ライフサイエンスコーパス: metabolic

1 ere pre-existing hemodynamic instability and metabolic abnormalities are combined with long periods o

2 er fat is more important than the associated metabolic abnormalities as the predictor of future liver

3 dels of diabetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and k

4 f phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids.

5 cretion of insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adip

6 ions correlates with changes in composition, metabolic activity and functional diversity of the micro

7 IFC tissue exhibited significantly lower metabolic activity and release of pro-inflammatory cytok

8 etabolism of the brain, but current tests of metabolic activity are only indirect markers of energy u

9 spectively examined the relationship between metabolic activity at FDG PET in the residual lesion ide

10 pted to the harsh environment and capable of metabolic activity at in situ temperatures, possessing a

11 t of the total community and maintained high metabolic activity but also had the highest proportion i

12 e enlargement, indicating that elevated cell metabolic activity early after infection is predictive o

13 significantly lower cerebral blood flow and metabolic activity in key brain areas compared with cont

14 iomass into electricity, based on the use of metabolic activity of bacteria.

15 nstrate that Raman-DIP can not only indicate metabolic activity using deuterated carbon sources but a

16 reased Wnt signalling activation, osteoblast metabolic activity, and bone nodule formation.

17 We found that apelin-36(L28A) retains full metabolic activity, but is 100-fold impaired in its abil

18 evealed that PknG is necessary for efficient metabolic adaptation during hypoxia.

19 study provides molecular insight that links metabolic adaptation to transgenerational epigenetic mod

20 Metabolic adaptations in early pregnancy are uncoupled f

21 y is mediated by coordinated muscle-placenta metabolic adjustments linked to internal clocks.

22 by renal salt loss, marked hypokalemia, and metabolic alkalosis.

23 naling network affecting multiple aspects of metabolic alterations after burn injury and as a novel p

24 socitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type ID

25 logy, attenuated the glycolytic-to-oxidative metabolic alterations occurring in SBMA muscles and indu

26 mbined with nuclear magnetic resonance-based metabolic analysis demonstrate the intracellular product

27 OCD is associated with an increased risk of metabolic and cardiovascular complications.

28 Among these, the conserved metabolic and developmental regulator ESRRA was highligh

29 at magnetic resonance imaging to compare the metabolic and hepatic outcomes of 1-year maintenance of

30 Therefore, metabolic and immunological alterations associated with

31 This strategy enables perturbation of the metabolic and regulatory networks in a modular, parallel

32 relationship between adiponectin levels and metabolic and reproductive functions in PCOS.

33 on by balancing functional requirements with metabolic and spatial constraints.

34 e 2 immunity, and also to integrate systemic metabolic and thermogenic responses.

35 tion to tease apart the influences of light, metabolic, and circadian clock signaling on rates of cel

36 ther inflammatory, granulomatous, infective, metabolic, and genetic causes that can mimic multiple sc

37 Clinical, metabolic, and imaging characterization of seven patient

38 regulate many systems, including the immune, metabolic, and nervous systems.

39 The metabolic basis of Alzheimer disease (AD) pathology and

40 9 individuals with RTS with respect to their metabolic bone status including bone mineral density, ca

41 ng that LP-induced increases in FGF21 impact metabolic but not thermogenic endpoints.

42 We introduce the calorimetric descriptor "metabolic capacity" and show that it correlates with enz

43 Induced by metabolic challenge, amoeboid movement may thus constitu

44 However, whether metabolic changes directly regulate cancer development a

45 To examine metabolic changes in astrocyte-spinal neuron co-cultures

46 changes that reprogram brain development and metabolic changes in early life that could be followed t

47 tokine production was associated with marked metabolic changes in the Irgm1-deficient macrophages, in

48 However, little is known about the metabolic changes that epimastigotes undergo before they

49 lR/CD320 gene defects appear to produce mild metabolic changes.

50 t does not appear to be completely driven by metabolic changes.

51 tween loss of CB1 in adipocytes and systemic metabolic changes.

