ライフサイエンスコーパス: metabolic regulation

1 d cellular RAS play diverse roles, including metabolic regulation.

2 ese data now provide powerful tools to study metabolic regulation.

3 suggested a link between p21 expression and metabolic regulation.

4 tabolic control analysis allows the study of metabolic regulation.

5 y roles in immunity, tissue homeostasis, and metabolic regulation.

6 liferative effects also manifest in specific metabolic regulation.

7 l of growth, whereas Akt2 has been linked to metabolic regulation.

8 modification are major means of fast-acting metabolic regulation.

9 a key center involved in nutrient-dependent metabolic regulation.

10 d particularly the hypothalamus for exerting metabolic regulation.

11 recognition of host environment to bacterial metabolic regulation.

12 ndamental role in controlling excitable cell metabolic regulation.

13 lar processes such as lifespan extension and metabolic regulation.

14 processes such as gene silencing, aging, and metabolic regulation.

15 ng, suggesting that at least some contribute metabolic regulation.

16 keletal systems, and to body composition and metabolic regulation.

17 localization in the flagellum and/or altered metabolic regulation.

18 target for central appetitive and peripheral metabolic regulation.

19 , and providing an additional mode of global metabolic regulation.

20 tifies a new level of phospholipase-mediated metabolic regulation.

21 ole for this family of regulators in central metabolic regulation.

22 iour, circadian rhythmicity, development and metabolic regulation.

23 se and these may be relevant for longer-term metabolic regulation.

24 is under investigation as a possible site of metabolic regulation.

25 ropriate, tissue-specific, developmental and metabolic regulation.

26 transcriptional control is involved in this metabolic regulation.

27 ol of available beta subunits is under tight metabolic regulation.

28 that is structurally specific and subject to metabolic regulation.

29 operate with TGF-beta effectors in mediating metabolic regulation.

30 e hormone oxytocin (OT) may be important for metabolic regulation.

31 linking protein phosphorylation cascades to metabolic regulation.

32 t is facilitated through transcriptional and metabolic regulation.

33 previously unrecognized role for snoRNAs in metabolic regulation.

34 during neonatal life is pivotal for lifelong metabolic regulation.

35 ealth of data into an understanding of plant metabolic regulation.

36 ments seem to indicate WWOX's involvement in metabolic regulation.

37 significant role in protein utilization and metabolic regulation.

38 cers through a mutant-specific dependency in metabolic regulation.

39 s that is thought to have a critical role in metabolic regulation.

40 nd implicate TLR3 as a key control system in metabolic regulation.

41 os(t)ide-metabolizing enzymes susceptible to metabolic regulation.

42 plication to both efficiency improvement and metabolic regulation.

43 egulatory T cells did not require leptin for metabolic regulation.

44 erm activation, aqueous humor formation, and metabolic regulation.

45 are powerful approaches to explore cellular metabolic regulation.

46 NO-CoA-mediated S-nitrosylation may subserve metabolic regulation.

47 tion that involves p53/NF-kappaB coordinated metabolic regulation.

48 t FXR-associated proteins that contribute to metabolic regulation.

49 branes is associated with cell signaling and metabolic regulation.

50 ic flux" was proposed as a novel impetus for metabolic regulation.

51 its glycolytic flux and uses this signal for metabolic regulation.

52 re we show that even in the heterogeneity of metabolic regulation a distinct signature encompassed mo

53 kinase implicated in energy homeostasis and metabolic regulation across eukaryotic species.

