ライフサイエンスコーパス: metabolic response

1 hagy, collectively indicative of a regulated metabolic response.

2 eductions from baseline were used to measure metabolic response.

3 risis, and triggers a marked region-specific metabolic response.

4 n, however, generates a complex hormonal and metabolic response.

5 play important roles in regulation of liver metabolic response.

6 onse, and three patients achieved a complete metabolic response.

7 sociated with improved insulin signaling and metabolic response.

8 ble metabolic disease or partial or complete metabolic response.

9 n accurately predict prognosis in MBC beyond metabolic response.

10 y standardized uptake value was defined as a metabolic response.

11 sense nutrients and implement an appropriate metabolic response.

12 onists into live mouse BAT and analyzing the metabolic response.

13 synthesis, cytoskeletal rearrangements, and metabolic responses.

14 ity, protein acetylation, and cellular lipid metabolic responses.

15 rm-dependent and -independent phenotypes and metabolic responses.

16 net anti-inflammatory and tissue-protective metabolic responses.

17 a1/Stat3 axis directs IL-13 signaling toward metabolic responses.

18 form for improved electrochemical studies of metabolic responses.

19 s, whereas mRNA profiling frequently detects metabolic responses.

20 le in mediating diverse hormone, stress, and metabolic responses.

21 FOXO family and PGC-1alpha directly modulate metabolic responses.

22 macrophages, and integrates inflammatory and metabolic responses.

23 EPRS phosphorylation mediates S6K1-dependent metabolic responses.

24 llular copper, and impaired copper-dependent metabolic responses.

25 atory responses as well as the downregulated metabolic responses.

26 ot be compensated by any other AEF or anoxic metabolic responses.

27 ium-dependent stress signalling and adaptive metabolic responses.

28 We evaluated the association between metabolic response after 2 cycles of neoadjuvant chemoth

29 The association of TMTV0 and AUC with metabolic response after 4 cycles, as well as progressio

30 to compare the whole-body and muscle protein metabolic responses after the consumption of whole eggs

31 h perspectives on a fast method of observing metabolic responses against toxic agents.

32 es regardless of VHL status, suggesting that metabolic responses alone are not sufficient to explain

33 Associations between metabolic response and clinical outcomes were explored.

34 lower-calorie beverages can produce greater metabolic response and condition greater brain response

35 ary dramatically in their glucose stimulated metabolic response and levels of insulin secretion.

36 suggests a significant correlation in tumor metabolic response and no association in lung FDG activi

37 25% change in TLG (PERCIST) for both partial metabolic response and progressive metabolic disease, wh

38 the initial negative and subsequent positive metabolic responses and may be directly relevant to ques

39 participates in integrating inflammatory and metabolic responses and thus plays a key role in systemi

40 In order to dissect metabolic responses and to identify promising metabolite

41 non-linear association between caloric load, metabolic response, and reinforcement potency, which is

42 ly therapeutic levels had at least a partial metabolic response, and three patients achieved a comple

43 etabolic response, two patients had complete metabolic response, and two patients had stable disease

44 The major metabolic responses anticipated from metabolite-specific

45 Current definitions of metabolic response are suboptimal and too simplistic.

46 ghly ordered interactions between immune and metabolic responses are evolutionarily conserved and par

47 nslational modification, gene expression and metabolic responses are induced.

48 will have broad utility where predictions of metabolic responses are needed.

49 ess is proportional to caloric load, greater metabolic responses are observed.

50 ion were among other factors correlated with metabolic response as revealed by PERCIST 1.0-defined de

51 athogens have the capacity to generate broad metabolic responses as a result of surface binding by pa

52 MCK-PGC-1alpha animals also showed improved metabolic responses as evident by increased insulin sens

53 nged survival, were those who showed a tumor metabolic response assessed using weekly (18)F-FDG PET s

54 We aimed to comprehensively reevaluate metabolic response assessment using accepted parameters,

55 totally clear, but potential factors include metabolic responses associated with these disorders that

56 Complete metabolic response versus no metabolic response at PET/CT and complete response versu

57 imaging revealed an early and sustained host metabolic response at sites of infection that may reflec

58 targeted therapy and correlated highly with metabolic responses at week 6 (R(2) = 0.81).

