ライフサイエンスコーパス: mesodermal cell

1 th similarly exhibit an altered migration of mesodermal cells.

2 entiation of neighboring neuroectodermal and mesodermal cells.

3 for FGF-dependent migrations of tracheal and mesodermal cells.

4 site, binds to nuclear proteins from several mesodermal cells.

5 nal-mediated induction of a subpopulation of mesodermal cells.

6 the embryo before navigating toward gonadal mesodermal cells.

7 extension for neural deep cells than for the mesodermal cells.

8 ly described for convergent extension of the mesodermal cells.

9 ific somatic muscle precursors and glia-like mesodermal cells.

10 iate into Pax6(+)-neural precursor cells and mesodermal cells.

11 this largely twist-independent population of mesodermal cells.

12 foster tissue repair, and differentiate into mesodermal cells.

13 genitor, the hemangioblast, or directly from mesodermal cells.

14 efinitive, in mice are derived from Flk-1(+) mesodermal cells.

15 rect cell fate specifications of a subset of mesodermal cells.

16 r the formation of FLK1-expressing (FLK1(+)) mesodermal cells.

17 re sufficient to impose these fates on other mesodermal cells.

18 for delivering high Wg levels to a subset of mesodermal cells.

19 ing of the apical surface of the presumptive mesodermal cells and a constriction of their apical diam

20 s characteristics of early nondifferentiated mesodermal cells and can be induced to express either my

21 ment, the PAAs emerge from nkx2.5-expressing mesodermal cells and connect the dorsal head vasculature

22 proliferating and differentiated neural and mesodermal cells and is particularly high in developing

23 lls (MAPCs) that can differentiate into most mesodermal cells and neuroectodermal cells in vitro and

24 By imaging fluorescently labeled mesodermal cells and surrounding extracellular matrix si

25 1 is sufficient to induce additional gonadal mesodermal cells and to alter the temporal course of gen

26 ially-injected undifferentiated-iPSCs, day 4 mesodermal cells, and day 8, day 20, and day 30 purified

27 ng gastrulation in involuting endodermal and mesodermal cells, and in vertebrates at least, this expr

28 uring gastrulation in endodermal or nonaxial mesodermal cells, and it has been suggested that nonnoto

29 d the Wnt-beta-catenin pathway in these limb mesodermal cells are critical for muscle patterning.

30 tail bud regions, which are sites where new mesodermal cells are generated.

31 intact in mutant epiblasts, the prospective mesodermal cells are not recruited into the primitive st

32 During Drosophila embryogenesis, mesodermal cells are recruited to form a complex pattern

33 This structure, where the first mesodermal cells arise, marks the posterior aspect of th

34 e identified 27 genes expressed in glial and mesodermal cells associated with the midline cells.

35 ellular source of an inducer acts to pattern mesodermal cells at a distance in Xenopus embryos, it do

36 Ch-en is also expressed in a small group of mesodermal cells at the base of the chaetal sacs.

37 rphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.

38 n of the limb bud and in a discrete group of mesodermal cells at the midproximal posterior margin.

39 ction in stimulating migration of presomitic mesodermal cells away from the PS and a second cell auto

40 s in a more episodic manner than that of the mesodermal cells because the neural cells' mediolateral

41 The recruited mesodermal cells become epithelial and differentiate int

42 e that controls dynamic actin remodeling and mesodermal cell behaviors during Xenopus gastrulation.

43 Analyses of mesodermal cell behaviors revealed that Galpha(12/13) ar

44 w C-cadherin-based contacts with neighboring mesodermal cell bodies.

45 not essential for the initial commitment of mesodermal cells, but are crucial for maintenance of mes

46 In the grasshopper embryo, large mesodermal cells called muscle pioneers extend between t

47 hat the E(+)F(+) fraction at E7.5 represents mesodermal cells competent to respond to TGFbeta1, BMP4,

48 During Drosophila gastrulation, the ventral mesodermal cells constrict their apices, undergo a serie

49 ecause the production of both endodermal and mesodermal cells continues until the late prism stage, w

50 It is notable that the AER changes and mesodermal cell death occur earlier in the Shh(-/-) fore

51 reatic transcription factor causes increased mesodermal cell death, and the severity of defects is de

52 at function in the processes of neuronal and mesodermal cell development.

53 Vascular development begins when mesodermal cells differentiate into endothelial cells, w

54 w that, in some regions of the embryo, total mesodermal cell displacements are mostly due to convecti

55 of avian blastoderm cells, which replicated mesodermal cell diversification.

56 ate during their convergent extension as the mesodermal cells do, we predict that a given intercalati

57 partitioned into the nascent ectodermal and mesodermal cells during cleavage and early gastrulation

58 nction of the homeobox gene tinman in dorsal mesodermal cells during early embryogenesis.

