance toward a reduced state that stimulat

37 Triton X-100 and oxygen affect the menaquinone binding site, but n-dodecyl beta-D-maltoside

38 the o-succinylbenzoate synthase reaction in menaquinone biosynthesis (kcat/Km = 2.5 x 10(5) and 7.5

39 ew compounds also target enzymes involved in menaquinone biosynthesis and electron transport, inhibit

40 he ubiE homolog is likely to be required for menaquinone biosynthesis and is located within the gerC

41 Small colony variants specifically lacking menaquinone biosynthesis arose after prolonged Spm expos

42 OSBS reaction; intriguingly, the operon for menaquinone biosynthesis in G. kaustophilus does not enc

43 Menaquinone biosynthesis is initiated by the conversion

44 hin biosynthesis, SCVs defective for heme or menaquinone biosynthesis were significantly more resista

45 AAE14 was able to restore menaquinone biosynthesis when expressed in an Escherichi

46 H. pylori uses an unusual pathway for menaquinone biosynthesis with 5'-methylthioadenosine/S-a

47 ic carbon metabolism, membrane transporters, menaquinone biosynthesis, and complexes I-IV of the euba

48 s independently confirmed the restoration of menaquinone biosynthesis, and similarly, analyses of iso

49 sport, amino acid metabolism, ubiquinone and menaquinone biosynthesis, cell surface adhesion, biosynt

50 , and also defective in either ubiquinone or menaquinone biosynthesis.

51 methylation reactions in both ubiquinone and menaquinone biosynthesis.

52 al pathways, autoinducer-2 biosynthesis, and menaquinone biosynthesis.

53 CoA to form OSB-CoA, the fourth step of the menaquinone biosynthetic pathway in Bacillus anthracis.

54 omparison with genes encoding enzymes of the menaquinone biosynthetic pathway in Escherichia coli.

55 zes an exergonic dehydration reaction in the menaquinone biosynthetic pathway in which 2-succinyl-6-h

56 obutyrate (o-succinylbenzoate or OSB) in the menaquinone biosynthetic pathway.

57 qnE) is a radical SAM enzyme involved in the menaquinone biosynthetic pathway.

58 losine in the second step of the alternative menaquinone biosynthetic pathway.

59 for a C-methyltransferase step in the Q and menaquinone biosynthetic pathways in Escherichia coli.

60 ll surface structures, while ubiquinones and menaquinones, both containing an essential prenyl moiety

61 synthetic pathway leading from chorismate to menaquinone, catalyzes the conversion of O-succinylbenzo

62 etermined.This study aimed to quantify fecal menaquinone concentrations and identify associations bet

63 ions and identify associations between fecal menaquinone concentrations and serum vitamin K concentra

64 s associated with any marker of inflammation.Menaquinone concentrations in the human gut appear highl

65 owever, interindividual variability in fecal menaquinone concentrations partitioned individuals into

66 omposition, and inflammation.Fecal and serum menaquinone concentrations, fecal microbiota composition

67 These menaquinones contribute to vitamin K nutriture during di

68 obacterial cytochrome bc1 :aa3 consists of a menaquinone:cytochrome c reductase (bc1 ) and a cytochro

69 The menaquinone:cytochrome c reductase, or bc complex, of Ba

70 es with the function of the subunit b of the menaquinone:cytochrome c reductase.

71 e total median (IQR) fecal concentrations of menaquinones decreased in the WG diet compared with the

72 rowth with glycerol and fumarate, Hyd-2 used menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydro

73 inds of quinones (ubiquinone for aerobic and menaquinone for anaerobic growth) in the electron-transp

74 identified genera were associated with >/=1 menaquinone form.

75 l differences in concentrations of different menaquinone forms rather than the diet group or the time

76 ntrations of individual menaquinones nor the menaquinone group was associated with any marker of infl

77 e futalosine pathway toward the synthesis of menaquinone in Chlamydiaceae.

78 r data indicate weaker hydrogen bonds of the menaquinone in cytochrome aa(3)-600 in comparison with u

79 Since utilization of menaquinone in the electron transport system is a charac

80 Thus, NR appears to replace the function of menaquinone in the fumarate reductase complex, and it en

81 is therefore not dependent on the levels of menaquinone in these cells.

82 2 and 8.The median total daily excretion of menaquinones in feces was 850 nmol/d but was highly vari

83 bacterially derived vitamin K forms known as menaquinones in health and disease, which may be attribu

84 The ubiquity of saturated menaquinones in the Archaea in comparison to Bacteria su

85 tol-dependent reduction of phylloquinone and menaquinone into their respective quinol forms.

86 A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyc

87 ved in the aerobic assimilation of iron, and menaquinone is involved in anaerobic electron transport,

88 Vitamin K (as phylloquinone and menaquinones) is an essential cofactor for the conversio

89 nts were no less susceptible to Spm implying menaquinone itself rather than general respiration is re

90 While MR1-CYMA retained menaquinone levels comparable to those of MR-1, it lost

91 lling studies and quantification of cellular menaquinone levels suggested that menaquinone synthesis,

92 This report demonstrates that the depressed menaquinone levels were the result of the rifampin resis

93 of rifampin resistance leading to decreased menaquinone levels, indicating that rifampin-resistant s

94 , we demonstrate that borinic esters inhibit menaquinone methyltransferase in gram positive bacteria

95 esis of both the respiratory chain component menaquinone (MK) and the siderophore 2,3-dihydroxybenzoa

96 Menaquinone (MK) biosynthesis pathway is a potential tar

97 ts identified in this screen inactivated the menaquinone (MK) biosynthesis pathway.

