ライフサイエンスコーパス: metabolic pathway

1 ween Cu homeostasis, CITF1, SPL7, and the JA metabolic pathway.

2 o as to maximize the productivity of a model metabolic pathway.

3 erating modules, each controlling a separate metabolic pathway.

4 1), a regulator of the GABA neurotransmitter metabolic pathway.

5 n-butanol can be achieved via more than one metabolic pathway.

6 ring cannot account for this novel secondary metabolic pathway.

7 nic acid was elucidated to be its ubiquitous metabolic pathway.

8 enzymes have been reported from a secondary metabolic pathway.

9 i have been implicated in the glycine/serine metabolic pathway.

10 fect of drugs targeting this cancer-specific metabolic pathway.

11 nges of specific lipids and their associated metabolic pathways.

12 n by stable epigenetic changes in immune and metabolic pathways.

13 bon flux exceeds the capacity of the central metabolic pathways.

14 binoid and cytochrome P450 (CYP) epoxygenase metabolic pathways.

15 nstrated transcriptional engineering of some metabolic pathways.

16 of gene expression, transport proteins, and metabolic pathways.

17 ic information through in vivo monitoring of metabolic pathways.

18 stimuli to regulate several cell growth and metabolic pathways.

19 erise (PPIase) and involved in various other metabolic pathways.

20 n in the presence of inhibitors of different metabolic pathways.

21 these changes could be mapped to overlapping metabolic pathways.

22 e-based tools that contain information about metabolic pathways.

23 ht into regulation or kinetic limitations of metabolic pathways.

24 ht resistance through modulation of multiple metabolic pathways.

25 a time-dependent inhibition of different key metabolic pathways.

26 to small cohort sizes or limited coverage of metabolic pathways.

27 dent protein deacylase that controls several metabolic pathways.

28 putative trans- regulators for a variety of metabolic pathways.

29 e, proteasome, oxidative phosphorylation and metabolic pathways.

30 odulation of discrete cellular functions and metabolic pathways.

31 the human genome; protein modifications; and metabolic pathways.

32 ic progression of gene expression in diverse metabolic pathways.

33 he fate of (13)C-enriched substrates through metabolic pathways.

34 utophagy also modulates levels of enzymes in metabolic pathways.

35 ons, which impose significant constraints on metabolic pathways.

36 y metabolism to the evolution of specialized metabolic pathways.

37 utilize and assimilate CO2 through different metabolic pathways.

38 s, and enhance flux through the encapsulated metabolic pathways.

39 tient groups were interrogated against known metabolic pathways.

40 molecule resulting from glycolysis and other metabolic pathways.

41 , pyruvate, and glyoxylate and dicarboxylate metabolic pathways.

42 licates FMOs in aging, several diseases, and metabolic pathways.

43 proteins, protein complexes, biochemical and metabolic pathways.

44 ites, and many other molecules from multiple metabolic pathways.

45 t also function naturally, albeit rarely, in metabolic pathways.

46 lated in response to disruption of glutamine metabolic pathways.

47 te sequential enzymatic reactions of diverse metabolic pathways.

48 This study shows that reconstruction of metabolic pathways - a common goal of omics studies - co

49 With progression to steatohepatitis, metabolic pathway activation persisted with additional a

50 Glutaminolysis is a metabolic pathway adapted by many aggressive cancers, in

51 signal transduction, and how alterations in metabolic pathways affect vessel morphogenesis.

52 iate from the prediction highlight potential metabolic pathways affected by species-species interacti

53 in-protein interaction networks and enriched metabolic pathways among other features.

54 id expression analysis identified changes in metabolic pathways among the patient groups.

55 tion for multiple comparisons, and conducted metabolic pathway analyses.

