ライフサイエンスコーパス: metabolically

1 ges in disease extent, both anatomically and metabolically.

2 tially toxic quantities of acid are produced metabolically.

3 from these substrates are compartmentalized metabolically.

4 re superimposed on diabetic hearts that were metabolically abnormal in normoxia, resulting in glycoly

5 r immunity, but how Treg cells behave in the metabolically abnormal tumor microenvironment remains un

6 We have developed a metabolically activated radiotracer for functional imagi

7 yclic aromatic hydrocarbon (PAH) that can be metabolically activated to benzo[a]pyrene diol epoxide (

8 Some N-nitroso compounds can be metabolically activated to yield diazoacetate, which is

9 Upon arrest, cells stay metabolically active and accumulate cell mass.

10 y of (18)F-FDG PET/CT to distinguish between metabolically active and inactive disease, this techniqu

11 with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium tubercul

12 like state upon inoculation into soil but is metabolically active and that VBNC cells should be taken

13 h stable burnt-out disease that is no longer metabolically active and those with active atheroma, fas

14 that allow psychrophilic bacteria to remain metabolically active at subzero temperatures result from

15 rting (FACS) allows for rapid enumeration of metabolically active bacilli after phage infection.

16 re detected in the subgroup of patients with metabolically active bone lesions (P = 0.02), but no dif

17 The presence or absence of metabolically active bone lesions was also recorded for

18 was correlated with both local expansion of metabolically active bone marrow documented by FDG uptak

19 that predation by increasingly powerful and metabolically active carnivores has been a major driver

20 cell viability and screen susceptibility of metabolically active cells (E. coli, B. subtilis, Entero

21 cies, each root tip can produce thousands of metabolically active cells daily, with specialized patte

22 sma membrane outer leaflet; the asymmetry of metabolically active cells was similar to that previousl

23 ucture, as well as its relative abundance in metabolically active cells, bacterial 16S rRNA sequence

24 Vertebrate photoreceptors are among the most metabolically active cells, exhibiting a high rate of AT

25 or combined imaging of T and O2 gradients in metabolically active cells.

26 respiration and converts persister cells to metabolically active cells.

27 lipid droplet became recognized as a unique, metabolically active cellular organelle and its surface

28 The gut microbiome is a complex and metabolically active community that directly influences

29 , we found that CD56(bright) cells were more metabolically active compared with CD56(dim) cells.

30 but also provide a microorganism-controlled metabolically active compartment essential for redirecti

31 te only one "half" of the SCN clock, the one metabolically active during circadian daytime.

32 ies to block the effects of IFN-gamma on the metabolically active endoplasmic reticulum in these cell

33 ability to reprogram root cells into unique metabolically active feeding sites.

34 on, and remains associated with membranes of metabolically active forms of Ct throughout development.

35 Plant roots, a metabolically active hotspot in the soil, take an essent

36 Brown adipose tissue (BAT) is metabolically active in human adults.

37 ling protein 1 (UCP1), has been described as metabolically active in humans.

38 commonly used in PET/CT that is retained by metabolically active inflammatory cells in granulomas, b

39 Pfn2 in HeLa and Hepa1-6 cells reduced their metabolically active iron pool.

40 ementation of TAX1BP1-deficient T cells with metabolically active L-cysteine rescued mTOR activation

41 cts related to metallic implants on adjacent metabolically active lesions in clinical simultaneous PE

42 ) values of metabolically inert feathers and metabolically active liver.

43 t cellular membrane system and also the most metabolically active organelle responsible for lipid syn

44 Peroxisomes are highly dynamic and metabolically active organelles that play an important r

45 e values and low contrast caused by adjacent metabolically active organs in this model.

46 ondrial health in ageing and the function of metabolically active organs, the results implicate NAM a

47 ilar correlation was observed between a high metabolically active phenotype and chemoresistance.

48 ounterparts (C200 and PEO4) exhibited a high metabolically active phenotype with the ability to switc

49 increased oxidative phosphorylation or high metabolically active phenotype.

50 sustained periods of N starvation, with the metabolically active population displaying compromised v

51 Vmax-40 is more likely to represent the most metabolically active portions of tumors than SUVpeakW, w

52 ure proper blood flow and oxygen delivery to metabolically active skeletal muscle.

