ライフサイエンスコーパス: metabolic activation

1 la typhimurium strain TA98 (with and without metabolic activation).

2 clopidogrel and prasugrel, does not require metabolic activation.

3 cleotide cofactor consistent with a need for metabolic activation.

4 hE in vivo either directly or as a result of metabolic activation.

5 s found to form multiple GSH conjugates upon metabolic activation.

6 extent by the pathway in which HNE undergoes metabolic activation.

7 locked stress-induced m-PFC DA, 5-HT, and NE metabolic activation.

8 or SEC may be attributable to differences in metabolic activation.

9 nella strains TA 100 and 98 with and without metabolic activation.

10 d increases in ATP demand and Ca2+-dependent metabolic activation.

11 A1 is more important in detoxication than in metabolic activation.

12 er procarcinogens that require P450-mediated metabolic activation.

13 local alterations in flow, inflammation, and metabolic activation.

14 y, thereby demonstrating the requirement for metabolic activation.

15 as an electrophile either directly or after metabolic activation; 2) be genotoxic; 3) alter DNA repa

16 Following metabolic activation, AA reacts with dA and dG residues

17 annels (permethrin) and a compound requiring metabolic activation (allyl alcohol).

18 However, mechanisms eliciting metabolic activation, an inseparable step for satellite

19 g/kg), inhibited both ketamine-induced brain metabolic activation and behavioral responses in the wil

20 induced hyperthermia via inhibition of brain metabolic activation and blockade of skin vasoconstricti

21 hen hepatotoxicity is mediated by an initial metabolic activation and covalent binding, and subsequen

22 One of these, CYP3A4/5 is involved in metabolic activation and detoxification of a wide number

23 ng mechanisms; individual differences in the metabolic activation and detoxification of carcinogens,

24 CYP1A1 and GSTM1 play a major role in the metabolic activation and detoxification of PAHs, respect

25 induced lung tumors is a result of decreased metabolic activation and DNA binding of NNK.

26 oxicity induced in SEC is determined by both metabolic activation and GSH detoxification in the hepat

27 BaP forms covalent DNA adducts after metabolic activation and induces mutations.

28 camptothecin analogue CPT-11, which requires metabolic activation and is toxic.

29 pendent on hepatic microsomal P450-catalyzed metabolic activation and that acetaminophen toxicity in

30 Both genotoxicity with and without metabolic activation and the induction of the oxidative

31 attributed to the changes in the rates of CY metabolic activation and/or detoxification.

32 cipating in induction of secretory activity, metabolic activation, and intracellular signaling/signal

33 Following metabolic activation, aristolochic acid reacts with DNA

34 to be Ah receptor-dependent, indicating that metabolic activation by CYP1A1 was required.

35 These procarcinogens undergo metabolic activation by N-oxidation of the exocyclic ami

36 al chemicals and blubber extracts subject to metabolic activation by rat liver S9 fraction.

37 ine phosphatases (PTPases) regulate cellular metabolic activation by reversing the effects of tyrosin

38 This toxic reaction is associated with metabolic activation by the P450 system to form a quinon

39 AHs are environmental carcinogens that, upon metabolic activation, can react with DNA to form bulky c

40 a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2)

41 emistry of the cations but to differences in metabolic activation/deactivation of individual amines.

42 e into play including differences in uptake, metabolic activation, degradation, and transport.

43 ization (LCGU) and the spatial extent of the metabolic activation following stimulation of the spared

44 of metabolites and has been shown to require metabolic activation for antiangiogenic activity.

45 ay testing and highlighted the importance of metabolic activation for TTR binding.

46 exposures above the median (implying slower metabolic activation) had a shorter survival than those

47 Despite the importance of metabolic activation in HCA carcinogenicity and the find

48 ketamine-induced behavior and regional brain metabolic activation in mice provides a useful model for

49 quantitative mathematical description of the metabolic activation in neurons and glial cells, as well

50 he essential role of pulmonary P450-mediated metabolic activation in NNK-induced lung cancer, and our

51 D(1A) knockout mice exhibited blunted metabolic activation in response to ketamine in a neuroa

52 ects in humans and both behavioral and brain metabolic activation in rodents.

53 adrenocortical activation, and dopaminergic metabolic activation in the m-PFC.

54 y microsomal cytochrome P450 (P450)-mediated metabolic activation in xenobiotic-induced lung cancer.

