ライフサイエンスコーパス: menthol

1 arable increase in the responses to cold and menthol.

2 , phosphatidylinositol 4,5-bisphosphate, and menthol.

3 of DRG neurons respond to the TRPM8 agonist menthol.

4 rees C-20 degrees C) and oral sensitivity to menthol.

5 so underlies the species-specific effects of menthol.

6 vated by cold and cooling compounds, such as menthol.

7 anner when activated by the cooling compound menthol.

8 from nonmammalian species are insensitive to menthol.

9 mice (TRPM8(EGFPf/+)) responded to cold and menthol.

10 the activation of TRPM8 by cold, icilin, and menthol.

11 icin and the activation of TRPM8 channels by menthol.

12 neurons by cold or by cooling agents such as menthol.

13 recombinant TRPM8 channels by both cold and menthol.

14 remain responsive to touch, temperature, and menthol.

15 ns that also respond to capsaicin but not to menthol.

16 by cold temperatures and by a cooling agent, menthol.

17 ffecting actions of A-967079 or the agonist, menthol.

18 hannels with augmented responses to cold and menthol.

19 d are required for the inhibition of itch by menthol.

20 type and knockout mice after application of menthol (0.05-50 mM) to the cornea.

21 A low concentration of menthol (0.1 mM) increased cool cell activity, yet a hig

22 15 degrees C and 39 degrees C-51 degrees C), menthol (10-100 microM), and hyperosmolar solutions (NaC

23 eurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased.

24 minant compounds were cis-menthone (27.43%), menthol (24.3%), trans-menthone (9.23%), limonene (5.84%

25 mproved the chiral purity of the contained d-menthol (3), an example of purification by "duplication"

26 iral terpene alcohols, including d- (3) or l-menthol (4), d-isomenthol (7), l-borneol (8), or d- (5)

27 l pyromellitate triacid chloride (30) with l-menthol (4).

28 l cell activity, yet a high concentration of menthol (50 mM) had no effect.

29 At the highest concentration, menthol (50 mM) increased tearing and nocifensive respon

30 (10 microm), resiniferatoxin (5 microm) and menthol (6 mm) reveal voltage-independent gating.

31 Menthol, a natural nonreactive cooling compound, is best

32 Menthol, a TRPM8 agonist, was ineffective at increasing

33 Menthol, a widely used additive in cigarettes, is a pote

34 Notably, menthol acted in a voltage-independent manner and reduce

35 The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-s

36 The activity of the cold- and menthol-activated transient receptor potential melastati

37 Ca(2+) signal and the prompt inactivation of menthol-activated transient receptor potential melastati

38 The cold- and menthol-activated transient receptor potential melastati

39 Here we investigated the mechanism by which menthol activates mouse TRPM8.

40 Menthol activates transient receptor potential melastati

41 ngly shifted the concentration dependence of menthol activation, raising the possibility that S2 infl

42 n of the trioxatricornan with amino acids or menthol afforded diastereomers that were resolved by pre

43 uorescent nAChR subunits, exposure to 500 nm menthol alone also increased nAChR number and favored th

44 Menthol alone also increases the number of alpha6beta2 r

45 mice containing fluorescent nAChR subunits, menthol alone increased the number of alpha4 and alpha6

46 We investigated the effect of long-term menthol alone on midbrain neurons containing nAChRs.

47 's effects were not specific to acrolein, as menthol also attenuated irritation responses to acetic a

48 Menthol also enhances nicotine-induced changes in DA neu

49 nyl of menthone is reduced to yield (-)-(3R)-menthol and (+)-(3S)-neomenthol by two distinct NADPH-de

50 D and converts (-)-menthone to 95% (-)-(3R)-menthol and 5% (+)-(3S)-neomenthol, and (+)-isomenthone

51 In a counter-balanced cross-over design, 10 menthol and 9 non-menthol smokers (10 females and 9 male

52 We found that menthol and capsaicin both caused a significant reductio

53 Two commercially available alcohols, L-menthol and citronellol, were coupled to the AB(2) monom

54 erature activation and a reduced response to menthol and cold stimuli.

55 the channel activity, sensitivity to icilin, menthol and cold, and impact on channel oligomerization.

56 These experiments demonstrate that menthol and eucalyptol, through activation of TRPM8, act

57 TRPM8 channel behavior upon menthol and icilin activation was distinguishable, and t

58 vated by cold and chemical agonists, such as menthol and icilin.