54 5)-trisphosphate) is potentially involved in metabolic regulation, activation of hypertrophy, and sur

55 ever, the mechanisms by which NOX4-dependent metabolic regulation affect the innate immune response r

56 including mitosis, signal transduction, and metabolic regulation, also differ between stem cells and

57 titute a useful probe into the mechanisms of metabolic regulation and an important target to develop

58 at unconventional activities of p53, such as metabolic regulation and antioxidant function, are criti

59 ly plays a significant role in mitochondrial metabolic regulation and apoptosis in response to cytoso

60 ence supporting VDAC's role in mitochondrial metabolic regulation and apoptosis, where VDAC oligomeri

61 As expected, genes associated with metabolic regulation and carbohydrate metabolism were di

62 calcium (mCa(2+)) has a central role in both metabolic regulation and cell death signalling, however

63 resent evidence for oncogene-directed cancer metabolic regulation and discuss the importance of ident

64 e in K(ATP) channel trafficking and membrane metabolic regulation and dysfunction in these pathways r

65 ant role in breast cancer progression and in metabolic regulation and energy homeostasis.

66 selenoprotein, and our understanding in the metabolic regulation and function of this abundant selen

67 r results suggest an intriguing link between metabolic regulation and hepatocarcinogenesis.

68 sociated with molecular processes related to metabolic regulation and inflammation.

69 rotein kinase (AMPK) family is important for metabolic regulation and is highly conserved from yeast

70 alian liver development and also crucial for metabolic regulation and liver function.

71 pite the importance of mitochondrial Ca2+ to metabolic regulation and mitochondrial function, and to

72 ) isoform-specific action; and cross-talk in metabolic regulation and neural development.

73 s work examines the interplay between these, metabolic regulation and the creatine kinase equilibrium

74 with its implications for issues related to metabolic regulation and the evolution of cellular metab

75 Here we show, surprisingly, that metabolic regulation and the heat-shock/stress response

76 ine a link between a key pathway controlling metabolic regulation and the regulation of the mammalian

77 etabolism suggest an intriguing link between metabolic regulation and TRPV channel activity.

78 However, ATM also has been implicated in metabolic regulation, and ATM deficiency is associated w

79 Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher

80 protection from apoptosis, drug resistance, metabolic regulation, and protein quality control/ubiqui

81 ly unknown interplay between SOD1 acylation, metabolic regulation, and SOD1-mediated cell survival.

82 proteins (IGFBPs) play a significant role in metabolic regulation, and there is growing evidence that

83 and have key roles in mechano-transduction, metabolic regulation, and vascular permeability.

84 oxia involve systemic physiological changes, metabolic regulation, and vascular remodeling.

85 ase in mycobacterial cell wall synthesis and metabolic regulation are discussed.

86 As a result, immune response and metabolic regulation are highly integrated and the prope

87 Very few examples of metabolic regulation are known in the gastric pathogen H

88 ontributions of direct and central inputs to metabolic regulation are likely of comparable magnitude,

89 yclin-dependent kinase/cyclin regulation and metabolic regulation as a means to limit proliferation,

90 These results identify metabolic regulation as a potential therapeutic target f

91 the roles of prostaglandin E(2) signaling in metabolic regulation beyond the reported stimulation of

92 al sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechani

93 te that the JNK2 isoform is also involved in metabolic regulation, but its function is not obvious wh

94 In mammals, the enzyme is subject to metabolic regulation, but regulatory mechanisms of bacte

95 is known about the mechanisms underlying the metabolic regulation by CDK4.

96 ulator of IGF bioavailability because of its metabolic regulation by glucoregulatory hormones.

97 s, prompting this investigation of potential metabolic regulation by Icmt.

98 bolism, but also affects non-cell-autonomous metabolic regulation by induced expression of a potent m

99 ea may be due to, at least in some part, the metabolic regulation by Sirtuin family proteins whose fu

100 ognition, and executive control can override metabolic regulation by talking to the hypothalamus.

