ライフサイエンスコーパス: mesothelial cell

1 ne marrow derived macrophages, as well as by mesothelial cells.

2 signaling pathway compared with normal human mesothelial cells.

3 f neutrophils via IL-1R/MyD88 on neighboring mesothelial cells.

4 tumor 1 gene (Wt1) is expressed only in the mesothelial cells.

5 -6 from macrophages but robust production in mesothelial cells.

6 assayed for in vitro cytotoxicity to murine mesothelial cells.

7 ar matrix proteins, as well as to peritoneal mesothelial cells.

8 of chemokine and antimicrobial responses in mesothelial cells.

9 stimulated by angiogenic factors produced by mesothelial cells.

10 orphologies and function compared to control mesothelial cells.

11 red chick embryonic and rat adult epicardial mesothelial cells.

12 lly expressed in MM cells compared to normal mesothelial cells.

13 in MM cells but had minimal effect on normal mesothelial cells.

14 We found that JCV did not infect human mesothelial cells.

15 l of a cell line derived from rat epicardial mesothelial cells.

16 required for the growth of SV40-transformed mesothelial cells.

17 ristically associated with SV40 infection of mesothelial cells.

18 xpression was restricted to human peritoneal mesothelial cells.

19 ers and is critical to the transformation of mesothelial cells.

20 rease in VEGF production from murine pleural mesothelial cells.

21 ely 40-fold higher levels of hDio2 mRNA than mesothelial cells.

22 g the adhesion of ovarian carcinoma cells to mesothelial cells.

23 interaction of ovarian carcinoma cells with mesothelial cells.

24 its limited expression in normal peritoneal mesothelial cells.

25 expression and TGF-beta1 expression in human mesothelial cells.

26 5) in a dose-dependent manner in rat pleural mesothelial cells.

27 in both rat lung epithelial and rat pleural mesothelial cells.

28 elial cells, follicular dendritic cells, and mesothelial cells.

29 been named mesothelin because it is made by mesothelial cells.

30 th factor or insulin-like growth factor-1 in mesothelial cells.

31 contribute to the tumorigenic conversion of mesothelial cells.

32 in 7 patients did not show TF expression by mesothelial cells.

33 FA mRNA (P < 0.05) and protein (P < 0.05) in mesothelial cells.

34 sed concentrations of ID1 mRNA (P < 0.05) in mesothelial cells.

35 on of IL-1beta and IL-18 production in human mesothelial cells.

36 he O-GlcNAc signal primarily originates from mesothelial cells.

37 ion in normal human tissues is restricted to mesothelial cells.

38 ntum, which are covered by a single layer of mesothelial cells.

39 al effects and transforming actions in human mesothelial cells.

40 lite exposures have similar effects on human mesothelial cells.

41 vide a novel mechanism for the generation of mesothelial cells.

42 n implicated previously in transformation of mesothelial cells.

43 PRRs) in bone marrow-derived macrophages and mesothelial cells.

44 elioma tumor cells in situ but not by normal mesothelial cells.

45 ted in asbestos-induced oncogenesis of human mesothelial cells.

46 in MM cell lines compared with non-malignant mesothelial cells.

47 al steps of OvCa metastasis and suggest that mesothelial cells actively contribute to metastasis.

48 Mesothelial cells also produced chemokines in response t

49 Furthermore, mesothelial cell and macrophage expression of VEGF-C inc

50 Ectopic hTERT expression immortalized normal mesothelial cells and a premalignant, p16(INK4a)-negativ

51 Mesotheliomas are tumors arising from mesothelial cells and are associated with asbestos expos

52 SV40 did not lyse mesothelial cells and caused a high rate of transformati

53 lls associated with the basal lamina beneath mesothelial cells and expressing activated leukocyte cel

54 ulture containing primary human fibroblasts, mesothelial cells and extracellular matrix can be adapte

55 reased phosphorylation of Tyr-216 in pleural mesothelial cells and GSK-3beta mobilization from the cy

56 f innate immune mediators from primary mouse mesothelial cells and human monocytic MonoMac6 cells, an

57 rt their ability to colonize and multiply in mesothelial cells and in both resident and recruited leu

58 However, normal mesothelial cells and mesothelioma cells from Bap1(+/-)

59 Immortalized human mesothelial cells and primary mesothelial cells, culture

60 y resident macrophages and then amplified by mesothelial cells and probably other cells of the perito

61 data identify distinctive fates for injured mesothelial cells and submesothelial fibroblasts during

62 t isolates may retain properties of reactive mesothelial cells and suggests that targets in addition

63 Both production of LPA by peritoneal mesothelial cells and the chemotactic activity in the co

64 submesothelial cells is higher than that of mesothelial cells and transitional cells.

