ライフサイエンスコーパス: mesoderm

1 eproductive ductal systems: the intermediate mesoderm.

2 that the endoderm is passively pushed by the mesoderm.

3 sts in the orientation of these axes for the mesoderm.

4 ession on the left side of the lateral plate mesoderm.

5 ateral mesoderm, but not in the intermediate mesoderm.

6 n after gastrulation to form spinal cord and mesoderm.

7 enters, such as the floor plate and paraxial mesoderm.

8 tion, and FN matrix assembly in the paraxial mesoderm.

9 ites should be regarded as posterior cranial mesoderm.

10 by contributing both to the spinal cord and mesoderm.

11 submesothelial region of the developing lung mesoderm.

12 cle progenitor cells within cardiopharyngeal mesoderm.

13 gating spinal cord and the adjacent paraxial mesoderm.

14 of ME genes that is required to form cardiac mesoderm.

15 scles of the head, which derive from cranial mesoderm.

16 namic gene expression within the pre-somitic mesoderm.

17 erived from progenitor cells in intermediate mesoderm.

18 1) in the module correlated with postcardiac mesoderm.

19 mmetrically into the left and right paraxial mesoderm.

20 Nodal and/or Fgf signaling, are specified as mesoderm.

21 e expression within definitive hematopoietic mesoderm.

22 e failure of the anterior extension of axial mesoderm.

23 activation and cell shape in the Drosophila mesoderm.

24 of southpaw expression in the lateral plate mesoderm.

25 we detected by analysis of the chick cranial mesoderm.

26 erm and posterior-primitive-streak hemogenic mesoderm.

27 a Cxcr4a-regulated tether of the endoderm to mesoderm.

28 and are found also in the dorsal splanchnic mesoderm accompanied by the expression of the secondary

29 in 1 (Strip1) that disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchyma

30 cell types within the anterior lateral plate mesoderm (ALPM) also underwent subduction, and that this

31 he nkx2.5(+) field of anterior lateral plate mesoderm (ALPM).

32 r that is expressed in the primitive streak, mesoderm and anterior mesendoderm of the mouse embryo.

33 y regulating cell motility in the presomitic mesoderm and by controlling specification of the paraxia

34 ct the anterior boundaries of the presomitic mesoderm and caudal progenitor pool.

35 trulation and is concentrated in the lateral mesoderm and ectoderm at the neurula stage.

36 a distinct type of adhesive contact between mesoderm and ectoderm cells that shows properties of a c

37 tentially be applied to enrich production of mesoderm and endoderm derivatives and be further differe

38 ough metabolic switching occurs during early mesoderm and endoderm differentiation, high glycolytic f

39 sis, differential anisotropic growth between mesoderm and endoderm drives diagonal folding.

40 uired for the correct initiation of both the mesoderm and endoderm gene regulatory networks.

41 We found that both mesoderm and endoderm invaginations are synchronous with

42 itor markers and lower levels of markers for mesoderm and endoderm lineages.

43 al promoters, including at genes involved in mesoderm and endoderm specification and at the Hox and F

44 ng is stably enhanced, giving rise to excess mesoderm and endoderm, an effect that can be rescued by

45 nd ectoderm, and slower aggregation favoring mesoderm and endoderm.

46 ssociation with impaired maturation of axial mesoderm and failed specification of paraxial mesoderm,

47 n did not generate lateral plate and cardiac mesoderm and favored instead somitic differentiation.

48 enes that were upregulated in both hemogenic mesoderm and hemogenic endothelial fractions targeted by

49 s on Delta/Notch signaling from skeletogenic mesoderm and is downstream of Gcm in the aboral NSM gene

50 found disruptions in the organization of the mesoderm and its derivatives, including a complete failu

51 Eng is expressed in early mesoderm and marks both haematopoietic and cardiac proge

52 stinct regions of the anterior lateral plate mesoderm and migrate to the midline where they coalesce

53 blishes the boundary between the presumptive mesoderm and neurogenic ectoderm of early Drosophila emb

54 scle in both animals are derived solely from mesoderm and not from neural crest.

55 sm of transcription initiation that involves mesoderm and organizer gene expression.

56 hat reflect mid-primitive-streak cardiogenic mesoderm and posterior-primitive-streak hemogenic mesode

57 p, they spontaneously initiate expression of mesoderm and primordial germ cell markers asymmetrically

58 om the tcf21 and nkx2.5 double-positive head mesoderm and require these two transcription factors for

59 can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying vent

60 enes and that of marker genes for presomitic mesoderm and the chordoneural hinge.

