ライフサイエンスコーパス: mesodermal

1 cell types that are typically categorized as mesodermal.

2 each germ layer, ectodermal, endodermal, and mesodermal.

3 Here, we show that a mesodermal ABCC (MRP) transporter is necessary for endod

4 nic developmental pathway through successive mesodermal and adipogenic progenitor stages.

5 Our results show mesodermal and anterior gut expression is a common featu

6 uction of cyclops expression, and subsequent mesodermal and axial defects.

7 id oral-aboral patterning of nonskeletogenic mesodermal and ectodermal domains in early development o

8 s indicate that developmental GRNs directing mesodermal and ectodermal specification have undergone m

9 eak-like cell population segregated into the mesodermal and endodermal lineages.

10 ells and are able to differentiate along the mesodermal and endodermal lineages.

11 ors that have important functions in several mesodermal and endodermal organs, including heart, liver

12 The consequences of disrupted mesodermal and endodermal RA signaling were restricted t

13 , and livers were analyzed for expression of mesodermal and epithelial markers.

14 itively supports a progenitor state for both mesodermal and neural progenitors.

15 , which supports the migration and fusion of mesodermal cardiac precursors.

16 -iPSC have a reduced ability to give rise to mesodermal, cardiac progenitors and mature cardiomyocyte

17 ion and characterization of a group of early mesodermal cardiovascular progenitor cells, induced by B

18 e that controls dynamic actin remodeling and mesodermal cell behaviors during Xenopus gastrulation.

19 w C-cadherin-based contacts with neighboring mesodermal cell bodies.

20 ishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and

21 ds to gastrulation defects without affecting mesodermal cell fate, whereas knockdown of USP12 in Xeno

22 Mesodermal cell migration defects in toddler mutants res

23 lts suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

24 verexpression of Zic1 and Pax3 in the 10T1/2 mesodermal cell model results in enrichment of these fac

25 e close ontogenic origins, and that an early mesodermal cell population has the potential to differen

26 ne at different embryonic stages and in four mesodermal cell types is governed by the binding of mult

27 ly, in oral or aboral domains, presaging the mesodermal cell types that will emerge.

28 lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types

29 and that the veg2 lineage also gives rise to mesodermal cell types.

30 ment, the PAAs emerge from nkx2.5-expressing mesodermal cells and connect the dorsal head vasculature

31 hat the E(+)F(+) fraction at E7.5 represents mesodermal cells competent to respond to TGFbeta1, BMP4,

32 During Drosophila gastrulation, the ventral mesodermal cells constrict their apices, undergo a serie

33 partitioned into the nascent ectodermal and mesodermal cells during cleavage and early gastrulation

34 We identify a population of mesodermal cells in a developing invertebrate, the marin

35 blebby transitional morphology of involuting mesodermal cells in a vertebrate embryo.

36 During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrat

37 l cells efficiently promote the emergence of mesodermal cells in the neighboring population through s

38 hat identifies impaired migration of nascent mesodermal cells in the primitive streak as the morphoge

39 MCs fail to repress the transfating of other mesodermal cells into the skeletogenic lineage.

40 ered that hlh-8 expression in differentiated mesodermal cells is controlled by two well-conserved E b

41 A subpopulation of mesodermal cells moving ventrally from the somatopleural

42 Mesodermal cells signal to neighboring epithelial cells

43 with decreased Notch activity originate from mesodermal cells that normally produce erythrocyte proge

44 fic RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adja

45 se that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signal

46 of SoxB1 proteins in the limb bud confers on mesodermal cells the potential to activate neural-specif

47 s mediated by regulation of Wnt signaling in mesodermal cells through activation of integrin-beta1.

48 and Gata2 is required in both ectodermal and mesodermal cells to enable mesoderm to commit to a hemat

49 indicate that RA inhibits the commitment of mesodermal cells to hematopoietic fates, functioning dow

50 ientation and migration behaviors of lateral mesodermal cells undergoing convergence and extension mo

51 -11/planar cell polarity signaling polarizes mesodermal cells undergoing convergent extension during

52 ntified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, expos

53 n, canonical Wnts promote the recruitment of mesodermal cells within this region into the pacemaker l

54 ially-injected undifferentiated-iPSCs, day 4 mesodermal cells, and day 8, day 20, and day 30 purified

55 RA, produced by newly generated mesodermal cells, provides feedback that initiates NMP g

56 cation and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs).

