ライフサイエンスコーパス: metabolic control

1 gnaling that is crucial to leptin action and metabolic control.

2 rmone (TH), reflecting its ancestral role in metabolic control.

3 nerve terminals as critical sites of proper metabolic control.

4 critical roles in neuronal functionality and metabolic control.

5 tanding the role of allosteric regulation in metabolic control.

6 ent on the nutrient conditions, suggesting a metabolic control.

7 ary for mannitol biosynthesis is under tight metabolic control.

8 ection rates with similar graft function and metabolic control.

9 tabolism, patient size, and desired level of metabolic control.

10 healthy hepatic Ca(2+) balance and systemic metabolic control.

11 h and differentiation of tissues involved in metabolic control.

12 etic patients can be ameliorated by improved metabolic control.

13 in other variables such as hypertension and metabolic control.

14 Ces1/Ces1g) has been shown to play a role in metabolic control.

15 be involved in so far unknown mechanisms of metabolic control.

16 tion, continuation and dynamic analyses, and metabolic control.

17 g to the significance of (posttranslational) metabolic control.

18 lasticity of these limits, as well as a high metabolic control.

19 ciated with reduced body weight and improved metabolic control.

20 dge of the gastrointestinal contributions to metabolic control.

21 -kinase (PI3K)/Akt pathway is at the core of metabolic control.

22 nvironment is critical to the maintenance of metabolic control.

23 ized PSI proteins in growth possibly through metabolic control.

24 family member involved in redox sensing and metabolic control.

25 protein function is a critical component of metabolic control.

26 m by which NO(3)(-) supplementation improves metabolic control.

27 oderators of cardiovascular disease risk and metabolic control.

28 IRT1 suggest that this response may be under metabolic control.

29 r a reduction of the islet mass required for metabolic control.

30 and function requires efficient and precise metabolic control.

31 (Cdk) with multiple roles in cell cycle and metabolic controls.

32 siologically and speaks to a higher level of metabolic control?

33 3) Is ATP modulation of transport subject to metabolic control?

34 94 showed that 29% of patients had excellent metabolic control (a hemoglobin A1c [HbA1c] level < or =

35 risk factors, especially diabetics with poor metabolic control, a long duration of the disease, and e

36 patients showed graft function with improved metabolic control (A1c, fasting glycemia, and metabolic

37 The improved metabolic control achieved by bilirubin-treated mice was

38 ay be particularly important in appetite and metabolic control, although the genetics of human obesit

39 Metabolic control analyses confirm that the control is w

40 Sensitivity and metabolic control analyses identified expected key enzym

41 marily in theories of metabolic control, and metabolic control analysis (MCA) is an important example

42 this framework, we then adapt the methods of metabolic control analysis (MCA) to determine which modi

43 glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and

44 Metabolic control analysis allows the study of metabolic

45 of mammalian muscle glycogen synthesis using metabolic control analysis and concluded that glycogen s

46 s and metabolic flux, and the application of metabolic control analysis and metabolic flux analysis t

47 Some recent misunderstandings of metabolic control analysis have led to the claim that th

48 mics of these networks by approaches such as metabolic control analysis may provide new insights into

49 measured and the flux control determined by metabolic control analysis of data, which shows that thi

50 steady state kinetics as a means of applying metabolic control analysis to hierarchical biochemical s

51 t a sensitivity analysis which is similar to metabolic control analysis used in the analysis of bioch

52 Metabolic control analysis, co-invented by Reinhart Hein

53 ned in vivo kinetic parameters were used for metabolic control analysis, in which flux control coeffi

54 ly kinetic Michaelis-Menten representations, metabolic control analysis, or biochemical systems theor

55 In the top down approach to metabolic control analysis, reactions are grouped togeth

56 results are presented as a generalization of Metabolic Control Analysis, which has been concerned pri

57 tion theorem (FST) is a central principle of metabolic control analysis.

58 he well-established (log)linear formalism of metabolic control analysis.

59 etabolism has been previously analysed using metabolic control analysis.

60 xyxylulose 5-phosphate synthase (DXS), using metabolic control analysis.

61 linear algebraic equations (NAEs), including metabolic control analysis; (iii) solving the non-linear

62 A theoretical metabolic-control-analysis approach has been used to stu

63 rtheless, clear benefits in terms of optimal metabolic control and absence of severe hypoglycemia are

64 ock pathways reported to be both involved in metabolic control and activated by HCMV infection.

65 tudies have found that sleep loss can impair metabolic control and body weight regulation.