59 Metabolic response based on (18)F-FLT was further compar

60 Metabolic responses between groups differed significantl

61 Individual best overall metabolic response (BOmR) was registered with both sets

62 (AMPK) has been implicated in the control of metabolic responses, but the role of endothelial cell re

63 We investigated the correlation between metabolic response by (18)F-FDG PET and objective respon

64 Metabolic response by (18)F-FDG PET predicts PFS and tim

65 After imatinib mesylate initiation, metabolic response by (18)F-FDG PET was documented earli

66 Metabolic response by (18)F-FDG PET/CT predicts overall

67 antibody titer, ASS1 methylation status, and metabolic response by 18F-fluorodeoxyglucose positron-em

68 No metabolic response by [(18)F]FDG-PET/CT scan at 2 weeks

69 Metabolic response by change in SUVpeak (7/17) and chang

70 Metabolic response by PERCIST (n = 44/73) was an indepen

71 l 23 (96%, 79-100%) also attained a complete metabolic response by PET.

72 In turn, these metabolic responses can affect the onset of insulin resi

73 A complete metabolic response (cMR) was defined as SUVmax of <4.

74 week 1, there were 3 patients with complete metabolic response (CMR), 33 with partial metabolic resp

75 ifty-four patients (47%) achieved a complete metabolic response (CMR), defined as a completely negati

76 atients into 4 response categories: complete metabolic response (CMR), partial metabolic response (PM

77 ment group, 24 of 37 patients had a complete metabolic response (CMR).

78 Complete metabolic responses (CMR) were observed in 24 (75%) pati

79 show any abnormal (18)F-FDG uptake (complete metabolic response [CMR]) in 55 patients whereas 32 disp

80 Metabolic response, defined by a significant reduction i

81 function, in T cells, helps to ensure proper metabolic response during activation.

82 rformed to determine the prognostic value of metabolic response during induction chemotherapy followe

83 s characteristics of the systemic immune and metabolic response during severe polymicrobial sepsis.

84 Results demonstrate dramatically distinct metabolic responses during cold exposure in BAT and WAT.

85 ng steady-state from non-steady-state muscle metabolic responses during whole-body exercise and (2) t

86 ts were included, and 19 were assessable for metabolic response evaluation with FLT-PET.

87 ions, mammals activate a complex multi-organ metabolic response for heat production.

88 line was used as a threshold for significant metabolic response for maximum SUV and, exploratively, f

89 ing and trans-acting eQTL for key immune and metabolic response genes and sepsis response networks.

90 PET evaluation revealed metabolic response (> 25% standardized uptake value decr

91 A partial metabolic response had an HR of 6.30 (95% CI, 2.73-14.56

92 lic response in 65 patients (70%), a partial metabolic response in 15 (16%), and progressive disease

93 Posttherapy FDG-PET showed a complete metabolic response in 65 patients (70%), a partial metab

94 els and bacterial strains according to their metabolic response in a multidimensional objective space

95 the human myocardium indicates a maladaptive metabolic response in diabetes, characterized by intramy

96 eity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statisti

97 Microscopy (FLIM) to quantify mitochondrial metabolic response in PCa cells by tracking auto-fluores

98 N Sunitinib demonstrated notable evidence of metabolic response in several patients with non-GIST sar

99 Thresholds for metabolic response in the multicenter multiobserver non-

100 ssion data from a reference state to predict metabolic responses in a genetically or environmentally

101 volved in regulating growth, remodeling, and metabolic responses in adult tissues.

102 P inhibition and radiation induced a similar metabolic responses in BRCA-mutant HCC1937 cells, but no

103 to modulate autonomic outflow and coordinate metabolic responses in liver and adipose tissue.

