ライフサイエンスコーパス: mesolimbic

1 This unique pattern of effects suggests that mesolimbic 5-HT(1B)Rs differentially modulate cocaine ab

2 esponses in laboratory animals-could inhibit mesolimbic activation elicited by subliminal cocaine cue

3 We found TOPJ and mesolimbic activation in children's response to humor, s

4 Mesolimbic activation of cholinergic projections to the

5 ical modulating structure in cocaine-induced mesolimbic activity and behavioral manifestation of rewa

6 tra-vHipp cannabinoid signaling may modulate mesolimbic activity states and emotional processing are

7 ipp) is a critical neural region controlling mesolimbic activity via glutamatergic projections to the

8 cholamine precursors will blunt dopaminergic mesolimbic activity, and (2) in controls, synthetic path

9 demonstrate that this phenomenon extends to mesolimbic afferents, and confirm that the released neur

10 Mesolimbic alpha6* nicotinic acetylcholine receptors (nA

11 both nicotine and cocaine may be mediated by mesolimbic alpha6beta2* nAChRs and that antagonists of t

12 e, they demonstrate a novel context in which mesolimbic and declarative memory systems interact.

13 d transmits representations of reward to the mesolimbic and mesocortical dopamine systems, thereby in

14 ssion, but also with a parallel shift toward mesolimbic and mesocortical function.

15 jections and in an animal model that affects mesolimbic and mesocortical function.

16 ircuitry, which may reflect abnormalities in mesolimbic and mesostriatal dopamine (DA).

17 or is driven by dopaminergic transmission in mesolimbic and mesostriatal systems.

18 t we focused on functional units such as the mesolimbic and motor circuits which were analyzed using

19 literature on food addiction indicates that mesolimbic and nigrostriatal dopamine systems often are

20 axon guidance of mDAs and the segregation of mesolimbic and nigrostriatal dopaminergic pathways.

21 , correlations of rates of metabolism in the mesolimbic and nigrostriatal systems with the amount of

22 They further suggest that mesolimbic and non-limbic basal ganglia dopamine circuit

23 The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based s

24 ation and reward processing were detected in mesolimbic and striatal areas.

25 OCD group displayed abnormal recruitment of mesolimbic and ventral striatal circuitry during reward-

26 egmental area, which form the nigrostriatal, mesolimbic, and mesocortical pathways.

27 of sexual behavior and neural activation in mesolimbic areas induced by mating-associated conditione

28 ias modification affects alcohol cue-induced mesolimbic brain activity.

29 e-based reinforcement signals, we found that mesolimbic brain areas encoded both anticipation and pre

30 , alcohol cues evoke increased activation in mesolimbic brain areas, such as the nucleus accumbens an

31 urbances of prefrontal control mechanisms on mesolimbic brain circuits have also been reported in bip

32 sized this effect arises from actions within mesolimbic brain regions that we targeted by viral gene

33 ion of Clock alters cellular function within mesolimbic brain regions, little remains known about how

34 f LepRb neurons and their projections within mesolimbic brain regions.

35 ew mechanisms by which dietary fat may alter mesolimbic circuit function and reward seeking.

36 rcuit normalizing top-down processes, 3) the mesolimbic circuit improving social reward experiences,

37 In conclusion, important relays of the mesolimbic circuit were involved in the inhibition of it

38 ss context-detecting function of the brain's mesolimbic circuit.

39 simultaneously illuminates nigrostriatal and mesolimbic circuitry and shows no overlap, demonstrating

40 utcome associations are thought to depend on mesolimbic circuitry involving the nucleus accumbens (NA

41 antipsychotic-like properties of CBD in the mesolimbic circuitry.

42 iet, consistent with greater responsivity of mesolimbic circuits in obesity-susceptible groups.

43 a critical role for ghrelin in dopaminergic mesolimbic circuits involved in food reward signaling.

44 ice and confidence reports and show that the mesolimbic confidence prediction error modulation derive

45 the role of the anterior and frontal lobes, mesolimbic connections and the right hemisphere.

46 cortico-striatal circuits and an increase in mesolimbic cross-structural coherence.

47 ciated with the illness and that blockade of mesolimbic D(2) receptors is responsible for the antipsy

48 y influence of intra-PFC CB1 transmission on mesolimbic DA activity.

