ライフサイエンスコーパス: metabolic abnormality

1 metabolic abnormality) or 'unhealthy' (>/=2 metabolic abnormalities).

2 e metabolic abnormality) or unhealthy (>/= 2 metabolic abnormalities).

3 hionine metabolism is a fundamental acquired metabolic abnormality.

4 of any underlying urinary-tract infection or metabolic abnormality.

5 some normal levels that are associated with metabolic abnormality.

6 e latter, 86 patients (39.3%) had at least 1 metabolic abnormality.

7 l product, beneficial in diabetes-associated metabolic abnormalities.

8 s protective in men and women with clustered metabolic abnormalities.

9 n the pathogenesis of obesity and associated metabolic abnormalities.

10 ividuals increased with increasing number of metabolic abnormalities.

11 otype of hematological, cardiopulmonary, and metabolic abnormalities.

12 role for B cells in the development of these metabolic abnormalities.

13 uld play a role in the pathogenesis of these metabolic abnormalities.

14 that folate exacerbates vitamin B-12-related metabolic abnormalities.

15 elop spontaneous intestinal inflammation and metabolic abnormalities.

16 ration AEDs are associated with a panoply of metabolic abnormalities.

17 ove energetics in athletes and patients with metabolic abnormalities.

18 lithiasis are more likely to have detectable metabolic abnormalities.

19 s (liver-specific macrophages, KCs) in these metabolic abnormalities.

20 ution and adipocyte size are associated with metabolic abnormalities.

21 rity nor defined growth hormone secretion or metabolic abnormalities.

22 entions for antipsychotic medication-induced metabolic abnormalities.

23 ted to insulin resistance and its associated metabolic abnormalities.

24 ogenic, while reducing abdominal obesity and metabolic abnormalities.

25 pe 2 diabetes is weight loss, which improves metabolic abnormalities.

26 ayed rate of weight gain, suggesting broader metabolic abnormalities.

27 nergic and serotonergic systems and cerebral metabolic abnormalities.

28 not significantly improve obesity-associated metabolic abnormalities.

29 sses of subcutaneous fat in association with metabolic abnormalities.

30 te function that leads to the development of metabolic abnormalities.

31 n signaling leads to hyperglycemia and other metabolic abnormalities.

32 n signaling leads to hyperglycemia and other metabolic abnormalities.

33 ortant: type, size, location, and underlying metabolic abnormalities.

34 ol mean +/- 2 SD, all lesions but one showed metabolic abnormalities.

35 y may do so independently of the established metabolic abnormalities.

36 re significant differences in the underlying metabolic abnormalities.

37 amatically improved both clinical course and metabolic abnormalities.

38 haracterized by reproductive, endocrine, and metabolic abnormalities.

39 antipsychotic-induced weight gain and other metabolic abnormalities.

40 kin-6, a common risk factor for diabetes and metabolic abnormalities.

41 n for SERT deficiency associated obesity and metabolic abnormalities.

42 lp to treat a range of human conditions with metabolic abnormalities.

43 se, side effects from chemotherapy, or toxic-metabolic abnormalities.

44 g obese subjects with asthma correlates with metabolic abnormalities.

45 ons between short sleep duration and chronic metabolic abnormalities.

46 etformin ameliorated cellular senescence and metabolic abnormalities.

47 ted levels of TWEAK in skeletal muscle cause metabolic abnormalities.

48 uced adipocyte senescence and attenuated the metabolic abnormalities.

49 mutant mice largely normalizes the bone and metabolic abnormalities.

50 mpared with normal weight individuals with 0 metabolic abnormalities.

51 onsiderable range of variation and potential metabolic abnormalities across the individuals in this c

52 with both FXR gene deletion and BA-mediated metabolic abnormalities after inactivation of FXR transc

53 These metabolic abnormalities, along with fasting hyperglycemi

54 ainst age-related obesity and its subsequent metabolic abnormalities, although their food intake is n

55 ated with a number of clinically significant metabolic abnormalities and an increased risk of prematu

56 AMPK activation prevents the metabolic abnormalities and apoptosis specifically cause

57 on and heart failure that is associated with metabolic abnormalities and autonomic impairment.

