ライフサイエンスコーパス: metabolism

1 ity, vascular tone, inflammation, and energy metabolism.

2 nsducing nutritional state to regulate lipid metabolism.

3 ization of the transcriptome and respiratory metabolism.

4 the citric acid (TCA) cycle, and amino acid metabolism.

5 the intermediacy of pseudolaratriene in PAB metabolism.

6 rugs systemically without hepatic first pass metabolism.

7 CRISPR-Cas immunity and central nucleic acid metabolism.

8 , but cooling causes shivering and increases metabolism.

9 n regulate oxidative stress and/or energetic metabolism.

10 +) into the mitochondrial matrix to modulate metabolism.

11 ng and cancer are diseases related to energy metabolism.

12 urate prediction of regional pediatric brain metabolism.

13 tion by reprogramming mitochondrial pyruvate metabolism.

14 ding protein vital for multiple steps in RNA metabolism.

15 hances immunity in addition to orchestrating metabolism.

16 is a key FAD-dependent enzyme of tryptophan metabolism.

17 ced changes of the gut microbiota and energy metabolism.

18 of substituted lysines tends to increase APP metabolism.

19 unosuppressive cytokines and show an altered metabolism.

20 otoxic stress responses control phospholipid metabolism.

21 es that regulate different aspects of energy metabolism.

22 7 B vitamins play essential roles in central metabolism.

23 nked to highly altered membrane phospholipid metabolism.

24 genes, indicating a role of SLC7A11 in lipid metabolism.

25 dently and synergistically regulating uremic metabolism.

26 ure and dynamics of gene clustering in plant metabolism.

27 involved in nutrient flux and hepatic lipid metabolism.

28 rocesses of circadian rhythm maintenance and metabolism.

29 expression profoundly alters cellular energy metabolism.

30 from protein degradation in the form of urea metabolism.

31 ile acid (BA) signaling regulates fatty acid metabolism.

32 meet cellular energy demands with anaerobic metabolism.

33 n that was consistent with altered bile acid metabolism.

34 gnaling, adhesion, motility, development and metabolism.

35 cer exhibits a targetable alteration in iron metabolism.

36 he primary source of energy to support their metabolism.

37 ith their downregulated amino and fatty acid metabolism.

38 interface between developmental biology and metabolism.

39 intestine and to partially modulate glucose metabolism.

40 (apoC-III) is a key regulator of lipoprotein metabolism.

41 s constraints that self-inhibition places on metabolism.

42 (GEMs) can assist in understanding cellular metabolism.

43 important step in the regulation of glucose metabolism.

44 of cardioprotection and modulation of energy metabolism.

45 time-resolved perturbations to the nitrogen metabolism.

46 f genes associated with the PG or tryptophan metabolism.

47 physiologic functions apart from fatty acid metabolism.

48 ticity and design cancer therapies targeting metabolism.

49 can be applied to study kidney diseases and metabolism.

50 to nucleotide-dependent processes and lipid metabolism.

51 he convergent evolution of plant specialized metabolism.

52 ccurs through alteration of endothelial cell metabolism.

53 elope biogenesis, protein translocation, and metabolism.

54 he various techniques used to study cerebral metabolism, (13)C magnetic resonance spectroscopy (MRS)

55 xhibit mild motor phenotypes, minor dopamine metabolism abnormalities, and no signs of dopaminergic n

56 factors associated with changes in secondary metabolism across natural environments.

57 we predict the behavioural diagnosis, brain metabolism and 1-year clinical outcome of individual pat

58 e with diet-induced obesity impaired glucose metabolism and AKT activation.

59 Metabolism and biodistribution of EDHB were analyzed usi

60 establish sex-specific differences in muscle metabolism and body weight development.

61 ained genes known to interact with estradiol metabolism and cancer.

62 ed proteins (RAPs) from categories including metabolism and cell cycle, as well as RNA- and protein-m

63 ytoglobin (CYGB) regulates nitric oxide (NO) metabolism and cell death.