52 NUAK1 supports engagement of the AMPK-TORC1 metabolic checkpoint, thereby protecting tumour cells fr

53 potential role for CT-1 in the regulation of metabolic circadian rhythms.

54 etween placental mRNA abundance of vitamin D metabolic components and circulating vitamin D metabolit

55 VOO and wine consumption and a high metabolic COMT capacity for methylation are key factors

56 based on the body mass index categories and metabolic condition.

57 and (3) no structural brain abnormalities or metabolic conditions that could explain the seizures.

58 The metabolic connectivity analyses crucially supported the

59 adipose tissue loss as well as its systemic metabolic consequences are far less understood.

60 Furthermore, variable metabolic content across samples result in sparse featur

61 We observed that basal metabolic content measured in lymphocytes by nuclear mag

62 , they cannot describe the complexity of the metabolic context, and new tools are required to visuall

63 Metabolic control may be relevant for refining inclusion

64 Protist predation influenced 14 metabolic core functions including membrane transport fr

65 d cytokine levels, and identifies immune and metabolic correlates of vaccine immunity.

66 also connect insulin resistance to extensive metabolic cross-talk between the liver, adipose tissue,

67 nzyme and whose activity can be modulated by metabolic cues.

68 odel that shows progressive neurological and metabolic decline, decreased complex III activity, and i

69 CGR signaling and protected mice against the metabolic deficits caused by the consumption of a high-f

70 During tumorigenesis, the high metabolic demand of cancer cells results in increased pr

71 o a metabolic inhibitor is dictated by their metabolic demands; cellular selectivity is based on dema

72 reduced oxygen consumption rates indicating metabolic depression and pointing to particular sensitiv

73 he mTORC1-HIF-1alpha pathway in burn-induced metabolic derangements.

74 sity confers significant risk for developing metabolic disease in obesity whereas preferential expans

75 Nonmetabolic responders (n = 6) (stable metabolic disease or progressive disease) showed a media

76 new avenues for therapeutic intervention in metabolic disease, neurodegeneration, and aging.

77 lp to elucidate disease-specific pathways in metabolic disease.

78 ents a potential target for the treatment of metabolic diseases and has been extensively investigated

79 metabolic pathways and connected with human metabolic diseases, central nervous system diseases, and

80 ty and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets

81 n and have been implicated in autoimmune and metabolic diseases.

82 ystem, muscle development, and especially to metabolic diseases.

83 in lipid homeostasis, with impact on various metabolic diseases.

84 HCS cause holocarboxylase deficiency, a rare metabolic disorder that can be life-threatening if left

85 with a variety of human diseases, including metabolic disorders and cancer.

86 sue compartments is tightly linked to severe metabolic disorders, including obesity, metabolic syndro

87 For both metabolic distances, we found that the probability of an

88 The metabolic distribution of bioactives in pomegranate peel

89 reening broad, natural genetic diversity for metabolic diversity.

90 en the therapeutic window for challenge with metabolic drugs during drug holidays.

91 ntribute significantly to the development of metabolic dysfunction and inflammation.

92 ys may reveal optimal targets for addressing metabolic dysfunction in ALS.

93 ed NAA/Cr levels suggests that mitochondrial metabolic dysfunction persists after surgery.

94 We found that DENV infection induced metabolic dysregulation and inflammatory responses and a

95 Metabolic dysregulation drives tumor initiation in a sub

96 ese results identify bile acids as important metabolic effectors under conditions of sustained BAT ac

97 etoprolol displays favorable hemodynamic and metabolic effects and could improve outcome in patients

98 nto the mechanisms underlying the beneficial metabolic effects induced by VSG.

99 RAL with a monoclonal antibody prevented the metabolic effects of GDF15 in rats.

100 and as the bona fide receptor mediating the metabolic effects of GDF15, enabling a more comprehensiv

101 To this end, we set out to investigate the metabolic effects of NO in cultured astrocytes from mice

102 However, the underlying metabolic effects of opioid withdrawal and replacement h

103 Moreover, these metabolic effects, particularly an increase in fatty aci

104 hanisms including binge eating and increased metabolic efficiency and fat storage.