65 asked whether asbestos induced apoptosis in mesothelial cells and whether reactive oxygen species we

66 synthesis and secretion by peritoneal-lining mesothelial cells and/or fibroblasts in response to stim

67 h factor (EGF) is a potent mitogen for human mesothelial cells, and autophosphorylation of the EGF re

68 two epithelial cell types, keratinocytes and mesothelial cells, and determined the effect on prolifer

69 tracellular matrix components, human primary mesothelial cells, and full-thickness human peritoneum a

70 In conclusion, mesothelial cells are an important source of VEGF.

71 In tuberculous pleurisy pleural mesothelial cells are exposed to mycobacteria in the ple

72 Mesothelial cells are generally thought to be "bystander

73 chanisms by which asbestos induces injury in mesothelial cells are not known.

74 Mesothelial cells are uniformly infected but not lysed b

75 on, this study identified O-GlcNAcylation in mesothelial cells as a potentially important molecular m

76 These results define mesothelial cells as microbial sensors through TLRs and

77 ressed by submesothelial fibroblasts but not mesothelial cells, attenuated the peritoneal fibrosis bu

78 ally in the developing mesothelium reveals a mesothelial cell-autonomous role for Ezh2 in repression

79 s to telomerase activity before the infected mesothelial cells become transformed and immortalized.

80 by this approach was abundant in normal rat mesothelial cells but not expressed in rat MM cell lines

81 induced telomerase activity in primary human mesothelial cells, but not in primary fibroblasts.

82 not control particles, induced apoptosis in mesothelial cells by all assays and induction of apoptos

83 We found that infection of human mesothelial cells by SV40 is very different from the sem

84 1, Tcf21) and Tbx18, can be induced in naive mesothelial cells by the liver bud, both in vitro and in

85 Indeed, knockdown of CD157 in Met-5A mesothelial cells changed their morphology and cytoskele

86 e, for the first time, that human peritoneal mesothelial cells constitutively produce bioactive lipid

87 We show here that human peritoneal mesothelial cells constitutively produce LPA, which acco

88 Pleural mesothelial cells contribute to pleural rind formation b

89 ms of interactions of pathogenic fibers with mesothelial cells, crucial signaling pathways, and genet

90 rtalized human mesothelial cells and primary mesothelial cells, cultured from human omentum or clinic

91 a induced MIP-1alpha and MCP-1 expression in mesothelial cells, demonstrating that mesothelial cell-d

92 ion in mesothelial cells, demonstrating that mesothelial cell-derived C-C chemokines play a biologica

93 We show that SV40 infection of human mesothelial cells directly causes overexpression of Notc

94 ) three Ca(2+) shuttling pathways in primary mesothelial cells during Ca(2+) oscillations: Ca(2+) shu

95 enesis and indicate that signals controlling mesothelial cell entry are organ specific.

96 We visualized WT1(+) mesothelial cell entry into the lung by live imaging and

97 e vertebrate heart originates from migratory mesothelial cells (epicardium) that give rise to coronar

98 Changes in p65 expression in pleural mesothelial cells exposed to asbestos in inhalation expe

99 Mesothelial cells exposed to asbestos or bleomycin for 9

100 nuclear translocation of p65 in rat pleural mesothelial cells exposed to asbestos.

101 also shown to efficiently rupture peritoneal mesothelial cells, exposing the submesothelial collagen

102 Mesothelial cells expressed podoplanin and ALCAM.

103 BKV and SV40 infected mesothelial cells, expressed viral oncoproteins, and cau

104 lly devoid of a mesothelium but that serosal mesothelial cells expressing the Wilm's tumor protein (W

105 ll lines than they were in normal peritoneal mesothelial cells from surgical specimens, in organ cult

106 wth gene, may encode a negative regulator of mesothelial cell growth.

