ライフサイエンスコーパス: metabolic effect

1 adipose-derived factors in relation to their metabolic effect.

2 been extensively studied for its beneficial metabolic effects.

3 y be critical determinants of long-term host metabolic effects.

4 target of POPs and may mediate part of their metabolic effects.

5 attenuates these SHP-mediated epigenomic and metabolic effects.

6 of offspring, underscoring the long reach of metabolic effects.

7 D36 in fat absorption and to its pleiotropic metabolic effects.

8 y state in AT, which may lead to detrimental metabolic effects.

9 yglucose (FDG-PET) were used to assess tumor metabolic effects.

10 iological roles of adiponectin go beyond its metabolic effects.

11 roliferative effects, whereas FGF21 has only metabolic effects.

12 regional atrophy substantially reduced most metabolic effects.

13 ut weight loss, exercise results in positive metabolic effects.

14 G(s) triggered qualitatively similar in vivo metabolic effects.

15 n tomography scans were used to assess tumor metabolic effects.

16 ceptor blockers have demonstrated beneficial metabolic effects.

17 AMPK is an important mediator of leptin's metabolic effects.

18 ics, but limited data are available on their metabolic effects.

19 substantially different short-term endocrine/metabolic effects.

20 al role of kinases upstream of AMPK in these metabolic effects.

21 ular abnormalities begin in this spectrum of metabolic effects.

22 dipose tissue-derived protein with important metabolic effects.

23 oes not cause hypercalcemia or other adverse metabolic effects.

24 and as a result they appear to have distinct metabolic effects.

25 on of dexamethasone with respect to multiple metabolic effects.

26 al transduction events and ultimate cellular metabolic effects.

27 ther inhibit or potentiate its mitogenic and metabolic effects.

28 ariatric procedures, induces weight loss and metabolic effects.

29 PAHSAs have beneficial metabolic effects.

30 olution of inflammation and exert beneficial metabolic effects.

31 ic probiotics also have immunomodulatory and metabolic effects.

32 ion can promote adiposity and its associated metabolic effects.

33 CK) exert important complementary beneficial metabolic effects.

34 a common anaerobe previously associated with metabolic effects.

35 nisms underlying atenolol-associated adverse metabolic effects.

36 al products), disregarding global downstream metabolic effects.

37 -pancreatic tissues as well as its composite metabolic effects across distinct tissues.

38 ol (RSV) and SRT1720 (SRT) elicit beneficial metabolic effects and are postulated to ameliorate obesi

39 etoprolol displays favorable hemodynamic and metabolic effects and could improve outcome in patients

40 In vivo metabolic effects and foraging ecology explain most of t

41 tissue injury, in addition to its well-known metabolic effects and functions.

42 Better understanding of vitamin D metabolic effects and the Wnt, frizzled, secreted frizzl

43 chanism of action of PCSK9 inhibitors, their metabolic effects, and clinical outcomes associated with

44 with more discontinuation for weight gain or metabolic effects, and perphenazine was associated with

45 Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of dif

46 arable results, indicating that the observed metabolic effects are directly caused by the lack of Shp

47 , supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibitio

48 These metabolic effects are not observed upon infection with &

49 ng, and its repression may cause some of the metabolic effects associated with DHEA.

50 leanness would be associated with beneficial metabolic effects at older ages.

51 However, the speed and potency of NO's metabolic effects at physiological concentrations are in

52 SD-1 deficiency or inhibition has beneficial metabolic effects, at least on liver metabolism.

53 s these FAs appear to exert their beneficial metabolic effects because of their actions in membranes.

54 In parallel with these beneficial metabolic effects, betaine supplementation robustly incr

55 To determine any differences in metabolic effects between MR and LR, this study compared

56 t physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW sy

57 These agents mediate their deleterious metabolic effects by reducing insulin secretion and incr

58 At the molecular level, Id1 mediates its metabolic effects by regulating the expression levels of

59 (+) production and suggested that downstream metabolic effects by TH can post-translationally activat

60 is a 16-kd hormone that mediates a range of metabolic effects by using a transduction pathway from t

61 s-evoked helplessness, to map regional brain metabolic effects caused by fluoxetine treatment.