49 oned appetitive behaviors known to depend on mesolimbic DA activity.

50 y role for the mPOA in the inhibition of the mesolimbic DA circuit.

51 ect evidence that drug-induced alteration in mesolimbic DA function underlies this hypersensitivity t

52 luene induces a target-selective increase in mesolimbic DA neuron synaptic transmission and strongly

53 Thus, subpopulations of mesolimbic DA neurons show different in vitro properties

54 mate is packaged and released by a subset of mesolimbic DA neurons, eliciting EPSCs onto medium spiny

55 riatal regions; and (iv) amphetamine-induced mesolimbic DA release (males increased; females decrease

56 on PFC terminals within the NAc that inhibit mesolimbic DA release and constrain reward-driven behavi

57 (KORs) have an important role in regulating mesolimbic DA signaling, and other kinds of stressors ha

58 naling controls energy balance by modulating mesolimbic DA signaling.

59 ncentive motivation through augmented phasic mesolimbic DA signaling.

60 neurons each modulate unique aspects of the mesolimbic DA system and behavior in response to leptin.

61 he mechanisms by which leptin influences the mesolimbic DA system and related behaviors.

62 omer, regulates the sensitivity of the mouse mesolimbic DA system to drugs with addictive potential.

63 f evidence suggest that leptin regulates the mesolimbic DA system via multiple neural pathways and pr

64 These results support a key role for the mesolimbic DA system, but a more nuanced role for endoge

65 ialysis and microinjection of drugs into the mesolimbic DA system, we demonstrate in mice and rats th

66 h LepRb neurons might directly influence the mesolimbic DA system, we examined the distribution of Le

67 and promotes a complex set of changes in the mesolimbic DA system.

68 caine induces long-lasting remodeling of the mesolimbic DA system.

69 induced by inflammatory pain on MOR-mediated mesolimbic DA transmission and on rat intravenous heroin

70 receptor subunits selectively in identified mesolimbic DA VTA, but not nigrostriatal DA SN, neurons.

71 oned to influence striatal functions through mesolimbic DA-striatal pathways.

72 vide the first conclusive demonstration that mesolimbic DAergic neurons in mice release glutamate and

73 vated by reward through interaction with the mesolimbic dopamine (DA) and endogenous opioid systems.

74 The mesolimbic dopamine (DA) circuitry determines which beha

75 The mesolimbic dopamine (DA) circuitry determines which beha

76 Mesolimbic dopamine (DA) circuits mediate a wide range o

77 similar to the effects of interference with mesolimbic dopamine (DA) function.

78 Mesolimbic dopamine (DA) is phasically released during a

79 Dynamic signaling of mesolimbic dopamine (DA) neurons has been implicated in

80 Orchestrated signaling from mesolimbic dopamine (DA) neurons is important for initia

81 Activation of KORs negatively regulates mesolimbic dopamine (DA) neurons, and KOR agonists produ

82 Glutamatergic input within the mesolimbic dopamine (DA) pathway plays a critical role i

83 ations in motivational systems including the mesolimbic dopamine (DA) pathway.

84 e memories and is functionally linked to the mesolimbic dopamine (DA) pathway.

85 is known to induce long-term alterations in mesolimbic dopamine (DA) signaling that are hypothesized

86 Understanding the interactions between the mesolimbic dopamine (DA) system (which mediates the ince

87 that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadap

88 The mesolimbic dopamine (DA) system encodes information abou

89 efrontal cortex (mPFC) is a component of the mesolimbic dopamine (DA) system involved in psychostimul

90 Synaptic plasticity in the mesolimbic dopamine (DA) system is critically involved i

91 biological reward mechanisms, especially the mesolimbic dopamine (DA) system.

92 ributed to the activation of KORs within the mesolimbic dopamine (DA) system.

93 e BLC is also one of the main targets of the mesolimbic dopamine (DA) system.

94 ypothalamic structures, leptin modulates the mesolimbic dopamine (DA) system.

95 psychosis is associated with disturbances in mesolimbic dopamine (DA) transmission, characterized by

96 tered mu opioid receptor (MOR) regulation of mesolimbic dopamine (DA) transmission.

