ライフサイエンスコーパス: metabolic profile

1 ia following ischemia, indicating an altered metabolic profile.

2 ementation did not affect the fasting plasma metabolic profile.

3 ked a distinctive longitudinal volumetric or metabolic profile.

4 ications to achieve desirable changes in the metabolic profile.

5 ter when obesity is combined with an adverse metabolic profile.

6 uced obesity, associated with overall better metabolic profile.

7 d when obesity is accompanied by a favorable metabolic profile.

8 y acids, and amino acids) on later offspring metabolic profile.

9 iponectin concentration affects the systemic metabolic profile.

10 substrates by cell lines harboring different metabolic profiles.

11 mycin as a tool compound to study changes in metabolic profiles.

12 investigate the potential differences in the metabolic profiles.

13 d, it induced primed hESC-like proteomic and metabolic profiles.

14 analysis was used to investigate patterns in metabolic profiles.

15 tissue could be distinguished based on their metabolic profiles.

16 and obtained mass-spectrometry-based urinary metabolic profiles.

17 atenin signaling, correlating with differing metabolic profiles.

18 relate the impact of co-cultivation to their metabolic profiles.

19 etatranscriptomic, metagenomic, and targeted metabolic profiling.

20 oscopy as powerful tool to define a complete metabolic profiling.

21 ta processing tools have enabled large scale metabolic profiling.

22 We determine rich metabolic profiles (31 metabolites identified) from samp

23 has been greatly facilitated by genomic and metabolic profiling advances.

24 In contrast, changes in the metabolic profiles after supplementation indicated pertu

25 Metabolic profiling allows simultaneous measurement of h

26 statistically significant differences in the metabolic profile among uninfected I. scapularis nymphal

27 Instead, metabolic profiling analyses led to the discovery that T

28 of organ damage, a more frequent unfavorable metabolic profile and a higher risk of new onset sustain

29 iated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit

30 l chicken can be differentiated based on the metabolic profile and multivariate analysis.

31 ink between the observed changes in the root metabolic profile and the regulation of transporter acti

32 nical trials--to elucidate a drug molecule's metabolic profile and to assess its toxicity.

33 es were detected between the lines when leaf metabolic profiles and activities of the main enzymes in

34 ed a high-fat diet because of improved lipid metabolic profiles and insulin sensitivity.

35 MRTFA(-/-) mice also show improved metabolic profiles and protection from diet-induced obes

36 Non-targeted metabolic profiling and a targeted pCPA dose-response st

37 n integrated high-throughput transcriptional-metabolic profiling and analysis pipeline, we characteri

38 scrutinized the impact of AGM on whole body metabolic profiling and gene expression and assessed a p

39 Detailed metabolic profiling and isotopic labeling experiments we

40 in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previou

41 , adaptation ability to diverse host niches, metabolic profiles, and stress responses.

42 for each diet and identified the associated metabolic profiles, and then validated the models using

43 % < 0.5%), making this pipeline suitable for metabolic profiling applications.

44 We used an untargeted global metabolic profiling approach for the discovery of novel

45 uclear magnetic resonance spectroscopy-based metabolic profiling approach with matching 16S microbiot

46 al water using a (1)H NMR spectroscopy-based metabolic profiling approach.

47 ss index (BMI) and offspring systemic cardio-metabolic profile are causal, via intrauterine mechanism

48 These metabolic profiles are consistent with the idea that big

49 nt defense hormones and that the NAD-induced metabolic profiles are similar to those of defense-expre

50 Although large-scale applications of metabolic profiling are still novel, it seems likely tha

51 , metabolomics profiling revealed an altered metabolic profile arising from exposure.

52 ent rates, and were associated with a benign metabolic profile as evidenced by significantly lower le

53 patterns of cross-sectional association with metabolic profile as for parental pre-pregnancy BMI asso

54 ransient elastography together with detailed metabolic profiling as baseline assessment.