105 nd three in the trastuzumab emtansine group [metabolic encephalopathy, neutropenic sepsis, and acute

106 y acids (LCFAs) are used as a rich source of metabolic energy by several bacteria including important

107 is review, recent advances regarding terpene metabolic engineering are highlighted, with a special fo

108 ion to direct extraction, recent progress in metabolic engineering of plants offers an alternative su

109 Now, advances in bioreactor technology, metabolic engineering, and analytical instrumentation ar

110 that introduces a methyl modification into a metabolic enzyme and whose activity can be modulated by

111 2017) identify reversible aggregation of the metabolic enzyme pyruvate kinase under environmental str

112 ions, they are good systems for studying how metabolic enzymes communicate via substrate channeling.

113 Genes encoding metabolic enzymes exhibited expression in metacyclics wi

114 ion (535 vs 540 seconds; P = .62), estimated metabolic equivalent of tasks (METs; 11.6 vs 11.7; P = .

115 significantly increased minutes per week of metabolic equivalents (4 studies; standardized mean diff

116 differences, 0.38; 95% CI, -0.15 to 0.92) or metabolic equivalents per week (3 studies; standardized

117 The metabolic etiology of her lens changes is known, whereas

118 ensively evaluate the optimality of putative metabolic exchange reactions between heterocysts and veg

119 LG-IH also altered metabolic expenditure and locomotor activities in male o

120 ence cellular inflammatory responses.Several metabolic factors affect cellular glucose metabolism as

121 The metabolic factors that affect its processing are incompl

122 n glycolysis for proliferation, the distinct metabolic features of regulatory T cells (Tregs) are les

123 ls demonstrates the dissociation between the metabolic fitness and the suppressive function of Foxp3-

124 reservoir for tumour cells highlighting the metabolic flexibility of this cancer.

125 We used (2)H/(13)C metabolic flux analysis to quantify intermediary metabol

126 adyCom optimization framework for predicting metabolic flux distributions consistent with the steady-

127 nd, real-time NMR enables the measurement of metabolic flux in the corresponding pathway.

128 may protect against DN by increasing glucose metabolic flux, inhibiting the production of toxic gluco

129 e differences were observed in terms of leaf metabolic fluxes, these variations were not tightly link

130 onditions by RB-TnSeq, highlighting specific metabolic functions associated with root colonization ge

131 trillions of bacteria that perform essential metabolic functions for their hosts.

132 REs have been used to discover and interpret metabolic functions, and to engineer novel network struc

133 This iron can be used for metabolic functions, stored within cytosolic ferritin, o

134 directly alters the expression of methionine metabolic genes to increase SAM, which in turn leads to

135 ific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.

136 ysis (Population FBA) successfully described metabolic heterogeneity in a population of independent E

137 The results indicate that metabolic heterogeneity is a distinct property of activa

138 administered thapsigargin, and by combining metabolic, histologic, physiologic, pharmacologic, therm

139 rom an energy-dense diet is known to disrupt metabolic homeostasis and contributes to the disease ris

140 stinal PPARdelta is important in maintaining metabolic homeostasis and suggest that intestinal-specif

141 ral but diverging roles in the regulation of metabolic homeostasis depending on the energetic state.

142 the overall function of SIRT5 in organismal metabolic homeostasis remains unclear.

143 These favorable effects on metabolic homeostasis suggest that the RGD integrin-bind

144 p and burns lipids and is linked to systemic metabolic homeostasis, we hypothesized that there might

145 sing pathway in developmental plasticity and metabolic homeostasis.

146 decreased body weight, adiposity, and serum metabolic hormones as expected and also elicited an incr

147 obesity, the sensitivity of reproduction to metabolic imbalance has significant public health implic

148 Metabolic imbalance in chronic diseases such as type-1 d

149 This metabolic imbalance may open the therapeutic window for

150 n sensitivity, insulin secretion, steatosis, metabolic inflammation, pancreatic islet morphometry, is

151 Here we show that the transmission of metabolic information to the hypothalamo-pituitary-gonad

152 r, the relative susceptibility of cells to a metabolic inhibitor is dictated by their metabolic deman

153 Based on the metabolic interventions suggested by this algorithm, gen

154 identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack

155 anohalogens could have primed development of metabolic machineries for their degradation, especially

156 ein cholesterol(LDL-C) is a well established metabolic marker of cardiovascular risk, however, its ro

157 were no differences in previously published metabolic markers of IBD.

