コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 rapy comprising ATRA, oral methotrexate, and mercaptopurine.
2 eukemia (ALL) includes prednisone and oral 6-mercaptopurine.
3 dose, and all patients received daily oral 6-mercaptopurine.
4 mined the efficacy of dexamethasone and IV 6-mercaptopurine.
5 ectiveness of the immuno-suppressive agent 6-mercaptopurine.
6 S-methylation of thiopurine drugs such as 6-mercaptopurine.
7 rove on azathioprine but responded well to 6-mercaptopurine.
8 ys 1 to 5, and a regimen of methotrexate and mercaptopurine.
9 1.27 (95% CI, 0.48-3.39) for azathioprine/6-mercaptopurine.
10 treated with the thiopurines azathioprine or mercaptopurine.
11 ntenance with ATRA, oral methotrexate, and 6-mercaptopurine.
12 lone or in combination with methotrexate and mercaptopurine.
13 ts a decreased V max and increased K m for 6-mercaptopurine.
14 sms in TPMT, can cause severe toxicity after mercaptopurine.
15 travenous methotrexate (1 g/m(2)) with daily mercaptopurine.
16 e mice were pretreated with leflunomide or 6-mercaptopurine.
17 , 11), whereas 6-thio NHD(+) (nicotinamide 6-mercaptopurine 5'-dinucleotide, 17) generates a cyclic d
21 he aim of the current trial was to compare 6-mercaptopurine (6-MP) and mesalamine with placebo for th
25 kemia (ALL) are generally instructed to take mercaptopurine (6-MP) in the evening and without food or
29 f immunomodulators [azathioprine (AZA), or 6-mercaptopurine (6-MP)] and newer biologic agents (inflix
31 ed for the simultaneously determination of 6-mercaptopurine, 6-thioguanine and dasatinib for the firs
32 for the selective and precise analysis of 6-mercaptopurine, 6-thioguanine and dasatinib in pharmaceu
33 ata revealed that the electro-oxidation of 6-mercaptopurine, 6-thioguanine and dasatinib is facilitat
34 at pH 8.0, the oxidation peak currents for 6-mercaptopurine, 6-thioguanine and dasatinib were found t
36 bolites of three clinically useful agents (6-mercaptopurine, 6-thioguanine, and Abacavir) can inhibit
41 ned either 6-thioguanine (750 patients) or 6-mercaptopurine (748 patients) during interim maintenance
42 ntenance therapy regimen included daily oral mercaptopurine (75 mg/m2) and weekly oral methotrexate (
43 lecular mechanism(s) of cellular response to mercaptopurine, a widely used antileukemic agent, we ass
44 azathioprine were superior to azathioprine/6-mercaptopurine: adalimumab (OR, 2.9; 95% CrI, 1.6-5.1),
45 In contrast, pretreatment of mice with 6-mercaptopurine, an inhibitor of de novo purine synthesis
47 conferred resistance to chemotherapy with 6-mercaptopurine and 6-thioguanine when expressed in ALL l
48 he MRP4 drug resistance profile extends to 6-mercaptopurine and 6-thioguanine, two anticancer purine
50 an syndrome, the activator of the prodrugs 6-mercaptopurine and allopurinol, and a target for antipar
51 -TP) medications, including 6-thioguanine, 6-mercaptopurine and azathioprine, commonly used for immun
52 he immunosuppressive agents, azathioprine, 6-mercaptopurine and cyclosporine A, are compatible with p
53 lguanine, 8-azaguanine, 6-thioguanine, and 6-mercaptopurine and do not recognize any of the PurP liga
55 -year treatment period with the following: 6-mercaptopurine and metronidazole [6MP/met] (comparator),
56 te the extensive clinical use and study of 6-mercaptopurine and other purine analogues, the cellular
58 g some of the antiproliferative effects of 6-mercaptopurine and potentially implicate Nurr1 as a mole
59 on of MSH6 was associated with resistance to mercaptopurine and prednisone, thereby providing a plaus
62 armacokinetic and pharmacodynamic studies of mercaptopurine and thioguanine were done in Tpmt(-/-), T