57 Its anterior daughter, MS, makes primarily mesodermal cells, while its posterior daughter E generat

58 nal-mediated induction of a subpopulation of mesodermal cells.

59 iate into Pax6(+)-neural precursor cells and mesodermal cells.

60 foster tissue repair, and differentiate into mesodermal cells.

61 this largely twist-independent population of mesodermal cells.

62 is derived from both neural crest cells and mesodermal cells; however, the majority of the bone, car

63 nd Delta (Dl) reveals segmentally reiterated mesodermal clusters ("cardiogenic clusters") that consti

64 e early stages of haematopoietic commitment (mesodermal colony formation) in vitro.

65 Finally, because our assay for mesodermal commitment is quantitative we are able to sho

66 isms underlying human embryonic development, mesodermal commitment, and cardiovascular specification.

67 We show that inactivation of Jagged1 in the mesodermal compartment of the coronal suture, but not in

68 development is separable from neural and/or mesodermal contributions.

69 nitors become temporarily sequestered in the mesodermal cores of pharyngeal arch 2 (PA2), where they

70 has not been characterised for this class of mesodermal CRMs.

71 after endodermal deletion of Nkx2.5 whereas mesodermal deletion engendered cardiac defects almost id

72 a new paradigm for how the kidney and other mesodermal derivatives arise during embryogenesis.

73 st is required to repress gene expression in mesodermal derivatives including muscle and notochord, a

74 f pharyngeal mesoderm and differentiation of mesodermal derivatives into vascular smooth muscle cells

75 specifically abolishes specification of late mesodermal derivatives such as the coelomic pouches to w

76 The ability of neural crest to contribute mesodermal derivatives to the bauplan has raised questio

77 th this, gene expression analysis shows that mesodermal derivatives within the trunk and tail of spt

78 but unlike Pax7, which is also expressed in mesodermal derivatives, this enhancer is not active in s

79 e and adults, which led to lethality; in the mesodermal derivatives, which led to pupal lethality; or

80 he body axis encompasses both ectodermal and mesodermal derivatives.

81 he intertwined processes of tail elongation, mesodermal development and somitogenesis.

82 ectively, this roadmap enables navigation of mesodermal development to produce transplantable human t

83 oadly conserved role for Foxd3 in vertebrate mesodermal development.

84 bx15 is a member of the T-box gene family of mesodermal developmental genes.

85 maintain Polycomb-mediated repression of non-mesodermal developmental regulators, suggesting cooperat

86 We have previously shown that the mesodermal developmental transcription factor Tbx15 is h

87 gh-level Wnt signaling is able to accelerate mesodermal differentiation cell-autonomously, just as we

88 sh Tbx16 (Spadetail) is capable of advancing mesodermal differentiation cell-autonomously.

89 Metabolic switching during endodermal and mesodermal differentiation coincides with a reduction in

90 ockdown, embryos fail to gastrulate and show mesodermal differentiation defects that we connect to in

91 how that NDST1 and NDST2 are dispensable for mesodermal differentiation into osteoblasts but necessar

92 Except for their potential for mesodermal differentiation into osteoblasts, the cells a

93 we are able to show that the acceleration of mesodermal differentiation is surprisingly incomplete, i

94 RA does not control pharyngeal mesodermal differentiation to endothelium, but instead p

95 ccompanies the earliest stages of neural and mesodermal differentiation.

96 ates body elongation and balances neural and mesodermal differentiation.

97 It is expressed in mesodermal domains flanking Mmp2-positive glia.

98 In contrast, mesodermal domains vary significantly in closely related

99 core mesoderm, we used Mesp1(Cre) and T-Cre mesodermal drivers in combination with inactivate Tbx1 a

100 o growth factor signaling and causes ectopic mesodermal, endodermal and epidermal fate commitment in

101 tor binding site motifs accurately predicted mesodermal enhancer activity.