58 d normal cardiac function despite myocardial metabolic abnormalities and cardiac-specific overactivat

59 avir is a protease inhibitor associated with metabolic abnormalities and cardiovascular disease.

60 s more on the improvement of obesity-related metabolic abnormalities and chronic disease risk reducti

61 nt association observed between IRS-defining metabolic abnormalities and colorectal cancer is determi

62 nimal model to study the interaction between metabolic abnormalities and experimentally induced asthm

63 peritoneal dialysis solutions may exacerbate metabolic abnormalities and increase cardiovascular risk

64 Abdominal obesity is associated with metabolic abnormalities and increased risk of atheroscle

65 alcium has been associated with a variety of metabolic abnormalities and may be associated with a gre

66 We examined baseline regional metabolic abnormalities and metabolic changes from pretr

67 t on growth may be related to both postnatal metabolic abnormalities and prenatal defective bone form

68 Noticeably, metabolic abnormalities and proliferation driven by insu

69 n individuals who are normal weight can have metabolic abnormalities and similar risks for cardiovasc

70 Metabolic abnormalities and targeted treatment trials ha

71 or development of obesity and its associated metabolic abnormalities, and abrogation of insulin signa

72 fined by profound circulatory, cellular, and metabolic abnormalities, and associated with a greater m

73 the duration of diabetes, insulin treatment, metabolic abnormalities, and autonomic neuropathy.

74 y and may lead to weight loss, correction of metabolic abnormalities, and regression of hepatic dysfu

75 ted > or =8 hours, two thirds had at least 1 metabolic abnormality, and nearly 1 in 10 had MetS.

76 These metabolic abnormalities appear to result from chronic el

77 icularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater ri

78 which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater ri

79 Maternal prenatal metabolic abnormalities are associated with high insulin

80 evidence indicates that obesity and related metabolic abnormalities are associated with increased in

81 ere pre-existing hemodynamic instability and metabolic abnormalities are combined with long periods o

82 We show how genetic and metabolic abnormalities are inextricably linked to dysre

83 bnormalities in the absence of structural or metabolic abnormalities are likely to have disease-causi

84 It follows that disease-related metabolic abnormalities are likely to impinge upon SIRT1

85 dvantageous for minority populations because metabolic abnormalities are present at higher levels of

86 These metabolic abnormalities are risk factors for kidney dise

87 Fat redistribution and metabolic abnormalities are seen increasingly in HIV-pos

88 y or fat re-distribution, and its associated metabolic abnormalities, are common in HIV patients.

89 ATF4 only in osteoblasts presented the same metabolic abnormalities as Atf4-/- mice.

90 er fat is more important than the associated metabolic abnormalities as the predictor of future liver

91 ; and transcription factor, ion channel, and metabolic abnormalities, as well as growth factor-depend

92 ntrations may be responsible for many of the metabolic abnormalities associated with abdominal obesit

93 Subclinical metabolic abnormalities associated with adrenal incident

94 ngs provide insight into the pathogenesis of metabolic abnormalities associated with diabetes.

95 ated receptor-gamma agonists may correct the metabolic abnormalities associated with disrupted adipog

96 ted therapies to improve liver histology and metabolic abnormalities associated with fatty liver are

97 P4-Wnt10b mice largely avert weight gain and metabolic abnormalities associated with genetic obesity.

98 Metabolic abnormalities associated with human immunodefi

99 y mass index (weight (kg)/height (m)(2)) and metabolic abnormalities associated with insulin resistan

100 ope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2.

101 s body weight, and increasing FGF21 improves metabolic abnormalities associated with obesity and diab

102 tributes to the insulin resistance and other metabolic abnormalities associated with severe lipodystr

103 Taken together, these findings reveal novel metabolic abnormalities associated with the CF pathologi

104 en species (ROS) is one of the major retinal metabolic abnormalities associated with the development

105 Identification of metabolic abnormalities associated with the progression

106 arietal hypometabolism is indeed the classic metabolic abnormality associated with AD.