59 The ectodermal cells contact migrating mesodermal cells during early gastrulation, concurrent w

60 In addition, Smad8 inhibits involution of mesodermal cells during gastrulation, a phenotype that i

61 suggest that Brn-4 enhances the survival of mesodermal cells during the mesenchymal remodeling that

62 umulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation.

63 Pw1 is initially expressed in all mesodermal cells early in development; however, its main

64 antation embryonic yolk sac, where clumps of mesodermal cells express PECAM before the development of

65 phila FGF is used, only in males, to recruit mesodermal cells expressing its receptor to become part

66 Mesodermal cells fail in their dorsal migrations after g

67 In the absence of Gravin, paraxial mesodermal cells fail to shut down the protrusive activi

68 cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell diffe

69 ishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and

70 nly in adipocyte differentiation but also in mesodermal cell fate determination.

71 he results suggest that the establishment of mesodermal cell fate requires the proper restriction of

72 A role for CeTwist in postembryonic mesodermal cell fate specification was indicated by ecto

73 ds to gastrulation defects without affecting mesodermal cell fate, whereas knockdown of USP12 in Xeno

74 transcriptional regulator to establish early mesodermal cell fate.

75 for initial specification of endodermal and mesodermal cell fate.

76 e important to ensure appropriate control of mesodermal cell fate.

77 iptional regulators, which, in turn, control mesodermal cell fate.

78 The two signals are known to regulate local mesodermal cell fates and to signal to the endoderm.

79 epithelial phenotype is to actively suppress mesodermal cell fates during early development.

80 a transcription factor that is required for mesodermal cell fates in all animals studied to date.

81 role in the decision between ectodermal and mesodermal cell fates in leech.

82 but they frequently lack the endodermal and mesodermal cell fates normally specified by a transcript

83 late is radially symmetrical with respect to mesodermal cell fates, single blastomeres of four cell s

84 asts (Flk1(+)/PECAM(-)), or undifferentiated mesodermal cells (Flk1(-)/PECAM(-)).

85 hat it exerts critical effects shortly after mesodermal cells form by gastrulation.

86 hat Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the

87 In addition, although dorsal mesodermal cells from lithium- or Wnt-exposed embryos ar

88 underlying this transition, we have isolated mesodermal cells from murine embryos at E7.5 with charac

89 ture of the cellular basis and regulation of mesodermal cell fusion and has important implications re

90 erive, respectively, from paraxial and axial mesodermal cell groups.

91 activation results in p53- and p21-dependent mesodermal cell growth arrest.

92 The extent to which specialized mesodermal cells homologous to the founders and pioneers

93 is derived from both neural crest cells and mesodermal cells; however, the majority of the bone, car

94 ilure of gastrulation movements, even though mesodermal cell identities are specified.

95 We identify a population of mesodermal cells in a developing invertebrate, the marin

96 blebby transitional morphology of involuting mesodermal cells in a vertebrate embryo.

97 d a population of lateral plate-derived limb mesodermal cells in both chick and mouse that expresses

98 the microtubule cytoskeleton of the visceral mesodermal cells in differentiation of the endodermal ce

99 wo genes are activated in specific groups of mesodermal cells in the anterior portions of each parase

100 During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrat

101 y expressed in the nucleus of endodermal and mesodermal cells in the cardiogenic plate.

102 During avian gastrulation, presumptive mesodermal cells in the dorsal epiblast ingress through

103 Here we demonstrate that individual mesodermal cells in the heart field gave rise to a clone

104 l cells efficiently promote the emergence of mesodermal cells in the neighboring population through s

105 hat identifies impaired migration of nascent mesodermal cells in the primitive streak as the morphoge

106 ired to determine the appropriate numbers of mesodermal cells in the third midgut chamber.

107 epithelial cells of the vulva as well as the mesodermal cells in the uterus of the somatic gonad.

108 We found that migrating mesodermal cells in vivo respond to Slit as both an attr

109 ibroblast growth factors (FGFs), made by the mesodermal cells, in promoting the proliferation, buddin

110 First, axial mesodermal cells, including prospective notochord, stop

111 Apical constriction of mesodermal cells initiates but is not completed.

112 he cell behaviors associated with neural and mesodermal cell intercalation, raising the possibility t

113 ic transcription factor Slouch, we asked how mesodermal cells interpret the steady flow of Wg.

114 The organization of mesodermal cells into endothelial and hematopoietic cell

115 The subdivision of mesodermal cells into muscle and non-muscle cells is cru

116 erentiation and propels a specific subset of mesodermal cells into somatic myogenesis.