64 Lipids play central roles in metabolism and cell signaling, and thus reflect the phen

65 chment for molecular functions such as xylan metabolism and cell wall development.

66 , these results suggest links between energy metabolism and cellular physiology, morphology, and symb

67 in visceral and subcutaneous WAT thermogenic metabolism and demonstrate the distinct metabolism of BA

68 arting sex differences in hepatic drug/lipid metabolism and disease risk.

69 ports the protein's diverse functions in RNA metabolism and DNA maintenance, establishing Nol12 as a

70 ways, providing potential cross talk between metabolism and epigenetic regulation of gene expression.

71 ed protein response, autophagy, and cellular metabolism and exploit these pathways to their advantage

72 nitric oxide synthase (iNOS) coordinates DC metabolism and function to limit DC-stimulated T-cell re

73 ameliorating PDH activity and mitochondrial metabolism and further affecting motor behavior in HD mi

74 nically relevant (13)C MRS studies of energy metabolism and further provides opportunities for evalua

75 which likely play important roles in obesity metabolism and identified microRNAs that significantly n

76 Ndfip1 restricts Treg cell metabolism and IL-4 production via distinct mechanisms,

77 are observed in vesicular trafficking, lipid metabolism and in the endoplasmic reticulum that could i

78 Little is known about placental vitamin D metabolism and its impact on maternal circulating vitami

79 DAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver.

80 current understanding of placental vitamin D metabolism and its role in modulating maternal circulati

81 ocuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

82 Sugar metabolism and lipid utilization are linked to the spati

83 actor EB (TFEB), a master regulator of lipid metabolism and lysosomal biogenesis and function.

84 hodology that permits integrated modeling of Metabolism and macromolecular Expression (ME) at genome-

85 Among these, lipid metabolism and mitochondrial dysfunction proteins were o

86 connection between AIBP-mediated cholesterol metabolism and Notch signaling, implicating AIBP as a po

87 to quantify how coupling of stream ecosystem metabolism and nutrient uptake responded to a realistic

88 ations (one [7%] at 300 mg twice a day), and metabolism and nutrition disorders (one [4%] at 200 mg t

89 r (HNF) family regulates complex networks of metabolism and organ development.

90 Polyphenol metabolism and possible toxic side effects are also cons

91 of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage.

92 chemical pathways associated with amino acid metabolism and redox status.

93 hich substantially influence many aspects of metabolism and related diseases.

94 The comparison of ABA metabolism and signaling in roots of flooded and water s

95 l-autonomous defect in the mitochondrial B12 metabolism and that itaconyl-CoA is a cofactor-inactivat

96 entified link between O-GlcNAcylation, lipid metabolism and the regulation of SREBP-1 in cancer and s

97 ds to growth inhibition and perturbs central metabolism and this burden varies with the protein being

98 life correspond with differences in cellular metabolism and transcriptomic profiles at birth.

99 lic exposure to chemicals via combined human metabolism and urban water fingerprinting assay.

100 itranscriptionally regulates triacylglycerol metabolism and vacuolar morphology through the long-chai

101 s a molecular brake that inhibits fatty acid metabolism and WAT browning.Histone deacetylases, such a

102 ed for various cellular functions, including metabolisms and proliferation.

103 ic AMPK activation, alterations in substrate metabolism, and an increased sensitivity to ischemic ins

104 yte inflammation, adversely regulate myocyte metabolism, and contribute to insulin resistance via par

105 rix, the vasculature, the immune system, and metabolism, and discuss the implications for the develop

106 getics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in diffe

107 idly increases hepatic lipid storage, energy metabolism, and insulin resistance.

108 -related signaling networks, intestinal cell metabolism, and physiology in a three-dimensional enviro

109 racellular localization plays in specialized metabolism, and sets the stage for understanding and con

110 in infant formula composition impact infant metabolism, and show that metabolomics is a powerful too

111 alterations in purine metabolism, glutamate metabolism, and the pentose phosphate pathway.