107 abolism, as noted on FDG PET imaging, is the metabolic abnormality associated with Alzheimer's diseas

108 hese relatives also had lower frequencies of metabolic abnormalities at baseline and exhibited no ove

109 Subjects with MDD had regional brain metabolic abnormalities at baseline that tended to norma

110 bited hepatic gluconeogenesis and alleviated metabolic abnormalities both in mice with diet-induced o

111 of the patients themselves also demonstrated metabolic abnormalities, both on and off galactose-restr

112 ing has been proposed to contribute to these metabolic abnormalities but has not been directly demons

113 revalence and correlates of the phenotype of metabolic abnormality but normal weight (MAN) for 5 raci

114 Puerto Rican adults have prevalent metabolic abnormalities, but few studies have explored f

115 N2), demonstrated significant functional and metabolic abnormalities, but grossly normal structure, i

116 The failing human heart is characterized by metabolic abnormalities, but these defects remains incom

117 sing CEACAM1 in liver curtailed diet-induced metabolic abnormalities by protecting hepatic insulin cl

118 among obese persons without obesity-related metabolic abnormalities, called metabolically healthy ob

119 Metabolic abnormalities can be identified in the majorit

120 ate that an increasing number of protein and metabolic abnormalities can cause primary myelin disorde

121 Dietary fructose that is linked to metabolic abnormalities can up-regulate its own absorpti

122 and that the obese phenotype, regardless of metabolic abnormalities, can adversely affect renal func

123 constriction, microcirculatory rarefaction, metabolic abnormalities, cardiac hypertrophy, and increa

124 The metabolic abnormalities caused by diabetes induce vascul

125 Whether homocysteine per se or a coincident metabolic abnormality causes vascular disease is still a

126 fic ablation of Mfn2 in mice led to numerous metabolic abnormalities, characterized by glucose intole

127 Metabolic abnormalities consistent with early indication

128 nts without diabetes, supports the idea that metabolic abnormalities contribute to their adverse outc

129 ars before the onset of type 2 diabetes) and metabolic abnormalities contribute.

130 authors to hypothesize that the incidence of metabolic abnormalities contributing to treatment-refrac

131 Hippocampal subfield and metabolic abnormalities detected at 7T appear to reflect

132 n asymptomatic stages, as illustrated by the metabolic abnormalities detected with PET and FDG in Hun

133 Metabolic abnormalities develop in various chronic disea

134 dy insulin sensitivity regulation and to the metabolic abnormalities developed in AR-deficient male m

135 ormal weight, overweight, and obesity) and 3 metabolic abnormalities (diabetes, hypertension, and hyp

136 In relation to AMI, obesity without metabolic abnormalities did not confer substantial exces

137 s led to the theory that diabetes-associated metabolic abnormalities directly impair neural retinal f

138 hange in functional islet mass correlated to metabolic abnormalities during the course of alloimmune

139 duction system and myocardium, postoperative metabolic abnormalities, electrolyte disturbances, and i

140 ges of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior corti

141 ed to motor neurons and includes synapse and metabolic abnormalities, endoplasmic reticulum (ER) stre

142 minates this gradient and is associated with metabolic abnormalities, functionally restoring the phys

143 in treatment in SU + MET rats prevented this metabolic abnormality (GIR = 20.0 +/- 2.2 mg.kg(-1).min(

144 w-up of 5.4 years, obese individuals with no metabolic abnormalities had a higher risk of CHD (multiv

145 This cluster of metabolic abnormalities has been termed the insulin resi

146 Disrupted mitochondrial function and metabolic abnormalities have a causal role too.

147 ildren, disrupted mitochondrial function and metabolic abnormalities have a causal role.