59 RPM8 is also activated by the cooling agents menthol and icilin.

60 found that membrane currents evoked by both menthol and innocuous cold were significantly enhanced i

61 the responsiveness of these neurons to both menthol and innocuous cold.

62 ld thermosensors are uniformly responsive to menthol and innocuous cool temperature (17 degrees C), i

63 Menthol and many of its derivatives produce profound sen

64 tential of major cyclic oxygenated terpenes (menthol and menthone) are conflicting.

65 We found that the HIPVs menthol and methyl salicylate at 1 and 10 nmol.ml(-1) im

66 ve (AUC), and T1/2 of BNA were found between menthol and non-menthol cigarettes across all subjects;

67 idence for differential associations between menthol and nonmenthol cigarettes indicates lower cancer

68 Menthol and other counterstimuli relieve itch, resulting

69 ereogenic compounds: Heating H3 PO2 with (-)-menthol and paraformaldehyde gives easily crystallized m

70 red in one step from naturally occurring (-)-menthol and readily available 1,2,3,4,5-pentacarbomethox

71 The nonelectrophilic compounds menthol and the cannabinoid Delta(9)-tetrahydrocannabior

72 -positive dorsal root ganglion neurons cold, menthol and WS-12, a selective TRPM8 agonist, evoked sig

73 ng the neurons that are altered by nicotine, menthol, and acetylcholine.

74 in-sensitive neurons increased, and that the menthol- and cold-evoked responses were significantly en

75 d in the regulation of TRPM8 channels during menthol- and cold-induced desensitization in vitro.

76 TRPM8, a cloned menthol- and cold-sensitive ion channel, has been sugges

77 a significant increase in the percentage of menthol- and cold-sensitive neurons and also a substanti

78 In small PLCdelta4(-/-) neurons, menthol application induced larger depolarizations and g

79 id closure) were quantified following cornea menthol application.

80 activated by noxious thermal stimulation and menthol applied to the corneal surface.

81 the cold-sensitizing effects of camphor and menthol are additive.

82 shment of protocols to regulatory the use of menthol as an anesthetic in aquaculture.

83 ound impact on channel gating by voltage and menthol, as evidenced by the modulation of the conductan

84 Moreover, menthol at concentrations up to 1 mM did not compete for

85 Menthol, at a concentration (16 ppm) lower than in smoke

86 7]helicene are obtained via resolution using menthol-based chiral siloxanes.

87 This platform was also expanded beyond menthol-based substrates to the selective hydroxylation

88 1008), but was independent of the icilin and menthol binding site residue Y745 and, essentially, the

89 , raising the possibility that S2 influences menthol binding.

90 The structure suggests that the menthol-binding site is located within the voltage-senso

91 noterpene reductases of mint involved in (-)-menthol biosynthesis.

92 e may be reduced to (-)-menthone en route to menthol, by pulegone reductase (PR), or oxidized to (+)-

93 muM) and a similar efficacy when compared to menthol; by contrast, compound 12 produced a concentrati

94 ] as the critical domain determining whether menthol can act as an inhibitor.

95 Taken together, our results indicate that menthol can act directly on presynaptic Ca2+ stores of s

96 from a natural chiral pool of (1R,2S,5R)-(-)-menthol can be efficiently prepared by two different met

97 studies indicated that low concentrations of menthol can increase lacrimation via TRPM8 channels with

98 At high concentrations, menthol can induce lacrimation and nocifensive behaviors

99 We used concentrations of menthol, capsaicin, and hypertonic saline that evoked co

100 we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory

101 and phenols, four natural products (eugenol, menthol, cholesterol, and estrone) were labeled in a sim

102 examples of increasing spectral complexity, menthol, cholesteryl acetate and a C(16) fatty acid, dem

103 n several aspects of nicotine addiction, and menthol cigarette smokers tend to upregulate beta2* nACh

104 lung cancer according to number of years of menthol cigarette use (>15, 1-15, 0), adjusting for demo

105 /2 of BNA were found between menthol and non-menthol cigarettes across all subjects; however, menthol

106 alth, but these results do not indicate that menthol cigarettes are associated with greater CVD risks

107 Menthol cigarettes are likely associated with greater ri

108 es than whites, raising the possibility that menthol cigarettes contribute to racial disparities in r

109 behavior and may help explain how smokers of menthol cigarettes exhibit reduced cessation rates.