102 posing the conserved and selective nature of mesodermal-epithelial communication in development and c

103 otein retains activity and can induce strong mesodermal expansion and axial dorsalization.

104 ntestinal setting that is not accompanied by mesodermal expression of Barx1, which is necessary for g

105 brates by the genomic complexity and the pan-mesodermal expression territory of Brachyury.

106 ound by Slou, Msh and other HD TFs that have mesodermal expression.

107 and Dfd (in both brachiopods) show staggered mesodermal expression.

108 ls co-express the neural factor Sox2 and the mesodermal factor Brachyury and differentiate into neura

109 yons that recapitulated ontogeny, with early mesodermal factors being expressed before mature endothe

110 stable switch, leading to maintenance of the mesodermal fate and repression of the bipotential progen

111 During vertebrate development, mesodermal fate choices are regulated by interactions be

112 cells to explore how these pathways control mesodermal fate choices in vitro.

113 understanding of the mechanisms that govern mesodermal fate decisions early during embryogenesis.

114 ies identify ER71 as a critical regulator of mesodermal fate decisions that acts to specify the hemat

115 id cell fate is suppressed via Nkx2-5 during mesodermal fate determination, and that the Gata1 gene i

116 (low)T(low) entity whose choice of neural or mesodermal fate is dictated by their position in the pro

117 fate and concomitantly skewed toward cardiac mesodermal fate.

118 hese cells are restricted to an intermediate mesodermal fate.

119 t ontogeny that is separable from neural and mesodermal fates.

120 We further demonstrate that a mesodermal Fgf24 convergence cue controlled by Tbx5a und

121 sensory neurons, and reveal a novel role for mesodermal Fgf8 on the early differentiation of the NC a

122 e found that Y397F embryos exhibited reduced mesodermal fibronectin (FN) and osteopontin expression a

123 These findings identify mesodermal foxc1a/b as a direct upstream regulator of et

124 on or axial development, indicating that the mesodermal function of Foxd3 is dependent on an active d

125 Here we show that sudden loss of the mesodermal gene (Brachyury) from CNH and the mesoderm pr

126 d-type embryos impaired dorsal organizer and mesodermal gene expression without perceptible earlier p

127 splays axial defects and reduced cyclops and mesodermal gene expression, and penetrance of the mesode

128 ated FGF activity and ectopically maintained mesodermal gene expression, implicating endogenous retin

129 gain-of-function results in expanded dorsal mesodermal gene expression, including the Nodal-related

130 ed inhibition of p53-directed ectodermal and mesodermal gene expression.

131 tem initiates non-interacting endodermal and mesodermal gene regulatory networks in veg2-derived cell

132 embryos results in reduction of a subset of mesodermal genes at gastrula stages.

133 n across species and found that Dl activates mesodermal genes at the same threshold levels in melanog

134 matin immunoprecipitation assays directed at mesodermal genes demonstrate that Geminin promotes Polyc

135 ression datasets indicate that regulation of mesodermal genes has diverged more markedly than regulat

136 displayed reduced expression of cyclops and mesodermal genes, axial defects similar to Nodal pathway

137 rmal state by not only activating downstream mesodermal genes, but also by repressing bipotential pro

138 ly derived from angioblasts specified in the mesodermal germ cell layer.

139 runk progenitors normally fated to enter the mesodermal germ layer can be redirected towards the neur

140 e a positive intergenic feedback loop in the mesodermal GRN.

141 ollective migration towards Fgf8a-expressing mesodermal guideposts.

142 from the epiblast, is a discrete part of the mesodermal heart field, and contributes myocardium after

143 Mesodermal identity is specified in a superficial layer

144 Mesodermal inactivation of Jagged1 also results in chang

145 s a key regulator of the signals involved in mesodermal induction of neural crest.

146 arch artery remodeling stem from the role of mesodermal integrin alpha5beta1 in neural crest prolifer

147 our studies demonstrate a requisite role for mesodermal integrin alpha5beta1 in signaling between the

148 netic events involving reciprocal endodermal-mesodermal interactions.