148 relatively unexplored despite the fact that metabolic abnormalities have been implicated in the path

149 g obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory network

150 occasionally is associated with endocrine or metabolic abnormality (hypothyroidism, panhypopituitaris

151 and sensory nerve conduction velocities, and metabolic abnormalities (i.e., mitochondrial and cytosol

152 scopic imaging permits detection of regional metabolic abnormalities in ALS, including not only the m

153 ic syndrome is characterized by a cluster of metabolic abnormalities in an individual, with insulin r

154 edictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and wo

155 nt studies have implicated physiological and metabolic abnormalities in autism spectrum disorders (AS

156 (18)F-FDG studies detect metabolic abnormalities in demented patients, but with l

157 hyperglycemia on the inflammatory response, metabolic abnormalities in diabetes, and the interaction

158 city accompanies the more clinically evident metabolic abnormalities in diabetes.

159 or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only pa

160 w in the future the early detection of focal metabolic abnormalities in diseases that affect the func

161 s of adiposity most strongly associated with metabolic abnormalities in elderly men.

162 ole in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent.

163 together, the results strongly suggest that metabolic abnormalities in HNF1alpha-null mice are cause

164 n atrophy and attenuates mutant-HTT-mediated metabolic abnormalities in Huntington's disease mice.

165 fic expression of AMPKgamma3(R225Q) prevents metabolic abnormalities in leptin-deficient ob/ob (ob/ob

166 of beta-oxidative genes, results in profound metabolic abnormalities in liver and heart.

167 y acid metabolism with future development of metabolic abnormalities in MHO individuals, we retrospec

168 y markers associated with the development of metabolic abnormalities in MHO individuals.

169 prevented and reversed high-fat diet-induced metabolic abnormalities in mice by decreasing PPARgamma

170 lities, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems.

171 (Tregs) could alleviate the pathological and metabolic abnormalities in ob/ob mice.

172 Thus, overstimulation of ENaC by metabolic abnormalities in obese individuals may be a li

173 :DCAS ratio may be a promising biomarker for metabolic abnormalities in obesity.

174 cid species is a potential biomarker for the metabolic abnormalities in obesity.

175 aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myo

176 eneration antipsychotics are associated with metabolic abnormalities in patients with schizophrenia.

177 ced nerve blood flow (NBF), and a variety of metabolic abnormalities in peripheral nerve that have be

178 rsenite exacerbated adipocyte senescence and metabolic abnormalities in pol eta(-/-) mice.

179 ocks, and whether disruptions are related to metabolic abnormalities in pregnancy, by studying day/ni

180 nourished donors also ameliorated growth and metabolic abnormalities in recipient animals.

181 ion of draggen mice uncovered novel systemic metabolic abnormalities in Scn4a mouse models and provid

182 efect in the neonatal beta cell fraction and metabolic abnormalities in the adult.

183 Dietary nitrate therefore alleviates metabolic abnormalities in the hypoxic heart, improving

184 ggest a role for 12alpha-hydroxylated BAs in metabolic abnormalities in the natural history of T2D an

185 vestigated clinical correlates of tryptophan metabolic abnormalities in the nontumoral hemisphere of

186 These additional defects indicate that metabolic abnormalities in these cells are not limited t

187 The metabolic abnormalities in these mice are improved by in

188 ptive transfer of BMDCs affects vascular and metabolic abnormalities in these mice.

189 ractile genes, leading to a feedback loop of metabolic abnormalities in these SMCs.

190 ncluding type 2 diabetes, and assessment for metabolic abnormalities in those with obstructive sleep

191 idative stress are processes that mark early metabolic abnormalities in vascular diseases.

192 mains unknown whether hyperglycemia, a major metabolic abnormality in diabetes, regulates MMP express

193 The presence of discrete patterns of metabolic abnormality in preclinical HD carriers may pro

194 These metabolic abnormalities, in turn, impair learning in the

195 ion syndromes as well as patients with other metabolic abnormalities including patients with chronic

196 Prenatal metabolic abnormalities, including higher pregravid BMI

197 sity in preschool children the prevalence of metabolic abnormalities, including hypertension, dyslipi

198 agents often lose subcutaneous fat and have metabolic abnormalities, including insulin resistance an

199 free testosterone levels as well as several metabolic abnormalities, including insulin resistance, d

200 e is associated with myocardial and systemic metabolic abnormalities, including low levels of total c

201 levels have been associated with a range of metabolic abnormalities, including obesity and insulin r

202 pitulate key aspects of diabetes without the metabolic abnormalities, including retinal vascular dama

203 e function and may predispose individuals to metabolic abnormalities independent of obesity.

