ライフサイエンスコーパス: metabolic intermediate

1 y in which CO is produced and then used as a metabolic intermediate.

2 n mucosal surfaces through the production of metabolic intermediates.

3 armaceuticals, and also represent endogenous metabolic intermediates.

4 and, in some cases, to small phosphorylated metabolic intermediates.

5 ical pathways by confining toxic or volatile metabolic intermediates.

6 ases, producing xylosyl-xylitol oligomers as metabolic intermediates.

7 ells, resulting in the accumulation of cycle metabolic intermediates.

8 enes can explain the decreases in associated metabolic intermediates.

9 3-oxo-4-cholestenoic acid, one of the first metabolic intermediates.

10 (CoAs) are critical regulatory molecules and metabolic intermediates.

11 umulated sugar-phosphates or to depletion of metabolic intermediates.

12 th amino acids for protein synthesis and for metabolic intermediates.

13 f secondary metabolic pathways by binding to metabolic intermediates.

14 protection against the accumulation of toxic metabolic intermediates.

15 f the flavonoid pathway and utilize the same metabolic intermediates.

16 ich necessitates multiple steps to transport metabolic intermediates.

17 esources into offspring that are mediated by metabolic intermediates.

18 here were corresponding changes in polyamine metabolic intermediates.

19 We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthr

20 ention in trypanosomatid protozoa to the key metabolic intermediate 5,10-CH(2)-THF, situated at the j

21 Feeding with excess l-DOPA showed that the metabolic intermediate 5,6-dihydroxyindole reached the h

22 m a key pathway for synthesis of the central metabolic intermediate acetyl coenzyme A (acetyl-CoA) fr

23 de chain of biotin, also produce the crucial metabolic intermediates acetyl-CoA and butyryl-CoA with

24 ism have led to the hypothesis that neuronal metabolic intermediates affect neural outputs that modif

25 expression in vSMCs treated with BaP or its metabolic intermediates alone, and in combination with a

26 stids, and also report copolymer production, metabolic intermediate analyses, and pathway dynamics.

27 d appears to be both an essential ubiquitous metabolic intermediate and a signaling lipid.

28 The metabolic intermediate and endocannabinoid signaling lip

29 Pyruvate, a natural metabolic intermediate and energy substrate, exerts anti

30 Processes that exchange both metabolic intermediates and cations between the cytosol

31 educed from the redistribution of label into metabolic intermediates and end products observed when c

32 duced from the redistribution of (13) C into metabolic intermediates and end products when cells were

33 mn produced relatively low concentrations of metabolic intermediates and had a greater proportion of

34 is most probably involves both production of metabolic intermediates and modulation of erythropoietin

35 adioactivity from 14C-labeled compounds into metabolic intermediates and total lipids was examined in

36 unique enzymes by nutrient availability and metabolic intermediates, and describe these properties i

37 in which the first step is rate-limiting and metabolic intermediates are short-lived.

38 ectronic RNO (R = alkyl and aryl) molecules (metabolic intermediates) are largely unknown.

39 Many chromatin modifying-enzymes utilize metabolic intermediates as cofactors or substrates, and

40 ve relevance of circulating lactate or other metabolic intermediates as fuels remains unclear.

41 Since all modifications use metabolic intermediates as substrates for chromatin-modi

42 echniques to identify diphosphate-containing metabolic intermediates at submillimolar concentrations

43 well as providing a mechanism for recycling metabolic intermediates back to the outer retina.

44 enzymes required to convert PCP to a common metabolic intermediate before entering the tricarboxylic

45 nstrated clear differences in the pattern of metabolic intermediates between amelanotic and melanotic

46 oid bases and their 1-phosphate are not only metabolic intermediates but also highly bioactive lipids

47 y is gut microbiota-dependent synthesis of a metabolic intermediate called TMA, and subsequent host-d

48 vity measurements, we show that a downstream metabolic intermediate can selectively remove the cataly

49 r, including mechanism-based inactivation by metabolic-intermediate complex formation, competitive in

50 uire accurate isotopic data of intracellular metabolic intermediates for stationary, nonstationary, a

51 ecently identified as an important source of metabolic intermediates for these processes.

52 These observations fit a model in which the metabolic intermediate formaldehyde is required for net

53 Propionyl-CoA arises as a metabolic intermediate from the degradation of propionat

54 e size provides Anaplasma with the necessary metabolic intermediates from the host cytoplasm.

55 Two metabolic intermediates, gamma-hydroxybutyrate and succi

56 Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular

57 fatty acids (BCFAs), amino acids, and other metabolic intermediates generated from acyl-coenzyme A,

58 ooA were important in the cycling of CO as a metabolic intermediate, global transcriptional analyses

59 light, ultimately generating ethanol and the metabolic intermediate glyoxylic acid hydrate.

60 signaling pathways through the production of metabolic intermediates has been increasingly noted.