107 sion of ovarian cancer cells into peritoneal mesothelial cells has also been analyzed and shown to re

108 Here we show that malignant mesothelial cells have an elevated Notch signaling pathw

109 y assays for PLA(2) indicate that peritoneal mesothelial cells have strong constitutive PLA(2) activi

110 ly, we reported that SV40 infection of human mesothelial cells (HM) causes aberrant methylation of th

111 SV40 infection of human mesothelial cells (HM) causes early cellular immortaliza

112 Asbestos is cytotoxic to human mesothelial cells (HM), which appears counterintuitive f

113 er mesothelial cells (SHM) and primary human mesothelial cells (HM).

114 s not induce transformation of primary human mesothelial cells (HM); instead, asbestos is very cytoto

115 1 production were measured in vitro in human mesothelial cells (HMC) in the presence or absence of me

116 Human peritoneal mesothelial cells (HPMC) constitutively expressed ICAM-1

117 Human peritoneal mesothelial cells (HPMCs), the main source of IL-6 and V

118 ning vesicle transportation in human pleural mesothelial cells (HPMCs).

119 ffluents, peritoneal tissues, and peritoneal mesothelial cells (HPMCs).

120 SV40 may be related to the very high rate of mesothelial cell immortalization that is characteristica

121 Treatment of mesothelial cells in culture with carboplatin resulted i

122 uption is repaired and replaced by surviving mesothelial cells in peritoneal injury, and not by subme

123 esive nanoparticles (BNPs) can interact with mesothelial cells in the abdominal cavity and significan

124 of transformation in infected primary human mesothelial cells in tissue culture, leading to the form

125 achment of ovarian tumor cells to peritoneal mesothelial cells in vitro and increases the numbers of

126 overexpression of ET-1 induced MMT in human mesothelial cells in vitro and promoted the early cellul

127 Blocking fibronectin production in primary mesothelial cells in vitro or in murine models, either g

128 roduction in pleural tissues in vivo, and by mesothelial cells in vitro.

129 TGF-beta increases the VEGF production by mesothelial cells in vivo and in vitro.

130 on of Wilms tumor 1 (WT1), a known marker of mesothelial cells, in various cell types in normal and f

131 r genetic mapping of Wilms' tumor-1-positive mesothelial cells indicated that peritoneal membrane dis

132 Activation of LPA1 on mesothelial cells induced these cells to express connect

133 this activity was undetectable or minimal in mesothelial cells infected and/or transformed by SV40 ta

134 tos did not influence telomerase activity in mesothelial cells infected with SV40.

135 ory effects of DLX4 on CD44 levels and tumor-mesothelial cell interactions were abrogated when IL-1be

136 gated the ability of DLX4 to stimulate tumor-mesothelial cell interactions.

137 Phenotype conversion of mesothelial cells into myofibroblasts, the so-called mes

138 RK1/2 activation in pulmonary epithelial and mesothelial cells is unclear.

139 ormal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antib

140 etastasis, potentiating invasion through the mesothelial cell layer and colonization of the submesoth

141 its ability to recruit an entirely exogenous mesothelial cell layer during development.

142 The epicardium, a mesothelial cell layer enveloping the myocardium, is act

143 The epicardium is a mesothelial cell layer essential for vertebrate heart de

144 tant contribution of somatic mesoderm to the mesothelial cell layer of the PE.

145 ovarian cancer metastasis, clearance of the mesothelial cell layer, to examine the clearance ability

146 cin promoted intercalation of filopodia into mesothelial cell layers and cell invasion.

147 A human mesothelial cell line (LP9/TERT-1) and isolated human pl

148 documented by immunocytochemistry in a human mesothelial cell line (MET5A) exposed to various concent

149 AR5 as well as LP9 cells, a human peritoneal mesothelial cell line, were analyzed by flow cytometry f

150 imens (n = 5), and MPM and SV40-immortalized mesothelial cell lines (n = 5).

151 SV40 oncoprotein expression in murine mesothelial cell lines enhanced spontaneous and asbestos

152 Murine mesothelial cell lines lacking wild-type p53 due to a po

153 addition, stress-induced senescence in human mesothelial cell lines was impaired by SV40 oncoprotein

154 immortal cell lines (SV40-transformed human mesothelial cell lines, S-HML).