158 These observations led us to propose a metabolic model for autotrophic growth by Ca. P. anaerol

159 asses and tumor types, and in a genome-scale metabolic model of leukemia.

160 criptomes in the expression of cell type and metabolic modeling markers, but less so for a subset of

161 c now supports running and modifying E. coli metabolic models directly on the EcoCyc website.

162 Switching between these metabolic modes requires a rapid transcriptional respons

163 As one of the key nodes in the metabolic network, the forkhead transcription factor FOX

164 the metabolomics data revealed that the same metabolic network-level trends previously reported for R

165 the set of reactions used to fill gaps in a metabolic network.

166 predicted enzymatic reactions in the tomato metabolic network.

167 ites, reactions and pathways in genome-scale metabolic networks (GEMs) can assist in understanding ce

168 , an extension of the software package MOST (Metabolic Optimization and Simulation Tool), satisfies (

169 ails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunoc

170 inant agent that affects circadian clocks in metabolic organs.

171 Overall mortality, in-hospital mortality, metabolic outcome, graft survival, and insulin-free surv

172 supplementation improves anthropometric and metabolic outcomes in overweight and obese adults, there

173 primer for metaflammation is the persistent metabolic overloading of the endoplasmic reticulum (ER),

174 re needed to evaluate whether the control of metabolic parameters can lower the incidence of psoriasi

175 ge disorders, neurodegenerative diseases and metabolic pathologies, as well as in the progression of

176 g a multistage clustering algorithm in which metabolic pathway associations are used along with inten

177 rosophila fragile X model, and thus reveal a metabolic pathway that can be targeted by new and alread

178 taset, we identified lipid metabolism as the metabolic pathway that most significantly correlated wit

179 1), a regulator of the GABA neurotransmitter metabolic pathway.

180 hways in cancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 1100) were

181 six salivary metabolites were mapped into 49 metabolic pathways and connected with human metabolic di

182 lation in the endothelium and uncovered core metabolic pathways and mechanisms of regulation that dri

183 phorylation, stronger regulation of genes in metabolic pathways and more dramatic glycolytic response

184 pe-enriched precursors to products to deduce metabolic pathways and networks.

185 ted carbon sources but also reveal different metabolic pathways by analyzing SCRS.

186 l killing, and the engineering or control of metabolic pathways for improved biochemical synthesis.

187 trate the therapeutic potential of targeting metabolic pathways in the treatment of inflammatory dise

188 The major perturbed metabolic pathways included purine and pyrimidine metabo

189 an inter-omics approach in understanding the metabolic pathways involved in IBD.

190 modulated by the obesity, with signaling and metabolic pathways of pathological significance.

191 These studies indicate that iPLA2-dependent metabolic pathways play an important role in tumor initi

192 but also participates in redox regulation of metabolic pathways previously established to be regulate

193 siae However, the roles of Msn2/4 in primary metabolic pathways such as fatty acid beta-oxidation are

194 The liver integrates multiple metabolic pathways to warrant systemic energy homeostasi

195 only the alterations in PPARgamma-regulated metabolic pathways, but also the increases in cytokine e

196 suggests that it may be involved in several metabolic pathways, but the molecular mechanisms which p

197 e new data types include protein microarray, metabolic pathways, compounds, quantitative proteomics,

198 s that impact hepatic inflammatory and lipid metabolic pathways, providing new insight into the mecha

199 ates and cofactors that are intermediates of metabolic pathways, providing potential cross talk betwe

200 hology is related to deregulation of central metabolic pathways, which may identify potential therape

201 n by stable epigenetic changes in immune and metabolic pathways.

202 of gene expression, transport proteins, and metabolic pathways.