55 oral P2Y(12) inhibitor that does not require metabolic activation, in patients undergoing nonurgent p

56 Metabolic activation increased the TTR binding potency o

57 xy-D-glucose scans were acquired to quantify metabolic activation, indicating local neutrophilic infl

58 says with the TA 100 strain with and without metabolic activation, indicating the mutagenic effect wa

59 e involvement of dopamine receptors in brain metabolic activation induced by ketamine is, however, un

60 s (PAHs) are potent carcinogens that require metabolic activation inside cells.

61 Metabolic activation is a key prerequisite for PAHs to c

62 This metabolic activation is dependent specifically on sensor

63 Its metabolic activation leads to trans-11,12-dihydroxy-11,1

64 After metabolic activation, many N-nitroso compounds are conve

65 However, the metabolic activation may occur as well.

66 ma (A549) cells, we provide evidence for the metabolic activation of (+/-)-trans-7,8dihydroxy-7,8-dih

67 e and recombinant p450s to contribute to the metabolic activation of 3-NBA by nitroreduction.

68 and 3A4 and of NADPH: p450 reductase in the metabolic activation of 3-NBA, catalyzing DNA adduct for

69 1A2 and 2C10 are important catalysts of the metabolic activation of 5-MeC and 6-MeC in human liver,

70 r interest, CYP2A13 was highly active in the metabolic activation of a major tobacco-specific carcino

71 d, the same enzyme inhibitors that block the metabolic activation of a series of nephrotoxic halogena

72 ome P450 enzymes play a critical role in the metabolic activation of acetaminophen, it is not yet cle

73 oxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxi

74 NAs) encoding cytochrome2E1 required for the metabolic activation of AOM and CCl(4) were observed bet

75 unosuppression and early death due to absent metabolic activation of BaP by CYP1B1 in immune cells.

76 gene superfamily and are responsible for the metabolic activation of both xenobiotics and endobiotics

77 ggested that oxidative stress resulting from metabolic activation of carcinogenic estrogens plays a c

78 dy the effect of complex PAH mixtures on the metabolic activation of carcinogenic PAH to DNA-binding

79 Electrophiles formed during metabolic activation of chemical carcinogens and reactiv

80 The results indicate that metabolic activation of DB[a,l]P by cytochrome P450 enzy

81 ain adducts formed in the same cell lines by metabolic activation of DB[a,l]P or (-)-DB[a,l]P-trans-1

82 Metabolic activation of drugs to electrophilic species i

83 Metabolic activation of endogenous and exogenous chemica

84 Metabolic activation of EQ and EN generates the catechol

85 he ATs are likely to be involved both in the metabolic activation of exogenous carcinogenic amines as

86 We now report the metabolic activation of FTY720 by sphingosine kinase-2 a

87 ary gland is catalytically active toward the metabolic activation of HCA food mutagens, and that this

88 However, both enzymes were active in the metabolic activation of hexamethylphosphoramide, a nasal

89 d CYP2A13 was more active than CYP2A6 in the metabolic activation of hexamethylphosphoramide, N,N-dim

90 We therefore propose that the metabolic activation of HNE involves formation of an acy

91 ATP sulfurylase/APS kinase catalyses the metabolic activation of inorganic sulfate to PAPS, the u

92 Metabolic activation of intermediate PAH trans-dihydrodi

93 ty acid-induced deleterious inflammatory and metabolic activation of macrophages.

94 calized NQO1 was not attributable to greater metabolic activation of MC but instead was the result of

95 ction against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic to

96 data demonstrate that Phb2 is essential for metabolic activation of mitochondria and, as a consequen

97 se data show a major in vivo role of NQO1 in metabolic activation of mitomycin C with implications in

98 at incretin-derived cAMP participates in the metabolic activation of mTOR by mobilizing intracellular

99 tability of 12 indicate the possibility that metabolic activation of N-nitrosomorpholine by hydroxyla

100 tively, and CYP2E1 plays a major role in the metabolic activation of nitrosamines.

101 A549 cells implicates the AKR pathway in the metabolic activation of PAH in human lung.

102 t tube or in cell culture these enzymes show metabolic activation of PAHs or arylamines, whereas in t

103 trating a need for additional studies on the metabolic activation of penclomedine to identify the ult

104 and should be applicable to the study of the metabolic activation of PhIP in various human tissues.

