ライフサイエンスコーパス: mesenchymal progenitor

1 niofacial skeleton are derived from a common mesenchymal progenitor.

2 ruption of Tsc2 in craniofacial and limb bud mesenchymal progenitors.

3 velopmental processes, including the fate of mesenchymal progenitors.

4 l system that are differentiated from common mesenchymal progenitors.

5 he osteoblast versus chondrocyte fate in the mesenchymal progenitors.

6 s are typically derived from tissue resident mesenchymal progenitors.

7 of patients with IPF with the properties of mesenchymal progenitors.

8 embryos but is also expressed in multipotent mesenchymal progenitors.

9 rs and functional properties consistent with mesenchymal progenitors.

10 one formation by expanding the population of mesenchymal progenitors.

11 steoblasts increased EGFR phosphorylation in mesenchymal progenitors.

12 egulate proliferation and differentiation of mesenchymal progenitors.

13 sts and decreased Cxcl12/SDF-1 production by mesenchymal progenitors.

14 (BMP2)-induced osteogenic differentiation of mesenchymal progenitors.

15 short-term HF progenitors, adult HFSCs, and mesenchymal progenitors.

16 nce of CD45(-)CD34(+)CD31(-)CD13(+)CD140b(+) mesenchymal progenitors/adipose stromal cells (ASC), whi

17 iated by cellular condensation, during which mesenchymal progenitors aggregate and form 3D structures

18 lar chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key ce

19 ) self-renew in bone marrow niches formed by mesenchymal progenitors and endothelial cells expressing

20 d vessel assembly, endothelial cells recruit mesenchymal progenitors and induce their differentiation

21 ed phosphorylated Akt and p38MAPK amounts in mesenchymal progenitors and inhibition of these pathways

22 s transmit different signals to bone-derived mesenchymal progenitors and play critical roles in both

23 These fibrogenic mesenchymal progenitors and their progeny represent an u

24 rmed between endothelial cells and recruited mesenchymal progenitors and whether intercellular commun

25 However, the identities of dental mesenchymal progenitors are largely unknown.

26 e 4 (TBX4), and determined that TBX4-lineage mesenchymal progenitors are the predominant source of my

27 These defects are not due to eliminating mesenchymal progenitors, as neural crest cells still mig

28 promotes osteogenic lineage allocation from mesenchymal progenitors but inhibits terminal differenti

29 e associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differe

30 nchored metalloproteinase MT1-MMP (Mmp14) in mesenchymal progenitors, but not in committed osteoblast

31 e marrow normally acts to maintain a pool of mesenchymal progenitors by suppressing osteoblast differ

32 Thus, mesenchymal progenitors can be organized into localized

33 expressed CXCL12 and the cytokine SCF, were mesenchymal progenitors capable of differentiation into

34 During vertebrate development, mesenchymal progenitors capable of forming bone, cartila

35 Our results demonstrate Tsc2-deficient mesenchymal progenitors cause aberrant morphogenic signa

36 otch pathway has recently been implicated in mesenchymal progenitor cell (MPC) differentiation from b

37 human endothelial colony forming cell (ECFC)/mesenchymal progenitor cell (MPC)-derived bioengineered

38 rate a critical role for Pod1 in controlling mesenchymal progenitor cell differentiation into SM and

39 profiling mRNA expression in the bone marrow mesenchymal progenitor cell line ST2, we discover that B

40 between differentiation and maintenance of a mesenchymal progenitor cell population determines the fi

41 SoxC genes therefore ensure neural and mesenchymal progenitor cell survival, and function in pa

42 context of chondrogenic differentiation of a mesenchymal progenitor cell.

43 ar remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes)

44 Here, we examine bone marrow-derived mesenchymal progenitor cells (BM-MPCs) that have previou

45 expression and HA production in bone marrow mesenchymal progenitor cells (bmMPCs) derived from multi

46 endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular network

47 gineering platform for the delivery of human mesenchymal progenitor cells (MPCs) by a fully biologica

48 ifferent developmental stages and in primary mesenchymal progenitor cells (MPCs) reveals that bone ma

49 covered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serve as a cell

50 Mesenchymal progenitor cells (MPCs) transformed with the

51 rentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from

52 (RNAseq) analysis on primary pediatric human mesenchymal progenitor cells (pMPCs) expressing EWS-FLI1

53 Knockdown of Pkp2 in cardiac mesenchymal progenitor cells also reduced miR-184 levels

54 al analysis of IPF lung tissue revealed that mesenchymal progenitor cells and cells with the characte

55 ater stages of differentiation can transform mesenchymal progenitor cells and generate tumors resembl