203 nges of specific lipids and their associated metabolic pathways.

204 to clinical hyperandrogenism alone showed a metabolic phenotype (p < 0.05) and insulin resistance (p

205 The metabolic phenotype of a cancer cell is determined by it

206 zed therapeutic response is related to tumor metabolic phenotype, and that altering tumor metabolism

207 erstood how the tumor environment influences metabolic phenotypes and whether macropinocytosis suppor

208 We characterized the metabolic phenotypes of PHD2-deficient RAW cells and pri

209 o enzyme assays indicate that these distinct metabolic phenotypes reflect the divergence of UGT89A2 e

210 how these factors are reflected in different metabolic phenotypes, is also discussed.

211 across muscles of different contractile and metabolic phenotypes.

212 LC-MS-based metabolic phenotyping (metabotyping) in urine samples co

213 Metabolic phenotyping of Foxp3-expressing IL-17A(+), ex-

214 re larger in size and more closely model the metabolic, physiological, and surgical aspects of humans

215 ism can serve as a platform to decode cancer metabolic plasticity and design cancer therapies targeti

216 ity as a regulatory mechanism for increasing metabolic power in human skeletal muscle.

217 cellular matrix organization, small molecule metabolic process, cell adhesion (GO IDs: 0030198, 00442

218 sceptibility interacts with folate-sensitive metabolic processes at the time of neural tube closure.

219 An essential coordinator of all DNA metabolic processes is Replication Protein A (RPA).

220 of energy and relies on a series of complex metabolic processes to achieve this normal function.

221 e biosynthesis pathway is essential for many metabolic processes, such as synthesis of DNA and RNA an

222 ing age, sex, and genotype, may affect these metabolic processes.

223 statistically significant differences in the metabolic profile among uninfected I. scapularis nymphal

224 ss index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrauterine mechanism

225 cated that OA patients possess a respiratory metabolic profile fully divergent from those obtained in

226 acterize the intracellular and extracellular metabolic profiles of four prostate cancer cell lines wi

227 The metabolic profiles of microtissues derived from normal o

228 for each diet and identified the associated metabolic profiles, and then validated the models using

229 Intracellular metabolic profiling revealed that PknG is necessary for

230 This metabolic program is observed in mouse and human Th17 ce

231 report that cold exposure in mice triggers a metabolic program that orchestrates lipoprotein processi

232 The identity of stage-specific metabolic programs and their impact on adult neurogenesi

233 The metabolic programs of functionally distinct T cell subse

234 , NAD(P)H FLIM has not been established as a metabolic proxy in bacteria.

235 ure (Tb ), electromyographic activity (EMG), metabolic rate (M) and whole-body thermal sensation on a

236 ization with all fish maintaining a standard metabolic rate and growth rate lower than expected when

237 lassically inferred from allometry of animal metabolic rates.

238 The metabolic rearrangements in RNAi seeds resulted in an al

239 dies have highlighted the importance of such metabolic regulation in the endothelium and uncovered co

240 in Caenorhabditis elegans larvae, the master metabolic regulator AMP-activated protein kinase (AMPK)

241 hermogenesis, and how O2 deficiency leads to metabolic reprograming in cancer.

242 olomics to investigate IDH1(R132H)-dependent metabolic reprogramming and its potential to induce bios

243 Understanding mechanisms underlying variable metabolic requirements of different Lyme disease spiroch

244 mic analysis confirmed no change in cellular metabolic response to a range of osmolytes when treated

245 Sex difference in mouse metabolic response to erythropoietin.

246 Although the diet can affect the metabolic response to exercise, the contribution of a se

247 Rescuing these metabolic restrictions was sufficient to reverse IDH1-me

248 5.36]) and in combination with an additional metabolic risk factor (hypertension, dyslipidemia, or di

249 rs in Taiwan, we associated a high burden of metabolic risk factors with increased risk of HCC; smoki

250 A metabolic risk score was computed from the following com

251 MS level relative to weight for having a low metabolic risk, which could be used to identify youths a

252 protein, with two biotin-dependent cytosolic metabolic roles and a distinct biotin-independent nuclea

253 plasma membrane driven by activation of the metabolic sensor AMP kinase.