149 Mesodermal iPSC-derived progenitors (MiPs) can regenerat

150 ic iPSCs and a specifically isolated pool of mesodermal iPSC-derived progenitors (MiPs) toward the st

151 The authors also identified a novel pool of mesodermal iPSC-derived progenitors (MiPs).

152 Using neural and mesodermal landmarks we demonstrate that the functions o

153 iation while up-regulating genes involved in mesodermal lineage decisions.

154 atin remodeling factors confer robustness to mesodermal lineage determination.

155 e for microRNAs (miRNAs) in establishing the mesodermal lineage leading to both HSC emergence and vas

156 ripotency, formation of primitive streak and mesodermal lineage progression are synchronized in EBs.

157 Both adipocytes and osteoblasts share the mesodermal lineage that derives from mesenchymal stem ce

158 other organs capable of differentiating into mesodermal lineage tissues.

159 postembryonic cell divisions, including the mesodermal lineage.

160 4d is the origin of mesodermal lineages and the germline in many spiralians.

161 Epigenetic changes in adult lung mesodermal lineages are thought to contribute towards di

162 ipotent stem cells toward 80%-99% pure human mesodermal lineages at most branchpoints.

163 .g., neural lineages by Myt1 Isl1, and St18; mesodermal lineages by Pitx1, Pitx2, Barhl2, and Lmx1a;

164 specification and survival of ectodermal and mesodermal lineages during embryoid body formation and u

165 are unique in their ability to generate all mesodermal lineages including hematopoietic, endothelial

166 hoices leading from pluripotency to 12 human mesodermal lineages, including bone, muscle, and heart.

167 cell populations contributed to alternative mesodermal lineages, including the cardiac lineage.

168 reviously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progen

169 umours arise from endodermal, ectodermal, or mesodermal lineages.

170 lopment, although it is expressed broadly in mesodermal lineages.

171 Mesodermal loss of Ezh2 leads to the formation of ectopi

172 Unlike the global reduction of Fgf8, mesodermal loss of Fgf8 leads to a deficiency in PG neur

173 ifferentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamine

174 pecification pathway, specifically the early mesodermal marker Brachy-T, the lateral plate mesodermal

175 esodermal marker Brachy-T, the lateral plate mesodermal marker FLK1, and the endothelial-specific mar

176 ent of hESC-derived progenitors expressing a mesodermal marker, platelet-derived growth factor recept

177 genes with expression profile similar to the mesodermal master regulator Twist.

178 Cell lineage tracing demonstrated that mesodermal mesenchymal cells including HSCs are the majo

179 Furthermore, differentiation of the mesodermal mesenchymal cells into oval cells was not obs

180 duct ligation surgery-mediated liver injury, mesodermal mesenchymal cells, including HSCs and PFs, di

181 d classical ideas about the contributions of mesodermal mesenchyme and neural crest to particular str

182 Because ectodermal and mesodermal mesenchyme can form in close proximity and gi

183 the cranial neural crest (CNC) and cephalic mesodermal mesenchyme.

184 ate reconstruction suggests that contractile mesodermal midline cells existed in bilaterian ancestors

185 ial motion is typically attributed to active mesodermal migration over the underlying endoderm.

186 and this similarity with planarians suggests mesodermal muscle originated at the base of the Bilateri

187 By contrast, mesodermal Mypt1 morphant cells transplanted into wild-t

188 it into distinct domains that specify future mesodermal, neural, and ectodermal territories.

189 development, the function of the pancreatic mesodermal niche in this process is poorly understood.

190 l mutation with neural crest defects, but no mesodermal or axial phenotypes.

191 protocol to bias the differentiation toward mesodermal or endodermal cell lineage.

192 geting of T to regulatory elements of either mesodermal or PGC genes has implications for differentia

193 helial balance in the development of certain mesodermal organs.

194 The mesodermal origin of Gryllus PGCs and absence of instruc

195 tor function is only disrupted in tissues of mesodermal origin where a significant amount of CTCF is

196 tions of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling

197 elf-renewal, differentiation into tissues of mesodermal origin, and expression of phenotypic surface

198 ll populations of ectodermal, endodermal and mesodermal origin.

199 tes demonstrate that the scapula has a mixed mesodermal origin.

200 pporting cell types from both endodermal and mesodermal origins in a hexagonal lobule unit.