101 Overexpression of Akt overcomes metabolic regulation by UCP3, rescuing carcinogenesis.

102 Also related to cellular metabolic regulation, cellular autophagy has also been f

103 Much of our knowledge about cardiac metabolic regulation comes from studies focused on mitoc

104 Whether this metabolic regulation contributes to premature Parkinsoni

105 mor suppressors implicated in cell signaling/metabolic regulation converge within the AKT signal tran

106 enance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing proce

107 ors confirm the importance of this target in metabolic regulation, describe novel models for assessin

108 reaction models, the models based on current metabolic regulation did not readily describe the phenot

109 Deviant metabolic regulation due to increased flux through aldos

110 derstanding of biological events relevant to metabolic regulation during climacteric and nonclimacter

111 rsue the identities of the genes involved in metabolic regulation during desiccation.

112 st that mitochondrial transcription is under metabolic regulation during early Xenopus embryogenesis.

113 y highlights the still unappreciated role of metabolic regulation during organogenesis, and suggests

114 n several physiological functions, including metabolic regulation, energy storage, and endocrine func

115 Our report suggests a mechanism of metabolic regulation for chlorosome biogenesis.

116 eceptor GPR50 plays an important function in metabolic regulation for entry into torpor.

117 ighting the significance of upstream primary metabolic regulation for the diversification of speciali

118 As well, lactate binding may affect metabolic regulation, for instance binding to G-protein

119 se presence and abundance are key to much of metabolic regulation, from subcellular compartments to w

120 s that several robust properties emerge from metabolic regulation, from the molecular level (e.g. hom

121 nisms of aging that invoke the importance of metabolic regulation, genetic stability and stress resis

122 aracterize the transcript level component of metabolic regulation, genome-wide changes in transcript

123 In recent years, the emerging role of p53 in metabolic regulation has been a topic of great interest.

124 of function of RELMbeta on colon cancer and metabolic regulation has not been fully elucidated.

125 The mechanisms underlying flavonoid-induced metabolic regulation have not been completely establishe

126 into amino acid, fatty-acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxid

127 ammals, and it underscores the importance of metabolic regulation in aging, suggesting a general appl

128 ctivator protein or CAP) plays a key role in metabolic regulation in bacteria and has become a widely

129 temporal ATP buffering and dynamic roles in metabolic regulation in cells displaying high and variab

130 system and the gut with strong relevance for metabolic regulation in context of inflammation.

131 e studies, with a number of implications for metabolic regulation in health and disease.

132 d YY1 functions broaden our understanding of metabolic regulation in intestinal stem cell homeostasis

133 its availability by G3PP adds a key level of metabolic regulation in mammalian cells, and G3PP offers

134 key role in insulin signaling, thus enabling metabolic regulation in mammalian cells.

135 ease of blubber sampling and its key role in metabolic regulation in marine mammals.

136 hypothesized that a combination of impaired metabolic regulation in obese animals prior to OVX plus

137 To examine metabolic regulation in postischemic hearts, we examined

138 rotein kinase (AMPK) family is important for metabolic regulation in response to stress.

139 Little is known about metabolic regulation in stem cells and how this modulate

140 Metabolic regulation in Streptomyces species is of inter

141 g a connection between genome plasticity and metabolic regulation in the early stages of stress respo

142 dies have highlighted the importance of such metabolic regulation in the endothelium and uncovered co

143 ess the role of the second adipocyte FABP in metabolic regulation in the presence and deficiency of o

144 enhancer to address the role of this FABP in metabolic regulation in the presence or absence of obesi

145 However, biological interpretations of metabolic regulation in these datasets are hindered by i

146 se model underscored the significance of p53 metabolic regulation in tumor suppression, while also al

147 m to study signaling, neurodegeneration, and metabolic regulation in vivo, we asked whether DJ-1 cont

148 e for insulin- and nutrient-mediated hepatic metabolic regulation in vivo.

149 xamined the Ci-dependent transcriptional and metabolic regulation in wild-type Synechocystis sp. PCC

150 ise new questions about oxygen transport and metabolic regulation in working muscles.