104 ee Ca(2)(+) ([Ca(2)(+)]m) that trigger these metabolic responses in mitochondria in nerve terminals h

105 ral upregulation of activity-dependent brain metabolic responses in PD.

106 e report organ-specific NH(3) dose-dependent metabolic responses in several microfluidic bioartificia

107 This study investigated metabolic responses in Synechocystis sp. strain PCC 6803

108 ntestinal hormone that mediates postprandial metabolic responses in the liver.

109 fied as a brain area suitable for monitoring metabolic responses in the penumbra region.

110 Metabolic responses in the primary tumors were evident a

111 roRNA (miRNA) expression, and behavioral and metabolic responses in the progeny.

112 nges did not always equate to a proportional metabolic response, in depth correlation analysis identi

113 Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression

114 This metabolic response induced genes encoding enzymes that c

115 by Ca2+ release from cellular stores, switch metabolic responses inside cells.

116 Although treatment stratification based on a metabolic response is an exciting potential application

117 In addition, an immediate HSR-independent metabolic response is triggered, resulting in an accumul

118 n a system to dynamically visualize cellular metabolic responses mediated by GAD1, we monitored the c

119 was to prospectively evaluate the timing of metabolic response monitoring with (18)F-FDG PET of (neo

120 visual analysis of PET scan, patients with a metabolic response (n = 28) had no significant differenc

121 s a novel microfluidic device to examine the metabolic response of a 2D layer of macrophage cells.

122 24 healthy individuals, to capture the acute metabolic response of a cereal breakfast (CB) and an egg

123 In this study, we investigated the metabolic response of adult mouse hearts expressing ssTn

124 itrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen avail

125 ity, and physiological data that capture the metabolic response of H. pluvialis under nitrogen starva

126 However, it is unclear what determines the metabolic response of the cell to darkness and thus the

127 dant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

128 A broad, drug-like phase II metabolic response of the host to metabolites generated

129 Thus, we have identified a conserved metabolic response of tissues to ischaemia and reperfusi

130 To investigate the potential metabolic response of tomato plants to drought, we recon

131 lly, we quantitatively demonstrated that the metabolic responses of biofilms to contaminant exposure

132 levels, including complex behaviours and the metabolic responses of brain regions to emotional stimul

133 the hypothesis that K(+) channels affect the metabolic responses of fat cells to nutrients.

134 nce that occludin levels largely control the metabolic responses of human pericytes to HIV.

135 r, soil, and water as well as monitoring the metabolic responses of living organisms to an ever chang

136 this study, we monitored the spatiotemporal metabolic responses of metabolically active Shewanella o

137 present study, we examined and compared the metabolic responses of nine soybean varieties grown unde

138 otope methodology, to assess hemodynamic and metabolic responses of older individuals to endurance ty

139 alt-stress conditions, and then compared the metabolic responses of the two species on different grow

140 A partial metabolic response on (18)F-FDG PET/CT scans was observe

141 was observed in patients who had a complete metabolic response on [(18)F]fluorodeoxyglucose PET.

142 To validate the association between the metabolic response on the 3-month posttherapy FDG-PET an

143 no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fi

144 management correlated strongly with lack of metabolic response (P < 0.001) and non-KIT exon 11-mutat

145 mitochondria, play a role in setting up the metabolic response pattern of astrocytes.

146 te metabolic response (CMR), 33 with partial metabolic response (PMR), 6 with stable metabolic diseas

147 : complete metabolic response (CMR), partial metabolic response (PMR), stable metabolic disease (SMD)

148 glycemic events had greater inflammatory and metabolic responses, prevalence of sepsis, multiple orga

149 The primary outcome end points were metabolic response, progression-free survival, and cause

150 We aimed to determine the metabolic response rate to vemurafenib in patients with

151 (18)F-FDG PET/CT metabolic response rates at weeks 2 and 6 were 71.6% and

152 mediastinum in up to 6 lesions, to determine metabolic response rates, indicated by negative posttrea

153 t does not mediate IL-2- or TCR-induced cell metabolic responses; rather, this role is assumed by oth

154 risk of recurrence based on the posttherapy metabolic response showing progressive disease was 32.57

155 tant with augmentation of glycogen stores, a metabolic response similar to post-exercise recovery.