62 with carvedilol had superior hemodynamic and metabolic effects compared with metoprolol CR/XL.

63 oss-sectional observations, yet with greater metabolic effects (correspondence 160% +/- 2%; R(2) = 0.

64 te (InsP3) in the nucleus, whereas insulin's metabolic effects did not depend on either of these even

65 rial complex 1, but they indicate that their metabolic effects differ depending on the stage of cellu

66 irisin as a serum factor that mediates these metabolic effects during progressive kidney injury by in

67 ality and cerebrovascular events, as well as metabolic effects, extrapyramidal symptoms, falls, cogni

68 Metabolic effects following combination antiretroviral t

69 Insulin, in addition to its metabolic effects, has promitotic and antiapoptotic acti

70 ar-weight multimer associated with favorable metabolic effects (i.e. greater insulin sensitivity, red

71 While it produced no major metabolic effects in chow-fed mice, increasing leucine i

72 cting GLP1R/GCGR dual agonist peptide exerts metabolic effects in diet-induced obese mice that are di

73 etary fibers, exhibit correlative beneficial metabolic effects in humans and rodents, including impro

74 ikewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetec

75 ted protein 2, a secreted adipocytokine with metabolic effects in liver.

76 he area of lipid metabolism, and we observed metabolic effects in macroH2A1 knockouts.

77 However, GPR30 had no significant metabolic effects in male mice fed the HFD and both sexe

78 entiation, pituitary hormone regulation, and metabolic effects in many organs.

79 abeled mensacarcin together with its unusual metabolic effects in melanoma cells provide evidence tha

80 Its long-term metabolic effects in patients with T2DM are, however, un

81 FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long d

82 ion, suggesting the persistence of anaerobic metabolic effects in skeletal muscle beyond the relative

83 Insulin's metabolic effects in the liver are widely appreciated, b

84 nd peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasi

85 el mechanism that may explain its beneficial metabolic effects in type 2 diabetes patients.

86 use model of T-cell lymphoma and examine the metabolic effects in vitro.

87 ate that RSV and SRT do not induce analogous metabolic effects in vivo.

88 o nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion

89 nhanced ARH neural projections and long-term metabolic effects, including increased body weight, visc

90 To determine if the AAPs have detrimental metabolic effects independent of weight gain or psychiat

91 urs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a paralle

92 Hepatic and metabolic effects induced by dietary fat and cholesterol

93 ced GLUT4 translocation, suggesting that the metabolic effects induced by Q209L-Galphaq are dependent

94 nto the mechanisms underlying the beneficial metabolic effects induced by VSG.

95 s also may produce longer term modulatory or metabolic effects involving NO/cGMP.

96 Rather, the activation is partly linked to metabolic effects involving redox signaling.

97 This metabolic effect is both necessary and sufficient to ind

98 However, this metabolic effect is not translated into an attenuated ri

99 eshold required to exert clinically relevant metabolic effects is unknown.This study aimed to determi

100 changes were aggregated in the quantitative metabolic effect level index (MELI), allowing effect est

101 man MSCs with NPIs demonstrated a beneficial metabolic effect likely as a result of earlier islet vas

102 ive nature of the disease and its consequent metabolic effects make this an attractive option for man

103 irect anti-apoptotic activity and beneficial metabolic effects, make HNG and SHLP2 exciting prospects

104 prising finding suggests that the pronounced metabolic effects mediated by activation of hepatic vaga

105 both virologically effective and has minimum metabolic effects, minimisation of traditional risk fact

106 e of modern regimens, which might have fewer metabolic effects, minimises the risk of myocardial infa

107 4) GlcN has metabolic effects not shared by high glucose.