254 In this study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as

255 ghlight the capacity of DA neurons to act as metabolic sensors by responding not only to hormones but

256 in body fat distribution contributes to the metabolic sequelae of obesity.

257 formate oxidation and oxygen respiration as metabolic signatures for inflammation-associated dysbios

258 Intravital FLIM revealed the metabolic signatures of S1 and S2 proximal tubules to be

259 ach metabolite on its own or other published metabolic signatures.

260 us ovarian cancer diagnosis based on altered metabolic signatures.

261 ives demonstrated markedly improved in vitro metabolic stability (t1/2 > 2 h).

262 al functional groups had variable effects on metabolic stability and efficacy, but the most effective

263 erase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates

264 of the tracer showed a 2.5-fold increase in metabolic stability of (18)F-4FMFES over (18)F-FES.

265 ovements in potency, aqueous solubility, and metabolic stability, which combined to give significant

266 d the human/rodent correlation in microsomal metabolic stability.

267 energy and explanations for the pathological metabolic state of obesity.

268 a master regulator of the cell's growth and metabolic state, and its dysregulation contributes to a

269 tidepressant efficacy, suggesting an adverse metabolic state.

270 lerant to antibiotics secondary to a reduced metabolic state.

271 The association of S/P with the metabolic status of obese individuals was further valida

272 tion, Gatm(c/c) colonocytes showed increased metabolic stress in response to DSS with higher levels o

273 be the temporal orchestration of a series of metabolic, structural, and functional changes after asep

274 A series of metabolic studies indicated that the enhanced cytokine p

275 ted to a known genotoxic scaffold, providing metabolic support of our mechanistic model for colibacti

276 ll discuss our current understanding of this metabolic supportive function of oligodendrocytes and it

277 Metabolic syndrome (MetS) has been associated with chron

278 at baseline in individuals with established metabolic syndrome (MetS) or diabetes identifies CHD and

279 ly associated with a higher incidence of the metabolic syndrome (OR=2.49; 95% CI 1.30-4.77), a steepe

280 were 1.60 (95% CI 1.30-1.96; P < 0.001) for metabolic syndrome and 1.37 (1.03-1.82; P = 0.021) for t

281 a therapeutic approach for treatment of the metabolic syndrome and dyslipidemia, while avoiding syst

282 Metabolic syndrome defines a cluster of interrelated ris

283 College completion is associated with lower metabolic syndrome for whites across all levels of child

284 of childhood disadvantage for depression and metabolic syndrome in young adulthood, across race/ethni

285 The progressive relation among metabolic syndrome, insulin resistance (IR), and dementi

286 vere metabolic disorders, including obesity, metabolic syndrome, lipodystrophy, and cachexia.

287 he non-digested and digested samples towards metabolic syndrome-associated enzymes (alpha-amylase, al

288 ion is associated with the increased risk of metabolic syndrome.

289 enine dinucleotide (NAD(+)) is emerging as a metabolic target in a number of diseases including heart

290 n variability in sensory behavior, informing metabolic therapeutic interventions to restore perceptua

291 Because BAT is a specialized metabolic tissue that takes up and burns lipids and is l

292 le isotope-labelled glucose and glutamine as metabolic tracers, we probed the phenotypic changes in m

293 Cancer cells share several metabolic traits, including aerobic production of lactat

294 bosyl transfers (NAD(P)H/NAD(P)(+)) to drive metabolic transformations in and across most primary pat

295 mino acids that activate mTOR and enable the metabolic transition of activated T cells.

296 structural framework of a plant cell to show metabolic, transport, genetic, developmental and signali

297 cate that EGFR mutations may drive different metabolic tumor phenotypes that are captured in PET imag

298 sed with PET/CT combined with baseline total metabolic tumor volume (TMTV) could detect early relapse

299 ing isotope, to a degree that depends on the metabolic turnover.

300 Metabolic variables, including glucose, insulin, insulin