53 ome of these mosses were able to return to a metabolically active state and remain alive.

54 ft in gene expression to switch cells from a metabolically active state to "stress-defence mode" when

55 ave defined CD56(bright) NK cells to be more metabolically active than CD56(dim) cells, which support

56 basal conditions, adult human OLs were less metabolically active than their progenitors and both wer

57 ed to significant interest in targeting this metabolically active tissue for treatment of obesity and

58 ed glucose disposal and insulin signaling in metabolically active tissues in Adipoq(-/-) and WT dams

59 sphorylation and mitochondrial biogenesis in metabolically active tissues.

60 ng the expansion of highly proliferative and metabolically active Treg cells and by preventing pathol

61 ors on (18)F-FDG PET images, such as SUVmax, metabolically active tumor volume (MATV), total lesion g

62 l studies have suggested that the parameters metabolically active tumor volume (MTV) and total lesion

63 In the PET images, the metabolically active tumor volume (MTV) of the primary t

64 lternative (18)F-FDG uptake measures such as metabolically active tumor volume and total lesion glyco

65 SUVmax, SUVmean, SUVpeak, TLG, metabolically active tumor volume, and tumor-to-blood an

66 Overall, patients with large and metabolically active tumors should be considered high ri

67 Cy7-TCP-1 activity localized not only in metabolically active tumors, as defined by (18)F-FDG ima

68 Metabolically active volumes were automatically delineat

69 Irradiated macrophages remained viable and metabolically active, despite DNA damage.

70 iated CTB, in contrast to the SCT, is highly metabolically active, has a high level of fuel flexibili

71 um falciparum sporozite (PfSPZ) Vaccine is a metabolically active, non-replicating, whole malaria spo

72 he majority of the bacteria (76 +/- 2%) were metabolically active, whilst AMR bacteria to carbenicill

73 ine when and under which conditions they are metabolically active.

74 etabolism of ILC and whether these cells can metabolically adapt in response to environmental signals

75 How cancer cells adapt to metabolically adverse conditions in patients and strive

76 ulation is offloaded from hypoxic cells onto metabolically altruistic normoxic neighbors.

77 Rather, LADA was metabolically an intermediate of type 1 and type 2 diabe

78 nations of double mutants were generated and metabolically analyzed with a focus on starch metabolism

79 These rewards are valuable metabolically and can be used to reinforce the behavior

80 Taxonomically, metabolically and functionally distinct bacterial commun

81 Heterocysts are metabolically and structurally specialized to enable O2-

82 ant bacilli in sputum are in a slow-growing, metabolically and synthetically downregulated state.

83 Metabolically, animals exhibited randomly increased seru

84 holestanol-metabolizing P450s from a pool of metabolically available cholestanol; and (iii) weak cere

85 he bivalve, however, appears to regulate the metabolically available fraction (MAF) of the total meta

86 orresponding coenzyme A thioesters to become metabolically available.

87 To assess the metabolically beneficial effects of fenugreek (Trigonell

88 In obesity, these metabolically beneficial immune pathways become dysregul

89 e most global benefit in mice that were most metabolically challenged (HFD-consuming offspring of obe

90 This remodeling metabolically channels AA into toxic HETEs promoting mPT

91 that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, where

92 we analyzed the fasting plasma metabolome in metabolically characterized human volunteers across a sp

93 vestigated the effects of PK11195 on hCAR in metabolically competent human primary hepatocytes (HPH)

94 Human MCL-5 cells (metabolically competent) were exposed to BaP or PhIP ind

95 We also tested a metabolically competent, but avirulent, Salmonella enter

96 apable of maintaining a stable co-culture of metabolically competitive Salmonella typhimurium strains

97 lerosis, glucose intolerance, and obesity in metabolically compromised mice.

98 ms of elevated sympathetic activity known in metabolically compromised patients and animal models.

99 Chemokine-controlled NADPH oxidases and metabolically controlled mitochondrial sources of H2O2 a

100 Importantly, metabolically corrected phospholipid composition and imp

101 to mitigate oxidative stress incurred during metabolically costly activities such as flight.

