ライフサイエンスコーパス: meniscal

1 The presence of meniscal and ACL tears was associated with more rapid ca

2 Meniscal and articular cartilage matrix calcification ar

3 ith aging-related cartilage calcification in meniscal and articular cartilages.

4 n and function were assessed preoperatively; meniscal and cartilage abnormalities were documented at

5 n and function were assessed preoperatively; meniscal and cartilage abnormalities were documented at

6 mine the relationships between inflammation, meniscal and cartilage pathology, and symptoms.

7 mine the relationships between inflammation, meniscal and cartilage pathology, and symptoms.

8 ide whether to refer patients with potential meniscal and ligament injuries, and we prefer clinical c

9 ion and magnetic resonance imaging (MRI) for meniscal and ligamentous knee damage.

10 lage lesions, bone marrow edema pattern, and meniscal and ligamentous lesions were frequently demonst

11 Meniscal and ligamentous tearing are the most frequent i

12 Baker cyst, effusion, internal derangement (meniscal and/or anterior cruciate ligament tears), media

13 , osteophytes, subchondral cysts, sclerosis, meniscal and/or ligamentous tears, joint effusion, synov

14 cal body was greater than that of the medial meniscal body (P <.05).

15 orn (P <.05), and enhancement of the lateral meniscal body was greater than that of the medial menisc

16 19.7%, P < .0001) but not in the group with meniscal but no root tear (76.7% vs 65.2%, P = .055).

17 vances in the understanding of the nature of meniscal calcification and its relationships with menisc

18 ve identified a guinea pig OA model in which meniscal calcification appears to correlate with aging a

19 Meniscal calcification correlated with cartilage degener

20 Recent findings support a pathogenic role of meniscal calcification in osteoarthritis.

21 Meniscal calcification is a new target for the developme

22 Meniscal calcification is positively associated with men

23 Meniscal calcification, similar to meniscal degeneration

24 ologic as well as quantitative evaluation of meniscal calcifications.

25 cond group of six monkeys (group 2), porcine meniscal cartilage and porcine articular cartilage plugs

26 1 expression was detectable in cultured knee meniscal cartilage cells.

27 r and a potential pathogenic factor for knee meniscal cartilage matrix calcification.

28 Upon explant, all meniscal cartilage samples in this group demonstrated hi

29 or possible human transplantation, xenograft meniscal cartilage was transplanted from pigs and cows i

30 nees, HB-IGF-1 was retained in articular and meniscal cartilage, but not in tendon, consistent with e

31 that is produced by chondrocytes within the meniscal cartilage.

32 effects of 3 PDNP-family NTPPPH isozymes on meniscal cell matrix calcification.

33 Meniscal cell TGase activity was stimulated by nitric ox

34 er of meniscal cells and in association with meniscal cell-derived matrix vesicles (MVs).

35 nt calcification inhibitor of osteoarthritis meniscal cell-mediated calcium deposition.

36 Only PC-1 was abundant at the perimeter of meniscal cells and in association with meniscal cell-der

37 transfected the isozymes in nonadherent knee meniscal cells cultured with ascorbic acid, beta-glycero

38 Osteoarthritis meniscal cells display a distinct gene-expression profil

39 nd produce more calcium minerals than normal meniscal cells in vitro.

40 Conversely, meniscal cells in younger patients appear to respond to

41 ene expression suggest that in older adults, meniscal cells might dedifferentiate and initiate a prol

42 direct transfection of chondrocytic TC28 and meniscal cells, both induced matrix apatite deposition.

43 ene-expression profile different from normal meniscal cells, have elevated expression of ankylosis pr

44 ification of each NTPPPH isozyme in vitro in meniscal cells.

45 monstrated in both knee menisci and cultured meniscal cells.

46 cification (with hydroxyapatite crystals) by meniscal cells.

47 CCL21 was more localized to chondrocytes and meniscal cells.

48 Neither diet nor treatment affected the meniscal collagen content.

49 Meniscal corner tears had a PPV of 0% medially and 50% l

50 h included meniscal displacement, peripheral meniscal corner tears, increased perimeniscal signal int

51 Since meniscal coverage and meniscal height diminished with su

52 nd varus malalignment (medially) and lateral meniscal damage (laterally).