108 NAD(+) synthesis, explaining the overlapping metabolic effects observed with the two compounds.

109 led a sufficiently rapid uptake to cause the metabolic effects observed.

110 We confirm the metabolic effects obtained with PX-478 treatment using a

111 etabolic study demonstrates that major lipid metabolic effects occur after replacing FO with VO in sa

112 We aim to determine the metabolic effect of a functional knockdown of TCF7L2 by

113 to determine the involvement of FGF21 in the metabolic effect of AHR.

114 hese rGBM patients strongly suggest a direct metabolic effect of cediranib and might also reflect an

115 rough elevated citrate levels or a secondary metabolic effect of citrate accumulation, and responds b

116 e research is needed to fully understand the metabolic effect of dietary fructose in humans.

117 Increased energy expenditure is a primary metabolic effect of dietary protein restriction, and req

118 A metabolic effect of folate deficiency is an elevation of

119 Accordingly, no direct metabolic effect of hydrogen sulfide is observed in larg

120 important implications for understanding the metabolic effect of OxLDL on the vessel wall and mechani

121 This points to a complex metabolic effect of RYGB that exceeds glucose normalizat

122 is increased after myocardial ischemia, the metabolic effect of supply-demand ischemia induced by do

123 This metabolic effect of Zaprinast does not depend on inhibit

124 ate carrier in retina does not attenuate the metabolic effect of Zaprinast.

125 Thus, we studied the metabolic effects of a 12-month vitamin D supplementatio

126 es including type 1 diabetes, the underlying metabolic effects of a genetically altered immune system

127 Here, we explored the metabolic effects of a sEH inhibitor (t-TUCB) in fat-1 m

128 The metabolic effects of adipocyte-specific knockout of Cx43

129 The metabolic effects of adiponectin are mediated by adipone

130 Although the known metabolic effects of AMPK activation are consistent with

131 ce to beta cells and relief from the adverse metabolic effects of an inflammatory state in insulin-se

132 We hypothesized that the specific metabolic effects of bacteriostatic and bactericidal ant

133 As the metabolic effects of bariatric surgery are better elucid

134 ) and carbohydrate oxidation and opposes the metabolic effects of beta-adrenergic stimulation.

135 patic insulin signaling, suggesting that the metabolic effects of beta-catenin occurred via a paralle

136 owever, recent animal studies suggest direct metabolic effects of BNP.

137 Severe resistance to the metabolic effects of both leptin and insulin ensued afte

138 tuin 1 (Sirt1), a mediator of the beneficial metabolic effects of calorie restriction, protects neuro

139 re no other measured systematic endocrine or metabolic effects of carotid body resection during eugly

140 It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweete

141 We hypothesized that the major metabolic effects of corticosteroids are mediated by cha

142 To understand better the metabolic effects of cyanide and to discover novel cyani

143 The metabolic effects of cyanide observed in zebrafish were

144 ts in the dairy matrix, which may modify the metabolic effects of dairy consumption.

145 Therefore, we examined the metabolic effects of dexamethasone and troglitazone, alo

146 isted in KO animals in which the confounding metabolic effects of diabetes were eliminated by islet t

147 The metabolic effects of dietary protein are complex.

148 gical mechanisms may exist to "memorize" the metabolic effects of early nutritional environments.

149 g approach is informative for predicting the metabolic effects of either an altered level of incident

150 esis, the enzymatic profile, and the in-vivo metabolic effects of endothelial lipase suggest that, li

151 ithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma.

152 ssue plays an integral role in mediating the metabolic effects of EPO.

153 ve study evaluated the safety, efficacy, and metabolic effects of exenatide in subjects with type 1 d

154 actors associated with obesity/diabetes, the metabolic effects of exercise on the heart are not well-

155 y induction may contribute to the beneficial metabolic effects of exercise.