66 As a first step in linking metabolic control and genetic regulatory networks, this

67 Troglitazone therapy improved metabolic control and increased body fat in patients wit

68 aling pathways related to stress resistance, metabolic control and inflammation, and therefore provid

69 nt NOD-SCID and CD1 strains were studied for metabolic control and islet function and gene regulation

70 indicators of suboptimal cardiovascular and metabolic control and lifestyle choices such as alcohol

71 ave important implications for understanding metabolic control and metabolic diseases.

72 ssed the unanswered research questions about metabolic control and non-insulin-dependent diabetes mel

73 dings reveal a role of the heart in systemic metabolic control and point to MED13 and miR-208a as pot

74 ched, with functions relating to cell cycle, metabolic control and signal transduction.

75 naling in uridine homeostasis and consequent metabolic control and thermoregulation.

76 SREBP1 suppression was inversely related to metabolic control and was normalized by 3 h of in vivo h

77 cin-induced diabetes was closely matched for metabolic control and was transplanted with 5,000 IEQ/kg

78 aluate the association of periodontitis with metabolic control, and 3) to evaluate periodontitis in d

79 nt mice suppresses FoxO1, a central node for metabolic control, and entirely prevents the development

80 neral role for the central nervous system in metabolic control, and have revealed the importance of a

81 t of these is dealt primarily in theories of metabolic control, and metabolic control analysis (MCA)

82 asma concentrations of inflammatory markers, metabolic control, and the effect of the Pro12Ala PPARG

83 t role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy

84 Insulin physiology and metabolic control are far more complex than previously t

85 The brain's contributions to metabolic control are more readily revealed and play a c

86 most advantageous circumstances of excellent metabolic control, are characterized by dynamic changes,

87 d progression, particularly those related to metabolic control, are poorly understood.

88 omyces cerevisiae) include the stringency of metabolic control at the level of oxygen consumption, th

89 erence and facilitate evaluation of a GFD on metabolic control, bone health and patient quality of li

90 For the attainment of intensive IHD metabolic control (BUNa = 60 mg/dl) at steady state, a r

91 r hand, for the attainment of intensive CRRT metabolic control (BUNs = 60 mg/dl), required urea clear

92 cent of offspring whose mothers did not have metabolic control by 20 weeks' gestation had a General C

93 se data illustrate an auxiliary mechanism of metabolic control by a morphogenic pathway with relevant

94 The reason for this secondary metabolic control by RibR is to couple sulfur metabolism

95 halamic neuropeptide oxytocin contributes to metabolic control by suppressing eating behavior.

96 c and developmental changes, as in mammalian metabolic control by the insulin receptor.

97 , the model predicts that the same degree of metabolic control cannot be achieved even with daily IHD

98 Here we analyse glycaemic and metabolic control, cardiovascular risk, medication use,

99 hat enable the experimental determination of metabolic control coefficients, and demonstrate these by

100 Simple, reliable methods of defining metabolic control combined with a feedback system in the

101 Poor metabolic control despite maximal medical therapy prompt

102 Metabolic control during pregnancy was good in all cases

103 rioration in insulin production and improves metabolic control during the first year of type 1 diabet

104 -regulated brain circuits that contribute to metabolic control, enabling the discovery of novel brain

105 rotein kinase family, which is essential for metabolic control, energy homeostasis, and stress respon

106 These data highlight a key metabolic control event early in exhaustion and suggest

107 ate how heat shock factor 1 (HSF1) uncouples metabolic control from proteostatic regulation and unvei

108 Estimates of metabolic control from records of diabetic patients in W

109 sition, accompanied by epigenetic changes in metabolic control genes.

110 a, and these enzymes have been implicated in metabolic control, growth control, and a variety of stre

111 omplex interplay between virus and host over metabolic control has only just begun to be deconvoluted

112 ddition, rational design approaches based on metabolic control have been reported to increase metabol

113 tion rates, including cytomegalovirus, or in metabolic control (HgbA1C, hypertension, and cholesterol

114 In addition, metabolic control (HgbA1C, hypertension, serum cholester

115 scriptional regulation as a central event in metabolic control hormones, drugs, and xenobiotics in th

116 e of transplanted islets required to achieve metabolic control in a mouse model of type 1 diabetes.

117 ort the importance of maintaining meticulous metabolic control in children with urea cycle disorders,

118 However, treatment directed at deranged metabolic control in diabetes is effective only in anima

119 mined whether a low-glucose regimen improves metabolic control in diabetic patients undergoing perito

120 al regulator that sits right at the heart of metabolic control in Escherichia coli.