53 There was also a strong association between meniscal damage and cartilage loss.

54 everal MR features (eg, bone marrow lesions, meniscal damage and extrusion, and synovitis or effusion

55 ed and older adults, any association between meniscal damage and the development of frequent knee pai

56 we found no independent association between meniscal damage and the development of frequent knee sym

57 cted tibial and femoral loss included medial meniscal damage and varus malalignment (medially) and la

58 in seems to be present because both pain and meniscal damage are related to OA and not because of a d

59 each predictor (meniscal position factor and meniscal damage as dichotomous predictors in each model)

60 ned lateral cartilage damage and progressive meniscal damage as increases in cartilage or meniscus sc

61 n, MRI is more sensitive for ligamentous and meniscal damage but less specific.

62 paucity of data regarding the prevalence of meniscal damage in the general population and the associ

63 To evaluate the effect of meniscal damage on the development of frequent knee pain

64 Lateral meniscal damage predicted every lateral outcome.

65 After full adjustment, medial meniscal damage predicted medial tibial cartilage volume

66 h there was a modest association between the meniscal damage score (range 0-3) and the development of

67 nded to the case-control status assessed the meniscal damage using the following scale: 0 = intact, 1

68 The effect of meniscal damage was analyzed by contingency tables and l

69 Meniscal damage was common at baseline both in case knee

70 adjusted for age, sex, and body mass index), meniscal damage was mostly present in knees with OA.

71 Cartilage and meniscal damage were scored on MRI in the medial and lat

72 The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and l

73 d for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effu

74 cartilage damage, the presence of high BMI, meniscal damage, synovitis or effusion, or any severe ba

75 effects, in part, by increasing the risk of meniscal damage.

76 valgus malalignment with progressive lateral meniscal damage.

77 body mass index (BMI), bone marrow lesions, meniscal damage/extrusion, synovitis, effusion, and prev

78 We show that, when placed into a meniscal defect, the controlled release of collagenase a

79 cal calcification and its relationships with meniscal degeneration and cartilage lesions in osteoarth

80 Its effect on preventing meniscal degeneration and the molecular mechanisms under

81 dels demonstrated that meniscal position and meniscal degeneration each contributed to prediction of

82 Cartilage and meniscal degeneration were scored on MRI in the medial a

83 redictor variables were MRI cartilage score, meniscal degeneration, and meniscal position measures.

84 Meniscal calcification, similar to meniscal degeneration, is a predisposing factor for cart

85 calcification is positively associated with meniscal degeneration, which is an early event in the de

86 The prevalence of a meniscal tear or of meniscal destruction in the right knee as detected on MR

87 p between synovitis and symptoms in isolated meniscal disease has not been reported.

88 p between synovitis and symptoms in isolated meniscal disease has not been reported.

89 Meniscal displacement (measured from the meniscal edge t

90 Meniscal displacement did not correlate with effusion.

91 f meniscocapsular separation, which included meniscal displacement, peripheral meniscal corner tears,

92 Meniscal displacement (measured from the meniscal edge to the tibia) was as great as 10 mm medial

93 e changes in the Lysholm and Western Ontario Meniscal Evaluation Tool (WOMET) scores (each ranging fr

94 We studied knee medial meniscal expression in situ of 3 NTPPPH isozymes of the

95 or tibiofemoral cartilage loss were baseline meniscal extrusion (adjusted OR 3.6 [95% CI 1.3-10.1]),

96 ars (adjusted OR, 3.19; 95% CI: 1.13, 9.03), meniscal extrusion (adjusted OR, 3.62; 95% CI: 1.34, 9.8

97 ication of tibio-femoral osteophytes, medial meniscal extrusion and medial femoral cartilage morpholo

98 Laxity and meniscal extrusion had inconsistent effects.

99 Meniscal extrusion is probably an effect of the complex

100 age, knee effusion, and body mass index with meniscal extrusion were assessed by using logistic regre

101 Apart from meniscal extrusion, all features of tissue abnormalities

102 femoral articular cartilage, osteophytes and meniscal extrusion, and of radiographic assessment of jo

103 nt as the meniscal tear, greater severity of meniscal extrusion, greater overall severity of joint de

104 s study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predic

105 amage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to rep

106 ion between clinical outcome and severity of meniscal extrusion, total BLOK score, and meniscal tear

107 Clinical results were worse with meniscal extrusion, with complaints of locking.

108 t, and cartilage damage were associated with meniscal extrusion, with odds ratios (ORs) of 6.3 (95% c

109 t, and cartilage damage were associated with meniscal extrusion, with ORs of 10.3 (95% CI: 7.1, 14.9)

110 l medial and lateral osteophytes, and medial meniscal extrusion.