55 ue, is key to the development of the adverse metabolic profile associated with circulating GC excess,

56 d by host cells, detection of changes in the metabolic profile associated with disease pathogenesis c

57 Our aims were to define the metabolic profile associated with higher blood adiponect

58 tebrate development, to elucidate changes in metabolic profiles associated with BMAA exposure.

59 eptors are long-lived, displaying a youthful metabolic profile at old age.

60 ly unstable over time and exhibited distinct metabolic profiles at different storage temperatures.

61 attenuation was associated with more adverse metabolic profiles at follow-up.

62 tivariate analyses were conducted to compare metabolic profiles at the 3 different periods and to ass

63 Metabolic profiles based on serum nuclear magnetic reson

64 ed as an animal model to discover changes in metabolic profiles between regular basal and high fat/hi

65 After the induction of inflammatory and metabolic profiles, both M-CSF and GM-CSF generated comp

66 heir differentiated progeny display distinct metabolic profiles, but how metabolic changes are couple

67 high degree of intra-species consistency in metabolic profiles, but inter-species diversity was high

68 The two species showed a very different metabolic profile by Phenotype MicroArray(TM).

69 Furthermore, evaluation of metabolic profiles by principle component analysis (PCA)

70 In this work, simultaneous targeted metabolic profiling by isotope dilution and non-targeted

71 Here, we demonstrate whole-plant metabolic profiling by stable isotope labeling and combu

72 as DNA and RNA sequencing, plus protein and metabolic profiling capacities and computational tools,

73 Although these two cohorts have different metabolic profiles, carriers in both cohorts had improve

74 Targeted metabolic profiling characterized by complementary platf

75 . hybridus, despite closed stomata, the leaf metabolic profiles combined with chlorophyll fluorescenc

76 Memory T cells display a distinct metabolic profile compared to effector T cells.

77 eated samples have a significantly different metabolic profile, compared to the control (in fact, as

78 ing identified 11 variants associated with a metabolic profile consistent with a common, subtle form

79 A metabolic profile could be generated while the drug was

80 dicate that nuclear magnetic resonance-based metabolic profiling could be used for diagnosis and mort

81 Metabolic profiling could be useful for patient stratifi

82 Our metabolic profiling data suggested that central carbon m

83 We also detail how integration of metabolic profiling data with genetics can enhance drug

84 Gene expression and metabolic profiling demonstrate that the Tbx15(Hi) pread

85 bly, S1 and distal tubules exhibited similar metabolic profiles despite apparent differences in morph

86 Metabolic profiles did, however, discriminate the coliti

87 In conclusion, improvements in metabolic profile due to vitamin D supplementation is in

88 This report, to our knowledge the first of metabolic profiling during sleep and sleep deprivation a

89 pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory c

90 A hierarchical clustering method of the metabolic profiles followed by Random Amplification of P

91 Metabolic profiles for BI and NV demonstrated distinct c

92 -MS data and identified parsimonious sets of metabolic profiles for distinguishing between cancer and

93 Based on publicly available metabolic profiles for the investigated species, we demo

94 The data provide proof-of-concept that metabolic profiling for early Lyme disease can achieve s

95 e key issues of study design and analyses of metabolic profiling for epidemiology.

96 ovel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.

97 eart surgery and to examine the potential of metabolic profiling for stratifying patients in terms of

98 ttern was confirmed with in silico generated metabolic profiles from a medium-size kinetic model of p

99 , we conducted mass spectrometry-based serum metabolic profiling from a model using humanized mice (h

100 cated that OA patients possess a respiratory metabolic profile fully divergent from those obtained in

101 esity is inherently a metabolic disease, and metabolic profiling has found widespread usage in metabo

102 n conclusion, obese persons with a favorable metabolic profile have a slightly increased risk of depr

103 Demographic data, metabolic profiles, hs-CRP (high-sensitivity C-reactive

104 Metabolic profiling identified reproducible signatures o

105 wed that high levels of sesamin affected the metabolic profile impartially of the n-6/n-3 ratio.