156 s the occurrence of differential patterns of metabolic responses specific to individual cues and berr

157 pite growth platform-specific phenotypes and metabolic responses suggests a considerable degree of ph

158 ) to demonstrate that heart muscle engages a metabolic response that limits ketone body utilization.

159 Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the

160 1R have been investigated, the corresponding metabolic responses that could contribute to T1R patholo

161 adaptation to salinity requires cellular and metabolic responses that differ from short-term osmotic

162 NA expression alone did not directly predict metabolic response, this correlation improved through in

163 Using metabolomics, we compared the acute metabolic response to 4 test breads between conventional

164 conclusions highlight the complexity of the metabolic response to a change in nitrogen nutrition.

165 n this study, comprehensive profiling of the metabolic response to a high-fat/high-sucrose diet (HFD)

166 ux-en-Y gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin sensitivity,

167 mic analysis confirmed no change in cellular metabolic response to a range of osmolytes when treated

168 Furthermore, metabolic response to amylin was enhanced in the nestin/

169 In simple organisms like E.coli, the metabolic response to an external perturbation passes th

170 ducted to assess the predictive value of the metabolic response to BR compared with the response by I

171 ces in burn resuscitation, management of the metabolic response to burns, and recent ideas in burn im

172 This is the first report on the metabolic response to cardiac surgery in children.

173 F-FDG have the potential to follow the early metabolic response to chemotherapy in patients with non-

174 olomics approach to characterize the initial metabolic response to cold exposure in multiple adipose

175 expenditure and BAT activation, but not the metabolic response to cold.

176 kinase (AMPK), a conserved regulator of the metabolic response to CR.

177 Eleven patients (32%) had a metabolic response to dasatinib.

178 ther human prostate tumors develop a similar metabolic response to different oncogenic drivers or a p

179 gy, we demonstrate that a shift in microbial metabolic response to different substrate inputs from pl

180 -sensing nuclear receptor that modulates the metabolic response to drugs and toxic agents.

181 Sex difference in mouse metabolic response to erythropoietin.

182 Although the diet can affect the metabolic response to exercise, the contribution of a se

183 stand how this complex network regulates the metabolic response to fasting, we aimed at isolating the

184 ignalling and nutrient levels coordinate the metabolic response to feeding in the liver.

185 l models of liver regeneration implicate the metabolic response to hepatic insufficiency as an import

186 Recent data suggest that the metabolic response to hepatic insufficiency might be the

187 ne exposure (DNE) alters the ventilatory and metabolic response to hyperthermia in neonatal rats (pos

188 Understanding the mitochondrial metabolic response to hypoxia is key to understanding is

189 The subcellular metabolic response to hypoxia was examined in vivo.

190 ent transcription, while adversely affecting metabolic response to hypoxia.

191 gree of overlap between these two species in metabolic response to infection but also showed Brachypo

192 As the metabolic response to injury was increasingly investigat

193 r sensor leading to the evasion and adaptive metabolic response to insect defense peptides.

194 ension, muscle microvascular recruitment and metabolic response to insulin were determined.

195 nderstand the time course of hemodynamic and metabolic response to intraarterial (IA) mannitol infusi

196 Using MRS, we monitored the brain metabolic response to lipopolysaccharides (LPS)-induced

197 The metabolic response to meal ingestion was markedly differ

198 intestinal tract bypass procedures alter the metabolic response to meal ingestion, by increasing earl

199 tions for rapid cellular-level assessment of metabolic response to molecular expression and drug acti

200 regulation, preventing the inhibition of the metabolic response to nutrient intake caused by deletion

201 The metabolic response to obesity and insulin resistance dif

202 to inflammation and plays a key role in the metabolic response to obesity, including insulin resista

203 ne if lean and obese rodents differ in their metabolic response to OVX-induced weight gain, and wheth

204 such as gluconeogenesis, lipogenesis, or the metabolic response to oxidative stress.