112 n regulating nitrogen movement in support of metabolism, and vegetative and reproductive growth are a

113 ich sedimentary rocks, but their affinities, metabolism, and, hence, their contributions to Earth sur

114 nnabis use whereby global and regional brain metabolism are altered in those with prolonged cannabis

115 Reference databases of pediatric brain metabolism are uncommon, because local brain metabolism

116 ose affecting reproduction, hibernation, and metabolism, are controlled by pituitary hormones release

117 is a major handler of protein and amino acid metabolism as it is responsible for the majority of prot

118 er Genome Atlas dataset, we identified lipid metabolism as the metabolic pathway that most significan

119 sure induced disturbance of energy and lipid metabolism as well as oxidative stress.

120 al metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response.

121 ded protein response, Wnt signalling and RNA metabolism, as critical cellular components governing in

122 ization-related roles in motility and carbon metabolism, as well as 44 other genes that had no or vag

123 r, the intervals they mapped to harbored few metabolism-associated genes, suggesting that the canaliz

124 i), and by using a pre-drawn overview map of metabolism based on the Roche map satisfies (ii) and com

125 he mechanism by which YAP reprograms glucose metabolism, but also highlights the therapeutic potentia

126 evidence that the microbiome regulates host metabolism, but specific mechanisms underlying these int

127 have been shown to regulate cellular energy metabolism, but their role in white adipose tissue physi

128 aling mediator, regulates several aspects of metabolism by activating 4 G-protein-coupled receptors,

129 w that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate

130 ifferential regulation of macrophage glucose metabolism by macrophage colony-stimulating factor (M-CS

131 RP6 regulates local inflammation and glucose metabolism by targeting macrophages and adipocytes, resp

132 n and highlight the relevance of cholesterol metabolism by the host for diet-induced changes of the g

133 Primary metabolism can be measured by the universally conserved

134 icant portion of a model community's overall metabolism can be predicted based on the metabolism of t

135 Dysregulated metabolism can broadly affect therapy resistance by infl

136 ism by which alterations in cellular glucose metabolism can influence cellular inflammatory responses

137 el simulations, our theoretical framework of metabolism can serve as a platform to decode cancer meta

138 , CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of

139 downregulation of pathways mediating energy metabolism, cell cycle, and B cell receptor signaling.

140 rtions of the flax stem, together with fibre metabolism characterization, helped to elucidate the gen

141 nt capacity and alterations in macronutrient metabolism contribute to increased susceptibility to chr

142 in hepatic free fatty acid (FFA) uptake and metabolism contribute to the development of prevalent li

143 However, how this altered metabolism contributes to tumour metastasis remains elus

144 t programmed differences in infant stem cell metabolism correspond with differences in body compositi

145 metabolic phenotype, and that altering tumor metabolism could change therapeutic outcome.

146 is cross-talk between nerves and endothelial metabolism could potentially be targeted as an anticance

147 YNA, a neuroinhibitory product of tryptophan metabolism) counteracts the rewarding effects of cannabi

148 posure to drugs with scarce or unknown human metabolism data.

149 lux transporter, cause a heritable manganese metabolism disorder resulting in elevated manganese leve

150 effects that perturbation of the one-carbon metabolism during gestation has on mice progeny.

151 st-translational mechanisms to regulate heme metabolism during normal development.

152 ternational experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed

153 ical processes such as abnormalities in cell metabolism, energy production and oxidative stress in ot

154 hose for putative enzymes and a carbohydrate metabolism enzyme, alkB2; this latter gene is not upregu

155 , after digestion in vitro, on carbohydrates-metabolism enzymes and to assess the bioacessibility of

156 The impact of diet on the metabolism-epigenome axis is poorly understood but could

157 mayonii-infected nymphal ticks by measuring metabolism every 24 hours over the course of their up to

158 metabolism are uncommon, because local brain metabolism evolves significantly with age throughout chi