56 Metabolic pathway analysis, combined with hydrocarbon co

57 ns including a non-canonical glutamine (Gln) metabolic pathway and that inhibition of downstream comp

58 New tools include GO, metabolic pathway and word enrichment analyses plus an o

59 lling pathways, transcription factors (TFs), metabolic pathways and 258 of them showed differential e

60 abase and explored the relationships between metabolic pathways and abiotic factors in glacier-fed st

61 Circadian genes are enriched in cellular metabolic pathways and coincide with two peaks of intrac

62 six salivary metabolites were mapped into 49 metabolic pathways and connected with human metabolic di

63 P has the potential to probe a wide range of metabolic pathways and functions at the single-cell leve

64 nscriptomic screenings were used to identify metabolic pathways and gene sets regulated by glycolytic

65 motes adipocyte differentiation via distinct metabolic pathways and independently of fatty acids.

66 lation in the endothelium and uncovered core metabolic pathways and mechanisms of regulation that dri

67 Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide

68 phorylation, stronger regulation of genes in metabolic pathways and more dramatic glycolytic response

69 Metabolic pathways and networks can be mapped and quanti

70 pe-enriched precursors to products to deduce metabolic pathways and networks.

71 of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency.

72 a number of different biological functions, metabolic pathways and pathophysiological processes.

73 ll activation showed extended proliferative, metabolic pathways and persistence of HCV target cells.

74 a are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate.

75 mTOR coordinates growth signals with metabolic pathways and protein synthesis and is hyperact

76 We connected salivary metabolites with human metabolic pathways and PubMed Medical Subject Heading (M

77 with cells that follow similar Mg uptake and metabolic pathways and serves to reveal Mg cycling in ec

78 oxin, NADPH and NADH, as well as influencing metabolic pathways and thiol/disulfide redox balance.

79 ns and (13) C composition to investigate the metabolic pathways and transport mechanisms driving mois

80 y reducing glucose uptake, altering cellular metabolic pathways, and activating inflammatory signalin

81 lations, a greater reliance on opportunistic metabolic pathways, and greater reliance on visual rathe

82 ted to self-reported diet, agnostically test metabolic pathways, and identify mechanistic mediators.T

83 We also demonstrate that specific metabolic pathways appear to be differentially required

84 d on 98 traits derived from known amino acid metabolic pathways (approach 1) and then on 92 traits ge

85 Defective autophagy and deranged metabolic pathways are common in cancer; pharmacologic t

86 Recent studies show that a wide range of metabolic pathways are controlled by circadian rhythms w

87 eased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferati

88 As host and microbial metabolic pathways are intimately connected with diet, w

89 umption, we found that pronounced rhythms in metabolic pathways are often favored by separation rathe

90 ere identified, and the underlying perturbed metabolic pathways are quite similar to the pathways fou

91 ired for latency, and we now show that these metabolic pathways are required for efficient lytic repl

92 evious work has shown that multiple cellular metabolic pathways are required for latency, and we now

93 A variety of metabolic pathways are sequestered in peroxisomes, conse

94 To ascertain which metabolic pathways are used to convert glucose and gluta

95 agon, a catabolic hormone that affects these metabolic pathways, are elevated during critical illness

96 These results identify COMMD1 and an E2F-metabolic pathway as key regulators of osteoclastogenic

97 ctivation induced extended proliferative and metabolic pathways as the HCV target cells survived.

98 c tissues to regulate lipid and carbohydrate metabolic pathways as well as energy homeostasis.

99 urpose of this study was to identify altered metabolic pathways associated with child stunting.We mea

100 que to HCA-positive CD4(+) T lymphocytes; 3) metabolic pathways associated with glutathione detoxific

101 g a multistage clustering algorithm in which metabolic pathway associations are used along with inten

102 tabolite involved in a multiplicity of plant metabolic pathways, being associated with mitochondrial

103 pproach by using the same pool to optimize a metabolic pathway (beta-carotene) and genetic circuit (X

104 Therefore, where differences exist in metabolic pathways between healthy and pathogenic cells,

105 thereby facilitating the characterization of metabolic pathways both in vivo and in vitro.

106 only the alterations in PPARgamma-regulated metabolic pathways, but also the increases in cytokine e

107 suggests that it may be involved in several metabolic pathways, but the molecular mechanisms which p

108 ng and a transcription factor E2F1-dependent metabolic pathway by the cytokine RANKL.