102 We investigated how GLP-1 secretion is metabolically coupled in L cells (GLUTag) and in vivo in

103 the primary tumor, and how cancer cells are metabolically coupled with other cancer cells that compr

104 sed bone formation and lipid accumulation in metabolically critical tissues.

105 r similarly variable relationships exist for metabolically defined body size phenotypes and colorecta

106 The association of metabolically defined body size phenotypes with colorect

107 ELW1 co-metabolically degraded up to 1.8 mumol of phenanthrene (

108 d, and adipocytes and other factors initiate metabolically deleterious type 1 inflammation that impai

109 Photoreceptors are the most numerous and metabolically demanding cells in the retina.

110 rvous system (SNS) activation in response to metabolically demanding emergencies.

111 Antibody production is a metabolically demanding process that is regulated by gut

112 Tissue repair after injury is a complex, metabolically demanding process.

113 sly released monocarboxylates, can fuel more metabolically demanding tasks such as vesicle recovery a

114 ing, yet uncultured 'ARMAN'-like archaea are metabolically dependent on other members of the microbia

115 ing that all free-living dinoflagellates are metabolically dependent on plastids.

116 ocarotenoids such as astaxanthin are usually metabolically derived via ketolation of dietary yellow c

117 re consortia of phylogenetically diverse and metabolically different microbes that cooperate to carry

118 Although T1R3KO mice did not present a metabolically disrupted phenotype, bioinformatic interpr

119 y, our findings show that the acquisition of metabolically distinct "Epulopiscium" symbionts in hosts

120 progeny arise during infection, constitute a metabolically distinct subpopulation, and are less virul

121 ves the genetically programmed generation of metabolically distinct subpopulations of cells, resultin

122 trate that rats that repeatedly consumed two metabolically distinct sugars (glucose and fructose), an

123 l (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic diffe

124 strate that SLiMEs support taxonomically and metabolically diverse microorganisms, which, through dev

125 Ascomycete yeasts are metabolically diverse, with great potential for biotechn

126 rapidly-dividing planktonic bacteria but not metabolically dormant biofilm cells.

127 rmone therapy (HT)-naive cells or HT-treated metabolically dormant populations with CAF-derived mtDNA

128 allows starving cells to differentiate into metabolically dormant spores that can survive extreme co

129 dies reveal a potent therapeutic strategy of metabolically driven synthetic lethality involving targe

130 The new findings enabled us to metabolically engineer entirely red-pigmented tobacco pl

131 Metabolically engineered yeast, Escherichia coli, cyanob

132 One approach is metabolically engineering oilseed crops to synthesize n-

133 or chronic B cell leukemia, which were also metabolically exhausted and had defective Akt/mTORC1 sig

134 capacity to immediately respond to the more metabolically expedient sugar, glucose, would seem advan

135 Debate surrounds the issue of how the large, metabolically expensive brains of Homo sapiens can be en

136 Staphylococcus aureus, a metabolically flexible gram-positive pathogen, causes in

137 Although older, more metabolically harmful antiretroviral regimens probably c

138 glucose administration is associated with a metabolically healthier phenotype, suggesting that it is

139 ncepts such as the fat-but-fit paradigm, the metabolically healthy but obese (MHO) phenotype and the

140 APNtg mice remained metabolically healthy despite DHT exposure, while APNko-

141 ulation, and participants were classified as metabolically healthy if below the first tertile of C-pe

142 isease, and heart failure than normal weight metabolically healthy individuals.

143 r risk of psoriasis incidence as compared to metabolically healthy non-obese subjects.

144 Increasing evidences support that metabolically healthy obese (MHO) is a transient state.

145 rable features; this group is referred to as metabolically healthy obese (MHO).

146 -17 cytokine, and IL-23R, in comparison with metabolically healthy obese and lean donors.

147 When compared with controls, metabolically healthy obese had lower LS, greater dyssyn

148 This study examined the associations among metabolically healthy obese individuals and 4 different

149 Metabolically healthy obese individuals had a higher ris

150 n unclear about the cardiovascular risks for metabolically healthy obese individuals.