110 ates to evaluate the hypothesis that smoking menthol cigarettes increases lung cancer risk compared w

111 y do not support the hypothesis that smoking menthol cigarettes increases the risk of lung cancer rel

112 rstanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers req

113 king and preference of sensory properties of menthol cigarettes may independently or jointly contribu

114 In contrast to whites, black smokers prefer menthol cigarettes over nonmenthol cigarettes by a large

115 he lung cancer risk for long-term smokers of menthol cigarettes was similar to that for smokers of no

116 l subjects; however, menthol relative to non-menthol cigarettes were associated with steeper initial

117 greater risks of smoking dependence than non-menthol cigarettes.

118 ntervals for all-cause and CVD mortality for menthol compared with nonmenthol cigarette smokers among

119 .03; P=0.10) mortality risks were similar in menthol compared with nonmenthol cigarette smokers.

120 aging study on DRG neurons demonstrated that menthol could directly release Ca2+ from intracellular C

121 tch recordings from DRG-DH pairs showed that menthol could potentiate evoked EPSCs (eEPSCs) and chang

122 ning and cooling perception of capsaicin and menthol demonstrate that these ion channels mediate ther

123 A suite of menthol derivatives was screened computationally and eva

124 ersion of the protocol was explored with (L)-menthol derived nonracemic substrates, and the correspon

125 ine) and trapping with Andersen's sulfinate (menthol derived).

126 An analogous preparation of menthol-derived phosphinite boranes is also described.

127 keleton rearrangement was observed using the menthol-derived substrate.

128 r enantiomer of Andersen's readily available menthol-derived sulfinate or the alpha-alkylation of ena

129 spectrum is acquired in 45 min for 400 ng of menthol dissolved in a total sample volume of 200 nL (12

130 , a concentration corresponding to 400 ng of menthol dissolved in Vobs = 31 nL (82.6 mM) yields a spe

131 2 degrees C to higher temperatures, and the menthol dose-response curve was displaced to lower conce

132 first sensory synapse in the CNS, we studied menthol effects on sensory synaptic transmission and the

133 ably, TRP domain mutations mainly attenuated menthol efficacy, suggesting that this domain influences

134 Using mouse models, we show that menthol enhances nicotine-induced changes in nicotinic a

135 ns in PIP2 had a similar effect on cold- and menthol-evoked currents.

136 ds to adaptation-like reductions in cold- or menthol-evoked TRPM8 currents in both heterologous and n

137 we show that activation of TRPM8 by cold or menthol evokes a decrease in cellular phosphatidylinosit

138 Furthermore, menthol exposure before nicotine abolished nicotine rewa

139 Pretreatment with menthol followed by its washout did not affect agonist-i

140 elds 94% (+)-(3S)-neomenthol and 6% (-)-(3R)-menthol from (-)-menthone as substrate, and 86% (+)-(3S)

141 e that neurons expressing TRPM8, a cold- and menthol-gated channel required for normal cold responses

142 ly folded assembly domain from the cold- and menthol-gated channel TRPM8.

143 t al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavi

144 lent as judged by capsule counts and urinary menthol glucuronide concentrations.

145 The receptor for menthol has been cloned and named cold- and menthol-sens

146 More recently, menthol has been shown to be an activator of mouse TRPA1

147 oling (<28 degrees C) and cooling compounds (menthol, icilin) and are implicated in sensing unpleasan

148 ivated by a wide range of stimuli, including menthol, icilin, and cold temperatures (<25 degrees C).

149 It is highly controversial whether menthol in cigarette smoke exerts pharmacological action

150 vide strong support for the putative role of menthol in enhancing BNA, although further studies shoul

151 nes was investigated with the sensor binding menthol in favor of analogous compounds.

152 lied to residual determination of anesthetic menthol in fish.

153 residual period for total metabolization of menthol in the fishes' organisms.

154 as been developed for the determination of L-menthol in the liquid phase.