201 ards maintenance of pluripotency and favours mesodermal over neural fates upon differentiation, but t

202 model developmental system for understanding mesodermal patterning and organogenesis, a process that

203 that Goosecoid is an essential regulator of mesodermal patterning in mammals and that it has specifi

204 restricting CM specification during anterior mesodermal patterning, suggesting that between the two z

205 ermal gene expression, and penetrance of the mesodermal phenotypes is enhanced by Foxd3 knockdown.

206 P) and posterior-like (low activin/high BMP) mesodermal populations.

207 d the precise cellular origins of the larval mesodermal posterior growth zone.

208 With multilineage mesodermal potential and possible ectodermal and endoder

209 neration and migration of axial and paraxial mesodermal precursor cells by regulating EMT.

210 These arise in an Eng(+)Flk1(+) mesodermal precursor population at embryonic day 7.5 (E7

211 o specify mesoderm from a bipotential neural/mesodermal precursor.

212 ation movements place endodermal precursors, mesodermal precursors and primordial germ cells (PGCs) i

213 e show that Sox7 is transiently expressed in mesodermal precursors as they undergo specification to t

214 analyses have suggested a common origin from mesodermal precursors called hemangioblasts, specified i

215 Axial and paraxial mesodermal precursors ectopically accumulate in the PS a

216 embryos, the lineage specification of early mesodermal precursors expressing or not the Forkhead tra

217 tional in vitro studies suggest instead that mesodermal precursors first generate hemogenic endotheli

218 poietic stem cells, ACE identifies embryonic mesodermal precursors responsible for definitive hematop

219 These conditions induced pluripotent mesodermal precursors that give rise to a variety of som

220 se interactions regulate the transition from mesodermal precursors to cardiac progenitor cells (CPCs)

221 m cells (hESCs) revealed that MIXL1-positive mesodermal precursors were enriched for transcripts enco

222 chastic mechanism of PGC specification, from mesodermal precursors, is conserved in vertebrates.

223 CD90(+)CD73(+)CD31(-) multipotent clonogenic mesodermal precursors, which can be isolated and efficie

224 es the endodermal gene regulatory network in mesodermal precursors.

225 cell population, referred to as intermediate mesodermal progenitor (IMP) cells, is capable of unlimit

226 They also elucidate that chd;spt tailbud mesodermal progenitor cells (MPC) behave autonomously an

227 mp signaling pathway to regulate the fate of mesodermal progenitor cells (MPCs).

228 aused by widespread cell death that includes mesodermal progenitor cells that have begun to precociou

229 ular Tbeta4 can stimulate differentiation of mesodermal progenitor cells to a mature mural cell pheno

230 his approach to convert human fibroblasts to mesodermal progenitor cells, including by non-integrativ

231 rition-responsive reactivation of neural and mesodermal progenitor cells.

232 orly located population of bipotential neuro-mesodermal progenitor cells.

233 and endothelial cells develop from a common mesodermal progenitor, the haemangioblast.

234 to mesenchymal transition (EMT) from NMP to mesodermal progenitor.

235 thought to promote the formation of paraxial mesodermal progenitors (PMPs) of the trunk region while

236 was sufficient to activate Scx in mouse limb mesodermal progenitors and mesenchymal stem cells.

237 of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis.

238 ing limb, cartilage cells differentiate from mesodermal progenitors in an ordered process that result

239 cranio-facial musculature derive from common mesodermal progenitors that express NKX2-5, ISL1, and TB

240 ent stem zone epiblast, which contains neuro-mesodermal progenitors that progressively generate the s

241 sms that govern lineage specification of the mesodermal progenitors to become endothelial and hematop

242 gnaling during gastrulation and this enables mesodermal progenitors to commit to a blood fate.

243 in actively restraining the specification of mesodermal progenitors to hematopoiesis.

244 roughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder tran

245 Thus, the embryonic mesodermal progenitors uniquely establish their own nich

246 previously reported, more lineage-restricted mesodermal progenitors.

247 Wnt autoregulatory loop within the posterior mesodermal progenitors.

248 ively specify myoblasts from a pool of naive mesodermal progenitors.