205 by 24 hours, kinetics that mirror the lipid metabolic response to permeability barrier disruption.

206 nd activity intensity appear to modulate the metabolic response to physical activity.

207 r of protein quality control, influences the metabolic response to pressure overload by direct regula

208 sent a composite biopattern of the pediatric metabolic response to septic shock and might be consider

209 To characterize cancer cell metabolic response to SFB, we measured oxygen consumptio

210 ull mice, BalphaKO mice have normal adaptive metabolic response to starvation and cold exposure in pe

211 ensures maximal respiration capacity and the metabolic response to starvation.

212 indicate that polyamine catabolism is a core metabolic response to stress.

213 of the innate immune system and controls the metabolic response to stress.

214 hese metabolites, might indicate a conserved metabolic response to stressors and, this data may be us

215 f living, decreased performance, and altered metabolic response to temperature stress-an indication o

216 accurately determine the ratio of the oxygen metabolic response to the hemodynamic response.

217 ptor modulator, galantamine, on the cerebral metabolic response to the selective serotonin reuptake i

218 f sugar uptake by a single bacterium and its metabolic response to the sugar application with time.

219 Recent research in the metabolic response to thermal injury has identified many

220 in beta cell dysfunction in diabetes and the metabolic response to thiazolidinediones (TZDs), which a

221 the naturally occurring fluctuations in the metabolic response to U(VI) of plant cell cultures.

222 tions were applied that describe the liver's metabolic response to whole body inflammation.

223 a distinct transcriptional regulator of the metabolic responses to a high-fat diet.

224 in a randomized crossover feeding trial the metabolic responses to a Mexican diet compared with a co

225 immunophenotype, and play a role in systemic metabolic responses to an HFD.

226 effect of baseline metabolome on the overall metabolic responses to berry intake.

227 emphasizes the importance of differences in metabolic responses to cancer treatments in different su

228 rder to implement appropriate behavioral and metabolic responses to changes in fuel availability.

229 hereas S. moellendorffii mounts only limited metabolic responses to dehydration stress.

230 d a sister group contrast to reveal adaptive metabolic responses to dehydration using untargeted glob

231 cate nutrient-sensing pathways fine tune the metabolic responses to dietary AAs in a highly conserved

232 We have examined hepatic, genomic, and metabolic responses to dietary protein restriction in th

233 The metabolic responses to diets were assessed by measuring

234 treatments, suggesting perturbation-specific metabolic responses to DSW and DOM.

235 ntestinal epithelium, and help to coordinate metabolic responses to food ingestion.

236 mATG reversed pancreatic insulitis, improved metabolic responses to glucose challenge, and rapidly in

237 s illustrate how stress and depression alter metabolic responses to high-fat meals in ways that promo

238 depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals.

239 ssociated mutations that deregulate cellular metabolic responses to hypoxia also reprogram carbon met

240 inducible factor 1 (HIF-1) mediates adaptive metabolic responses to hypoxia, including increased flux

241 cancer cells to reveal both known and novel metabolic responses to hypoxia.

242 scular action and significantly improved the metabolic responses to insulin in HFD male rats and thes

243 Although AT(1)R activity restrains muscle metabolic responses to insulin via decreased microvascul

244 Sequential metabolic responses to intravenous (I.V.) glucose (I.V.

245 Sickness behaviors and metabolic responses to invading pathogens are common to

246 However, metabolic responses to local environmental conditions in

247 ggest that distinct tissues exhibit specific metabolic responses to loss of ketone body oxidation.