155 the invasion of tumor cell clusters into the mesothelial cell lining of peritoneal cavity organs; how

156 mas (MMs) are aggressive tumors derived from mesothelial cells lining the lungs, pericardium and peri

157 eads by implantation of tumor cells onto the mesothelial cells lining the peritoneal cavity.

158 g through the mesothelium, a single layer of mesothelial cells lining the peritoneal cavity.

159 Endogenous peritoneal macrophages and mesothelial cells lining the peritoneum contain MCP-1, w

160 Binding of mesothelin on normal mesothelial cells lining the pleura or peritoneum to the

161 Activation of mesothelial cell LPA1 induced CTGF expression by inducin

162 BKV replicated faster than SV40 and caused mesothelial cell lysis, not cellular transformation.

163 n the developing liver, lung, and intestine, mesothelial cells (MCs) differentiate into specific mese

164 Mesothelial cells (MCs) form a single epithelial layer a

165 Mesothelial cells (MCs) line the peritoneal cavity and h

166 onstrated that MesP1+ mesoderm gives rise to mesothelial cells (MCs), which differentiate into HSCs a

167 itol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, bu

168 0-kDa glycoprotein present on the surface of mesothelial cells, mesotheliomas, and ovarian cancers.

169 13), and primary peritoneal and immortalized mesothelial cells (MeT5A) by immunohistochemistry, qRT-P

170 rom this organism, adhered to primary murine mesothelial cells (MMCs) in vitro.

171 e adherence of human PMN to human peritoneal mesothelial cell monolayers and examines the importance

172 cancer cell death during adhesion to normal mesothelial cell monolayers.

173 loss-of-function mice, we demonstrated that mesothelial cell movement into the lung requires the dir

174 le for this vascular defect was the yolk sac mesothelial cells, not the cardiomyocytes or the VSMC.

175 es apoptosis in MMC without affecting normal mesothelial cells of the pleura.

176 Novel findings include the following: mesothelial cells of the serosa transduce Hedgehog signa

177 proliferation in this tissue, rabbit ovarian mesothelial cells (OMC) were transfected in vitro with a

178 l ester "mixed isomers" (CCFSE) dye to label mesothelial cells on the surface of the embryonic lung.

179 single-chain urokinase-bound rabbit pleural mesothelial cells or lung fibroblasts with kinetics simi

180 Although primary cultures of mesothelial cells or submesothelial fibroblasts each exp

181 podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial c

182 ggregation and increases in EGF-R protein in mesothelial cells phagocytizing long asbestos fibers wer

183 wth factor-beta1 (TGF-beta1) induces pleural mesothelial cell (PMC) transformation into myofibroblast

184 n of interleukin (IL)-8 in activated pleural mesothelial cells (PMC) and the migration of PMNL across

185 investigate whether talc stimulates pleural mesothelial cells (PMC) to release C-X-C and/or C-C chem

186 t mesothelioma cells (MMC) or normal pleural mesothelial cells (PMC).

187 Results indicate pleural mesothelial cells (PMCs) express ICAM-1 in tuberculous p

188 ies using NIH 3T3 fibroblasts and peritoneal mesothelial cells (PMCs) showed that CTGF blockade suppr

189 this study we demonstrate that mouse pleural mesothelial cells (PMCs), when stimulated with BCG or IF

190 Pleural mesothelial cells (PMCs), which are derived from the mes

191 ary vessels arise from a unique extracardiac mesothelial cell population, the proepicardium, which de

192 ic grafting and subsequent identification of mesothelial cell populations, we demonstrate that a diff

193 anation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbes

194 ese findings indicate that cancer-associated mesothelial cells promote colonization during the initia

195 gates the role of dynamic O-GlcNAcylation of mesothelial cell proteins in cell survival during exposu

196 Pleural mesothelial cells (rabbit or human) were exposed to asbe

197 Fas expression rendering transformed ovarian mesothelial cells resistant to apoptosis.

198 Upon exposure to bacterial products, mesothelial cells secrete chemokines, but the signaling

199 pic 3D cultures, we found that primary human mesothelial cells secrete fibronectin in the presence of

200 Together, our data provide evidence that mesothelial cells serve as a source of vascular smooth m

201 P-1) activity in both primary Syrian hamster mesothelial cells (SHM) and primary human mesothelial ce

202 line (LP9/TERT-1) and isolated human pleural mesothelial cells showed rapid and protracted asbestos-i

203 A subset of mesothelial cells situated atop the immune aggregates wa

204 In contrast, areas of reactive mesothelial cells stained positively for these enzymes.

205 Conditioned medium from peritoneal mesothelial cells stimulate migration, adhesion, and inv

206 nd, VCAM-1, inhibits EMT of chick epicardial mesothelial cells stimulated by TGFbeta isoforms.