111 t cartilage damage, bone marrow lesions, and meniscal extrusion.

112 he effects of age, body mass index, sex, and meniscal extrusion.

113 ars are not the only factors associated with meniscal extrusion; other factors include knee malalignm

114 on to determine the relative contribution of meniscal factors and cartilage morphologic features to J

115 Abnormal-appearing meniscal fascicles had a PPV of 8% for lateral meniscoca

116 Meniscal fibrocartilage shows yet another V/XI phenotype

117 Incidental meniscal findings on MRI of the knee are common in the g

118 A meniscal flounce is a fold that occurs in the absence of

119 Meniscal GAG content was increased in the contralateral

120 TNF mAb may be useful clinically to promote meniscal healing following injury.

121 Since meniscal coverage and meniscal height diminished with subluxation, less covera

122 effusions were seen in 26 (87%) of 30 knees, meniscal hypoplasia in 11 (37%) of 30 knees, and abnorma

123 meniscal injuries (30%), followed by lateral meniscal injuries (21%).

124 diagnostic certainty was greatest for medial meniscal injuries (30%), followed by lateral meniscal in

125 Agreement was lowest for medial meniscal injuries (54 of 84).

126 ynovial pathology in patients with traumatic meniscal injuries and determine the relationships betwee

127 ynovial pathology in patients with traumatic meniscal injuries and determine the relationships betwee

128 ere undergoing arthroscopic meniscectomy for meniscal injuries were recruited.

129 OA undergoing arthroscopic meniscectomy for meniscal injuries were recruited.

130 Significantly fewer meniscal injuries were suspected after MR imaging (P < .

131 d (SF) from patients with early knee OA with meniscal injury could lead to inflammatory activation of

132 onstrate that sCD14 in the setting of OA and meniscal injury sensitizes FLS to respond to inflammator

133 In patients with traumatic meniscal injury undergoing arthroscopic meniscectomy wit

134 ngs indicate that in patients with traumatic meniscal injury undergoing arthroscopic meniscectomy wit

135 n, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part

136 s were found in 95 (79.0%) of 120 knees, and meniscal lesions were found in 54 (45%) of 120 knees.

137 Meniscal lesions were graded by using modified subscores

138 Determination of meniscal lesions, using McMurray test, had an LR of 1.3

139 ne marrow edema pattern, and ligamentous and meniscal lesions.

140 sions (OR, 4.00; 95% CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95% CI: 1.13, 2.99), effu

141 e medial tibiofemoral joint, each measure of meniscal malposition was associated with an increased ri

142 MR imaging assessment of meniscal morphologic characteristics, meniscal position,

143 n intermediate-weighted images, (b) abnormal meniscal morphology, (c) likelihood of a typical postope

144 morphology, subchondral bone marrow lesions, meniscal morphology/extrusion, synovitis, and effusion.

145 meniscal tear without root tear, and neither meniscal nor root tear.

146 The composite examination for specific meniscal or ligamentous injuries of the knee performed m

147 When the history suggests a potential meniscal or ligamentous injury, the physical examination

148 While most meniscal or ligamentous knee injuries heal with nonopera

149 efects of cartilage, osteophytes, sclerosis, meniscal or ligamentous tears, joint effusion, and synov

150 scal tear without root tear, and 264 without meniscal or root tear.

151 XIIIa and tTGase expression in cartilage and meniscal organ cultures.

152 Loading also led to osteophyte formation, meniscal ossification, synovial hyperplasia and fibrosis

153 nt of synovial inflammation in patients with meniscal pathology; they also represent potential therap

154 nt of synovial inflammation in patients with meniscal pathology; they also represent potential therap

155 variance explained in JSN, and the change in meniscal position accounts for a substantial proportion

156 change in medial joint space, both change in meniscal position and change in articular cartilage scor

157 he results from the models demonstrated that meniscal position and meniscal degeneration each contrib

158 used to assess the effect of each predictor (meniscal position factor and meniscal damage as dichotom

159 cartilage score, meniscal degeneration, and meniscal position measures.