61 ly separated germ layers, namely the somitic mesoderm and the endoderm, in quail embryos.

62 Mesenchyme originates from both mesoderm and the neural crest, an ectodermal cell popula

63 o different tissues, namely the lateral head mesoderm and the prechordal mesendoderm, gradually induc

64 mitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific

65 ent KDR(+)CD235a(-) definitive hematopoietic mesoderm and WNT-independent KDR(+)CD235a(+) primitive h

66 vg1 fail to form endoderm and head and trunk mesoderm, and closely resemble nodal loss-of-function mu

67 s: pluripotent stem cells, mesoderm, cardiac mesoderm, and differentiated cardiomyocytes.

68 t with myoblasts derived from the pharyngeal mesoderm, and Dlx5 disruption leads to altered prolifera

69 nd coactivator complexes onto neuroectoderm, mesoderm, and endoderm genes.

70 ion experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any

71 , Shh is expressed transiently in prechordal mesoderm, and is governed by unprocessed Nodal.

72 ile PGCs are en route to the somatic gonadal mesoderm, and previous studies have shown that CVM impac

73 from the hindbrain, DAN is expressed in the mesoderm, and then it becomes absent along cell migrator

74 ndothelium was generated from posterior-like mesoderm, and vessel-forming CD31(+) endothelial cells w

75 ent studies reveal that Tbx1 is required for mesoderm- and neural crest-derived osteoblast differenti

76 mesenchymal stem cells to differentiate into mesoderm- and nonmesoderm-derived tissues, their immunom

77 mber and size, restriction of the presomitic mesoderm anterior border, somite chevron morphology and

78 on ancestor of fungi and animals long before mesoderm appeared.

79 on, although we understand little of how the mesoderm arose.

80 tent neuromesodermal progenitors (NMPs) into mesoderm at the expense of neuroectoderm.

81 reshadow the coordinated invagination of the mesoderm at the onset of gastrulation.

82 During embryonic development, the paraxial mesoderm becomes segmented into somites, within which pr

83 We studied the cleft-like ectoderm-mesoderm boundary in Xenopus laevis and zebrafish gastru

84 anar cell polarity signaling at the ectoderm-mesoderm boundary to lower cell adhesion and facilitate

85 of high nbeta-catenin segregate the endoderm/mesoderm boundary, which is further reinforced by Delta/

86 ts, we demonstrate that BRA is essential for mesoderm but not for endoderm formation.

87 signaling interactions between endoderm and mesoderm, but how these signals are interpreted in the g

88 os show Raldh2 downregulation in the lateral mesoderm, but not in the intermediate mesoderm.

89 vels of Wnt signaling induce a transition to mesoderm by directly activating tbx16, which in turn act

90 ECs derived from cardiogenic and hemogenic mesoderm can be matured into >90% CD31(+)/VE-cadherin(+)

91 C lines at 4 stages: pluripotent stem cells, mesoderm, cardiac mesoderm, and differentiated cardiomyo

92 paralogs, uniquely regulates PRC1 to specify mesoderm cell fate in embryonic stem cells.

93 is known about the mechanisms that regulate mesoderm cell migration in vivo.

94 stream of key myogenic genes needed for core mesoderm cell survival and fate, between E9.5 and E10.5,

95 investigated early lineage-restricted human mesoderm cell types and their precursors going back to p

96 row, whereby approximately 1,000 presumptive mesoderm cells exhibit coordinated apical constrictions

97 Further, prechordal mesoderm cells in which Fgfr3 expression is reduced by F

98 -to-mesenchymal transition and ingression of mesoderm cells through the primitive streak, including f

99 We first differentiated hPSCs into mesoderm cells using a glycogen synthase kinase-3beta in

100 composed of mixed neural crest and paraxial mesoderm cells, as well as cells from adjacent neuroepit

101 larity and adherens junction organization in mesoderm cells, suggesting that extruding cells undergo

102 lly redundant role in specifying the cardiac mesoderm (CM) as eliminating the functions of both Forkh

103 onsequent lineage fate decisions that define mesoderm commitment.