109 ted carbon sources but also reveal different metabolic pathways by analyzing SCRS.

110 , we analyzed the circadian orchestration of metabolic pathways by direct measurement of enzyme activ

111 be measured simultaneously and the affected metabolic pathways can be revealed.

112 Therefore, inhibition of specific cellular metabolic pathways can both eliminate latently infected

113 emonstrate that the key components of a core metabolic pathway central to energy transduction and ami

114 messenger RNA (mRNA) abundance of vitamin D metabolic pathway components were quantified.

115 e new data types include protein microarray, metabolic pathways, compounds, quantitative proteomics,

116 Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch

117 Most metabolic pathways contain more reactions than metabolit

118 stress, but also identified novel genes and metabolic pathways controlled by Spx during peroxide str

119 ke traits and whether the inhibition of this metabolic pathway could represent a novel therapeutic ap

120 ent metalloenzymes are widespread throughout metabolic pathways, coupling the reduction of O2 with th

121 hat vitamin D affects multiple signaling and metabolic pathways critical for T-cell activation and di

122 Inhibiting other metabolic pathways critical for the supply of building b

123 Using this pipeline, we generated metabolic pathway databases for 22 species and identifie

124 etic or pharmacologic disruption of the GABA metabolic pathway decreased the incidence of brain metas

125 e-based metabolomics analysis identified key metabolic pathway deficits in SNRK knockdown cardiomyocy

126 Validation of major metabolic pathways demonstrated alterations in oxidative

127 ole was associated with reversal of the same metabolic pathways described above.

128 cosystem models have advanced to incorporate metabolic pathways discovered with genomic sequencing, b

129 that may directly influence the flux through metabolic pathways during the seed-to-seedling transitio

130 Integration of signaling and metabolic pathways enables and sustains lymphocyte funct

131 products, their function and regulation, new metabolic pathways, enzymes and cofactors are regularly

132 facilitate, and contribute to, the study of metabolic pathway evolution and engineering.

133 immunosuppressive, glycolysis is a prominent metabolic pathway exerted only by IL-17A(+)Foxp3(+) cell

134 ellular phenotypes and controlling multigene metabolic pathway expression.

135 he enzymes, providing increased control over metabolic pathway fluxes.

136 The metabolic pathway for ascorbate and aldarate was disturb

137 However, the metabolic pathways for BCAA breakdown are largely unknow

138 a strain AG77 features a core set of primary metabolic pathways for degradation of simple carbohydrat

139 cations for clinical candidates, addition of metabolic pathways for drugs and calculation of structur

140 l killing, and the engineering or control of metabolic pathways for improved biochemical synthesis.

141 uch information is useful for bioengineering metabolic pathways for specific terpenes.

142 l and marine bacteria have evolved intricate metabolic pathways for using environmentally derived aro

143 r results identify a previously unidentified metabolic pathway from NaAD using unprecedented carboxyl

144 ediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to acc

145 ent gene cassette replacement in a synthetic metabolic pathway gene array as a proof of principle.

146 ory, antiinflammatory, T-cell signaling, and metabolic pathway gene sets.

147 y genes, which in turn, regulated downstream metabolic pathway genes to biosynthesize resistance rela

148 single-nucleotide polymorphisms in vitamin D metabolic pathway genes, serum vitamin D3 concentrations

149 Many of these metabolic pathways go through intermediates such as vani

150 The complex metabolic pathways governing c-di-GMP synthesis and degr

151 A multitude of genetic, molecular, and metabolic pathways have been identified, which may promo

152 ation of hepatic progenitor cell markers and metabolic pathways: high-risk tumors were characterized

153 to perform rapid 'in situ' analyses of human metabolic pathways (HMPs) demonstrates disposable screen

154 ic acid (TCA) cycle being one of the primary metabolic pathways impaired by hyperglycaemia.

155 novel link between chronic inflammation and metabolic pathways important in liver cancer.