106 he CB1-encoding gene had an overall improved metabolic profile in addition to reduced body weight and

107 t gained less weight and maintained a normal metabolic profile in comparison with WT and Sln(-/-) mic

108 al BMI was associated with an adverse cardio-metabolic profile in offspring.

109 its pharmacological administration improves metabolic profile in preclinical species and humans.

110 opic approach was used at 3 T to explore the metabolic profile in the putamen of patients with Parkin

111 tion, qualitative analyses of changes in the metabolic profile in those tissues after drug administra

112 able effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) pat

113 cture, functional metagenome, and associated metabolic profiles in a sex-specific manner.

114 ethod paves the way for the study of complex metabolic profiles in live brain tissue under both physi

115 is associated with long-term risk of adverse metabolic profiles in offspring, and if so, whether this

116 Metabolic profiles in PAH are strongly related to surviv

117 Metabolic profiles in plasma could effectively different

118 lowed for the rapid acquisition of full LogP metabolic profiles in plasma samples obtained from cogni

119 ematic analysis of untargeted (1)H NMR-based metabolic profiles in quantitative genetic contexts.

120 nalysis, identified accessions with distinct metabolic profiles in the fingerprint regions of compoun

121 ological and dietary risks, its residual and metabolic profiles in the fruit vegetable ecosystem stil

122 conventional 1D (1)H NMR as part of routine metabolic profiling in large data sets and show that app

123 Detailed metabolic profiling in large-scale epidemiologic studies

124 entary in vitro signaling assays and in vivo metabolic profiling in obese mice to investigate the eff

125 redicting post-MI LVEF and ISZ, we performed metabolic profiling in the GIPS-III randomized clinical

126 ted synergistically to result in an improved metabolic profile including high alphavbeta6+ tumor upta

127 d a widespread impact on gene expression and metabolic profiling including (a) activation of peroxiso

128 Here, large scale metabolic profiling including UPLC-PDA-MS and GC-MS with

129 2013, participants aged >40 years underwent metabolic profiling, including measurement of hemoglobin

130 cates that work stress is associated altered metabolic profile, increased systemic inflammation, and,

131 Metabolic profiling indicated increased energy expenditu

132 The metabolic profiling indicated Pb or Cd stress could caus

133 and related to alterations in endocrine and metabolic profile induced by maternal p110alpha deficien

134 ) and WT mice displayed similar weight gain, metabolic profile, insulin resistance, and hepatic steat

135 t the main factor influencing the cocoa bean metabolic profile is the fermentation level.

136 We discuss why quantitative metabolic profiling is becoming widespread in epidemiolo

137 A major purpose of exploratory metabolic profiling is for the identification of molecul

138 Global metabolic profiling is increasingly being utilized to ch

139 The number of epidemiologic studies that use metabolic profiling is still limited, but it is fast gai

140 sponder) and for generation of an individual metabolic profile, leading to a better understanding of

141 in concentration associated with a favorable metabolic profile, lower prevalence rates of comorbiditi

142 These metabolic profiles may serve as diagnostic and/or progno

143 cardiovascular risk exemplifies how detailed metabolic profiling may inform underlying aetiology via

144 In accordance with the metabolic profiles, microarray analysis identified a str

145 r-term effect of EGCG+RES supplementation on metabolic profile, mitochondrial capacity, fat oxidation

146 The metabolic profile observed in cancer cells often include

147 Considering only well fermented beans, the metabolic profile obtained by (1)H NMR permitted to disc

148 zing the causal effect of adiponectin in the metabolic profile of </=37 545 adults.

149 Here we report the metabolic profile of 300 tomato accessions (Solanum lyco

150 In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded tha

151 This deviation from the metabolic profile of arachidonic acid may limit the util

152 ietary sesamin on the liver and white muscle metabolic profile of Atlantic salmon (Salmo salar).