97 teractions between neural systems supporting mesolimbic dopamine activation, episodic memory, and per

98 tween natural and drug rewards, and identify mesolimbic dopamine as a key mediator of changes in vuln

99 we have identified major projections to the mesolimbic dopamine circuit from the lateral hypothalamu

100 synaptic circuits.SIGNIFICANCE STATEMENT The mesolimbic dopamine circuit integrates signals from key

101 and lateral hypothalamus that project to the mesolimbic dopamine circuit.

102 piate exposure begins with activation of VTA mesolimbic dopamine circuitry, providing a mechanism for

103 Prolonged mesolimbic dopamine concentration changes have been dete

104 However, the role of mesolimbic dopamine for sexual behavior or cross-sensiti

105 n relation to alcohol-related phenotypes and mesolimbic dopamine function in both mice and adolescent

106 d long-term adaptations in eCB-regulation of mesolimbic dopamine function, and thereby hijack neural

107 ccomplished via eCB-dependent alterations in mesolimbic dopamine function, which plays an obligatory

108 These findings demonstrate a role of mesolimbic dopamine in the interaction between natural a

109 pse due to conditioned craving and implicate mesolimbic dopamine in this process.

110 ial shell of nucleus accumbens (NAc) and its mesolimbic dopamine inputs mediate forms of fearful as w

111 effort, and effort-related decision-making, mesolimbic dopamine is only one part of a distributed ci

112 motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational sympt

113 or example, although it is often stated that mesolimbic dopamine mediates reward, there is no standar

114 cate a role for RASGRF2 in the regulation of mesolimbic dopamine neuron activity, reward response, an

115 everse both vHipp hyperactivity and aberrant mesolimbic dopamine neuron function in the MAM model of

116 To molecularly profile mesolimbic dopamine neurons and their presynaptic inputs

117 ese data suggest that the firing patterns of mesolimbic dopamine neurons in vivo mediate an individua

118 The firing of mesolimbic dopamine neurons is important for drug-induce

119 We previously reported that the activity of mesolimbic dopamine neurons of the ventral tegmental are

120 electively enhanced the bursting activity of mesolimbic dopamine neurons that were excited by aversiv

121 DA receptor (NMDAR)-mediated transmission in mesolimbic dopamine neurons, a form of synaptic plastici

122 Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-se

123 cated that 5-HT2B receptors are expressed by mesolimbic dopamine neurons.

124 tant regulator of drug-induced plasticity of mesolimbic dopamine neurons.

125 drive future feeding behavior by "rewiring" mesolimbic dopamine neurons.

126 ese studies identify important inputs to the mesolimbic dopamine pathway and further show that PRV ci

127 The mesolimbic dopamine pathway receives inputs from numerou

128 to arise from maladaptive plasticity in the mesolimbic dopamine pathway.

129 raise the possibility that disinhibition of mesolimbic dopamine pathways contributes to impaired att

130 hese findings support the involvement of the mesolimbic dopamine pathways in the hedonic mechanisms c

131 aversive events may correspond to segregated mesolimbic dopamine pathways; however, this prediction h

132 The mesolimbic dopamine projection from the ventral tegmenta

133 clofen-a GABAB receptor agonist that reduces mesolimbic dopamine release and conditioned drug respons

134 eking actions, induced an increase in phasic mesolimbic dopamine release and produced slower elevatio

135 ntrary to the prevailing view, inhibition of mesolimbic dopamine release does not mediate the aversiv

136 tly accepted theories suggest that transient mesolimbic dopamine release events energize reward seeki

137 These data suggest that those phasic mesolimbic dopamine release events thought to signal rew

138 These data suggest that phasic mesolimbic dopamine release mediates the influence that

139 ese data show that subsecond fluctuations in mesolimbic dopamine release predict when rats will succe

140 We observed greater cue-evoked mesolimbic dopamine release to options yielding the high

141 scan cyclic voltammetry, we monitored phasic mesolimbic dopamine release, in real time, as rats perfo

142 -opioid systems and subsequent depression of mesolimbic dopamine release.

143 In part, this might reflect perturbed mesolimbic dopamine responses.

144 ntral tegmental area--a key component of the mesolimbic dopamine reward and motivation system--predic

145 in-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown.