105 also been implicated in participating in the metabolic activation of polycyclic aromatic hydrocarbon

106 1A1 and 1B1 are the major P450s involved in metabolic activation of polycyclic aromatic hydrocarbons

107 (393)/Ser(395)) and that this is mediated by metabolic activation of protein phosphatase 2A in comple

108 Human aldo-keto reductases catalyze the metabolic activation of proximate carcinogenic PAH trans

109 Metabolic activation of retinol (vitamin A) via sequenti

110 Metabolic activation of retinol into the hormone retinoi

111 Metabolic activation of some N-nitroso compounds (NOCs),

112 These data suggest a proficient metabolic activation of tamoxifen in human liver and an

113 enicity of tamoxifen have been attributed to metabolic activation of tamoxifen to an electrophile.

114 servation that CYP2D6 is responsible for the metabolic activation of tamoxifen to endoxifen.

115 (SRD5A2) gene, the product of which controls metabolic activation of testosterone to dihydrotestoster

116 Metabolic activation of the aristolochic acids leads to

117 hese findings provide the first evidence for metabolic activation of the caudate nuclei in working me

118 electrophilic tamoxifen species generated by metabolic activation of the drug.

119 Metabolic activation of the K-region trans-8,9-diol of t

120 dence of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the

121 important mutagenic lesion formed following metabolic activation of the tobacco-specific carcinogen

122 s of pyridyloxobutylation resulting from the metabolic activation of the tobacco-specific nitrosamine

123 , whereas P450 1A1 plays a major role in the metabolic activation of these compounds in human lung.

124 tic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens.

125 CYP2A13, which is highly active in the metabolic activation of tobacco-specific nitrosamines, i

126 as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione

127 reductase (P450R) plays a major role in the metabolic activation of TPZ.

128 ly, l-NA treatment did not alter the area of metabolic activation on either the non-deafferented side

129 intracerebrally and is believed to be on the metabolic activation pathway of penclomedine.

130 antiviral activity and/or use an alternative metabolic activation pathway, and/or display a unique me

131 Following metabolic activation, PhIP causes bulky DNA lesions at t

132 alpha-CNPs (i) do not require metabolic activation (phosphorylation), (ii) bind direct

133 racts from Aristolochia species, form (after metabolic activation) pro-mutagenic DNA adducts in renal

134 -T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differ

135 is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine.

136 onization mass spectrometry, we identify the metabolic activation related protein complex of CD147-CD

137 Metabolic activation resulted in both enhanced and reduc

138 acting with DNA either directly or following metabolic activation, resulting in covalently linked com

139 murium strain TA98 was used with and without metabolic activation (S9 mix).

140 phimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.

141 In addition, metabolic activation should always be included within in

142 gen phosphorylase a (GPa) is correlated with metabolic activation, suggesting its potential use as a

143 ckade by clozapine of ketamine-induced brain metabolic activation suggests that antagonism of the con

144 and TA97a, in the presence and absence of a metabolic activation system prepared from the livers of

145 otoxicity of thiopurine drugs involves their metabolic activation, the resultant generation of 6-thio

146 e been isolated as arising from this mode of metabolic activation, there are no selective, total synt

147 revealed a highly differentiated pattern of metabolic activation throughout the rostrocaudal extent

148 defect filtering) have enabled screening for metabolic activation to become routine during drug devel

149 addition of Sia to glycoconjugates requires metabolic activation to CMP-Sia, catalyzed by CMP-Sia sy

150 neurotoxicant tri-o-cresyl phosphate, after metabolic activation to cresyl saligenin phosphate makes

151 ntagonism by Itpkb restricts pre-TCR induced metabolic activation to enforce coincidence-detection of

152 hionamide (ETA), a prodrug that must undergo metabolic activation to exert its cytotoxic effects, is

153 ycyclic aromatic hydrocarbons (PAHs) require metabolic activation to exert their carcinogenic effects

154 TPZ requires metabolic activation to give a cytotoxic free radical sp

155 CPA undergoes metabolic activation to phosphoramide mustard and nornit

156 drug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite th

157 Reports that HU undergoes metabolic activation to species that induce mutation app

158 Upon metabolic activation to the reactive epoxide, AFB1 forms

159 ding to their elimination and often to their metabolic activation to toxic products.

160 t that AF is uniquely able to induce its own metabolic activation via CYP1A1/1A2 in duction to cytoto

161 Moreover, metabolic activation with CL316,243 further reduced mito

162 hemical species can react, directly or after metabolic activation, with DNA to yield DNA adducts.