156 We demonstrate that disruption of glutamine metabolic pathways improves the efficacy of gemcitabine

157 Thus, our findings newly implicate this metabolic pathway in BDV-induced neurodegeneration.

158 y precedes CO2 fixation via the reductive C1 metabolic pathway in C. thermocellum These findings demo

159 MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for

160 nd aerobic respiration to be overrepresented metabolic pathways in a chemically induced murine model

161 le biosynthesis is one of the most essential metabolic pathways in almost all organisms.

162 ecules in silico as substrates for essential metabolic pathways in bacteria, followed by in vitro upt

163 As sPPases are essential for many metabolic pathways in eukaryotic cells, our findings ide

164 ced the mRNA expression of genes involved in metabolic pathways in gonadal adipose tissue of WT and A

165 etabolomics can shed light on alterations in metabolic pathways in many diseases, including neurodege

166 malities in pregnancy, by studying day/night metabolic pathways in murine models and samples from pre

167 fungal genomes, an atypical arrangement for metabolic pathways in other eukaryotes.

168 method that allows noninvasive monitoring of metabolic pathways in real time.

169 syntrophs utilize unconventional alternative metabolic pathways in situ producing butyrate, cyclohexa

170 ized to the plasma membrane, affects several metabolic pathways in Synechocystis in autotrophic growt

171 In order to gain insights into altered metabolic pathways in the onset and progression of EC ca

172 trate the therapeutic potential of targeting metabolic pathways in the treatment of inflammatory dise

173 originated in the sea and evolved its early metabolic pathways in water [1, 2].

174 progressively, in contrast with conventional metabolic pathways, in which the first step is rate-limi

175 The major perturbed metabolic pathways included purine and pyrimidine metabo

176 alling is involved in the control of several metabolic pathways including glycolysis, mitochondrial r

177 ot tissue showed tremendous induction in key metabolic pathways including sugar metabolism, amino aci

178 We observed effects in several metabolic pathways, including a decrease in glycerophosp

179 androgens increased the activity of several metabolic pathways, including aerobic glycolysis, mitoch

180 t the saliva exposome represents at least 14 metabolic pathways, including amino acid metabolism, TCA

181 olecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeosta

182 e found that SIRT1 inhibition down-regulates metabolic pathways, including glycolysis and pyruvate me

183 ells are sensitive to inhibitors of cellular metabolic pathways, including glycolysis, glutaminolysis

184 ites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuram

185 KSHV infection induces and requires multiple metabolic pathways, including the glycolysis, glutaminol

186 olism (FOCM) is an interconnected network of metabolic pathways, including those required for the de

187 rategies lies in our incomplete knowledge of metabolic pathways, including those that can be used to

188 Mbp genome points at severe voids in central metabolic pathways, indicating dependence on the host, C

189 quality measurement and determine underlying metabolic pathways influenced by diet quality.

190 Plants sequester intermediates of metabolic pathways into different cellular compartments,

191 thus be part of the expanding compendium of metabolic pathways involved in cancer biology directly c

192 an inter-omics approach in understanding the metabolic pathways involved in IBD.

193 s new insights into molecular mechanisms and metabolic pathways involved in whitebark pine ISR.

194 s were postulated to explain the alternative metabolic pathways involved, but as yet, a direct analys

195 performed RNA sequence analyses to identify metabolic pathways involving MIR122.

196 creas tumor models suggests that use of some metabolic pathways is defined by lineage rather than by

197 Elucidation of the isoprenoid metabolic pathways is indispensable for the rational des

198 are a hallmark of cancer, and inhibition of metabolic pathways is now a major strategy in medicinal

199 nd-P, whose proper distribution to alternate metabolic pathways is required to maintain normal cell s

200 analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue d

201 ndent enzymatic reactions, linking two major metabolic pathways known to be highly up-regulated in in

202 The dysregulation of metabolic pathways leading to abundance shifts between p

203 A conventional metabolic pathway leads to a specific product.

204 omyces, they additionally regulate secondary metabolic pathways like antibiotic production.