121 We discuss the implications for metabolic control in facultative anaerobes, and for ener

122 FADS3 AT, conserved in primates and under metabolic control in human cells, are a putative mediato

123 id hormone activation and thus may influence metabolic control in humans.

124 aning (SRP) may help to improve glycemic and metabolic control in patients with chronic periodontitis

125 fectiveness of SRP in improving glycemic and metabolic control in patients with CP and DM2.

126 ta-cell actions of GLP-1 analogs may improve metabolic control in patients with insulinopenic diabete

127 etreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but it

128 e primary care setting are needed to improve metabolic control in patients with NIDDM.

129 r of transplanted islets required to achieve metabolic control in STZ-induced diabetic mice.

130 positive impact of islet transplantation on metabolic control in T1 diabetes.

131 tool for investigating mechanisms underlying metabolic control in the heart.

132 and emphasize the importance of PKA-mediated metabolic control in the pathogenic potential of A. fumi

133 ated with elevated GLP-1 levels and improved metabolic control in these animals, resulting in improve

134 However, metabolic control in these neurons is different.

135 These studies indicate that decreased metabolic control in type 2 diabetics results in increas

136 e independent and tissue-specific effects on metabolic control in vivo.

137 provides evidence for multiple mechanisms of metabolic control in yeast aging.

138 Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes

139 evealed the specificity of leptin signals in metabolic control, including the role for leptin-STAT3 s

140 eneral Cognitive Index decreased as weeks to metabolic control increased (r = -0.58; P<.001).

141 c women because of insulin therapy and tight metabolic control, infants of diabetics still experience

142 besity or insulin resistance may be based on metabolic control intrinsic to skeletal muscle.

143 Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity en

144 We conclude that poor metabolic control is associated with significant patholo

145 Among these processes, metabolic control is coming to the forefront, because it

146 This metabolic control is exerted via inhibitory phosphorylat

147 In glycolysis, metabolic control is frequently considered vested in cla

148 mellitus, especially in individuals in whom metabolic control is poor, and cigarette smoking.

149 ion of the C. elegans serotonergic system in metabolic control is similar to mammalian serotonergic i

150 evel understanding of temporal molecular and metabolic controls is needed to define the cellular beha

151 rdependency, by balancing contractility with metabolic control, is crucial for cells of the cardiovas

152 Improved metabolic control may also decrease mortality rates.

153 Metabolic control may be relevant for refining inclusion

154 ubstrate supply, the nonlinear properties of metabolic control may induce complex dynamic behavior.

155 off insulin for 24 months and shows improved metabolic control (mean HbA(1c) 7.58 before and 6.18% af

156 ic genome activation, suggesting a conserved metabolic control mechanism underlying early pre-implant

157 The significant improvement in metabolic control observed for the patients described in

158 A number of recent studies have implicated metabolic control of adenosine generation at sites of ti

159 nd also provides a mechanism contributing to metabolic control of apoptosis.

160 tabolic needs, yet little is known about the metabolic control of B cell fate.

161 e gene regulatory mechanisms involved in the metabolic control of cardiac fatty acid oxidative flux,

162 e results implicate circadian, sleep, and/or metabolic control of CPEB-mediated subcellular trafficki

163 exposed to the flow of medium, suggesting a metabolic control of detachability.

164 Poor metabolic control of diabetes mellitus (DM) has often be

165 tment of periodontal disease on the level of metabolic control of diabetes.

166 ion in vitro and in vivo and may improve the metabolic control of diabetes.

167 th an insulin receptor antagonist, revealing metabolic control of expression.

168 gulated lipid metabolism; however, the basic metabolic control of fatty acid metabolism in neurons re

169 implicate opioid transmission in hedonic and metabolic control of feeding, although roles for specifi

170 ll morphology, chemokine expression, and the metabolic control of fibroblasts.

171 The PEPCK-C gene provides a model for the metabolic control of gene transcription.

172 Having an established influence in the metabolic control of glucose and lipids, herein, we desc

173 ntial link between cell-cycle regulation and metabolic control of glucose homeostasis.

174 This deficiency in metabolic control of glucose production critically depen

175 Periodontal treatment and metabolic control of her diabetes resulted in significan

176 is method is a long-needed tool to study the metabolic control of histone methylation.

177 it is not currently possible to measure the metabolic control of histone methylation.