151 limation also induced such adaptations in 10 metabolically healthy obese male subjects.

152 GG provides a new model of the metabolically healthy obese phenotype.

153 k representations of the "obesity paradox," "metabolically healthy obese," "metabolic syndrome," and

154 These findings show that metabolically healthy obesity is not a harmless conditio

155 This phenomenon has been termed "metabolically healthy obesity" (MHO), and it has receive

156 urnal highlights several limitations of the "metabolically healthy obesity" concept and calls into qu

157 sity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored.

158 of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (with

159 beige) adipocytes is correlated with a lean, metabolically healthy phenotype, but whether a causal re

160 sferred from patients with T2DM but not from metabolically healthy subjects caused insulin resistance

161 ciated with an increased incidence of CKD in metabolically healthy young and middle-aged participants

162 (MU), while those with none were considered "metabolically healthy" (MH).

163 nerate increased adipose tissue that appears metabolically healthy.

164 c health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m2), (2

165 BMI used to define adiposity, compared with metabolically healthy/normal weight individuals, we obse

166 healthy/normal weight (BMI < 25 kg/m2), (2) metabolically healthy/overweight (BMI >/= 25 kg/m2), (3)

167 5% CI 1.01-1.94) participants, but not among metabolically healthy/overweight individuals (OR = 0.96,

168 ower colorectal cancer risk was observed for metabolically healthy/overweight individuals compared wi

169 s support the idea that individuals with the metabolically healthy/overweight phenotype (with normal

170 ent of novel therapies that influence a more metabolically "healthy" skeletal muscle and potentially

171 Moreover, metabolically heterogeneous regions were identified with

172 and that T cells from leukemic hosts become metabolically impaired.

173 lavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose

174 st immune systems with this subpopulation of metabolically inactive cells, and direct effects of host

175 this to be due to the presence of a distinct metabolically inactive pool of Phe, likely localized in

176 hogen Mycobacterium tuberculosis may enter a metabolically inactive state that is less susceptible to

177 ed mutant of Mtb and examined its ability to metabolically incorporate radiolabeled oleic acid into T

178 We demonstrate that x-alk-16 can be metabolically incorporated into known S-palmitoylated pr

179 an unnatural d-amino acid dipeptide that is metabolically incorporated into Lipid II molecules.

180 ied fluorescein-trehalose analogues that are metabolically incorporated into the trehalose mycolates

181 Metaflammation, an atypical, metabolically induced, chronic low-grade inflammation, p

182 saturated carbons, were recently designed as metabolically inert cobalamins, classified as "antivitam

183 s would therefore support the development of metabolically inert drugs and help to assess health risk

184 ured hydrogen isotope (delta(2) H) values of metabolically inert feathers and metabolically active li

185 We describe metabolically inert l-glucosamine-based glycosylated ant

186 In this state beta-cells become metabolically inflexible, losing the ability to select b

187 570 microbial species and 3 human cell types metabolically interacting through >4,400 small-molecule

188 ylserine (PS) are ubiquitously expressed and metabolically interconnected glycerophospholipids in euk

189 ole assemblies, microbial communities harbor metabolically interdependent groups that recur across di

190 ly activated, enable the spatial labeling of metabolically introduced azides in vitro and on live zeb

191 Metabolically, knockdown of SLC13A5 in HepG2 and Huh7 ce

192 Using 5-ethynyl uridine (EU) to metabolically label nascent RNA, we measured a sevenfold

193 sed on numerical modeling of mass spectra of metabolically labeled dolichols (Dols), designed to quan

194 Using a combination of metabolically labeled glycans, a bioorthogonal copper(I)

195 ics platform for characterization of intact, metabolically labeled glycopeptides at the whole-proteom

196 For this analysis, an antibody was metabolically labeled with (13)C3,(15)N-cysteine and inc

197 roteins as judged by two-dimensional PAGE of metabolically labeled/immunoprecipitated PMEL and by mas

198 , with or without 1'-substituents, carries a metabolically labile 2',3'-ester group.

199 These findings demonstrate that metabolically labile electrophilic groups can endow cova

200 ther optimization studies in which potential metabolically labile sites on compound 1b were removed o

201 ssumption, and also implying that tumors are metabolically less homogeneous than previously supposed.