151 nduced p21 expression in tissues involved in metabolic regulation including liver, pancreas and hypot

152 s possible that Trx functioned originally in metabolic regulation independently of O2, thus raising t

153 stent environmental contaminants that affect metabolic regulation, inflammation, and other factors im

154 Metabolic regulation influences cell proliferation.

155 Homeostatic metabolic regulation is achieved through metabolite sens

156 es that occur during long-term infection, as metabolic regulation is complex and takes place on diffe

157 Whether alternative splicing contributes to metabolic regulation is largely unknown.

158 Metabolic regulation is mediated by changes in ATP and M

159 adipose tissue homeostasis and its impact on metabolic regulation is not understood.

160 ion of recombination, chromosomal stability, metabolic regulation, meiosis, and aging.

161 tro and in vivo and discuss how differential metabolic regulation might facilitate T-cell function vi

162 sults highlight a unique autophagy-dependent metabolic regulation of adaptive and innate T cells, whi

163 ivity in C57BL/6 mice and is involved in the metabolic regulation of adipose tissue.

164 ional regulation of tight junction proteins, metabolic regulation of barrier components, and changes

165 re interested to determine if examination of metabolic regulation of BCL-2 proteins may provide insig

166 NO has been implicated in the local metabolic regulation of blood flow in contracting skelet

167 rtant post-translational modification in the metabolic regulation of both prokaryotes and eukaryotes.

168 iology and clarify mechanisms underlying the metabolic regulation of CaMKII and apoptosis.

169 Investigation of the metabolic regulation of cancer stem cells is an emerging

170 However, the metabolic regulation of CD4 Tmem differentiation is not

171 ons in the ventromedial hypothalamus prevent metabolic regulation of circadian responses to light dur

172 d rectifier K(+) channels may be involved in metabolic regulation of coronary and cerebral blood flow

173 s provides a versatile method to monitor the metabolic regulation of electrophilic cofactors and disc

174 is the nonerythroid action of EPO, including metabolic regulation of fat accumulation and glucose hom

175 The evidence for metabolic regulation of flavonoid genes during seedling

176 rative effects during liver regeneration and metabolic regulation of FXR was elusive.

177 The metabolic regulation of glucose release and gluconeogene

178 ential for both tissue-specific and hormonal/metabolic regulation of GLUT4 expression.

179 Our results suggest that the metabolic regulation of GS expression in plants is contr

180 e A (acetyl-CoA), we investigated a role for metabolic regulation of histone acetylation during the D

181 efore, our study reveals a novel paradigm of metabolic regulation of histone modifications.

182 We delineated the mechanism of metabolic regulation of HNF-1alpha/FXR signaling.

183 Understanding metabolic regulation of HSC function has significant imp

184 establishes a crucial role of PTPMT1 in the metabolic regulation of HSC function.

185 f Cited2 and the underlying mechanism in the metabolic regulation of HSCs will provide a better under

186 cent studies have helped define and redefine metabolic regulation of HSCs.

187 m cells (HSCs) and its potential role in the metabolic regulation of HSCs.

188 ing that these neurons are downstream of the metabolic regulation of hunger.

189 s may be relevant to both hypoxic damage and metabolic regulation of IP3 signaling processes.

190 Metabolic regulation of K-ATP channels is mediated by ch

191 Although metabolic regulation of KATP channel activity is believe

192 ar second messengers mediate transmitter and metabolic regulation of Kir channels.

193 Feedback metabolic regulation of MTHFS by 10-formylTHF indicates

194 The metabolic regulation of neuronal genes by CtBP will open

195 s suggest that SnRK2.6 mediates hormonal and metabolic regulation of plant growth and development and

196 glucose dependence may occur in part through metabolic regulation of pro-apoptotic Bcl-2 family prote

197 ovides novel opportunities for signaling and metabolic regulation of protein deacetylation.