153 though the analysis provides a comprehensive metabolic profile of berries, the resulting distinctive

154 oupled to mass spectrometry, we analyzed the metabolic profile of brain regions of the mouse, and fou

155 emonstrate that FGF21 treatment improves the metabolic profile of Bscl2(-/-) lipodystrophic mice, par

156 We characterized the physiologic/metabolic profile of cavin-1 knock-out mice and determin

157 ique combined with chemometrics to study the metabolic profile of cocoa (Theobroma cacao L.) beans of

158 Enhancement of autophagy improved the metabolic profile of hIAPP-expressing mice fed a high-fa

159 ancy in the T-cell lineage and may alter the metabolic profile of malignant T cells.

160 as to investigate the dynamic changes in the metabolic profile of mouse sera during T. gondii infecti

161 ing FAO, suggesting that CTLA-4 sustains the metabolic profile of non-activated cells.

162 al effect of a maternal high-fat diet on the metabolic profile of offspring.

163 Furthermore, the metabolic profile of plants with PhlD in either the cyto

164 estigate changes in the low molecular weight metabolic profile of raw mullet (Mugil spp.) roes during

165 The metabolic profile of Romeiko, Malvasia, Xinomavro, Sangi

166 f BAT in lean humans but also to improve the metabolic profile of skeletal muscle to benefit glucose

167 proach was applied to analyze changes in the metabolic profile of the bivalve mollusk Mytilus gallopr

168 Instead, helminth infection altered the metabolic profile of the intestine, which directly enhan

169 We then analyzed the metabolic profile of the mouse brain after excitotoxic i

170 ) gene sets deviated in composition from the metabolic profile of the organism, being enriched in gen

171 The metabolic profile of tumor cells has been suggested to r

172 est whether succinate modifies the (18)F-FDG metabolic profile of tumors, we performed in vitro and i

173 Metabolic profiles of 32 Negroamaro red wines were analy

174 es, we monitored the growth and compared the metabolic profiles of a MC-producing as well as two non-

175 The results showed that metabolic profiles of AIS patients generally deviated fr

176 For example, although signaling and metabolic profiles of breast tumors with PIK3CA or AKT1

177 om meat as complementary foods on growth and metabolic profiles of breastfed infants.

178 Lastly, metabolic profiles of each system show considerable over

179 The metabolic profiles of fecal water samples were more stab

180 acterize the intracellular and extracellular metabolic profiles of four prostate cancer cell lines wi

181 MS) to image and chemically characterize the metabolic profiles of HGSC, BOT, and normal ovarian tiss

182 We have investigated the metabolic profiles of human breast cancer (BC) cell line

183 In the current study, ex vivo metabolic profiles of image-guided tissue samples obtain

184 Metabolic profiles of mice were determined using metabol

185 The metabolic profiles of microtissues derived from normal o

186 ometry (LC-Q-TOF-MS) was utilized to acquire metabolic profiles of muscle, heart, and liver tissue fr

187 re significant differences in the NMR plasma metabolic profiles of NPC1 patients when compared to hea

188 Targeted, quantitative comparisons of serum metabolic profiles of pregnant Nos3(-/-), COMT(-/-) and

189 The PCA model comparing the metabolic profiles of roes before and after processing s

190 A clear separation between patterns in the metabolic profiles of the 4 diet groups was seen, with v

191 NMR spectroscopy data indicated that urinary metabolic profiles of the four diets were distinct.

192 he gut community has striking impacts on the metabolic profiles of the gut compartments and the hemol

193 apse imaging revealed dynamic changes in the metabolic profiles of the interstitium, urinary lumen, a

194 cant differences were identified between the metabolic profiles of the polymyxin-susceptible and -res

195 study to show substantial differences in the metabolic profiles of the polymyxin-susceptible and -res

196 e more potent biguanide in both systems, the metabolic profiles of these drugs are remarkably similar