155 At low concentrations, menthol increased tear production in TRPM8 wild type and

156 We found that menthol increased the frequency of miniature EPSCs (mEPS

157 avour components of peppermint (menthone and menthol) increased, while the contents of the main const

158 Menthol increases the potency of PI(4,5)P(2) to activate

159 We sought to test the hypothesis that menthol increases the rate of brain nicotine accumulatio

160 iosynthesis of the principal monoterpene (-)-menthol indicated that all but one biosynthetic enzyme h

161 Menthol-induced Ca2+ release was abolished by 2-APB but

162 ts connect changes in midbrain DA neurons to menthol-induced enhancements of nicotine reward-related

163 Menthol-induced increases of mEPSC frequency were blocke

164 d to capsaicin, and had significantly larger menthol-induced inward current densities than medium-lar

165 uced a concentration-dependent inhibition of menthol-induced TRPM8 currents (IC50 = 367 +/- 24 nM).

166 urpose of our study was to determine whether menthol induces corneal cool cell activity and lacrimati

167 f these mutants indicated that activation by menthol involves a gating mechanism distinct and separab

168 Menthol is a cooling compound derived from mint leaves a

169 We conclude that menthol is more than a tobacco flavorant: administered a

170 cold, voltage, and cooling compounds such as menthol, is the principal molecular detector of cold tem

171 e menthone reductases account for all of the menthol isomers found in the essential oil of peppermint

172 nces, we classify agonists as either type I (menthol-like) or type II (AITC-like), and provide a kine

173 We also found that menthol--like camphor--potently inhibits Kv7.2/3 channel

174 Menthol markedly decreased nAChR activity as assessed by

175 rough suppression of respiratory irritation, menthol may facilitate smoke inhalation and promote nico

176 -(13)C residual dipolar couplings (RDCs) for menthol measured in the gels depended on the cross-link

177 Menthol, menthone, pulegone and eucalyptol were identifi

178 ist-induced desensitization, suggesting that menthol must be present during the application of agonis

179 tudies should explore the apparent effect of menthol on BNA in men.

180 the effect of low and high concentrations of menthol on corneal cool cells.

181 ord, we examined the effect of capsaicin and menthol on glutamatergic mEPSCs in postnatal day (P) 0-1

182 thysmography, we investigated the effects of menthol on the respiratory sensory irritation response i

183 and action potential frequencies induced by menthol or by current injections were also higher in PLC

184 When exposed to menthol or cold, TRPM8 behaves like many ligand-gated ch

185 o 25 degrees C and cooling compounds such as menthol or icilin.

186 e, the participant smoked exclusively either menthol or non-menthol research cigarettes for approxima

187 gnificantly larger currents induced by cold, menthol or WS-12, a specific TRPM8 agonist, compared to

188 ctivated by chemical cooling agents (such as menthol) or when ambient temperatures drop below approxi

189 tinguish between the D- and L-enantiomers of menthol owing to the enantioselectivity of the imprinted

190 ace preference (CPP) assay, we observed that menthol plus nicotine produces greater reward-related be

191 Menthol plus nicotine upregulates nAChR number and funct

192 Thus, chronic menthol produces a cell-type-selective upregulation of a

193 Taken together, these data indicate that menthol promotes desensitization of alpha3beta4 nAChRs b

194 hannel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR1)--is activated by chemical cool

195 Here we have characterized and cloned a menthol receptor from trigeminal sensory neurons that is

196 amily, TRPM8, commonly known as the cold and menthol receptor is the major component of testosterone-

197 ponses in vivo are dependent on the cold and menthol receptor transient receptor potential melastatin

198 technique to study the human cold-sensitive menthol receptor transient receptor potential melastatin

199 tential (TRP) family, including the cold and menthol receptor TRPM8.

200 N- and C-terminal deletions on the cold and menthol receptor, TRPM8, expressed heterologously in Sf2

201 en either the capsaicin receptor, TRPV1, the menthol receptor, TRPM8, or the ionotropic purinergic re

202 tential (TRP) ion channels, most notably the menthol receptor, TRPM8.

203 ivation temperature compared to the cold and menthol receptor, TRPM8.

204 mmature primary afferents express functional menthol receptors that are capable of modulating transmi

205 brain slices and cultured midbrain neurons, menthol reduced DA neuron firing frequency and altered D

206 , namely the ketoreductases (-)-menthone:(-)-menthol reductase and (-)-menthone:(+)-neomenthol reduct

207 used to acquire the former menthone:(-)-(3R)-menthol reductase directly from mRNA isolated from the o

208 The recombinant menthone:(-)-(3R)-menthol reductase has a deduced size of 34,070 D and con

209 hol cigarettes across all subjects; however, menthol relative to non-menthol cigarettes were associat

210 AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the m

211 ant smoked exclusively either menthol or non-menthol research cigarettes for approximately 1 week pri

212 evoked by 1-oleolyl-2-acetyl-sn-glycerol and menthol, respectively.