160 Meniscal position was measured to the nearest millimeter

161 5 plates of each tibiofemoral joint, and the meniscal position was measured using eFilm Workstation s

162 ent of meniscal morphologic characteristics, meniscal position, and cartilage morphologic characteris

163 OA cartilage damage undergoing arthroscopic meniscal procedures.

164 All patients with meniscal repair (n = 16) needed MR arthrography to diagn

165 pair in vitro and therefore may also inhibit meniscal repair during arthritis or following joint inju

166 that IL-1Ra and TNF mAb promoted integrative meniscal repair in an inflammatory microenvironment sugg

167 concentrations of IL-1 and TNFalpha inhibit meniscal repair in vitro and therefore may also inhibit

168 All patients with meniscal repair required MR arthrography.

169 than 25% meniscal resection, and those with meniscal repair.

170 No patient with less than 25% meniscal resection (n = 23) needed MR arthrography to de

171 Patients with less than 25% meniscal resection did not need MR arthrography.

172 Sixteen of 61 patients with more than 25% meniscal resection needed MR arthrography to demonstrate

173 All patients with meniscal resection of more than 25%, who did not have se

174 meniscal resection, those with less than 25% meniscal resection, and those with meniscal repair.

175 into three groups: those with more than 25% meniscal resection, those with less than 25% meniscal re

176 nty-nine patients had clear MR evidence of a meniscal retear without any contrast material injected i

177 Isolated medial posterior meniscal root tear is associated with incident and progr

178 finitely improve after APM was observed if a meniscal root tear was present.

179 er overall severity of joint degeneration, a meniscal root tear, and a longer meniscal tear at preope

180 d spin-echo coronal and sagittal imaging for meniscal scoring and axial and coronal spoiled gradient

181 Second-look arthroscopic confirmation of meniscal status was available in all patients.

182 ne and knee replacement (KR) associated with meniscal surgery in subjects with and those without a re

183 ubjects without a reported preceding trauma, meniscal surgery is not independently associated with in

184 Results Meniscal surgery with a history of preceding knee trauma

185 Subjects who underwent meniscal surgery with a preceding knee trauma at baselin

186 However, meniscal surgery without a history of preceding knee tra

187 Meniscal T1(rho) and T2 values correlate with clinical f

188 Correlations of meniscal T1(rho) and T2 values with age, cartilage-deriv

189 Correlations of meniscal T1(rho) and T2 values with subject age (R(2) =

190 root tear than in the group without root or meniscal tear (76.7% vs 19.7%, P < .0001) but not in the

191 A relationship with meniscal tear and degenerative joint disease independent

192 tic patients 45 years of age or older with a meniscal tear and evidence of mild-to-moderate osteoarth

193 She has undergone arthroscopic surgery for a meniscal tear and has taken nonsteroidal anti-inflammato

194 meniscectomy for symptomatic patients with a meniscal tear and knee osteoarthritis results in better

195 knee osteoarthritis (OA) and without medial meniscal tear at baseline were studied.

196 neration, a meniscal root tear, and a longer meniscal tear at preoperative MR imaging.

197 tilage damage in the root tear group and the meniscal tear group, with the no tear group serving as a

198 group and 1.84 (95% CI: 1.32, 2.58) for the meniscal tear group.

199 of meniscal extrusion, total BLOK score, and meniscal tear length.

200 Efficacy studies were conducted in a rat meniscal tear model of OA.

201 3965 potently alleviated joint pain in a rat meniscal tear model of osteoarthritis.

202 The prevalence of a meniscal tear or of meniscal destruction in the right kn

203 most always associated with a far peripheral meniscal tear or with a meniscocapsular junction injury

204 odel, the hazard ratio for developing medial meniscal tear was 18.2 (95% confidence interval: 8.3, 39

205 igns of osteoarthritis), the prevalence of a meniscal tear was 63% among those with knee pain, aching

206 Tear length was measured, and type of meniscal tear was classified.

207 solated medial posterior root tear, 294 with meniscal tear without root tear, and 264 without menisca

208 separated into three groups: root tear only, meniscal tear without root tear, and neither meniscal no

209 fect was used to evaluate the risk of medial meniscal tear, adjusting for age, sex, body mass index,

210 solated medial posterior root tear, 270 with meniscal tear, and 245 with no tear.

211 ificant associations (P < .01) for effusion, meniscal tear, and degenerative arthropathy, independent

212 icant associations (P < .001) with effusion, meniscal tear, and degenerative arthropathy.

213 marrow edema in the same compartment as the meniscal tear, greater severity of meniscal extrusion, g

214 idered a risk factor for medial degenerative meniscal tear.