205 nce, and suggest that subtle changes in core metabolic pathways may contribute to overcoming host-imp

206 Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new ther

207 Thus, hypoxic and metabolic pathways may modulate TNF responses during chr

208 Manipulation of metabolic pathways may represent a novel point for the m

209 This property holds true for a set of metabolic pathway motifs (e.g., linear chains and branch

210 The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to

211 The metabolic pathway of de novo lipogenesis is frequently u

212 Moreover, the intermediary metabolic pathway of de novo lipogenesis, which synthesi

213 somal acid lipase (LAL), a key enzyme in the metabolic pathway of neutral lipids, has a close connect

214 pendent and nondestructive approach to probe metabolic pathways of carbon substrates at the single-ce

215 modulated by the obesity, with signaling and metabolic pathways of pathological significance.

216 icals often functioning as inhibitors of key metabolic pathways or as prodrugs.

217 the association between sodium intake and 38 metabolic pathways or groups.Six pathways were associate

218 ated with circulating metabolites in various metabolic pathways, particularly lipids, amino acids, an

219 plays a key role in regulating secretion in metabolic pathways, particularly triglyceride homeostasi

220 hways in cancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 1100) were

221 Metabolic pathways play a vital yet poorly understood ro

222 These studies indicate that iPLA2-dependent metabolic pathways play an important role in tumor initi

223 exact roles that individual metabolites and metabolic pathways play have not been well understood.

224 provide models that could account for major metabolic pathways present in dormant switchgrass rhizom

225 but also participates in redox regulation of metabolic pathways previously established to be regulate

226 Inhibition of metabolic pathways provides novel therapeutic approaches

227 s that impact hepatic inflammatory and lipid metabolic pathways, providing new insight into the mecha

228 ates and cofactors that are intermediates of metabolic pathways, providing potential cross talk betwe

229 erogeneity and conducts a robust analysis of metabolic pathways (RAMP).

230 ion is due to interference with specific Mtb metabolic pathways rather than a generalized cAMP toxici

231 A putative model on metabolic pathway regulation is proposed.

232 metabolites and is a useful tool for finding metabolic pathways related to disease processes.

233 aracterize and integrate transcriptional and metabolic pathways related to drought stress in sunflowe

234 In order to find genetic and metabolic pathways related to phenotypic traits of inter

235 tion induced significant changes to more key metabolic pathways relative to either monotherapy.

236 clear receptors also regulate numerous other metabolic pathways relevant to liver energy balance.

237 ine how SbMyb60 overexpression impacts other metabolic pathways, RNA-Seq and metabolite profiling wer

238 mography (PET) tracers addressing tryptophan metabolic pathways should allow the detection of differe

239 Alterations in metabolic pathways, some linked to altered peroxisome pr

240 siae However, the roles of Msn2/4 in primary metabolic pathways such as fatty acid beta-oxidation are

241 bolically versatile, retaining mitochondrial metabolic pathways, such as a TCA cycle and ETC-driven A

242 During nephritis, the altered activity of metabolic pathways, such as retinol metabolism, occurs d

243 dependent effect of BMAA on several relevant metabolic pathways suggesting a multifaceted toxicity of

244 f the ARMAN-like archaeon Mia14 has lost key metabolic pathways, suggesting dependence on the host ar

245 olites that are associated with the 1-carbon metabolic pathway than those without ophthalmic issues.

246 The extract disturbed more metabolic pathways than the three most abundant chemical

247 ay respiration) was identified as a low-flux metabolic pathway that accompanies photosynthesis.