56 36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentia

57 Wilms' tumor-1 (Wt1) leads to a reduction in mesenchymal progenitor cells and their derivatives.

58 ing evidence that proliferating, multipotent mesenchymal progenitor cells can be programmed to yield

59 Our findings identify a population of mesenchymal progenitor cells capable of giving rise to a

60 ulations, regulates lineage specification of mesenchymal progenitor cells during BMP-induced differen

61 Adult mesenchymal progenitor cells expressed CHL2, and its lev

62 appears to be derived from proliferation of mesenchymal progenitor cells followed by differentiation

63 tion factors, induces the differentiation of mesenchymal progenitor cells from the bone marrow into a

64 During organogenesis, neural and mesenchymal progenitor cells give rise to many cell line

65 ailed characterization of the most primitive mesenchymal progenitor cells in the adult murine bone ma

66 ed a significant reduction in colony-forming mesenchymal progenitor cells in the bone marrow of Apc(M

67 vate scleraxis expression in a population of mesenchymal progenitor cells in the dorsal sclerotome.

68 Moreover, inactivation of beta-catenin in mesenchymal progenitor cells in vitro causes chondrocyte

69 Knockdown of miR-184 in HL-1 cells and mesenchymal progenitor cells induced and, conversely, it

70 o promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

71 e by coimplantation of human endothelial and mesenchymal progenitor cells isolated from blood and bon

72 enitors isolated from nonfibrotic lungs, IPF mesenchymal progenitor cells produce daughter cells mani

73 Removal of beta-catenin early in mesenchymal progenitor cells promoted chondrocyte differ

74 romoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes.

75 gs of patients with IPF contain pathological mesenchymal progenitor cells that are cells of origin fo

76 Postnatal bone marrow houses mesenchymal progenitor cells that are osteoblast precurs

77 ese amphibians form a "blastema", a group of mesenchymal progenitor cells that specifically directs t

78 Moreover, BMP7 triggers commitment of mesenchymal progenitor cells to a brown adipocyte lineag

79 formation, from their initial induction from mesenchymal progenitor cells to their terminal maturatio

80 ricted to the luminal aspect of the vessels; mesenchymal progenitor cells were adjacent to lumens, co

81 In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly

82 MCs induced alkaline phosphatase activity in mesenchymal progenitor cells, and this was abrogated by

83 In murine 10T1/2 mesenchymal progenitor cells, expression of mutant IDH2

84 tation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility

85 three different cell types (C3H10T1/2 murine mesenchymal progenitor cells, primary human adipose tiss

86 Fibrocytes, which are bone marrow-derived mesenchymal progenitor cells, were increased to a greate

87 dipocytes arise from resident adipose tissue mesenchymal progenitor cells.

88 ication, but with massively dying neural and mesenchymal progenitor cells.

89 al transition and recruitment of circulating mesenchymal progenitor cells.

90 om resident adipose tissue preadipocytes and mesenchymal progenitor cells.

91 BMP-9-induced osteogenic differentiation of mesenchymal progenitor cells.

92 A-184 was predominantly expressed in cardiac mesenchymal progenitor cells.

93 d/or osteoblast differentiation of endosteal mesenchymal progenitor cells.

94 ng microRNAs in human OS cells compared with mesenchymal progenitor cells.

95 skeleton by inhibiting Hedgehog signaling in mesenchymal progenitor cells.

96 ing in smooth muscle cell differentiation of mesenchymal progenitor cells.

97 ochondrocytic differentiation of multipotent mesenchymal progenitor cells.

98 n profile of all known 27 human TRP genes in mesenchymal progenitors cells during white or brown adip

99 r developmental ancestry by Tie2-expressing (mesenchymal?) progenitor cells during development.

100 re we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cel

101 ish expressing constitutively active Akt2 in mesenchymal progenitors develop WDLPS that closely resem

102 of Wnt signaling, we treated rat metanephric mesenchymal progenitors directly with recombinant Wnt pr

103 required for osteoblast differentiation from mesenchymal progenitors during endochondral bone formati

104 e bone repair by supporting inflammatory and mesenchymal progenitor egress into the zone of injury.