198 Metabolic regulation of Puma was mediated through combin

199 Secondly, we examined the metabolic regulation of pyruvate dehydrogenase (PDH) and

200 the possible mechanisms contributing to the metabolic regulation of retinal blood flow under physiol

201 ent in male and female rats, suggesting that metabolic regulation of rWAT and iWAT is sexually dimorp

202 rient-responsive and plays multiple roles in metabolic regulation of signaling and gene expression.

203 rtance of mitochondrial bioenergetics in the metabolic regulation of sirtuins and cytosolic signaling

204 Here, we examined the role and metabolic regulation of the antiapoptotic Bcl-2 family p

205 , we examined the involvement of RAS2 in the metabolic regulation of the clock in the circadian model

206 sufficient for tissue-specific and hormonal/metabolic regulation of the fatty-acid synthase (FAS) ge

207 the developmental, cell-specific, light and metabolic regulation of the homologous C4 PPCZm1 promote

208 article, we review current knowledge of the metabolic regulation of the KATP channel and provide evi

209 deux orchestrates the pivotal role of ATP in metabolic regulation of the KATP channel.

210 DMADP constitutes an important mechanism of metabolic regulation of the MEP pathway and indicates th

211 Understanding the metabolic regulation of the MEP pathway is important con

212 ctivity potentially provides a mechanism for metabolic regulation of the reactions catalyzed by these

213 Metabolic regulation of vascular tone is an important de

214 toll-like receptors, and key changes in the metabolic regulation of visceral white adipose tissue.

215 D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on heal

216 involve myogenic, neural control as well as metabolic regulations of cerebral vasculature in respons

217 es yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome.

218 was higher in M5, suggesting a difference in metabolic regulation or a butyrate stress response in M5

219 Autophagy, for either metabolic regulation or defence, involves the formation

220 , many highly conserved proteins involved in metabolic regulation or the cell stress response have a

221 rocess affecting brain regions necessary for metabolic regulation or whether they drive the degenerat

222 ns of common biological pathways that affect metabolic regulation, organ function, antioxidant defens

223 sic connections between p53-mediated DDR and metabolic regulation remain incompletely understood.

224 lic behaviors, but the system-wide impact of metabolic regulation remains largely uncharacterized.

225 recently described functions in genetic and metabolic regulation, signal transduction, and DNA repai

226 ochromatic gene silencing as a mechanism for metabolic regulation, since repeated sequences nucleate

227 method has great potential in RNA decay and metabolic regulation studies via individual mRNA labelin

228 acellular glutamine levels are under tighter metabolic regulation than previously thought.

229 Thus, 32 provides insight into the amount of metabolic regulation that can be restored following achi

230 protein expression modifications and altered metabolic regulation that define glioblastoma.

231 tions suggest novel roles of FAT10 in immune metabolic regulation that impact aging and chronic disea

232 To investigate this metabolic regulation, the Leishmania GMPR was cloned and

233 the interplay between enzyme specificity and metabolic regulation, the metabolic interdependence of m

234 vides an adequate supply, in contrast to the metabolic regulation theory which requires permanent hyp

235 te-secreted proteins play important roles in metabolic regulation through autocrine, paracrine, and e

236 a metabolic checkpoint in Tregs that couples metabolic regulation to immune homeostasis and tolerance

237 sting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biolog

238 Leptin-mediated metabolic regulation was critical, as transgenic express

239 tent with the emerging views of caspase-1 in metabolic regulation, we find that caspase-1-deficient m

240 all changes in genes related to intermediary metabolic regulation were replicated in cultured fetal h

241 ort suggested that the thioredoxin-dependent metabolic regulation, which is widespread in all domains

242 factor signaling may coordinately integrate metabolic regulation with established signaling function

243 n linked to cancer signaling pathways and to metabolic regulation with involvement in autophagy, cell

244 ne is subject to complex tissue-specific and metabolic regulation, with a profound impact on insulin-

245 ssion of lactate formation by DCA may impair metabolic regulation within the diaphragm during resisti

246 S polymerization disrupts E. coli growth and metabolic regulation without reducing CTP levels.