64 of TPMT on activation versus inactivation of mercaptopurine and thioguanine, we used a retroviral gen
67 etabolites revealed elevated 6-MMP (6-methyl mercaptopurine) and low 6-TGN (6-thioguanine nucleotide)
68 andard dose of thiopurine (azathioprine or 6-mercaptopurine), and patients homozygous for a variant r
69 vement of guanylate kinase in 6-thioguanine, mercaptopurine, and abasic guanosine analog (e.g., ganci
70 hiopurines including 6-thioguanine ((S)G), 6-mercaptopurine, and azathioprine are effective anticance
71 ine drugs, including 6-thioguanine ((S)G), 6-mercaptopurine, and azathioprine, are widely employed an
72 ptions for 5-aminosalicylates azathioprine/6-mercaptopurine, and corticosteroids were extracted from
73 sessed the pharmacokinetics of methotrexate, mercaptopurine, and erythrocyte thioguanine nucleotide l
74 ians in optimizing therapeutic response to 6-mercaptopurine, and in identifying individuals at increa
75 city during consolidation therapy containing mercaptopurine, and remained significant in a multivaria
78 th doxorubicin, vincristine, corticosteroid, mercaptopurine, and weekly high-dose asparaginase; and c
79 tarabine/etoposide; high-dose methotrexate/6-mercaptopurine; and daunorubicin, vincristine, prednison
82 nd Arg221, the only polar amino acids near 6-mercaptopurine, are highlighted as possible participants
83 ceptor Nurr1, interestingly, we identified 6-mercaptopurine as a specific activator of this receptor.
84 d following treatment with 10 daily doses of mercaptopurine at 100 mg/kg/d (0%, 68%, and 100% 50-day
85 resolution and the chemotherapeutic agent 6-mercaptopurine at 2.6 A resolution have been determined,
86 web-based randomisation system to oral daily mercaptopurine at a dose of 1 mg/kg bodyweight rounded t
87 ictor of outcome, but a direct comparison of mercaptopurine AUC in the remission and relapsed patient
89 Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the
90 the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibi
92 ntial 6-methylmercaptopurine production on 6-mercaptopurine/azathioprine (odds ratio, 3.0; 95% CI, 1.
94 rticosteroids alone, 52 patients receiving 6-mercaptopurine/azathioprine alone or with corticosteroid
95 who were receiving corticosteroids and/or 6-mercaptopurine/azathioprine before surgery compared with
96 bowel disease receive corticosteroids and 6-mercaptopurine/azathioprine during elective bowel surger
97 adjusted odds ratio for patients receiving 6-mercaptopurine/azathioprine for any and major infectious
98 ine/azathioprine alone and the addition of 6-mercaptopurine/azathioprine for patients receiving corti
102 acid decreases V max and increases K m for 6-mercaptopurine but not K m for S-adenosyl- l-methionine.
103 xic effects of thiopurine prodrugs such as 6-mercaptopurine by methylating them in a reaction using S
107 regimens containing either oral (PO) MTX, PO mercaptopurine, dexamethasone, and vincristine or IV MTX
110 undred ninety-one methotrexate doses and 190 mercaptopurine doses were monitored in 89 patients.
113 teroids and/or cyclosporine, azathioprine, 6-mercaptopurine, FK-506, methotrexate) were identified an
116 p analysis, three (10%) of 29 smokers in the mercaptopurine group and 12 (46%) of 26 in the placebo g
117 pared with 13 (13%) of 99 non-smokers in the mercaptopurine group and 14 (16%) of 86 in the placebo g
119 treatment in 39 (30%) of 128 patients in the mercaptopurine group versus 41 (37%) of 112 in the place
120 topurine; however, patients assigned to IV 6-mercaptopurine had decreased survival after relapse.