146 aration of costs and benefits indicates that mesolimbic dopamine scales with the value of pending rew

147 ansmission in key brain circuits such as the mesolimbic dopamine system and medial prefrontal cortex

148 e implicates cue-triggered activation of the mesolimbic dopamine system as an important contributing

149 Exogenous activation of the mesolimbic dopamine system facilitates motivated behavio

150 ys that modulate the activity of the cortico-mesolimbic dopamine system have been shown to alter drin

151 characterizing the effects of smoking on the mesolimbic dopamine system in humans.

152 The mesolimbic dopamine system is believed to be a pathway t

153 The mesolimbic dopamine system is strongly implicated in mot

154 fore, the identification of pathology of the mesolimbic dopamine system may aid in understanding thei

155 evidence that glutamate receptors within the mesolimbic dopamine system play an essential role in alc

156 ewly identified TLR4/MD2 actions, affect the mesolimbic dopamine system that amplifies opioid-induced

157 ent activation of the ventral tegmental area mesolimbic dopamine system triggers the expression of an

158 Although numerous studies link the mesolimbic dopamine system with these processes, how dop

159 mPFC circuits is a critical regulator of the mesolimbic dopamine system's ability to respond to volat

160 The results suggest that the mesolimbic dopamine system, especially the ventral tegme

161 ed activation in brain regions that form the mesolimbic dopamine system, including the nucleus accumb

162 ncluding classic pleasure electrodes and the mesolimbic dopamine system, may not generate pleasure af

163 Within the mesolimbic dopamine system, optogenetics has helped sepa

164 daptations in inhibitory circuits within the mesolimbic dopamine system, suggesting that addictive be

165 We specifically targeted the mesolimbic dopamine system, the site of action for virtu

166 ulates dopaminergic neurotransmission in the mesolimbic dopamine system, thereby influencing the rewa

167 aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aS

168 es dopamine D(2) receptor sensitivity in the mesolimbic dopamine system, which contributes to drug re

169 whether its regulatory effects involved the mesolimbic dopamine system, which mediates motivated and

170 stimulus, with a crucial involvement of the mesolimbic dopamine system.

171 volve common neural circuitry, including the mesolimbic dopamine system.

172 esity involves altered activation within the mesolimbic dopamine system.

173 f withdrawal involve reduced activity in the mesolimbic dopamine system.

174 tral tegmental area (VTA), the origin of the mesolimbic dopamine system.

175 urons and orexin receptor-1 signaling in the mesolimbic dopamine system.

176 donic feeding via positive modulation of the mesolimbic dopamine system.

177 These processes are thought to involve the mesolimbic dopamine system.

178 volve common neural circuitry, including the mesolimbic dopamine system.

179 attributed to their ability to activate the mesolimbic dopamine system.

180 , in part, by modulating the activity of the mesolimbic dopamine system.

181 , the similarities between nigrostriatal and mesolimbic dopamine systems can be as important as their

182 l evidence for independent nigrostriatal and mesolimbic dopamine systems has, however, long been obso

183 tend beyond the hedonic hotspots, as well as mesolimbic dopamine systems, and corticolimbic glutamate

184 n error) defined by a computational model of mesolimbic dopamine systems.

185 e learning processes through perturbation of mesolimbic dopamine systems.

186 ion making and an associated perturbation in mesolimbic dopamine transmission in adulthood.

187 Recent theories addressing mesolimbic dopamine's role in reward processing emphasiz

188 nsmission evoked by the strong activation of mesolimbic dopamine-a defining feature of all addictive

189 s in motivation may be due to alterations to mesolimbic dopamine.

190 RK3 KO mice showed a blunted response of the mesolimbic dopaminergic (DA) pathway to ethanol, as asse

191 in the central system, including portions of mesolimbic dopaminergic circuitry that play a role in af

192 Muscarinic modulation of mesolimbic dopaminergic neurons in the ventral tegmental

193 mmatory pain and loss of MOR function in the mesolimbic dopaminergic pathway that increases intake of

194 n on physiology and behavior mediated by the mesolimbic dopaminergic pathway, particularly in the ter

195 ties of ethanol are related to activation of mesolimbic dopaminergic pathways resulting in a release

196 ble for the segregation of nigrostriatal and mesolimbic dopaminergic pathways.

197 tral tegmental area (VTA), the origin of the mesolimbic dopaminergic reward system.