159 whether early or late components of glucose metabolism, exemplified by fluorine 18 ((18)F) fluorodeo

160 ies (ROS) oxidation, extracellular oxidative metabolism (EXOMET), and inorganic chemical reactions, c

161 olic pathways included purine and pyrimidine metabolism, fatty acid beta-oxidation, phospholipid cata

162 on, as well as host and microbiota bile acid metabolism, favor bile acid accumulation that contribute

163 bolic flux analysis to quantify intermediary metabolism fluxes in both sedentary and treadmill-runnin

164 tracers, we probed the phenotypic changes in metabolism following a single copy knock-in of mutant PI

165 s, we identified novel alterations in purine metabolism, glutamate metabolism, and the pentose phosph

166 role of metabolites produced from stem cell metabolism has been emerged as signaling molecules to re

167 egulation of bile acid synthesis and hepatic metabolism has been studied extensively.

168 lulose biomaterials, and more broadly fungal metabolism, has implications for diverse research discip

169 However, beyond its role in metabolism, HCS participates in the regulation of biotin

170 oregulators in the fine tuning of organismal metabolism.HDAC3 is a critical mediator of hepatic lipid

171 Besides its effects on cell metabolism, HO-1 is also capable of modulating host inna

172 se (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHFR activity in oligodendroc

173 the ability to regulate development, growth, metabolism, immune defense, and reproduction in response

174 ts shed new light on the interaction between metabolism, immunity, and tissue communication.

175 M detachment), cancer cells must alter their metabolism in a fashion that promotes survival and ultim

176 ata provide a timeline of global thermogenic metabolism in adipose depots during acute cold exposure.

177 ultaneously targeting dysregulated polyamine metabolism in cancer, thereby providing an elegant and e

178 a mimic and targeting dysregulated polyamine metabolism in cancer.

179 Inhibition of glutamine metabolism in ECs did not cause energy distress, but imp

180 Brocadia and sheds light on their metabolism in engineered ecosystems.

181 he available evidence on the role of arsenic metabolism in individual susceptibility to the developme

182 increased ATP production and improved energy metabolism in injured kidneys from mPGC-1alpha mice.

183 Cellular metabolism in mammalian cells represents a challenge for

184 Metabolism in plants is compartmentalized among differen

185 neurotransmitters that regulate behavior and metabolism in relation to energy status.

186 s use multiple feedback controls to regulate metabolism in response to nutrient and signaling inputs.

187 results support the rationale for targeting metabolism in sepsis with recombinant human IL-7 as a tr

188 nd experimental approaches to compare energy metabolism in the causative agent of sleeping sickness,

189 Areas of cortical lobar hypo (hyper)-metabolism in the cerebrum that were 2 SDx from the mean

190 D2A, which is required for DHA retention and metabolism in the gut vasculature.

191 ntists assembled at the EMBO/EMBL Symposium 'Metabolism in Time and Space' to discuss how metabolism

192 ets the altered form of mitochondrial energy metabolism in tumour cells, causing changes in mitochond

193 as HDAC3, have been shown to alter cellular metabolism in various tissues.

194 between endothelial glutamine and asparagine metabolism in vessel sprouting.

195 sential roles in enzymes involved in primary metabolism including energy transduction and deoxynucleo

196 ple membrane-less organelles involved in RNA metabolism, including stress granules.

197 ted with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM

198 d in activation of pathways involved in drug metabolism, including those involved in metabolizing che

199 t and metabolite subnetworks linked to lipid metabolism, inflammation and glycerophospholipid metabol

200 Metabolism in Time and Space' to discuss how metabolism influences cellular and developmental process

201 y of calcium into mitochondria is central to metabolism, inter-organelle communication, and cell life

202 The currently accepted model for AOB metabolism involves NH3 oxidation to nitrite (NO2(-)) vi

203 te that the switch from aerobic to anaerobic metabolism is brought about by changes in the levels of

204 orms, suggesting that this intermediate-type metabolism is dictated by the availability of nutrients

205 Metabolism is highly complex and involves thousands of d

206 d genes, suggesting that the canalization of metabolism is largely controlled by regulatory genes.