215 rography to diagnose a residual or recurrent meniscal tear.

216 raphy to demonstrate a residual or recurrent meniscal tear.

217 raphy to demonstrate a residual or recurrent meniscal tear.

218 nly in the absence of other indications of a meniscal tear.

219 site on knee MR images does not represent a meniscal tear.

220 ccuracy (P = .05) for helping detect lateral meniscal tears (73.2% sensitivity and 88.4% accuracy for

221 interval [CI]: 1.01, 1.23), the presence of meniscal tears (adjusted OR, 3.19; 95% CI: 1.13, 9.03),

222 ely to have defects of cartilage (P = .001); meniscal tears (P = .001); and osteophytes, subchondral

223 medial meniscal tears (P = .04) and lateral meniscal tears (P = .01) and significantly higher accura

224 cantly higher accuracy for detecting lateral meniscal tears (P = .03) than IDEAL GRASS.

225 ntly higher sensitivity for detecting medial meniscal tears (P = .04) and lateral meniscal tears (P =

226 Four meniscal tears also demonstrated flouncelike folds.

227 ntional MR imaging at helping detect lateral meniscal tears and bone marrow edema lesions.

228 These will be discussed in reference to meniscal tears and injuries of the cruciate ligaments as

229 Among individuals with degenerative meniscal tears and OA, easily obtainable clinical inform

230 Meniscal tears and osteoarthritis (OA) frequently coexis

231 When meniscal tears are found, it is commonly assumed that th

232 Meniscal tears are not the only factors associated with

233 Traumatic and degenerative meniscal tears have different anatomic features and diff

234 Traumatic and degenerative meniscal tears have different anatomic features and diff

235 Sixty-one percent of the subjects who had meniscal tears in their knees had not had any pain, achi

236 Patients who had sustained meniscal tears showed a higher average rate of progressi

237 The parameters for detecting 31 lateral meniscal tears were 58.0%, 90.6%, and 80.0% for IDEAL GR

238 espective parameters for detecting 50 medial meniscal tears were 85.0%, 91.1%, and 87.9% for IDEAL GR

239 sions, anterior cruciate ligament tears, and meniscal tears were calculated.

240 methods for detecting cartilage lesions and meniscal tears were determined.

241 ents undergoing arthroscopy for degenerative meniscal tears were recruited under Institutional Review

242 he general population and the association of meniscal tears with knee symptoms and with radiographic

243 four with flouncelike folds associated with meniscal tears) with an S-shaped fold in the free edge o

244 e ligament tears, collateral ligament tears, meniscal tears, and bone marrow edema lesions within the

245 erior and posterior cruciate ligament tears, meniscal tears, and bone marrow edema lesions, first by

246 to detect cartilage lesions, ligament tears, meniscal tears, and bone marrow edema lesions.

247 s were analyzed, including ACL tears, medial meniscal tears, and other lateral femorotibial compartme

248 d to functional knee instability, subsequent meniscal tears, and the development of early degenerativ

249 vitis in posttraumatic joint injury, such as meniscal tears, and the protective role of the pericellu

250 For meniscal tears, joint line tenderness is sensitive (75%)

251 Cross-sectional associations of severity of meniscal tears, knee malalignment, tibiofemoral cartilag

252 of anterior cruciate ligament tears, medial meniscal tears, or lateral meniscal tears.

253 Laterally, meniscal tears, valgus malalignment, and cartilage damag

254 Medially, meniscal tears, varus malalignment, and cartilage damage

255 lar surface and to determine the presence of meniscal tears.

256 lower sensitivity and accuracy for detecting meniscal tears.

257 als ages 45-65 years with knee pain, OA, and meniscal tears.

258 ent tears, medial meniscal tears, or lateral meniscal tears.

259 conventional SE imaging for the detection of meniscal tears.

260 for calcifications than for the surrounding meniscal tissue (P<.001).

261 to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction

262 ential means of examining the time course of meniscal tissue change in the development and progressio

263 Articular chondrocytes and meniscal tissue were also infected by FIV(HuMOR), which

264 closely associated with pain behavior in the meniscal transection model of OA.

265 nduced in male Lewis rats (n=8 per group) by meniscal transection.

266 ion, and synovial angiogenesis 35 days after meniscal transection.

267 ents (29 menisci) underwent MR imaging after meniscal transplantation.

268 discoid meniscus is the most common abnormal meniscal variant in children.