202 ic glutamine synthase, is likely to become a metabolically limiting factor in the latest stages of de

203 mechanism in coordinating the biogenesis of metabolically linked organelles in eukaryotes.

204 on of long-term protective immunity based on metabolically modified cytotoxic CD8(+) T cells.

205 LHb was found to be metabolically modified in dyskinetic monkeys and its neu

206 the mitochondrial energy state or detecting metabolically more active cancer cells.

207 ) noninvasive cells that were angiogenic and metabolically near-normal.

208 study with metabolic syndrome compared with metabolically normal controls.

209 esis of one of the most densely modified and metabolically obscure ribosome-derived molecules found i

210 Contrastingly, VC was metabolically oxidized by ethenotrophs in low-TOC sedime

211 propose that tissue-resident macrophages are metabolically poised in situ to protect and exploit thei

212 We designed a tooling and methodology to metabolically profile and compare 2D cultures with cance

213 In this study, we have metabolically profiled several individual frequently occ

214 cular phylogeny data were used to identify a metabolically prolific strain of Tolypocladium that was

215 these parasites previously considered to be metabolically quiescent are, in fact, active and able to

216 lling activity when parasites developed into metabolically quiescent stage V gametocytes.

217 habitat for Vibrios is a replete medium with metabolically redundant substrates.

218 In addition, such metabolically regulated active forces cause global membr

219 inking the distinct receptor systems through metabolically related ligands with potential functional

220 tory polypeptide) receptor (GIPR), are three metabolically related peptide hormone receptors.

221 by a single oxygen atom even as the two are metabolically related.

222 nylalanine and L-tyrosine but it may be that metabolically-related compounds directly influence insec

223 KK2 and demonstrate its utility for treating metabolically-related hepatic disease.

224 Real-time monitoring of metabolically relevant biochemicals released in minuscul

225 ty to reverse obesity-linked inflammation in metabolically relevant tissues.

226 s indicate that TRAF3 deficiency suffices to metabolically reprogram B cells, a finding that improves

227 ung CD11b(+) DCs were not changed, they were metabolically reprogrammed to skew allergic inflammation

228 In a subgroup of 7 animals, defect of the metabolically resistant catecholamine (11)C-hydroxyephed

229 e group by a spirobutyrolactone to produce a metabolically resistant derivative.

230 bility studies demonstrated that 14 was more metabolically resistant than salvinorin A.

231 larly with punctuated cell-to-cell contacts, metabolically responsive to environmental stimuli, dispe

232 , we show that glucose consumption by tumors metabolically restricts T cells, leading to their dampen

233 and paves the way for the exploitation of a metabolically rich but traditionally overlooked group of

234 ndidates for (18)F-incorporation as they are metabolically robust and therefore widely used by medici

235 al injection of compounds that stimulate the metabolically-sensitive thin fibre muscle afferents.

236 re conjugation of bile acids is likely to be metabolically significant.

237 For example, it may be possible to identify metabolically similar species as groups of organisms tha

238 stly be prevalent among phylogenetically and metabolically similar species.

239 probability of antagonism increased the more metabolically similar the strains were.

240 ure of human Argonaute-2 in complex with the metabolically stable 5-(E)-vinylphosphonate (5-E-VP) gui

241 Pharmacologic studies revealed that MPC6 was metabolically stable and displayed a low plasma clearanc

242 Therefore, we developed metabolically stable and receptor-selective agonists for

243 Moreover, the inhibitor was metabolically stable and selective toward LAT1.

244 These episomes are metabolically stable and support long-term expression of

245 ls have led to the identification of potent, metabolically stable compounds with improved in vivo ora

246 nd 13b, one of the most active compounds, is metabolically stable in both human and mouse liver micro

247 This compound was metabolically stable in liver microsomes and displayed a

248 nt interactions, which allowed us to develop metabolically stable inhibitors with high activities aga

249 In this work, we report a cell-permeable and metabolically stable nonphosphorylated bicyclic peptide

250 velopment of new NT derivatives based on the metabolically stable peptide sequence NLys-Lys-Pro-Tyr-T

251 l and modified amino acids resulted in novel metabolically stable peptides that demonstrated a signif

252 lipophilicity, resulting in a selective and metabolically stable profile.