117 ntinues to play additional roles, allocating mesodermal cells into the body wall muscle fate and patt

118 rected migration of individual lateral-plate mesodermal cells into the future limb-bud-producing regi

119 MCs fail to repress the transfating of other mesodermal cells into the skeletogenic lineage.

120 Acquisition of a cardiac fate by embryonic mesodermal cells is a fundamental step in heart formatio

121 ion of Xdsh at the membrane of normal dorsal mesodermal cells is consistent with Xdsh controlling cel

122 ered that hlh-8 expression in differentiated mesodermal cells is controlled by two well-conserved E b

123 episodic, whereas the protrusive activity of mesodermal cells is more continuous.

124 on of transient, serially repeated blocks of mesodermal cells known as somites.

125 in the Drosophila embryo defines a subset of mesodermal cells known as the muscle "pioneer" or "found

126 To explore the diversification of individual mesodermal cells, labeled QCE-6 cells were incorporated

127 polarizing cell movements between different mesodermal cell layers.

128 on, ectopic expression of cas in presumptive mesodermal cells leads to their transfating into endoder

129 Previous studies have shown that this quail mesodermal cell line possesses characteristics of early

130 e repressing their transformation into other mesodermal cell lineages (e.g. myocytes).

131 , sea urchin embryos eventually form various mesodermal cell lineages and a gut consisting of fore-,

132 age markers and could be differentiated into mesodermal cell lineages, including osteocytes and adipo

133 ins regulate the differentiation of distinct mesodermal cell lineages.

134 activity is produced by a selective group of mesodermal cells located adjacent to the choice point.

135 positive domain is continuous with a central mesodermal cell mass ventral and lateral to the dorsal a

136 rowth cones approach the choice point, these mesodermal cells migrate away, suggesting that unplugged

137 The recruited mesodermal cells migrate into the disc late in developme

138 bronectin-rich extracellular matrix on which mesodermal cells migrate using the same alpha5beta1 inte

139 Mesodermal cell migration defects in toddler mutants res

140 lts suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

141 ush is also required for mesodermal cell migration early in embryogenesis, where

142 We now report that proper mesodermal cell migration is dependent on the function o

143 However, htl-dependent mesodermal cell migration is not affected in dlp mutant

144 roblast growth factor (FGF) signaling guides mesodermal cell migration; however, we found some direct

145 verexpression of Zic1 and Pax3 in the 10T1/2 mesodermal cell model results in enrichment of these fac

146 During this process, mesodermal cells move toward the future dorsal side of t

147 During amphibian gastrulation, mesodermal cell movements depend on both cell-cell and c

148 The biophysical mechanisms driving mesodermal cell movements during gastrulation in amniote

149 A subpopulation of mesodermal cells moving ventrally from the somatopleural

150 sal closure cells), in a small percentage of mesodermal cells (muscle pioneers), and throughout the d

151 evel syndecan-3 expression in the outgrowing mesodermal cells of explants of the posterior mesoderm o

152 In the mouse embryo, the splanchnic mesodermal cells of the anterior heart field (AHF) migra

153 abundantly expressed by the distal subridge mesodermal cells of the chick limb bud and also by the A

154 lycan that is highly expressed by the distal mesodermal cells of the chick limb bud that are undergoi

155 9 at full germ-band extension in a subset of mesodermal cells organized in a stereotypic pattern in e

156 e close ontogenic origins, and that an early mesodermal cell population has the potential to differen

157 The recent finding that distinct mesodermal cell populations are segregated within the no

158 nstrated that Runx1 is expressed in yolk sac mesodermal cells prior to the establishment of the blood

159 is, in enhancing FGF signaling that leads to mesodermal cell proliferation without induction of myoge

160 RA, produced by newly generated mesodermal cells, provides feedback that initiates NMP g

161 s raises the question of how the presumptive mesodermal cells recognize the multiple TGF-beta signals

162 In insects, specialized mesodermal cells serve as templates to organize myoblast

163 Mesodermal cells signal to neighboring epithelial cells

164 Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic da

165 oncomitant induction of an ambivalent neural/mesodermal cell state.

166 r Twist and its own gene product in visceral mesodermal cells, supporting the idea that twist and NK-

167 SCL is first expressed in mesodermal cells that give rise to embryonic blood cells

168 1) TAL1 and Flk1 are coexpressed in isolated mesodermal cells that give rise to endothelial cells and

169 ement generates a stereotyped arrangement of mesodermal cells that is essential for their correct pat

170 with decreased Notch activity originate from mesodermal cells that normally produce erythrocyte proge

171 fic RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adja

172 tructures differentiate from extra-embryonic mesodermal cells that underlie the visceral endoderm.