125 eport our experience with azathioprine and 6-mercaptopurine in patients with microscopic colitis.
126 potential benefit from the earlier use of 6-mercaptopurine in T-ALL therapy or the development of ad
127 = 39) comparing methotrexate, azathioprine/6-mercaptopurine, infliximab, adalimumab, certolizumab, ve
130 oietic toxicity in vivo after treatment with mercaptopurine is attenuated but not abolished by MSH2 d
132 es of the human polymorphism; indicates that mercaptopurine is more affected by the TPMT polymorphism
134 nosuppressant thiopurines, azathioprine or 6-mercaptopurine, is associated with acute skin sensitivit
135 (TPMT) are known to have a marked effect on mercaptopurine metabolism and toxicity; however, some pa
136 rine methyl transferase and measurement of 6-mercaptopurine metabolites appear to be valuable for man
138 f vincristine, adriamycin, prednisone, and 6-mercaptopurine (MP) and after continuous infusion of hig
139 ubstitution of oral 6-thioguanine (TG) for 6-mercaptopurine (MP) and triple intrathecal therapy (ITT)
141 uorouracil, cytosine arabinoside (araC), and mercaptopurine (MP) demonstrated that Hmgb1(-/-) mouse e
144 widely used antileukemic agent, we assessed mercaptopurine (MP) sensitivity in mismatch repair (MMR)
149 -cell ALL included 2 years of treatment with mercaptopurine, MTX, vincristine, and prednisone (POMP).
152 ower risk of isolated CNS relapse than did 6-mercaptopurine (odds ratio [OR] 0.53, 95% CI 0.30-0.92,
154 s in the azathioprine group were switched to mercaptopurine or methotrexate therapy because of intole
155 rexate sodium (OR, 0.60; 95% CI, 0.29-1.22), mercaptopurine (OR, 0.62; 95% CI, 0.15-2.53), and mycoph
156 s (OR, 3.4; 95% CI, 1.8-6.2), azathioprine/6-mercaptopurine (OR, 3.1; 95% CI, 1.7-5.5), and inflixima
157 xposed to 5-aminosalicylates, azathioprine/6-mercaptopurine, or corticosteroids during their first tr
158 iffered among genotypes after treatment with mercaptopurine (P < 0.0001 and P = 0.044, respectively)
161 rine regulation of Nurr1 demonstrates that 6-mercaptopurine regulates Nurr1 through a region in the a
165 (p < 0.05) increased the S6-(4-nitrobenzyl)-mercaptopurine riboside (NBMPR) IC50 values by approxima
168 contrast, TPMT+ cells were more sensitive to mercaptopurine than MOCK cells (IC(50) = 0.52 +/- 0.20 m
169 bo-controlled trial reported the efficacy of mercaptopurine therapy for children newly diagnosed with
171 adenosyl- l-homocysteine and the substrate 6-mercaptopurine, to 1.8 and 2.0 A resolution, respectivel
172 identify additional genetic determinants of mercaptopurine toxicity, a genome-wide analysis was perf
173 with wild-type TPMT develop toxicity during mercaptopurine treatment for reasons that are not well u
174 econd DI; however, replacement of PO MTX, PO mercaptopurine, vincristine, and dexamethasone during IM
175 ars post-CR date, alternated three cycles of mercaptopurine, vincristine, methotrexate, and prednison
176 The higher sensitivity of TPMT+ cells to mercaptopurine was associated with higher concentrations
178 used antileukemic agents (eg, methotrexate, mercaptopurine), we determined the rate of DNPS and the
179 that 6-thioguanine is more effective than 6-mercaptopurine, we compared the efficacy and toxicity of
180 xhibited a haploinsufficient phenotype after mercaptopurine, whereas haploinsufficiency was less prom
183 ient response to the chemotherapeutic drug 6-mercaptopurine, with some model parameters being patient
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。