253 phore for further modification, resulting in metabolically stable quinolones effective against multi

254 e crystal structure of human Ago2 bound to a metabolically stable siRNA containing extensive backbone

255 use of 1,4-disubstituted 1,2,3-triazoles as metabolically stable trans-amide bond surrogates in radi

256 ther bacterial species and eukaryotic cells, metabolically stable, and apparently not susceptible to

257 atrix libraries provided a number of potent, metabolically stable, and in vivo active compounds.

258 eviously reported chemical series, is highly metabolically stable, despite the foreseen potential sit

259 highly protein bound, highly permeable, and metabolically stable.

260 conclude that reduced expression of PAX6 in metabolically stressed beta cells may contribute to beta

261 ploited for eliciting synthetic lethality in metabolically stressed cancer cells using high-affinity

262 ACSS2 expression is upregulated under metabolically stressed conditions and ACSS2 silencing re

263 tion can improve cellular energy state under metabolically stressed conditions in a robust, reduction

264 actor and interleukin-6-like signalling from metabolically stressed tumour cells, whereas tumour grow

265 y contributing to energy mobilization during metabolically stressful episodes.

266 Metabolically, the brain is a highly active organ that r

267 ulated in a scmR deletion mutant (DeltascmR) Metabolically, the DeltascmR strain displays a hyperacti

268 de the increased amount of protons generated metabolically, thus maintaining physiologic values for t

269 lar localization that help the plant respond metabolically to fluctuating light conditions.

270 Cancer cells adapt metabolically to proliferate under nutrient limitation.

271 a pathogen is the ability to sense and adapt metabolically to the diverse range of conditions encount

272 subset of obese individuals does not exhibit metabolically unfavorable features; this group is referr

273 ictive of the persistence or resolution of a metabolically unfavorable state.

274 er risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/o

275 if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile.

276 The metabolically unhealthy non-obese (MUNO) subjects (hazar

277 , have been shown to be lower in MHO than in metabolically unhealthy obese (MUO).

278 eater frequency of Th17 cells in tissue from metabolically unhealthy obese donors, revealed not only

279 se in human visceral adipose tissue (VAT) of metabolically unhealthy obese patients.

280 95% confidence interval [CI], 1.22-1.37) and metabolically unhealthy obese subjects (MUO; HR, 1.33; 9

281 e inflammation it might drive development of metabolically unhealthy obesity.

282 Metabolically unhealthy status was associated with highe

283 pidaemia) in the index year were considered "metabolically unhealthy" (MU), while those with none wer

284 y healthy/overweight (BMI >/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m2),

285 served a higher colorectal cancer risk among metabolically unhealthy/normal weight (odds ratio [OR] =

286 lthy/normal weight (BMI < 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI >/= 25 kg/m2).

287 dds ratio [OR] = 1.59, 95% CI 1.10-2.28) and metabolically unhealthy/overweight (OR = 1.40, 95% CI 1.

288 healthy/overweight individuals compared with metabolically unhealthy/overweight individuals (OR = 0.6

289 This study reveals a metabolically unique mycoplasma colonizing a premature n

290 the prostate cancer-derived PC3 cell line is metabolically unstable in cells because its N-terminal t

291 Thus, metabolically unstable LBR variants may serve as long-so

292 Gid4 is also a metabolically unstable protein.

293 le LBR truncations render the mutant protein metabolically unstable, leading to its rapid degradation

294 ic photosynthesis, including the activity of metabolically versatile cyanobacteria, played an importa

295 B) are key drivers of arsenic methylation in metabolically versatile mixed anaerobic enrichments from

296 B. motovehiculus MROs are metabolically versatile, retaining mitochondrial metabol

297 Hadesarchaea are distinctly streamlined, yet metabolically versatile.

298 Metabolically, we show that the N-desmethyl metabolite i

299 igodendrocytes make myelin and support axons metabolically with lactate.

300 ied Salmonella strain may be able to compete metabolically with most, if not all, Salmonella serovars