173 se that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signal

174 of SoxB1 proteins in the limb bud confers on mesodermal cells the potential to activate neural-specif

175 In the zebrafish embryo, a subset of mesodermal cells, the adaxial cells, delineates the pros

176 cation and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs).

177 the muscle pattern is organised by specific mesodermal cells, the founder myoblasts, which initiate

178 ct towards a group of posterior intermediate mesodermal cells, the metanephric mesenchyme, and induce

179 s mediated by regulation of Wnt signaling in mesodermal cells through activation of integrin-beta1.

180 en implicated in the commitment of embryonic mesodermal cells to a hematopoietic fate in a number of

181 ht to provide a signal that induces adjacent mesodermal cells to adopt a cardiac fate.

182 Vasculogenesis, the differentiation of mesodermal cells to angioblasts and the subsequent forma

183 in acts within a subpopulation of splanchnic mesodermal cells to control an essential early step in s

184 This domain is crucial for the allocation of mesodermal cells to distinct fates, such as heart, gut a

185 and Gata2 is required in both ectodermal and mesodermal cells to enable mesoderm to commit to a hemat

186 Founders appear to recruit fusion-competent mesodermal cells to establish a particular muscle fiber

187 as a central role in the induction of dorsal mesodermal cells to form the Spemann organizer.

188 indicate that RA inhibits the commitment of mesodermal cells to hematopoietic fates, functioning dow

189 tive feedback loop that limits allocation of mesodermal cells to the extreme ventral fate, with direc

190 ion must occur at or prior to the arrival of mesodermal cells to the heart field.

191 fy mesoderm and the subsequent allocation of mesodermal cells to the somatic muscle fate.

192 tive neural ectodermal cells, or upon dorsal mesodermal cells, to cause a loss of anterior pattern.

193 ability of GATA5 to respecify ectodermal and mesodermal cells towards endoderm suggests an important

194 protein (Bmp) signaling is known to regulate mesodermal cell type determination along the medio-later

195 One mesodermal cell type resulting from this in vivo inducti

196 mal specification and the differentiation of mesodermal cell types (twist, snailA, snailB, forkhead,

197 requires inductive interactions with diverse mesodermal cell types and the action of transcription fa

198 Neuronal and mesodermal cell types are generated in separate cell lin

199 In C. elegans, many mesodermal cell types are made by descendants of the pro

200 a significant delay in the formation of all mesodermal cell types examined.

201 icular interest because it induces different mesodermal cell types in a concentration-dependent manne

202 beta family member activin induces different mesodermal cell types in a dose-dependent fashion in the

203 ne at different embryonic stages and in four mesodermal cell types is governed by the binding of mult

204 and perhaps other BMP inhibitors secreted by mesodermal cell types that flank the ventral neural tube

205 ly, in oral or aboral domains, presaging the mesodermal cell types that will emerge.

206 is required for a variety of ectodermal and mesodermal cell types, including cells in the hindgut; (

207 stage of embryogenesis, generates primarily mesodermal cell types, including pharynx cells, body mus

208 LvNumb is necessary for the specification of mesodermal cell types, including pigment cells, blastoco

209 ry and sufficient for the development of two mesodermal cell types, pigment cells and blastocoelar ce

210 lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types

211 ioserosa as well as different ectodermal and mesodermal cell types.

212 may function differentially in neuronal and mesodermal cell types.

213 s for the normal development of neuronal and mesodermal cell types.

214 and that the veg2 lineage also gives rise to mesodermal cell types.

215 oliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fa

216 During gastrulation, zebrafish mesodermal cells undergo a series of conversions from am

217 on with or immediately after subducting, the mesodermal cells undergo an epithelial-to-mesenchymal tr

218 The resulting unspecified mesodermal cells undergo programmed cell death.

219 ientation and migration behaviors of lateral mesodermal cells undergoing convergence and extension mo

220 -11/planar cell polarity signaling polarizes mesodermal cells undergoing convergent extension during

221 tes cell polarization and axial alignment of mesodermal cells undergoing gastrulation independent of

222 ess zone, the highly proliferating posterior mesodermal cells underneath the apical ectodermal ridge

223 Prx1 promotes EC differentiation, fetal lung mesodermal cells were transfected with full-length Prx1

224 Its anterior daughter, MS, makes primarily mesodermal cells, while its posterior daughter E generat

225 ntified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, expos

226 tive within the M lineage and in a number of mesodermal cells with nonstriated muscle fates.

227 tic stem cells (HSCs) are first derived from mesodermal cells within a region of the embryonic para-a

228 undreds of ectodermal cells and internalized mesodermal cells within Drosophila embryos over 2 hours

229 common or separate progenitor populations of mesodermal cells within the heart field.

230 n, canonical Wnts promote the recruitment of mesodermal cells within this region into the pacemaker l