104 It is thought that coordinate mesoderm constriction depends on high levels of myosin a

105 In the trunk vasculature, MCs derived from mesoderm covered the ventral side of the dorsal aorta (D

106 Caudal visceral mesoderm (CVM) cells migrate from posterior to anterior

107 eparation, showed that its expression in the mesoderm depends on noncanonical Wnt signaling, and demo

108 ion of the zebrafish kidney, a ventrolateral mesoderm derivative, and show that AP patterning of the

109 ng embryos, FOXF1 marks most extra-embryonic mesoderm derivatives including the chorion, the allantoi

110 l posterior primitive streak extra-embryonic mesoderm derivatives with the remarkable exception of th

111 oietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensivel

112 ate that the cellular and anatomical fate of mesoderm-derived cardiac cells is specified very early.

113 nstrate that partial direct reprogramming of mesoderm-derived cardiomyocytes into neurons is feasible

114 le, and benchmarked them with donor-matched, mesoderm-derived femur/tibia HSCs, including clonogenic

115 C. elegans mutants in which the presumptive mesoderm-derived I4 neuron adopts a muscle-like cell fat

116 erived hyoid bone primordium, in addition to mesoderm-derived osteochondral progenitors.

117 In conclusion, the mesoderm-derived paracrine signals promote hepatocyte ma

118 lvic junction were derived from intermediate mesoderm-derived renal progenitors and were distinct fro

119 ve Hedgehog signaling in murine intermediate mesoderm-derived renal progenitors results in hydronephr

120 ) and osteopontin expression and died during mesoderm development akin to FAK kinase-dead mice.

121 lthough the factors that regulate early lung mesoderm development are unknown.

122 trulation, as demonstrated by the absence of mesoderm development at E7.5.

123 s-1 mutants exhibit striking defects in endo-mesoderm development but have wild-type distributions of

124 lix-loop-helix family, play crucial roles in mesoderm development in all animals.

125 n and single-cell gene expression changes in mesoderm development uncovered somite segmentation, a pr

126 T-box gene family, is a key gene in chordate mesoderm development.

127 ssical Polycomb protein during early cardiac mesoderm differentiation by repressing pluripotency, lin

128 regulatory role of the FOX TFs in enhancing mesoderm differentiation capacity of hESCs.

129 in Wnt reporter assays and in Wnt-dependent mesoderm differentiation in embryonic stem cells.

130 yment invokes Tbx6, a T-box factor, to drive mesoderm differentiation of NMPs.

131 WNT3 and EOMES which are potent inducers of mesoderm differentiation.

132 ll adhesions and show enhanced Wnt-dependent mesoderm differentiation.

133 not require Wnt/beta-catenin signalling for mesoderm differentiation.

134 beta-catenin, which initiates and reinforces mesoderm differentiation.

135 has been analysed extensively to investigate mesoderm diversification and differentiation and continu

136 tic fate enhances our understanding of early mesoderm diversification and may lead to improved protoc

137 These genes are inactive in the mesoderm due to transcriptional quenching by the Snail r

138 pological within the fin-field lateral plate mesoderm during early fin bud initiation.

139 es and had the ability to differentiate down mesoderm, ectoderm, and endoderm lineages, demonstrating

140 epresenting intermediate stages of endoderm, mesoderm, ectoderm, and neural crest (NC) development.

141 Cs derived from either neural crest cells or mesoderm emerged around the preformed EC tubes, prolifer

142 ver complex interactions between the cardiac mesoderm, endoderm, and the rest of the embryo, whereby

143 y reveals a novel role for these proteins in mesoderm-endoderm signaling during embryogenesis.

144 muscle is a central question when discussing mesoderm evolution.

145 Analysis of cultured mesoderm explants and mouse embryonic fibroblasts from n

146 tion of Tbx6 as a bistable switch that turns mesoderm fate 'on' and progenitor state 'off', and thus

147 by controlling specification of the paraxial mesoderm fate in the tail bud.

148 The choice of mesoderm fate is Wnt/beta-catenin dependent.

149 ion of msgn1, a master regulator of paraxial mesoderm fate, or if transplanted into the bipotential p

150 s representing a transient cell state in the mesoderm-fated NMP lineage.

151 oderm; and activation of ets1 and erg in the mesoderm-fated territory requires the highest nbeta-cate

152 , achieve precise spatial expression of endo-mesoderm fates in C. elegans embryos.