156 does not play a role in mediating favorable metabolic effects of FGF21 administration in DIOs housed

157 orie is just a calorie" and suggest that the metabolic effects of food may matter as much as its ener

158 The combined cerebral metabolic effects of galantamine and citalopram suggest,

159 ysis and/or gluconeogenesis in mediating the metabolic effects of GalN.

160 nisms as well as their impact on the overall metabolic effects of GBP surgery.

161 RAL with a monoclonal antibody prevented the metabolic effects of GDF15 in rats.

162 and as the bona fide receptor mediating the metabolic effects of GDF15, enabling a more comprehensiv

163 AL is a receptor for GDF15 that mediates the metabolic effects of GDF15.

164 or at local sites of GH action, whereas the metabolic effects of GH are considered to be intrinsic t

165 To study the direct metabolic effects of GH in the muscle, we specifically i

166 he present study we compared the feeding and metabolic effects of ghrelin and NPY following pretreatm

167 igate whether the growth hormone release and metabolic effects of ghrelin on AMPK activity of periphe

168 Our data suggest that the metabolic effects of ghrelin on AMPK in peripheral tissu

169 metabolism and cell death by evaluating the metabolic effects of glucose deprivation on mouse photor

170 riginal studies were published regarding the metabolic effects of growth hormone therapy in pediatric

171 rs' diets, and 3) the latest research on the metabolic effects of HFCS.

172 e objective of this study was to examine the metabolic effects of high-dose resveratrol in obese huma

173 These studies indicate that, unlike the metabolic effects of highly restricted neuronal subsets

174 Given the opposing metabolic effects of hypoxia and diabetes, we questioned

175 aracterized a variety of the biochemical and metabolic effects of inactivation of the mouse gene for

176 Nevertheless, the metabolic effects of increasing eNOS levels have not bee

177 eem to be major mediators of the detrimental metabolic effects of insufficient sleep, through favouri

178 B, best known as a negative regulator of the metabolic effects of insulin, is required for the effect

179 IR-B promotes the metabolic effects of insulin, whereas IR-A rather signal

180 /AKT pathway, is hypothesized to inhibit the metabolic effects of insulin.

181 Aeration limitation not only obscured the metabolic effects of iron limitation but also overrode t

182 The aim of the study was to assess long-term metabolic effects of laparoscopic sleeve gastrectomy (LS

183 The signalling pathways that mediate the metabolic effects of leptin remain undefined.

184 ach component in mediating the anorectic and metabolic effects of leptin, and in regulating the parti

185 individual carotenoids, possibly reflecting metabolic effects of lifestyle and physiologic factors o

186 nsive exercise programme, to investigate the metabolic effects of local human renin-angiotensin syste

187 in-1beta, cytokines that mediate many of the metabolic effects of LPS, increased hepatic GlcCer synth

188 Although a few metabolic effects of metformin and the related biguanide

189 These findings suggest that the metabolic effects of metformin in subjects with type 2 d

190 , MLYCD, is experimentally validated and the metabolic effects of MLYCD depletion investigated.

191 s MAO people are predisposed, to the adverse metabolic effects of moderate weight gain and that incre

192 of ergoreceptors (afferents sensitive to the metabolic effects of muscular work) may be a link betwee

193 Most methods for the detection of the metabolic effects of myocardial ischemia are highly inva

194 Metabolic effects of NLRX1 deficiency are observed in a

195 cose and cholesterol metabolism and that the metabolic effects of Nnmt in the liver are mediated by i

196 To this end, we set out to investigate the metabolic effects of NO in cultured astrocytes from mice

197 50-100 pmol) pretreatment on the feeding and metabolic effects of NPY.