61 kinase isoform (PKM2) reduces the levels of metabolic intermediates important for biosynthesis and i

62 e ability to initiate the synthesis of a key metabolic intermediate in an allosterically regulated fa

63 Formaldehyde is an essential metabolic intermediate in human cells and can also enter

64 hether measurement of concentrations of this metabolic intermediate in plasma could provide a new met

65 phosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol,

66 ince trans-aconitate does not appear to be a metabolic intermediate in these cells but forms spontane

67 The compounds measured included metabolic intermediates in central carbohydrate metaboli

68 Pantothenic acid and beta-alanine are metabolic intermediates in coenzyme A biosynthesis.

69 The changes in metabolic intermediates in response to K+ were like thos

70 f vitamin A (all-trans-retinol) and serve as metabolic intermediates in the formation of the visual c

71 Pim occurred as a result of lower levels of metabolic intermediates in the glycolytic and pentose ph

72 applied targeted metabolomics to measure the metabolic intermediates in the most relevant pathways fo

73 entrations and flux rates of metabolites and metabolic intermediates in vivo.

74 rincipally by the adenine nucleotides, other metabolic intermediates, including long chain acyl-CoA e

75 ting fatty acids to acyl-CoAs and downstream metabolic intermediates increases cellular fatty acid up

76 study demonstrates that the known tryptophan metabolic-intermediate indole-3-pyruvate is a proagonist

77 Here, we show that lactate, an important metabolic intermediate, induces browning of murine white

78 s the flow of glucose- and glutamine-derived metabolic intermediates into the Tricarboxylic Acid (TCA

79 as distinct structures compartmentalizing a metabolic intermediate involved in regeneration of the v

80 In the liver, citrate is a key metabolic intermediate involved in the regulation of gly

81 ly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulatio

82 of <2 s at 100 degrees C, yet this critical metabolic intermediate is found even in organisms that g

83 of defensive compounds are derived from the metabolic intermediate, isopentenyl diphosphate (IPP).

84 to regenerate NAD from NADH by reducing the metabolic intermediate L-lactaldehyde to propanediol whi

85 The accumulation patterns of metabolic intermediates (metabolite-to-gene correlation)

86 t is lost during catalysis in a pathway with metabolic intermediates of metal-chelating properties.

87 derangement of many signaling molecules and metabolic intermediates; of these, the massively increas

88 ationship between the two species in which a metabolic intermediate produced by E. coli was used and

89 Many metabolic intermediate products of neutral lipids serve

90 steps in the pathway that yield the central metabolic intermediates pyruvate and propionyl coenzyme

91 involves the sequestration of sirohaem as a metabolic intermediate rather than as a prosthetic group

92 progression is believed to involve reactive metabolic intermediates reacting with constituents of Br

93 method employs two-photon excitation of the metabolic intermediate, reduced nicotinamide adenine din

94 ng the production of mitochondrial-dependent metabolic intermediates required for cell growth, and th

95 es of M. tuberculosis specifically generates metabolic intermediates reserved for re-initiation of pe

96 s fungal pathogen to synthesize the critical metabolic intermediate S-adenosylmethionine and work by

97 res were treated with trichodiene, the first metabolic intermediate specific to the trichothecene bio

98 e elasticity in permitted pool sizes for key metabolic intermediates such as pyruvate and acetyl-CoA.

99 Metabolic intermediates, such as succinate and citrate,

100 otein, chlorophyll), total phenols and major metabolic intermediates (sugars, starch, nitrate, amino

101 Quantitation of metabolic intermediates suggested that cellular metaboli

102 Pyruvate is a key metabolic intermediate that, when rerouted to other meta

103 f protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin.

104 of the CNS monitor and respond to levels of metabolic intermediates that reflect peripheral energy s

105 need to reduce the build-up of thermolabile metabolic intermediates that would be susceptible to des

106 hough 2,6-dichlorohydroxyquinol is a logical metabolic intermediate, the enzyme hardly uses it as a s

107 and chemicals are generated from short-chain metabolic intermediates through pathways that require ca

108 ine, and they actively synthesize and export metabolic intermediates to the apical side to nourish th

109 ustness of the biocatalysts that convert the metabolic intermediates to, in some cases, finished and

110 we demonstrate by mass spectrometry that the metabolic intermediates UDP-GalNGc and UDP-GlcNGc serve

111 atic synthesis of phosphorylated high-energy metabolic intermediates under conditions considered to h

112 Channeling of metabolic intermediates via enzyme complexes may enhance

113 ncy of cholesterol and accumulation of toxic metabolic intermediates, we assessed the efficacy of com

114 DHA and all its metabolic intermediates were detected in RPE cells from

115 ue amino acid levels, enzyme activities, and metabolic intermediates were measured.

116 ely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vecto

117 Glucose 6-phosphate (G6P) is a metabolic intermediate with many possible cellular fates

118 ymethyl pyrimidine moiety of thiamine shares metabolic intermediates with purine biosynthesis.

119 mn generated periodic high concentrations of metabolic intermediates, with Bacteria and methanogens d

120 Ammonium serves as key nitrogen source and metabolic intermediate, yet excess causes toxicity.