248 demands on the liver to adaptively regulate metabolic responses to maintain basic liver functions.

249 and computational pipeline to annotate leaf metabolic responses to Manduca sexta herbivory.

250 Additionally, diverse metabolic responses to medications among the volunteers

251 Few data exist on the metabolic responses to mixed meals with different glycem

252 metabolism and the attenuated regional brain metabolic responses to MP were observed in female CA but

253 nses could reflect a general upregulation of metabolic responses to neural activation.

254 riments with bioinformatic and RNA-seq data, metabolic responses to nitrate or NO and how nitrate and

255 ays a pivotal role in integrating peripheral metabolic responses to nutrients and hormones, we examin

256 However, evidence supporting similar metabolic responses to nutritional interventions is lack

257 nd that FGF21 is required for behavioral and metabolic responses to protein restriction.

258 n malignant cells that must develop adaptive metabolic responses to reach their energetic and biosynt

259 Adaptive metabolic responses to sepsis can prevent bioenergetic f

260 alk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autop

261 dinate endocrine, behavioral, autonomic, and metabolic responses to stress and play additional roles

262 dinate endocrine, behavioral, autonomic, and metabolic responses to stress and play important roles w

263 Abnormalities in coronary flow and metabolic responses to stress have been reported by seve

264 erries or nectars, optimize the postprandial metabolic responses to sucrose.

265 This observation and the delayed metabolic responses to the low-CO2 shift in ndhR, specif

266 solution functional imaging to map intrinsic metabolic responses to tones and to guide retrograde tra

267 We further applied this platform to study metabolic responses to traumatic brain injury in hippoca

268 To assess muscle protein metabolic responses to varied protein intakes during ED,

269 -elevation lakes will have larger or smaller metabolic responses to warming than higher latitude/elev

270 Based on enzyme activity assays and metabolic responses to waterlogging of the legume Lotus

271 We also identified adaptive metabolic responses triggered by nutrient signals and hy

272 Of these, 11 patients had partial metabolic response, two patients had complete metabolic

273 itical role in the induction of autophagy, a metabolic response typically associated with cell surviv

274 omparisons and characterization of the plant metabolic response under eight different light and/or te

275 n the present study, we explore the cerebral metabolic responses under extreme hypoxia and hypercapni

276 However, the metabolic response varies with the type of chemotherapy.

277 Complete metabolic response versus no metabolic response at PET/C

278 The metabolic response was classified on the basis of Europe

279 bone marrow, and unaffected lung tissues; a metabolic response was defined as a response in which th

280 An integral aspect of the metabolic response was downregulation of genes related t

281 species, then upon extended exposure a broad metabolic response was induced.

282 A greater than 85% metabolic response was observed as early as days 1-7 in

283 Metabolic response was significantly associated with ove

284 To decipher the significance of this metabolic response, we found that depletion of PDK4 or a

285 saturated fatty acids (PUFAs) have different metabolic responses.We investigated whether the epigenom

286 on patient care, and the predictive value of metabolic response were assessed.

287 Tumor and lung metabolic responses were assessed qualitatively by physi

288 Metabolic responses were compared between subjects who m

289 Metabolic responses were compared with study outcomes as

290 anisms, as well as growth platform-dependent metabolic responses were identified.

291 n tomography in the expansion cohorts, seven metabolic responses were observed.

292 When metabolic responses were restricted to photoreceptors, l

293 oxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increas

294 S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity.

295 acute hypoxaemia involves cardiovascular and metabolic responses, which include peripheral vasoconstr

296 acute response and they induced the expanded metabolic response with only minimal exposure to stress.

297 hematical model of resource availability and metabolic response within colony features.

298 and between tissues to co-ordinate adaptive metabolic responses within the organism as a whole.

299 esis was that patients who exhibited a tumor metabolic response would survive longer than those who d

300 The combination of myogenic, shear, CO2, and metabolic responses yields the best autoregulation (fact