204 Leptin treatment dramatically improves metabolic abnormalities (insulin resistance and hyperlip

205 t loss induced by GBP surgery normalizes the metabolic abnormalities involved in the pathogenesis and

206 The pathophysiology of glucose metabolic abnormalities is poorly understood, but insuli

207 However, the link between energetic and metabolic abnormalities is unknown.

208 keletal proteins and is also associated with metabolic abnormalities, is discussed.

209 istance, by promoting dyslipidemia and other metabolic abnormalities, is part of the proatherogenic m

210 lin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic t

211 dhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascu

212 ctual developmental disorder and unexplained metabolic abnormalities led to a diagnosis in 68%, the i

213 sitive K+ (KATP) channel plays a role during metabolic abnormality, little information is available a

214 The metabolic abnormalities may be partially or completely c

215 In addition, metabolic abnormalities may influence the results obtain

216 We speculate that the MRSI metabolic abnormality may represent a more generalized p

217 ggest insulin resistance, and its associated metabolic abnormalities, may underlie many of the cardio

218 nvestigate whether obesity in the absence of metabolic abnormalities might be a relatively benign con

219 siology of CFRD, and imply that carbohydrate metabolic abnormalities might begin at much younger ages

220 dels of diabetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and k

221 H and idiopathic PAH BOECs recapitulated the metabolic abnormalities observed in pulmonary artery end

222 development of obesity and the accompanying metabolic abnormalities observed in the insulin resistan

223 extent to which skeletal muscle (SM) energy metabolic abnormalities occur and contribute to EI and i

224 Correction of metabolic abnormalities occurred only with KD.

225 ing DC were resistant to the weight gain and metabolic abnormalities of an HFD.

226 one are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limi

227 gamma (PPAR-gamma) agonists not only improve metabolic abnormalities of diabetes and consequent diabe

228 The metabolic abnormalities of diabetes cause mitochondrial

229 Our results show that the metabolic abnormalities of DIO can be mitigated by sensi

230 This study examines the hypothesis that metabolic abnormalities of dysmetabolic syndrome are ris

231 y, this failed to correct the aforementioned metabolic abnormalities of Hyp mice.

232 The metabolic abnormalities of individuals with IFG, compare

233 ons have been shown to reproduce some of the metabolic abnormalities of obesity.

234 role for these cells in the etiology of the metabolic abnormalities of obesity/type 2 diabetes.

235 ifically targeted to ameliorate the systemic metabolic abnormalities of this disorder.

236 In severe cases, the metabolic abnormalities of TLS can cause renal failure,

237 provides a unifying mechanism for the common metabolic abnormalities of type 2 diabetes.

238 Correction of metabolic abnormalities offers unique opportunities for

239 In order to study the effects of metabolic abnormalities on arrhythmias without the compl

240 motility disorder caused initially either by metabolic abnormalities or by a primary motility alterat

241 lassified as 'metabolically healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (>/=2 metabolic ab

242 sified as metabolically healthy (zero or one metabolic abnormality) or unhealthy (>/= 2 metabolic abn

243 y no evidence of basal inflammatory disease, metabolic abnormalities, or enhanced resistance to Salmo

244 mbocytopenia, gastrointestinal disturbances, metabolic abnormalities, peripheral neuropathy, and hype

245 dings suggest that both the reproductive and metabolic abnormalities persist with age in PCOS.

246 To define the metabolic abnormalities predisposing individuals in thes

247 ve damage is a cause or a consequence of the metabolic abnormalities present in diabetic subjects.

248 ch supports the concept that obesity-related metabolic abnormalities, rather than cirrhosis, initiate

249 of this characterization and multiple other metabolic abnormalities recently associated with ccRCC,

250 onsumption, already associated with numerous metabolic abnormalities, reduces rates of intestinal Ca(

251 lower when other cerebral physiological and metabolic abnormalities reflected depressed neuronal fun

252 elevated ferritin may be just one of several metabolic abnormalities related to the underlying proces

253 plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and c

254 , plasma formic acid concentrations fell and metabolic abnormalities resolved in all patients.