198 on were monitored to determine the immediate metabolic effects of nuclear stains, including SYTO, DAP

199 The metabolic effects of obesity have made this highly preva

200 y acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministratio

201 The metabolic effects of omega-6 polyunsaturated fatty acids

202 However, the underlying metabolic effects of opioid withdrawal and replacement h

203 The metabolic effects of OXM have been attributed primarily

204 ctions of thiazolidinediones, we studied the metabolic effects of pioglitazone in spontaneously hyper

205 rvation provides important insights into the metabolic effects of postmenopausal hormones but is insu

206 The adverse metabolic effects of prescribed and endogenous glucocort

207 targeting glycogen is not sufficient for the metabolic effects of PTG.

208 However, very little is known about the metabolic effects of PTG.

209 ling pathways in the brain contribute to the metabolic effects of PTP1B deficiency remains unclear.

210 B signaling may contribute to the beneficial metabolic effects of PTP1B deficiency.

211 The metabolic effects of RA or RARbeta are mimicked by FGF21

212 , thereby enabling in vivo monitoring of the metabolic effects of reperfusion strategies.

213 PKalpha1 or -alpha2 to determine whether the metabolic effects of resveratrol are mediated by AMPK.

214 Here, we report that the metabolic effects of resveratrol result from competitive

215 f resveratrol, is the central target for the metabolic effects of resveratrol.

216 e, we investigated in a Rhcg mouse model the metabolic effects of Rhcg haploinsufficiency, the role o

217 study evaluated the acute cardiovascular and metabolic effects of SAAP with HBOC-201 in an exsanguina

218 -HSD1-deficient mice were resistant to these metabolic effects of salicylate.

219 ular mechanisms involved in these beneficial metabolic effects of salsalate by treating mice with sal

220 In order to determine the metabolic effects of selenide administration, we exposed

221 We also examined the metabolic effects of selenide administration.

222 he distal small bowel mucosa may explain the metabolic effects of SG occurring before substantial wei

223 tituted with activation-defective SIRT1, the metabolic effects of STACs were blocked.

224 tein turnover, but little is known about the metabolic effects of stretch.

225 biota compositions and the physiological and metabolic effects of TCDF.

226 te, the osmotic effects of glycerol, and the metabolic effects of the accumulation of a phosphorylate

227 The early metabolic effects of the anti-HER2 therapies on the prim

228 nto the structure, function, regulation, and metabolic effects of the glycogen-targeting subunits of

229 e receptor that mediates the somatogenic and metabolic effects of the growth hormone (GH).

230 When metabolic effects of the knockout are impaired, NLRX1-de

231 Feeding and metabolic effects of the MC-R agonist melanotan II (MTII

232 estion is unclear.We sought to determine the metabolic effects of the pharmacologic inhibition of STR

233 ew we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the

234 iology of myotoxicity most probably involves metabolic effects of the statins on the isoprenoid pool

235 Bariatric or metabolic effects of the surgical procedures appear inde

236 The metabolic effects of the treatment are not attributed to

237 The metabolic effects of the two interventions differed in t

238 rt to the adverse renal, cardiovascular, and metabolic effects of these agents.

239 C-1alpha in skeletal muscle for the systemic metabolic effects of these compounds has so far not been

240 To study the metabolic effects of these proteins in more detail, we e

241 xamined this notion using PET to compare the metabolic effects of these treatment approaches.

242 The metabolic effects of these two peptides with respect to

243 a high consumption raises concern about the metabolic effects of this sugar.

244 findings provide a mechanism for integrating metabolic effects of THs with the tumor suppressor activ

245 These studies reveal for the first time the metabolic effects of tissue-specific increases in NAD sy

246 "beiging" of WAT, regulation of adipokines, metabolic effects of trained adipose tissue on systemic

247 ted into recipient mice further improved the metabolic effects of transplantation.

248 synthesis of other stress effectors, or the metabolic effects of trehalose biosynthetic intermediate

249 thioredoxin, and it is not known whether the metabolic effects of Txnip are related to its ability to

250 riment characterized further the feeding and metabolic effects of UCN by examining its impact after d

251 In separate rats (n=8), the metabolic effects of UCN were monitored using an open ci

252 Recently, the deleterious metabolic effects of visceral fat [visceral adipose tiss

253 obese" (MAO), are protected from the adverse metabolic effects of weight gain.