153 ibutions of SKN-1, a key determinant of endo-mesoderm fates.

154 r nuclei, where it negatively regulates endo-mesoderm fates.

155 ription but are refined by repression in the mesoderm following mitosis.

156 t gene that is required in both ectoderm and mesoderm for primitive hematopoiesis to occur.

157 in the anterior mesendoderm, but not in the mesoderm, for formation of the head.

158 Mesoderm formation and subsequent anterior-posterior (A-

159 TGFbeta member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholo

160 rst transcriptome-wide in vivo view of early mesoderm formation during mammalian gastrulation.

161 h necessary and sufficient to direct cardiac mesoderm formation in frog embryos and human embryonic s

162 anscription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which

163 by repressing two inhibitors of cardiogenic mesoderm formation-Tcf3 and Foxa2-and activating inducer

164 blocking a direct route to embryonic cardiac mesoderm formation.

165 4d and demonstrate that embryonic segmental mesoderm forms via teloblastic divisions, as in clitella

166 to be critical for the formation of FLK1(+) mesoderm, from which the hemangiogenic fate is specified

167 g with Mesp1-Cre mice revealed that Mesp1(+) mesoderm gave rise to liver MCs but not peritoneal MCs.

168 During development, the lung mesoderm generates a variety of cell lineages, including

169 e conserved "kernel" of the bilaterian heart mesoderm GRN is operational in N. vectensis, which reinf

170 lly-fated progeny of 4d (germline, segmental mesoderm, growth zone) display significantly different c

171 Within the posterior mesoderm, hand2 is expressed laterally adjacent to the I

172 obtain and identify, via CD235a expression, mesoderm harboring exclusively primitive or definitive h

173 interface between the pharyngeal and cardiac mesoderm, identify the transcription factor code require

174 rogenitors originate within the intermediate mesoderm (IM), but the pathways that set the boundaries

175 hin definitive hematopoietic KDR(+)CD235a(-) mesoderm in a WNT- and fibroblast growth factor-dependen

176 We induced mesoderm in human pluripotent stem cells with ACTIVIN an

177 We fate-map this mesoderm in the axolotl (Ambystoma mexicanum), which ret

178 highlight the importance of cardiopharyngeal mesoderm in the evolution of the vertebrate heart and ne

179 ot derive from somites, but mainly form from mesoderm in the pharyngeal region.

180 velopment of muscles derived from the 4th PA mesoderm in the soft palate, likely via interactions bet

181 and to muscles derived from cardiopharyngeal mesoderm in the urochordate Ciona, where a related gene

182 nforces the hypothesis that the endoderm and mesoderm in triploblastic bilaterians evolved from the b

183 electroporation of Fgfr3 siRNA to prechordal mesoderm in vivo results in premature Shh downregulation

184 orters initially delineate the lateral plate mesoderm, including heart progenitors.

185 node induces a neural plate whereas the head mesoderm induces placodes.

186 r to what extent the molecular mechanisms of mesoderm induction are conserved between gastrula and po

187 Mesoderm induction begins during gastrulation.

188 om several vertebrate species indicates that mesoderm induction continues after gastrulation in neuro

189 rowth factor (FGF) signaling is required for mesoderm induction during gastrulation through positive

190 n of lineage-specific gene expression during mesoderm induction.

191 Brg1 is required for enhancer activation in mesoderm induction.

192 t distal enhancers that are activated during mesoderm induction.

193 e Brachyury/T transcription factor, reducing mesoderm ingression and slowing down the elongation proc

194 ophila melanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius.

195 ommon contractile cell-shaping mechanism, as mesoderm invagination fails in Rab35 compromised embryos

196 Both genes are expressed and required for mesoderm invagination in the fruit fly Drosophila melano

197 The AP cell elongation gradient remains when mesoderm invagination is blocked but is abolished in the

198 genes in C.riparius is sufficient to invoke mesoderm invagination similar to D.melanogaster.

199 The mesoderm is a key novelty in animal evolution, although

200 on between the endoderm and adjacent cardiac mesoderm is crucial for heart development.

201 Our data revealed that FOXF1-expressing mesoderm is derived from FLK1(+) progenitors and that in

202 phila melanogaster gastrula is delayed until mesoderm is internalized, despite the early expression o

203 GATA-binding protein 4 (GATA4) (postcardiac mesoderm), JUN and FOS families, and MEIS2 (cardiomyocyt

204 issues (e.g. neural tube, axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to drive ax

205 ell delamination and migration by inducing a mesoderm-like cell fate.