197 diversity, combined with the mostly unknown metabolic profiles of these new SCs, poses a big challen

198 ging (DESI-MSI) generates spatially resolved metabolic profiles of tissues and supports an objective

199 We hypothesised that metabolic profiles of urine samples developed under cont

200 METHODS AND We performed metabolic profiling of 231 lipoprotein and metabolite me

201 Global metabolic profiling of bacteriostatic antibiotic treatme

202 Metabolic profiling of blood plasma was undertaken using

203 Metabolic profiling of cancer cells has recently been es

204 Metabolic profiling of cells in 2D culture systems often

205 Hence, metabolic profiling of complex microtissues is necessary

206 Metabolic profiling of dao1-1 root tissues revealed a 50

207 Global metabolic profiling of ephrin-A1-null, HER2-overexpressi

208 ive mass spectrometer has been developed for metabolic profiling of head and neck squamous cell carci

209 Metabolic profiling of human cancer cell line revealed t

210 By transcriptional and metabolic profiling of human patients with sepsis, we fo

211 Metabolic profiling of human prostate tumors identified

212 Metabolic profiling of individuals with type 2 diabetes

213 Technologies enabling in situ metabolic profiling of living plant systems are invaluab

214 obal liquid chromatography-mass spectrometry metabolic profiling of lung tissue and urine.

215 Detailed metabolic profiling of mutant strains produced by system

216 Here, we present a method for untargeted metabolic profiling of non-sterile rhizosphere soil.

217 ed in a complementary manner with the aim of metabolic profiling of plant leaves that have been colle

218 We performed metabolic profiling of plasma from presymptomatic HD tra

219 Metabolic profiling of sera obtained from 22 SLE patient

220 cted a comprehensive mass spectrometry-based metabolic profiling of serum, lung tissue and bronchoalv

221 Metabolic profiling of these seeds revealed that, in add

222 To test this hypothesis, metabolic profiling of wild-type and pmat1 seedlings tre

223 In this report we performed metabolic profiling on a strain of Schizosaccharomyces p

224 METHODS AND We performed metabolic profiling on brain tissue samples from 43 indi

225 In current study, we performed a metabolic profiling on human-derived colon cancer LoVo c

226 Targeted metabolic profiling or untargeted metabolomics based on

227 not influence maternal fasting glucose, the metabolic profile, or pregnancy outcomes in obese women.

228 ntitative genetics studies with metabolomics/metabolic profiling platforms, genomics, and transcripto

229 prising two classes of tumours with distinct metabolic profiles, prognosis and therapeutic susceptibi

230 -wide association scans with high-throughput metabolic profiling provide unprecedented insights into

231 serve a full metabolic cycle in C. albicans, metabolic profiling provides an avenue for rapid antimic

232 The rapid microbore metabolic profiling (RAMMP) approach was based on scalin

233 We thus conclude that NAD triggers metabolic profiles rather similar to that of pathogen-as

234 Metabolic profiling revealed an altered activity of the

235 Metabolic profiling revealed enhanced mitochondrial meta

236 Metabolic profiling revealed that depletion of p62 in Ts

237 Metabolic profiling revealed that MDCA is converted in p

238 Metabolic profiling revealed that metabolites involved i

239 Intracellular metabolic profiling revealed that PknG is necessary for

240 Metabolic profiling revealed that pyruvate dehydrogenase

241 signature of Ndfip1-deficient Treg cells and metabolic profiling reveals elevated glycolysis and incr

242 6 weeks transverse aortic constriction, the metabolic profile reversed with impaired insulin sensiti

243 The LC-DAD and LC-ESI-(HR)MS(n) metabolic profiles showed high levels of kaempferol deri

244 Metabolic profiling showed an accumulation of IAA and ch

245 Additionally, metabolic profiling showed increased fat accumulation in

246 RA classification using metabolic profiles shows a sensitivity of 91% and specif

247 onded to calcium channel blocker therapy had metabolic profiles similar to those of healthy control s

248 Metabolic profiling studies aim to achieve broad metabol

249 ethods and will be suited to high-throughput metabolic profiling studies of BM.