249 Mesodermal progeny generated using such small molecules

250 ssion was induced when the isolated paraxial mesodermal progeny were treated with SAG1 (a hedgehog re

251 e effective generation from ESCs of paraxial mesodermal progeny, and to their further differentiation

252 on and propagation of a cell population with mesodermal properties.

253 rough the bilaterally symmetric divisions of mesodermal proteloblast DM'' and ectodermal proteloblast

254 However, symmetric cleavage of the mesodermal proteloblast was rescued by full length const

255 These studies demonstrate that mesodermal PTEN has a key role in controlling the amplif

256 To determine the role of mesodermal PTEN in the ontogeny of various mesenchymal c

257 We provide evidence for a model of trunk mesodermal RA action in which forelimb induction require

258 cupancy of Lmd-bound regions with additional mesodermal regulators revealed that different transcript

259 res, studies of TF cooccupancy by additional mesodermal regulators, TF binding site determination usi

260 We propose that variation in mesodermal size occurs at a fast evolutionary rate and i

261 organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factor

262 ovements during gastrulation, independent of mesodermal specification.

263 Tbx16 locks cells into the mesodermal state by not only activating downstream mesod

264 ient and required via SMAD2/3 to drive mouse mesodermal stem cells towards the tendon lineage ex vivo

265 Although mesodermal stem cells undergo normal rounds of division

266 brates is prefigured by reiterated embryonic mesodermal structures called somites.

267 er specifying the axial position relative to mesodermal structures of the hindbrain territory.

268 Thus, activin/BMP gradients specify distinct mesodermal subpopulations that generate cell derivatives

269 e streak (PS) and patterns subsequently into mesodermal subtypes and organ precursors.

270 etic protein 4 (BMP4) to polarize cells into mesodermal subtypes that reflect mid-primitive-streak ca

271 neural crest core mesoderm and specifically, mesodermal Tbx1, in shaping the lower jaw.

272 1 in osteochondro-progenitor (Tbx1(OPKO)) or mesodermal (Tbx1(MKO)) lineage partially recapitulates t

273 anscription factors strongly enlarges dorsal mesodermal territories.

274 sion of a corridor through a less-permissive mesodermal territory.

275 ere, we show that coordination of neural and mesodermal tissue at the zebrafish head-trunk transition

276 Changes in neural or mesodermal tissue configuration arising from defects in

277 Our understanding of how mesodermal tissue is formed has been limited by the abse

278 pathway - being robustly established within mesodermal tissue on the left side only.

279 ing cues specify germ layer contribution and mesodermal tissue type specification of multipotent stem

280 by coordinating the production of neural and mesodermal tissue.

281 t have been one of the earliest functions of mesodermal tissue.

282 he axial skeleton with origins from distinct mesodermal tissues have repatterned over the course of e

283 production is distributed between neural and mesodermal tissues in the dorsal isolate, and the notoch

284 hancers identified by eFS as being active in mesodermal tissues revealed enriched DNA binding site mo

285 t the functions of RA in aligning neural and mesodermal tissues temporally precede the specification

286 tion, patterning and alignment of neural and mesodermal tissues that are essential for the organizati

287 TACC1 and TACC2, which are also expressed in mesodermal tissues, including somites.

288 ex (Tin-C) controls the patterning of dorsal mesodermal tissues, including the dorsal vessel or heart

289 the development and homeostasis of multiple mesodermal tissues.

290 signaling can occur without inducing ectopic mesodermal tissues.

291 trulation and is unlikely to operate through mesodermal tissues.

292 migration phase and aberrantly contribute to mesodermal tissues.

293 the axial midline, which patterns neural and mesodermal tissues.

294 lier origin of NC, independent of neural and mesodermal tissues.

295 The hlh-8 gene encodes the C. elegans mesodermal transcription factor CeTwist.

296 Here we show that the mesodermal transcription factor T-box 15 (Tbx15) is high

297 own and putative, previously uncharacterized mesodermal transcription factors.

298 igration during Drosophila gastrulation: (I) mesodermal tube formation, (II) collapse of the mesoderm

299 an oncolytic agent extends to nonhematologic mesodermal tumors and that unusually strong resistance t

300 s secreted from the prospective dorsolateral mesodermal zone during gastrulation.