206 ctive and repressive chromatin states during mesoderm lineage commitment, in particular the activatio

207 events and drive naive-type piPSC along the mesoderm lineage, and, in combination with the DNA methy

208 fate decisions to occur in this multipotent mesoderm lineage.

209 In the Drosophila mesoderm, linked epithelial cells apically constrict, wi

210 HPSCs) through an intermediate lateral plate mesoderm (LM) stage.

211 In chicken, lateral plate mesoderm (LPM) adjacent to occipital somites is a recent

212 hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of t

213 ntiation, such as T and eomesodermin (EOMES; mesoderm), lymphoid enhancer-binding factor 1 (LEF1) and

214 of YAP(-/-) hESCs to Activin induces cardiac mesoderm markers (BAF60c and HAND1) without activating W

215 EYFP+ cells that strongly expressed cardiac mesoderm markers and cardiac transcription factors, but

216 tion factors, but not pluripotent or nascent mesoderm markers.

217 on factor 1 (MESP1; from mesoderm to cardiac mesoderm), meis homeobox 1 (MEIS1) and GATA-binding prot

218 he mouse [mouse embryonic stem cells (ESCs), mesoderm (MES), cardiac progenitors (CP) and cardiomyocy

219 n spectroscopy within the zebrafish paraxial mesoderm mesenchyme reveals a physical association betwe

220 Exposure of prechordal mesoderm microcultures to Nodal-conditioned medium, the

221 fibroblasts from null mutants shows that the mesoderm migration defect is correlated with decreased c

222 Regulated mesoderm migration is necessary for the proper morphogen

223 esoderm and failed specification of paraxial mesoderm, mimicking phenotypes in embryos with gain-of-f

224 s of gastrulation most subapical clusters in mesoderm not only persist, but move apically and enhance

225 , which are a subset of the non-skeletogenic mesoderm (NSM) cells.

226 and show that AP patterning of the non-axial mesoderm occurs across the classic gastrula stage DV axi

227 ly, these genes were detected in the nascent mesoderm of early gastrulating embryos.

228 cells from the epiblast and nascent Flk1(+) mesoderm of gastrulating mouse embryos using single-cell

229 transcripts are stabilized in the presomitic mesoderm of mutant mice, suggesting that both transcript

230 Hox6 genes are expressed exclusively in the mesoderm of the developing pancreas.

231 with cardiac progenitor cells in pharyngeal mesoderm of the second heart field (SHF) and branchial a

232 e great arteries are derived from splanchnic mesoderm of the second heart field (SHF), an important s

233 g early stages (ie, from mesoderm to cardiac mesoderm) of cardiomyocyte differentiation remains limit

234 s, delaminate and migrate along the paraxial mesoderm on either side of the neural tube, eventually d

235 nd state that can be further programmed into mesoderm or endoderm lineages.

236 ome animal species can generate neurons from mesoderm or endoderm, but the underlying mechanisms rema

237 autonomous, as expression of mutant GlyRS in mesoderm or muscle alone results in similar pathology.

238 in is absent, the normal Snail expression in mesoderm, or ectopic Snail expression in ectoderm, is su

239 +) endothelial cells were generated from all mesoderm origins.

240 ic overexpression of either htl or fz in the mesoderm partially rescues the defective CM specificatio

241 ACTIVIN and BMP-induced mesoderm patterned into cardiac but not somitic subtypes

242 rd blood CD34(+) cells, indicating incorrect mesoderm patterning.

243 e been employed to examine the mechanisms of mesoderm patterning.

244 ocess of somitogenesis in which the paraxial mesoderm periodically segments into bilateral tissue blo

245 tissue strain generated by the gastrulating mesoderm plays a major role in determining the global ax

246 g the convergence of posterior lateral plate mesoderm (PLM), well before aorta formation and runx1 tr

247 at FGF is continuously required for paraxial mesoderm (PM) induction in post-gastrula NMPs.

248 Mesoderm posterior 1 (Mesp1) is well recognized for its

249 ymphoid enhancer-binding factor 1 (LEF1) and mesoderm posterior BHLH transcription factor 1 (MESP1; f

250 s - both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal fi

251 Lateral/ventral mesoderm progenitors represent a distinct committed stat

252 activin A-induced endoderm and BMP4-induced mesoderm progenitors.