207 These findings suggest that phospholipid metabolism is linked to the cell cycle and that changes

208 the role of Xpp1 as a repressor of secondary metabolism is shown by gene expression analyses of polyk

209 d insulin resistance (IR) or impaired tissue metabolism is unknown.

210 ipose tissue (BAT) in regulating gestational metabolism is unknown.

211 rrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarcinomas.

212 ontributes to aging and cancer at the energy metabolism level.

213 Products of bacterial anaerobic metabolism, like butyrate and other short-chain fatty ac

214 Here we describe a form of metabolism linking anoxygenic photosynthesis to anaerobi

215 bolism, tryptophan metabolism, phenylalanine metabolism, lysine biosynthesis and degradation, and bil

216 nd further suggest that alterations in lipid metabolism may affect iNKT cell homeostasis through effe

217 e Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking cessation rates.

218 d better preservation of temporoparietal FDG metabolism (mean [SD] FDG: Abeta-N+, 1.25 [0.11] vs Abet

219 titis, and significantly decreased glutamate metabolism metal transport in oral cancer patients.

220 erobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pha

221 ssion and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance

222 ses shape the micro-diversity of specialized metabolism observed in closely related environmental bac

223 Furthermore, overflow metabolism observed may indicate that mitochondrial cata

224 ase (ACS) enzyme plays a central role in the metabolism of anaerobic bacteria and archaea, catalyzing

225 irty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzyme

226 enic metabolism and demonstrate the distinct metabolism of BAT during cold exposure.

227 ons was found to be due to a reduced further metabolism of beta-carotene.

228 The metabolism of carbohydrate polymers drives microbial div

229 bioproducts from atmospheric CO2 Growth and metabolism of cyanobacteria are inherently tied to the d

230 utcomes arising from sequential, multi-organ metabolism of drugs and xenobiotics.

231 Metabolism of glutamine and related analogs by GDH in th

232 tion of activated T cells requires increased metabolism of glutamine.

233 The metabolism of glycerol-3-phosphate (G3P) is important fo

234 Recent data indicate that the metabolism of Mycobacterium tuberculosis (Mtb) inside it

235 ults support a new paradigm that GOT enables metabolism of otherwise neurotoxic extracellular Glu thr

236 e identified proteins, those involved in the metabolism of sugars and stress response were highlighte

237 Here we engineer the carbon metabolism of Synechococcus elongatus PCC 7942 to improv

238 s known to cause perturbations in the energy metabolism of the brain, but current tests of metabolic

239 HS-SPME and LLE-GC/MS analyses revealed that metabolism of the compounds by salivary enzymes was invo

240 all metabolism can be predicted based on the metabolism of the individuals.

241 the regulation of both primary and secondary metabolism of Trichoderma reesei Xpp1 was previously des

242 ot likely to have a direct role in adipocyte metabolism or adaptive thermogenesis.

243 s and other proteins related to amyloid-beta metabolism or Alzheimer's disease were quantified by enz

244 Perturbation of glucose metabolism or disruption of Myc function or sterol biosy

245 te signals from multiple pathways to control metabolism, oxidative stress response, and cell cycle.

246 th treatments had neutral effects on glucose metabolism parameters.

247 t may be a useful probe for examining energy metabolism, particularly in BRAF-mutant melanoma, and re

248 The DEGs significantly enriched in six metabolism pathways including phenylpropanoid biosynthes

249 tifying individual genetic variation in drug metabolism pathways is of importance not only in livesto

250 ive fluxes through glycolysis and nucleotide metabolism pathways were consistent across the studied t

251 an cancers, and the glycolytic and glutamine metabolism pathways were shown to be deregulated in panc

252 changes in the expression of genes in lipid metabolism pathways.