178 recent work addressing metabolic changes and metabolic control of inflammation and immunity.

179 ew recent work addressing tissue hypoxia and metabolic control of inflammation and immunity.

180 findings shed light on a novel mechanism for metabolic control of inflammation by regulating HMGB1 re

181 channel, implicating the BAD-K(ATP) axis in metabolic control of neuronal excitation and seizure res

182 ed cells and represents a potential site for metabolic control of NO synthesis.

183 Adenosine is a determinant of metabolic control of organ function increasing oxygen su

184 lon(tau) genetic circadian rhythm disorders, metabolic control of PER2 stability, and how drugs that

185 cient mice are very similar, suggesting that metabolic control of PRX O-GlcNAcylation is crucial for

186 The metabolic control of respiration is still poorly underst

187 ore, these findings reveal a new pathway for metabolic control of ROS production in vivo, while demon

188 Thus, metabolic control of T cell locomotion provides new oppo

189 last few years, a full understanding of the metabolic control of T-cell functions, particularly duri

190 These results suggest that metabolic control of T1D affects the functional characte

191 osis and reinforce the importance of careful metabolic control of the acidosis to prevent and manage

192 ains were used to examine the regulation and metabolic control of the Calvin-Benson-Bassham (CBB) red

193 These findings may have implications for metabolic control of the many CaMKII-controlled and prot

194 and stimulatory influences may be aspects of metabolic control of the pathway and thus of glycoprotei

195 In the present study we found another metabolic control of the proteasome via cAMP-dependent p

196 The most compelling issue was the effect of metabolic control on both the development and progressio

197 AMP-dependent pathway and exerts significant metabolic control on the Neurospora circadian clock.

198 ween the hematopoietic organ and the central metabolic control organ of the host fly.

199 profile was not found to be associated with metabolic control other than a very moderate association

200 c regulatory circuit and implementing direct metabolic control over cell culture processes.

201 tive regulatory gene, suggesting a degree of metabolic control over this pathway.

202 otein kinase) family, has important roles in metabolic control, particularly in response to nutrient

203 The action of daf-18 in this metabolic control pathway suggests that mammalian PTEN m

204 during pregnancy with the aim of maintaining metabolic control (plasma phenylalanine < or =10 mg/dL [

205 emonstrate that ethylmalonyl-CoA mutase is a metabolic control point in the EMC pathway, expanding ou

206 SCD1, therefore, appears to be an important metabolic control point, and inhibition of its expressio

207 s been an effective strategy for identifying metabolic control points.

208 with PKU is associated with lack of maternal metabolic control prior to or early in pregnancy.

209 Offspring of women who had metabolic control prior to pregnancy had a mean (SD) sco

210 t as a simple thioredoxin inhibitor but as a metabolic control protein.

211 uggest a link between telomeric proteins and metabolic control, providing an additional mechanism by

212 Implementation of this metabolic control resulted in an oscillatory malonyl-CoA

213 Tri-level metabolic control results in saturated cells containing

214 Clinical outcome, metabolic control, severe hypoglycemia, kidney function,

215 evelop renal disease despite moderately good metabolic control, suggesting other risk factors may pla

216 rnative sugars, such as fructose, circumvent metabolic control systems and exacerbate this phenotype.

217 tical representation for use in the study of metabolic control systems make this enzyme an ideal subj

218 These data indicate that the level of metabolic control that determines acyl chain flux betwee

219 pathways with two models of enzyme kinetics: metabolic control theory (MCT) and Michaelis-Menten satu

220 Along a common paradigm of metabolic control theory, it is hypothesized that a larg

221 s effect is consistent with predictions from metabolic control theory.

222 thway revealed that recycling was subject to metabolic control through the Rag GTPases Gtr1 and Gtr2,

223 signaling node linking nutrient sensing and metabolic control to cell fate.

224 attempts at intensified insulin therapy for metabolic control) underwent solitary pancreas transplan

225 70% of the metabolic control was in the lipid assembly block of rea

226 In an attempt to highlight metabolic control, we explore genotypic differences in c

227 ndicators of proinflammatory activation, and metabolic control, were evaluated.

228 rvations in rodent models of food intake and metabolic control, where TLQP-21 shows activity.

229 ical input parameter is the desired level of metabolic control, which is the time-averaged BUN (BUNa)

230 an endogenous function of ghrelin that links metabolic control with higher brain functions and sugges

231 Laboratory tests showed that she had poor metabolic control, with 497 mg/dl fasting blood glucose