198 oral and dopaminergic neuronal correlates of mesolimbic dopaminergic sensitization, via a direct inte

199 One major regulator of the mesolimbic dopaminergic system is the medial prefrontal

200 The integrity of the mesolimbic dopaminergic system was assessed using tyrosi

201 ions on opioid receptors, which modulate the mesolimbic dopaminergic system, and provides a neurobiol

202 rmed to assess possible modifications of the mesolimbic dopaminergic system, which is critically invo

203 activity was used as a general 'read out' of mesolimbic function after 'junk-food' consumption.

204 d diet- vs obesity-associated alterations in mesolimbic function and receptor expression.

205 y deficit in the paralimbic cortex or in its mesolimbic input.

206 ms: the limbic brain imparting risk, and the mesolimbic learning processes reorganizing the neocortex

207 heroin doses with concomitant alterations in mesolimbic MOR function suggested by DA microdialysis.

208 self-activation was accompanied by increased mesolimbic network connectivity.

209 A mesolimbic network supports reward learning, but it is u

210 tion of the ventral tegmental area (VTA) and mesolimbic networks is essential to motivation, performa

211 l cannabinoid signaling in the modulation of mesolimbic neuronal activity states and suggest that dys

212 de polymorphism in the Eif2s1 gene modulates mesolimbic neuronal reward responses in human smokers.

213 schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys

214 Here we evaluated the contribution of mesolimbic NMDARs and AMPARs in mediating alcohol-seekin

215 Most of the literature focuses on the mesolimbic nuclei as the core of reward behavior regulat

216 ecently, the ventral tegmental area (VTA), a mesolimbic nucleus important for food intake and reward,

217 al reward and drugs of abuse converge on the mesolimbic pathway and activate common mechanism of neur

218 ral reward by causing neuroplasticity in the mesolimbic pathway during the natural reward experience.

219 se KOR inhibition of dopamine release in the mesolimbic pathway has been proposed to mediate the dysp

220 reward anticipation was detected within the mesolimbic pathway in healthy and psychiatric participan

221 hat pain-induced loss of MOR function in the mesolimbic pathway may promote opioid dose escalation an

222 ion of these behaviors via 5-HT(1B)Rs in the mesolimbic pathway may vary depending on the stage of th

223 exhibited increased dopamine release in the mesolimbic pathway while also exhibiting a decrease in d

224 riphery to mesolimbic reward circuits (spino-mesolimbic pathway) and the activation of somatosensory

225 rats exhibited decreased DA D2R mRNA in the mesolimbic pathway, and increased 5-HT2cR mRNA in the or

226 Gyrus (t=2.049, p=0.007), along the dopamine mesolimbic pathway, had higher neuronal oscillations in

227 terized by hyperdopaminergic activity in the mesolimbic pathway.

228 fferent to the nucleus accumbens, within the mesolimbic pathway.

229 with mTOR/p70S6 kinase signaling within the mesolimbic pathway.

230 othalamic, extended amygdala, brainstem, and mesolimbic pathways.

231 ns, revealing complex GABAergic control over mesolimbic processes.

232 rd-related phasic population activity of the mesolimbic projection.

233 The ventral tegmental area (VTA) and its mesolimbic projections are critical structures involved

234 In both birds and mammals, mesolimbic projections arise primarily from the ventral

235 n of fluoxetine would produce adaptations in mesolimbic regions after 2 weeks of treatment.

236 ion results in dysfunction of prefrontal and mesolimbic regions in the preweanling rat brain that may

237 PJ), involved in incongruity resolution, and mesolimbic regions, involved in reward processing.

238 hich exclusively correlated with activity in mesolimbic regions.

239 e it should show alterations in the cortical-mesolimbic response.

240 istent results, showing either bidirectional mesolimbic responses of activation for gains and deactiv

241 contextual cues during oestrus have enhanced mesolimbic responses to these cues in the absence of dru

242 vation amplifies reactivity throughout human mesolimbic reward brain networks in response to pleasure

243 bsence of hypothalamic hypocretin control on mesolimbic reward centers is crucial in determining cata

244 Although long-term modifications of mesolimbic reward circuit following cocaine exposure are

245 mans, COAs have different functioning of the mesolimbic reward circuitry beyond previous substance us

246 n spinal cord that ascends from periphery to mesolimbic reward circuits (spino-mesolimbic pathway) an

247 the hypothesis that TG might directly target mesolimbic reward circuits to control reward-seeking beh

248 ey an inhibitory input from the periphery to mesolimbic reward circuits.