207 In vitro, pleural mesothelial cells stimulated with bacille Calmette-Gueri

208 In cultured mesothelial cells, TGF-beta1 upregulated the expression

209 ovarian tumor cells as well as in peritoneal mesothelial cells that are in direct contact with dissem

210 ember proto-oncogenes in lung epithelial and mesothelial cells that are linked to proliferation and c

211 ereby favoring survival and proliferation of mesothelial cells that have sustained DNA damage.

212 inflammasome, a component of macrophages or mesothelial cells that leads to production of chemotacti

213 Mesothelial cells that line the serous cavities and oute

214 RAC1/SMAD-dependent signaling pathway in the mesothelial cells that promotes a mesenchymal phenotype

215 We observed that, in primary mesothelial cells, the plasmalemmal Ca(2+) influx played

216 Mesothelial cells, the progenitor cell of the asbestos-i

217 /apyrimidinic (AP)-endonuclease, in isolated mesothelial cells, the progenitor cells of malignant mes

218 s are up-regulated in asbestos-exposed human mesothelial cells through an epidermal growth factor rec

219 in peritoneal macrophages (TLR2/4, C5aR) and mesothelial cells (TLR2, C5aR).

220 hese data demonstrate an intrinsic origin of mesothelial cells to a coelomic organ and provide a nove

221 Exposure of mesothelial cells to asbestos complemented SV40 mutants

222 of rat lung epithelial cells and rat pleural mesothelial cells to asbestos increased binding of nucle

223 Recent studies have proposed mesothelial cells to be an important source of myofibrob

224 hesize that SV40 oncoproteins will sensitize mesothelial cells to DNA damage induced by asbestos or c

225 ty of the conditioned medium from peritoneal mesothelial cells to ovarian cancer cells.

226 the unusual susceptibility of primary human mesothelial cells to SV40 carcinogenesis.

227 s of erionite, and examined the hallmarks of mesothelial cell transformation in vitro and in vivo.

228 Here, we demonstrate that asbestos-induced mesothelial cell transformation is linked to increases i

229 There was evidence of mesothelial cell transition to a mesenchymal phenotype w

230 hese observations support a scenario whereby mesothelial cells undergo a series of chronic injury, in

231 The mesothelial cell VEGF production was significantly reduc

232 eport that stimulation of primary peritoneal mesothelial cells via nucleotide-binding oligomerization

233 conclude that asbestos induces apoptosis in mesothelial cells via reactive oxygen species.

234 Yet, Nod1 stimulation of mesothelial cells via RICK enhanced chemokine secretion

235 uced inflammasome/inflammation activation in mesothelial cells was CREB dependent, further supporting

236 2, TLR4, TRIF, or inflammasome components in mesothelial cells was critical for the production of CXC

237 ng anti-ALCAM antibodies, submesothelial and mesothelial cells were isolated by FACS.

238 cer cell apoptosis during adhesion to normal mesothelial cells which line the peritoneum.

239 because its normal expression is limited to mesothelial cells, which are dispensable.

240 he direct interaction of the OvCa cells with mesothelial cells, which cover the surface of the omentu

241 nment of chronic IL-1beta signaling in human mesothelial cells, which may promote mesothelial to fibr

242 entified in the allantois: an outer layer of mesothelial cells, whose distal portion will become tran

243 sbestos induces a fibroblastic transition of mesothelial cells with a gain of mesenchymal markers (vi

244 pathway could allow the abnormal survival of mesothelial cells with asbestos-induced mutations.

245 Finally, infection of mesothelial cells with Listeria monocytogenes induced pr

246 Stimulation of human peritoneal mesothelial cells with OSM induced phosphorylation of gp