248 rosophila fragile X model, and thus reveal a metabolic pathway that can be targeted by new and alread

249 CoA, an intermediate in the C5-dicarboxylate metabolic pathway that includes itaconate, a recently id

250 iration should be viewed as a highly dynamic metabolic pathway that interacts with photosynthesis and

251 taset, we identified lipid metabolism as the metabolic pathway that most significantly correlated wit

252 A reductase, the rate-limiting enzyme of the metabolic pathway that produces cholesterol and other is

253 ia, which function in vital biosynthetic and metabolic pathways that are critical for bacterial survi

254 Metabolic pathways that contribute to adiposity and agei

255 - or myocyte-related alterations in cellular metabolic pathways that correspond with increased adipos

256 This comprehensive analysis has identified metabolic pathways that could provide the basis for the

257 Mitochondria house metabolic pathways that impact most aspects of cellular

258 AFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of

259 prescribed with other medications that share metabolic pathways that may increase major bleeding risk

260 The metabolic pathways that produce SMs are found in contigu

261 markably little is known about the microbial metabolic pathways that produce them.

262 ritional status to control key signaling and metabolic pathways that regulate multiple cancer cell ph

263 repressor Loz1 with the goal of identifying metabolic pathways that were altered by cellular zinc st

264 stering of children to identify the dominant metabolic pathways that were influential in each cluster

265 By targeting different metabolic pathways, these differences allow for selectiv

266 However, metabolic pathways through which PGRPs induce these bact

267 Targeting a glutamate-dependent metabolic pathway thus represents a new strategy for dev

268 e combined with other catalysts in synthetic metabolic pathways to access a variety of challenging an

269 Low CO2 caused many metabolic pathways to be remodeled.

270 Fumarate is therefore a key link connecting metabolic pathways to DKD pathogenesis, and measuring ur

271 ed molecular mechanism linking longevity and metabolic pathways to neural mechanisms of learning.

272 Compartmentalization of metabolic pathways to particular organelles is a hallmar

273 which as eukaryotes have different anaerobic metabolic pathways to prokaryotes such as bacteria and a

274 The liver integrates multiple metabolic pathways to warrant systemic energy homeostasi

275 provides is a visual comparative analysis of metabolic pathway topologies across pre-computed pathway

276 [(13)C] uric acid synthesis through multiple metabolic pathways, uncovering a metabolic link at the c

277 om serine to histones through the one-carbon metabolic pathway, using stable-isotope labeling and det

278 Here an overview of the metabolic pathways utilized by gut microbes to produce t

279 oxO1, regulates gluconeogenesis and controls metabolic pathways via mitochondrial ROS mediated ERK ac

280 ion, providing a comprehensive framework for metabolic pathway visualization.

281 The 'light reaction' metabolic pathway was identified as a markedly enhanced

282 xpression for regulating endocytic and lipid metabolic pathways was perturbed by benzo[a]pyrene.

283 he expression of key genes involved in these metabolic pathways was significantly different in KATPHI

284 observed that six enzymes of the folic acid metabolic pathway were overexpressed in HGS ovarian canc

285 nly in S54, while photosynthesis and several metabolic pathways were affected in both genotypes with

286 Metabolic pathways were also activated on days 1 and 3 p

287 volved in diverse cellular and mitochondrial metabolic pathways were identified among the carbonylate

288 lmost the complete set of reactions in major metabolic pathways were identified, including the cytoso

289 /MS-based urinary metabolomics showed that 5 metabolic pathways were modulated, including purine meta

290 Forty metabolic pathways were perturbed in patients with T1R,

291 llular matrix (ECM)-receptor interaction and metabolic pathways were the top two KEGG pathways signif

292 This correlation analysis also pinpointed metabolic pathways which are significant for the seed-to

293 esity-induced inflammation is conducted by a metabolic pathway, which eventually causes activation of

294 ture descriptors to explore sensing-enabling metabolic pathways, which are putative biochemical trans

295 hology is related to deregulation of central metabolic pathways, which may identify potential therape

296 etermining the percentage of gene pairs in a metabolic pathway with significant expression correlatio

297 s a complex protein network connecting other metabolic pathways with an influence on cancer cell meta

298 series of building blocks of signalling and metabolic pathways with compartmental organization.

299 Blocking metabolic pathways with metformin diminished cytokine pr

300 ologists also seek to encapsulate engineered metabolic pathways within vesicles or proteinaceous shel