250 evant when identifying biomarkers in urinary metabolic profiling studies.

251 Additionally, metabolic profiling suggested that both glycolysis and t

252 found in both managed and wild dolphins; its metabolic profile suggests a capacity for denitrificatio

253 Metabolic profiling technologies provide a global overvi

254 roducts from their diet might have different metabolic profiles than meat eaters.

255 with lactation meant to "reset" the adverse metabolic profile that develops as a part of normal preg

256 Our results confirm that TNBC has a unique metabolic profile that may be exploited for therapeutic

257 ast, early IL-2 signals induce effector cell metabolic profiles that are more conducive to memory for

258 luid samples, enabling integration of global metabolic profiling that is a prerequisite for personali

259 on of the gut microbiome converts the global metabolic profile to one that favours C. difficile germi

260 We performed comprehensive metabolic profiling to assess how circulating metabolite

261 Here we use a combination of genetics and metabolic profiling to characterize a pathway from the g

262 In this study, we combined cytokine and metabolic profiling to examine the effect of postoperati

263 iferation and integrated gene expression and metabolic profiling to gain a better understanding of th

264 We used metabolic profiling to identify and validate uremic meta

265 We applied metabolic profiling to systematically interrogate these

266 n but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are or

267 ERalpha with estrogen-induced transcript and metabolic profiling, to demonstrate that ERalpha reprogr

268 f TF interactions and their integration with metabolic profiles under different developmental conditi

269 We performed metabolic profiling using liquid chromatography/mass spe

270 To this end, model samples mimicking the metabolic profile variations in serum from subjects affe

271 We found that the metabolic profile was different for the two considered c

272 e relation between patients' tumor stage and metabolic profiles was assessed.

273 The difference in metabolic profiles was mainly explained by the lower con

274 (1)H NMR urine metabolic profiling was performed on samples collected w

275 SSAGE: By integration of transcriptional and metabolic profiles we identified pathways and hubs trans

276 Taking advantage of the altered metabolic profile, we were able to selectively target CL

277 oassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria

278 Similar aberrations in the metabolic profile were observed already 10 years before

279 Her complete blood count and basic metabolic profile were unremarkable.

280 The metabolic profiles were analyzed using a detailed kineti

281 Metabolic profiles were assessed at baseline and after 3

282 The effects of beta-catenin activity on metabolic profiles were assessed in mice with colon-spec

283 Metabolic profiles were distinguished in relation to ing

284 Serum metabolic profiles were firstly explored between 30 AIS

285 Metabolic profiles were generated from elicited leaves o

286 Differences in the protein and metabolic profiles were identified, both among treatment

287 Serum 25(OH)D and metabolic profiles were measured at baseline and after 1

288 Metabolic profiles were measured with the use of high-re

289 l function, kidney histopathology as well as metabolic profiles were observed between CKD and control

290 In addition unique metabolic profiles were observed for tumors of differing

291 that >2000 mass spectral features from urine metabolic profiles were significantly associated with th

292 Routine serum metabolic profiles were unremarkable.

293 regeneration, and comprehensive genomic and metabolic profiling were conducted.

294 Plasma, urine, and CSF metabolic profiling were performed by coupled gas chroma

295 mmonalities and heterogeneities across their metabolic profiles when cells are grown in identical con

296 lysis, 'browning' of white fat and a healthy metabolic profile, whereas a patient with congenital CID

297 alterations to the gut microbiota and global metabolic profiles which may contribute to a depressive

298 st approach for qualitative and quantitative metabolic profiling, which can be used in conjunction wi

299 We used in vitro and in vivo metabolic profiling with [(13)C]glucose tracers to inves

300 mals revealed significant differences in the metabolic profiles, with biochemical phenotypes indicati