254 Intervention studies have indicated that the metabolic effects of whole dairy may be different than t

255 With these metabolic effects, oleate also supported a 25% improveme

256 isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism an

257 oxide synthase 2 (NOS2)]- indicating minimal metabolic effect on the cysH mutant survival in these mi

258 t that AICAR induces profound cytostatic and metabolic effects on 1CT+7 cells, but not on their isoge

259 l sweeteners have previously uncharacterized metabolic effects on adipocyte differentiation and metab

260 menon of caffeine intolerance other than its metabolic effects on elevating brain lactate.

261 Leptin has potent metabolic effects on fat and glucose metabolism.

262 modulating bile acid levels, and additional metabolic effects on glucose metabolism, nonalcoholic li

263 AKT/mTOR metabolic effects on hepatocytes, after insulin stimulat

264 ct the outcome of parasitic diseases through metabolic effects on host immunity and/or the parasite.

265 However, L-NAME has negative metabolic effects on protein synthesis that suppress the

266 is limited information concerning caffeine's metabolic effects on the human brain, the authors applie

267 vity in CF HBE cells, presumably through non-metabolic effects on upstream regulatory pathways.

268 Moreover, these metabolic effects, particularly an increase in fatty aci

269 In addition to metabolic effects, PMA treatment also translocated PKM2,

270 en linked to both beneficial and deleterious metabolic effects, potentially confounded by diverse det

271 Beyond these metabolic effects, PPARgamma agonists exhibit antineopla

272 n homozygosis: Deltay A set of molecular and metabolic effects, reminiscent of those observed in the

273 actions appear to be independent of leptin's metabolic effects.SIGNIFICANCE STATEMENT Sexual maturati

274 ese data demonstrate that cerulenin produces metabolic effects similar to effects of leptin, but thro

275 and the entorhinal cortex showed the largest metabolic effect size.

276 Metabolic effect sizes were determined with and without

277 f this class, has been shown to have several metabolic effects such as reducing weight gain and visce

278 Antiretroviral agents associated with fewer metabolic effects, such as tenofovir and abacavir, remai

279 had experienced comparable or more favorable metabolic effects than those assigned to the Zone, Ornis

280 al activity in the elderly are the result of metabolic effects that are not reflected well by maximal

281 hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global altera

282 summary, aldosterone excess has detrimental metabolic effects that contribute to the metabolic syndr

283 gon receptor from cAMP production results in metabolic effects that could reduce hepatocyte glucose p

284 Coffee has several metabolic effects that could reduce the risk of gallston

285 T in human beings could also have beneficial metabolic effects that might resolve common complication

286 c studies suggest that sleep restriction has metabolic effects that predispose to weight gain.

287 of the Western 'fast-food' diet, have unique metabolic effects that suggest they may be key contribut

288 Metabolic effects that were not excluded as possible con

289 silencing of Opa-1 or Mfn2 prevented all the metabolic effects triggered by insulin.

290 These adducts may exert metabolic effects unrelated to their effect on gluconeog

291 n methyl-pool homeostasis and determined its metabolic effects using the methionine and choline-defic

292 that olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C.

293 The metabolic effect was also negated by coinfusion with tet

294 These beneficial metabolic effects were accompanied by the enhanced expre

295 Similar metabolic effects were also evident, albeit in the absen

296 Changes in metabolic effects were assessed following cART in the AI

297 At a cellular level, these metabolic effects were paralleled by inhibition of postr

298 Hepatocellular damage, inflammation, and metabolic effects were quantified by enzyme activities,

299 Berry intake has overall metabolic effects, which depend on the cardiometabolic r

300 d in microgram quantities, inhibition of its metabolic effects with potent PTH antibodies should be p