249 n the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway.

250 ction between auditory cortical networks and mesolimbic reward networks.

251 uced connectivity between brain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala)

252 ctivation were found in key areas within the mesolimbic reward pathway, which were significantly more

253 n of multiple excitatory synapses in cortico-mesolimbic reward pathways contributes, in part, to the

254 ditioning, memory-related behaviors, and the mesolimbic reward pathways.

255 ate that, in addition to DAergic mechanisms, mesolimbic reward signaling may involve glutamatergic tr

256 imuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced mot

257 reward-related contextual information to the mesolimbic reward system known to be involved in social

258 ontal areas exerting top-down control on the mesolimbic reward system was reduced in this group.

259 ractions with the social control network and mesolimbic reward system, are conserved among vertebrate

260 reward that are exerted at the level of the mesolimbic reward system.

261 drome was associated with alterations in the mesolimbic reward system.

262 context: the social behavior network and the mesolimbic reward system.

263 Rs are expressed in several key nodes of the mesolimbic reward system; however, their function remain

264 ne is central to the nigrostriatal motor and mesolimbic reward systems.

265 ke of high-fat and high-sugar food activates mesolimbic reward, gustatory, and oral somatosensory bra

266 tive reinforcement through activation of the mesolimbic reward-valuation circuitry.

267 Patients with the greatest atrophy in a mesolimbic, reward-related (affiliation) network exhibit

268 to question the therapeutic relevance of the mesolimbic selectivity of second-generation antipsychoti

269 signaling, which orchestrate activity of the mesolimbic social decision-making network.

270 Second, we review evidence concerning the mesolimbic striatal system and its involvement in reward

271 epigenetic regulation of PDYN expression in mesolimbic striatonigral/striatomesencephalic circuits p

272 essed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward.

273 of food reward could be driven from two key mesolimbic structures-ventral tegmental area and nucleus

274 hat process TG-enriched particles, including mesolimbic structures.

275 tep for the functional reorganization of the mesolimbic system after drug exposure.

276 riatum is a central part of the dopaminergic mesolimbic system and contributes both to the encoding a

277 oanatomical locus modulating activity in the mesolimbic system and emergent behavioral expressions of

278 lar mediator of alcohol's actions within the mesolimbic system and put forward the potential value of

279 known whether glutamate receptors within the mesolimbic system are involved in mediating the addictiv

280 However, the mesolimbic system does not operate in isolation, and inp

281 Nalmefene blunts BOLD response in the mesolimbic system during anticipation of monetary reward

282 standing of the functional properties of the mesolimbic system during memory encoding and retrieval.

283 rgic neurotransmission that occur within the mesolimbic system following cocaine exposure.

284 mesolimbic system.SIGNIFICANCE STATEMENT The mesolimbic system is involved in the encoding and retrie

285 ds also increase dopamine release within the mesolimbic system, a neural pathway generally implicated

286 egulates the release of dopamine (DA) in the mesolimbic system, as well as the rewarding properties o

287 ing the striatum, but not other parts of the mesolimbic system, in tracking context-dependent salienc

288 od reward/motivation by interacting with the mesolimbic system, indicate an entirely novel mechanism

289 euroanatomical connections with areas of the mesolimbic system, particularly the ventral tegmental ar

290 atterns in the major output structure of the mesolimbic system, the ventral pallidum (VP).

291 inase in the regulation of DA release in the mesolimbic system, which leads to the control of alcohol

292 ohol-induced allostatic DA deficiency in the mesolimbic system.

293 ocaine-induced neurochemical activity in the mesolimbic system.

294 lar in aspects to the role of the vertebrate mesolimbic system.

295 y modulates the functional properties of the mesolimbic system.SIGNIFICANCE STATEMENT The mesolimbic

296 al for the induction of cortico-striatal and mesolimbic theta oscillatory activity, the influence of

297 pain as failure of avoidant behavior, and a mesolimbic threshold process that gates the transformati

298 ling in the prefrontal cortex (PFC) promotes mesolimbic transmission and drug-induced behaviors, the

299 We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefronta

300 that D2R signaling differentially regulates mesolimbic- versus nigrostriatal-mediated functions.