98 tively, i.e., close to the Em,7 value of the menaquinone (MK) pool, indicating a collisional interact

99 Menaquinone (MK, vitamin K2) is a lipid-soluble molecule

100 Menaquinone (MK-4) supplementation rescued MRSA growth,

101 mes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme.

102 monas viridis [containing ubiquinone (UQ) or menaquinone (MQ) at QA site, respectively].

103 We identify that both ubiquinone (UQ) and menaquinone (MQ) can form stacking and hydrogen-bonded i

104 weight-cytochrome c3) complex-linked reverse menaquinone (MQ) redox loop become increasingly importan

105 cation process (electron confurcation) and a menaquinone (MQ) redox loop-mediated reverse electron fl

106 h both natural quinones, ubiquinone (UQ) and menaquinone (MQ), at a single quinone binding site.

107 In a menaquinone (MQ)-based electron confurcation reaction, t

108 Menaquinones (naphthoquinones, MK) are isoprenoids that

109 d neither fecal concentrations of individual menaquinones nor the menaquinone group was associated wi

110 the first committed step for biosynthesis of menaquinone, or vitamin K2, a key cofactor for electron

111 piratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberc

112 Type-II NADH-menaquinone oxidoreductase (NDH-2) is an essential respi

113 nothiazine analogs specifically inhibit NADH:menaquinone oxidoreductase activity.

114 th chains can be initiated with type II NADH:menaquinone oxidoreductase.

115 und FeS oxidoreductase functioning as an ETF:menaquinone oxidoreductase.

116 tty acids, as well as in the biosynthesis of menaquinone, peptide antibiotics, and peptide siderophor

117 ether, these data demonstrate that a reduced menaquinone pool directly or indirectly triggers inducti

118 enaquinone was added, demonstrating that the menaquinone pool is a limiting factor in regulon inducti

119 The menaquinone pool is central to the electron transport sy

120 enaquinone pool or decreased the size of the menaquinone pool itself.

121 mpounds that occluded electron flow into the menaquinone pool or decreased the size of the menaquinon

122 rons from periplasmic cytochrome c(3) to the menaquinone pool.

123 However, the relevance of menaquinones produced by gut bacteria to vitamin K requi

124 The menaquinone reduction site associated with a possible pr

125 During growth, the wild type releases a menaquinone-related redox-active small molecule into the

126 plementation of growth medium with exogenous menaquinone rescued both growth and oxygen consumption o

127 Under truly anaerobic conditions, menaquinone shuttles electrons to alternate final electr

128 The MST enzymes (menaquinone, siderophore, and tryptophan biosynthetic en

129 DhbC is also 35% identical to the Bs menaquinone-specific isochorismate synthase, MenF, illus

130 rismate, a reaction that is catalyzed by the menaquinone-specific isochorismate synthase, MenF.

131 signaling via DosS and rescue inhibition of menaquinone synthesis and is less toxic.

132 chorismate synthase specifically involved in menaquinone synthesis encoded by the menF gene.

133 Mutations that eliminated menaquinone synthesis eradicated the superoxide formatio

134 ase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plan

135 tive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram

136 Menaquinone synthesis provides another target for agents

137 f cellular menaquinone levels suggested that menaquinone synthesis, and consequently electron transpo

138 owth on succinate and in both ubiquinone and menaquinone synthesis.

139 ylhydrolase (HpMTAN) proposed to function in menaquinone synthesis.

140 an outward-facing formate dehydrogenase via menaquinones to a fumarate reductase located at the cyto

141 ron acceptor, electrons are transferred from menaquinones to outward-facing CprA, via an as-yet-unide

142 normally and synthesize wild-type levels of menaquinone under anaerobic conditions in iron-sufficien

143 Biochemical analysis of menaquinones upon entry into hypoxic/anaerobic condition

144 , synthesized and evaluated against MRSA and menaquinone utilizing bacteria in aerobic conditions.

145 the first report of a Rieske protein from a menaquinone-utilizing organism.

146 step in the classical biosynthetic route to menaquinone (vitamin K(2)) is a Stetter-like conjugate a

147 s deficiency was overcome by the addition of menaquinone (vitamin K(2)).

148 is a key intermediate in the biosynthesis of menaquinone (vitamin K2) in both gram-negative and gram-

149 li, the biosynthesis of the electron carrier menaquinone (vitamin K2) involves at least seven identif

150 first committed step in the biosynthesis of menaquinone (vitamin K2) is the conversion of chorismate

151 Bacterial enzymes of the menaquinone (Vitamin K2) pathway are potential drug targ

152 biosynthesis of ubiquinone (coenzyme Q) and menaquinone (vitamin K2), essential isoprenoid quinone c

153 ynthesis of the siderophore enterobactin and menaquinone (vitamin K2).

154 n during hypoxia was observed when exogenous menaquinone was added, demonstrating that the menaquinon

155 Menaquinones were not detected in serum, and neither fec

156 le to reduce Fe(III) in the absence of added menaquinone when formate was used as the electron donor.

157 esis that this bacterial overgrowth produces menaquinones, which would meet the vitamin requirement i

158 It reduces both ubiquinones and menaquinones with similar efficiencies and preferably us

159 Saturated and monounsaturated menaquinones with six isoprenoid units forming the alkyl