255 Metabolic abnormalities responsible for stone recurrence

256 disease characterized primarily by numerous metabolic abnormalities, retinal degeneration, cardiomyo

257 n this review, we describe changes involving metabolic abnormalities secondary to hyperglycemia, oxid

258 are commonly seen, and the severity of these metabolic abnormalities seems to be related to the exten

259 hat partial RYR2 loss is sufficient to cause metabolic abnormalities seen in heart disease.

260 R-alpha overexpression without affecting the metabolic abnormalities seen in these hearts.

261 define chronic kidney disease (CKD) identify metabolic abnormalities similarly in minority and nonmin

262 es resulting from mitochondrial dysfunction, metabolic abnormalities, storage diseases, and inborn er

263 The treatment of associated metabolic abnormalities such as insulin resistance and h

264 AT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type

265 lescents appear to be more likely to develop metabolic abnormalities such as pronounced weight gain,

266 binoid receptor reduces obesity and improves metabolic abnormalities such as triglycerides, HDL chole

267 d to both cancer metabolism as well as other metabolic abnormalities, such as fatty liver disease and

268 These factors include metabolic abnormalities, such as hyperglycemia, elevated

269 se long-term outcomes even in the absence of metabolic abnormalities, suggesting that there is no hea

270 though lean hypertensive patients have fewer metabolic abnormalities than obese hypertensive patients

271 predominantly negative symptoms have greater metabolic abnormalities than subjects with predominantly

272 VHL-mutant cells exhibit metabolic abnormalities that can cause chronic endoplasm

273 Kidney transplantation corrects most of the metabolic abnormalities that cause renal osteodystrophy.

274 ogies often coexist with drug toxicities and metabolic abnormalities that complicate the development

275 , the primary in vitro model of IBC, exhibit metabolic abnormalities that distinguish them from other

276 bolic syndrome is a group of obesity-related metabolic abnormalities that increase an individual's ri

277 in providing a means to link the myocardial metabolic abnormalities that occur in rat of disease wit

278 l PET are consistent with the expected early metabolic abnormalities that occur in this well-characte

279 nd to potentially minimize fetal exposure to metabolic abnormalities that program future disease.

280 on, oxidant stress, inflammation, and muscle metabolic abnormalities that provide opportunities for t

281 alterations in blood pressure, or can cause metabolic abnormalities that subsequently increase risk

282 plasma ferritin levels, may induce baseline metabolic abnormalities that ultimately result in diabet

283 bese population who appear to be free of the metabolic abnormalities that usually accompany excess ad

284 postprandial hyperlipidemia is one specific metabolic abnormality that is typically associated with

285 onfirmed chronic prostatitis may demonstrate metabolic abnormality that leads to false-positive diagn

286 , including fluid infusion and correction of metabolic abnormalities, to save more lives.

287 Metabolic abnormalities underlying diabetes are primaril

288 is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are p

289 Dose-limiting grade 3 metabolic abnormalities were also observed.

290 s estimated from serum creatinine values and metabolic abnormalities were defined by 5th or 95th perc

291 fferent mouse models of breast cancer, these metabolic abnormalities were found to accelerate the dev

292 Metabolic abnormalities were more common in minority pop

293 bolically healthy, the active with clustered metabolic abnormalities were not at elevated risk of car

294 Significant metabolic abnormalities were observed in the thigh muscl

295 However, these metabolic abnormalities were prevented when liver was de

296 red throughout the development of intestinal metabolic abnormalities, which could contribute to dysli

297 he host in response to tumour presence cause metabolic abnormalities, which result in decreased prote

298 Maladaptive RVH shares metabolic abnormalities with cancer including aerobic gl

299 to investigate the associations of prenatal metabolic abnormalities with insulin and adiponectin in

300 gat1 in HTF-C diet-fed mice improves hepatic metabolic abnormalities without attenuating liver inflam