213 jor role in desensitization of both cold and menthol responses.

214 ad drastically reduced cold responses and no menthol responses.

215 se in TRPM8 expression and the percentage of menthol-responsive cutaneous sensory neurons.

216 ht specific residues within TM5 critical for menthol responsiveness.

217 ard-related behavior may be mediated through menthol's ability to stabilize lower-sensitivity nAChRs

218 We examined menthol's effects on recombinant human alpha3beta4 nAChR

219 Menthol's effects were not specific to acrolein, as ment

220 Menthol's effects were reversed by a TRPM8 antagonist, A

221 ple of the molecular transducer for cold and menthol sensation.

222 itive behavioral changes, TRPM8 and/or other menthol-sensitive channels appear to underpin a much lar

223 d that camphor sensitizes a subpopulation of menthol-sensitive native cutaneous nociceptors in the mo

224 his study we characterized two subclasses of menthol-sensitive neurons from cultures of dissociated m

225 The cold- and menthol-sensitive receptor TRPM8 (transient receptor pot

226 This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP

227 menthol has been cloned and named cold- and menthol-sensitive receptor-1 (CMR1) or transient recepto

228 stellation of ion channels expressed in each menthol-sensitive subclass.

229 ssed TRPM8 receptors, that the percentage of menthol-sensitive/cold-sensitive/capsaicin-sensitive neu

230 The increase in cool and menthol sensitivity correlated with a significant increa

231 We identified determinants of menthol sensitivity in two regions: putative transmembra

232 ly, member 8 (TRPM8) is the primary cold and menthol sensor in humans.

233 Menthol significantly increased the mEPSC frequency with

234 Further, menthol slowed or prevented the recovery of nAChRs from

235 nced cross-over design, 10 menthol and 9 non-menthol smokers (10 females and 9 males; mean age 44.3)

236 nity-based cohort with the largest number of menthol smokers being traced.

237 kers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that ar

238 l cigarettes indicates lower cancer risk for menthol smokers, but for cardiovascular disease (CVD) mo

239 Thus, menthol stabilizes lower-sensitivity alpha4* and alpha6

240 by destabilizing the closed channel, whereas menthol stabilizes the open channel, relative to the tra

241 Menthol stimulates olfactory sensations, and interacts w

242 that were also seen following capsaicin and menthol stimulation.

243 m the use of pharmacological agents, such as menthol, that elicit a cooling sensation.

244 Menthol, the cooling agent in peppermint, is added to al

245 tral intermediate in the biosynthesis of (-)-menthol, the most significant component of peppermint es

246 ld lead to improved production yields of (-)-menthol, the principal and characteristic flavor compone

247 a commercial nanoprobe for the same mass of menthol, these two examples reduce data acquisition time

248 From menthol to cholesterol to Taxol, terpenes are a ubiquito

249 Capsaicin and menthol, two other topically applied agents widely used

250 Conversely, activating TRPM8 with menthol up-regulated UCP-1 expression and augmented unco

251 performed experiments on ethyl crotonate and menthol, using three different types of NMR chips aiming

252 On-line detection of menthol vapor emitted from a cough drop is reported.

253 The detectability of L-menthol was 200 ppb with a response range of 0-1.0 ppm.

254 Menthol was efficiently absorbed in the respiratory trac

255 ession, and mitigated uncoupled respiration; menthol was less capable of augmenting uncoupled respira

256 formation of the methyl ether of (1R,2S,5R)-menthol was the only organic reaction product observed i

257 TRP channel agonists anandamide and (-)menthol were found to inhibit and activate RyR1, respect

258 A2) form of the enzyme, whereas responses to menthol were less sensitive to iPLA2 inhibition.

259 sations of hot or cold, such as capsaicin or menthol, were instrumental in the discovery of thermal d

260 e show that human TRPA1 is only activated by menthol, whereas TRPA1 from nonmammalian species are ins

261 lones that are affected in their response to menthol while retaining channel function.

262 Coapplication of menthol with acetylcholine or nicotine increased desensi