253 cular oscillator expressed within presomitic mesoderm (PSM) cells.

254 sly produced posteriorly from the presomitic mesoderm (PSM) during body formation.

255 vity of signaling pathways in the presomitic mesoderm (PSM).

256 om somites, which derive from the presomitic mesoderm (PSM).

257 lial somites from the mesenchymal presomitic mesoderm (PSM).

258 Replacement of intermediate by lateral mesoderm recapitulates the evolutionary origin of the di

259 cell fate decisions are regulated in nascent mesoderm remains mostly unknown.

260 The iCPCs were cardiac mesoderm-restricted progenitors that could be expanded e

261 dent KDR(+)CD235a(+) primitive hematopoietic mesoderm revealed strong CDX gene expression within defi

262 confirm that BAP treated hESC (ESCd) lack a mesoderm signature and are a subtype of placental cells

263 xtensive morphogenesis, including splanchnic mesoderm sliding over the endoderm, results in HT format

264 ort that, unlike in other vertebrates, snake mesoderm-specific enhancers are mostly located within th

265 showed reduced expression levels of several mesoderm-specific genes as compared with wild-type count

266 howed previously that Setd1a is required for mesoderm specification and hematopoietic lineage differe

267 The molecular mechanisms orchestrating early mesoderm specification are still poorly understood.

268 lighted extensive divergence of skeletogenic mesoderm specification in the sister clade of euechinoid

269 exogenous CDX4 expression exclusively during mesoderm specification resulted in a >90% repression in

270 croenvironment could differentially modulate mesoderm specification.

271 d neural differentiation and limited cardiac mesoderm specification.

272 gf, to determine the pattern of endoderm and mesoderm specification.

273 progenitors in the pharyngeal and splanchnic mesoderm (SpM), but how these progenitors are deployed t

274 ed RNA AK127400 in the module related to the mesoderm stage; E-box-binding homeobox 1 (ZEB1) in the m

275 a also disrupted cell differentiation of the mesoderm, suggesting aberrant epithelial-mesenchymal sig

276 rce of myocardium and of the pharyngeal arch mesoderm that gives rise to skeletal muscles.

277 ntain the Fgf8 'wavefront' in the presomitic mesoderm that underpins axial elongation, (ii) sustain t

278 8/+7/+9-kb enhancers, targeted cells in FLK1 mesoderm that were enriched for blast colony forming pot

279 ongation by generating spinal cord and trunk mesoderm tissue.

280 y networks underlying early stages (ie, from mesoderm to cardiac mesoderm) of cardiomyocyte different

281 ior BHLH transcription factor 1 (MESP1; from mesoderm to cardiac mesoderm), meis homeobox 1 (MEIS1) a

282 th ectodermal and mesodermal cells to enable mesoderm to commit to a hematopoietic fate.

283 transporter Mdr49 functions in the embryonic mesoderm to facilitate the transmission of the PGC attra

284 (HPCs) move from the anterior lateral plate mesoderm to the ventral midline, undergoing a mesenchyma

285 tically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hematopoietic an

286 the mouse embryo, we map the progression of mesoderm toward blood using single-cell gene expression

287 also positively regulates expression of key mesoderm transcription factors, revealing an unexpected

288 axolotl is congruent between LPM and somitic mesoderm, unlike in chicken and possibly other amniotes.

289 itional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a d

290 Cardiogenic mesoderm was generated under conditions specifying anter

291 utions in individual cells of the developing mesoderm, we engineered all five disease-associated alle

292 achyury prior to the evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the d

293 nt to establish haematopoietic fate in early mesoderm when BMP and Wnt crosstalk is disturbed.

294 edgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in induction and

295 ed under conditions specifying anterior-like mesoderm, whereas blood-forming endothelium was generate

296 have expressed markers of cranial pharyngeal mesoderm, whereas other muscles in the neck arise from P

297 ral gene expression in both the endoderm and mesoderm, whereas Wnt/beta-catenin acts as a genome-wide

298 r and posterior territories in the non-axial mesoderm while retinoic acid (RA) functions later, but a

299 ) subtypes from cardiogenic versus hemogenic mesoderm with high efficiency without cell sorting.

300 efinitive endoderm, precardiac or presomitic mesoderm within the first 24 h of differentiation, respe