105 mber of the nuclear receptor superfamily, in mesenchymal progenitors favors osteoblast and myoblast d

106 The mesenchymal progenitors, fibrocytes, may be involved in

107 mice and asked whether these multipotential mesenchymal progenitors from bone marrow can adopt neura

108 Mesenchymal progenitors from Cx43-/- murine embryos and

109 A common molecular marker for all osteogenic mesenchymal progenitors has not been identified.

110 tin-green fluorescent protein (GFP)-positive mesenchymal progenitors have all been implicated in HSC

111 hese cells and investigate the role of local mesenchymal progenitors in fibrogenesis after lung trans

112 w that deleting Kindlin-2 in Prx1-expressing mesenchymal progenitors in mice causes neonatal lethalit

113 ticolor reporters to characterize individual mesenchymal progenitors in the developing mouse lung.

114 itogens to promote the expansion of adjacent mesenchymal progenitors, including those of the smooth m

115 skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.

116 OPG in blocking the differentiation of early mesenchymal progenitors into RANK-expressing pre-osteocl

117 Fibrocytes are mesenchymal progenitors involved in normal and pathologi

118 The characterization of mesenchymal progenitors is central to understanding deve

119 dings indicate that PPR signalling in dental mesenchymal progenitors is essential for tooth root form

120 markers but positive for Pax7, Sca1, and the mesenchymal progenitor marker PDGFRalpha.

121 Thus, mesenchymal progenitors may be expanded in vitro by acti

122 When tested in noncancer mesenchymal progenitor (MePR) cells, 2 and 3 induced lit

123 As such, these mesenchymal "progenitors" might not represent the best p

124 h the growth plate, termed here "metaphyseal mesenchymal progenitors" (MMPs), are essential for cance

125 scovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among le

126 to mesenchymal transition (EMT) to form the mesenchymal progenitors of the AV valves.

127 Loss of Vhl in mesenchymal progenitors of the limb bud caused severe fi

128 ndrogenesis, we conditionally deleted VHL in mesenchymal progenitors of the limb bud, i.e. in cells n

129 We show that the cultivation of hESC-derived mesenchymal progenitors on 3D osteoconductive scaffolds

130 bone substitutes by culturing hiPSC-derived mesenchymal progenitors on osteoconductive scaffolds in

131 Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific d

132 kx2-5 and derepression of p15Ink4b in spleen mesenchymal progenitors, perturbing the cell cycle.

133 entiation, undifferentiated transitional and mesenchymal progenitor phenotypes, and mediators of cyto

134 late the activity of beta-catenin within the mesenchymal progenitor pool in mice, we investigated the

135 ix2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated

136 Renal vesicles are established from a mesenchymal progenitor population in response to inducti

137 c tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital re

138 phrons of the metanephric kidney form from a mesenchymal progenitor population that differentiates en

139 usly uncharacterized adipose tissue resident mesenchymal progenitor population.

140 We observe a diversity of mesenchymal progenitor populations with different locati

141 Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiat

142 floxed alleles were specifically targeted to mesenchymal progenitors (Prx1Cre) or committed chondrocy

143 Conditional Il7 deletion in mesenchymal progenitors reduced B-lineage committed CLPs

144 ner medulla and described as a population of mesenchymal progenitors, released erythropoietin under h

145 Thus Gli1 marks mesenchymal progenitors responsible for both normal bone

146 iation by maintaining Shh1 responsiveness in mesenchymal progenitors (see the related article beginni

147 l pre-osteoblasts, Bmpr1b mutant bone marrow mesenchymal progenitors showed compromised differentiati

148 is an increased interest in rheumatology in mesenchymal progenitor/stem cells (MPCs) and their roles

149 ooth muscle actin-expressing macrophages and mesenchymal progenitors such as CXC chemokine ligand (CX

150 row reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the

151 ular region, including endothelial cells and mesenchymal progenitors, supports HSCs.

152 ells, we analyzed mutant mice lacking Vhl in mesenchymal progenitors that give rise to the soft tissu

153 ng to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper deve

154 ck apoptosis and regulate differentiation of mesenchymal progenitors through inhibition of glycogen s

155 During development, mesenchymal progenitors tightly regulate the balance bet

156 cells, which acts on the EGFRs expressed on mesenchymal progenitors to stimulate the Akt and p38MAPK

157 t mechanisms: facilitating the commitment of mesenchymal progenitors to the osteoblast lineage in ass

158 gly, deletion of Cxcl12 from nestin-negative mesenchymal progenitors using Prx1-cre (Prx1 also known

159 expression and osteogenic mineralization of mesenchymal progenitors via beta-catenin.

160 Notably, mesenchymal progenitors were undetectable in the bone ma

161 kinases suppress expansion of the primitive mesenchymal progenitors, where YAP activation also preve

162 soluble chemotactic factors for bone marrow mesenchymal progenitors, which express a low amount of P

163 -catenin is essential in determining whether mesenchymal progenitors will become osteoblasts or chond