253 abolism, sphingolipid metabolism, tryptophan metabolism, phenylalanine metabolism, lysine biosynthesi

254 ysis of pesticide concentration detected via metabolism/photosynthesis of Chlamydomonas reinhardtii a

255 train fluxes through a genome-scale model of metabolism, Population flux balance analysis (Population

256 r in vivo non-invasive detection of cerebral metabolism post-TBI, providing a new tool to monitor the

257 present in a cell, and is tightly linked to metabolism, proliferation and gene expression.

258 nesis, TCA cycle, starch biosynthesis, lipid metabolism, protein biosynthesis and processing.

259 ed by DO concentration (affected by cellular metabolism), rather than potential nucleation sites prov

260 l participants potentially involved in fibre metabolism regulation and cell wall formation.

261 in DNA methylation and altered expression of metabolism-relevant genes.

262 However, the regulation of methionine metabolism remains unclear.

263 tyrate, produced through anaerobic microbial metabolism represent a major energy source for the host

264 a fundamental question in biology: How does metabolism respond to genetic, environmental or phenotyp

265 Dysregulated lipid and carbohydrate metabolism resulting from insulin resistance leads to hy

266 tabolism, arachidonic acid and linoleic acid metabolism, sphingolipid metabolism, tryptophan metaboli

267 eds resulted in an altered sulfur-associated metabolism, such as lower amounts of Cys and glutathione

268 potent cell-based inhibition of this cancer metabolism target.

269 Downstream sites also had stronger carbon metabolism than upstream sites.

270 ne regulation, and other aspects of cellular metabolism that reinforce thermostable polymerase produc

271 bolism, inflammation and glycerophospholipid metabolism that were associated with IL6, AMPK and PPAR

272 Specifically, we study metabolisms that are viable on one of 50 different carbo

273 portant biochemical pathways such as vitamin metabolism, the citric acid (TCA) cycle, and amino acid

274 n given to targeting mitochondrial glutamate metabolism to control neurotransmitter levels.

275 ustain the increased activity of respiratory metabolism to fuel plant defences.

276 soil carbon persistence, shifting microbial metabolism to less efficient anaerobic respiration, and

277 peron ensures that switching of tetrapyrrole metabolism toward bacteriochlorophyll is coordinated wit

278 ated to signal recognition and transduction, metabolism, transport and catabolism.

279 were observed for GC signaling or other drug metabolism/transport-related genes.

280 d and linoleic acid metabolism, sphingolipid metabolism, tryptophan metabolism, phenylalanine metabol

281 ated lipolysis that plays important roles in metabolism, tumor progression, viral replication, and sk

282 stem cell, cell survival/death, and cellular metabolism under both physiological and pathological con

283 Metabolism was dependent on the expression of a long iso

284 ent regarding whether decreased or increased metabolism was observed.

285 entral role of skeletal muscle in whole-body metabolism, we aimed at studying muscle lipid profiles i

286 ate that mitochondrial UCP3 activity affects metabolism well beyond fatty acid oxidation, regulating

287 Parameters of glucose metabolism were analyzed according to the oral minimal m

288 MR imaging measures of brain perfusion and metabolism were compared among eight patients who were t

289 al function, autophagy, ER stress, and lipid metabolism were measured in pancreatic tissue, acinar ce

290 he effects of age on regional relative brain metabolism were modeled using multiple linear and nonlin

291 used to evaluate how levels of cortical FDG metabolism were predictive of subsequent cognitive decli

292 ysfunctional mitochondria and altered energy metabolism, which further leads to systemic oxidative st

293 c cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-au

294 However, knowing how different species' metabolisms will integrate to reach a desired outcome is

295 to confirm possible interactions of arsenic metabolism with B vitamins and AS3MT variants on diabete

296 mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrient

297 The association of arsenic metabolism with HOMA2-IR differed by B-vitamin intake an

298 spective association of arsenic exposure and metabolism with type 2 diabetes and insulin resistance.

299 ng of hypoxia-induced changes in cancer cell metabolism, with an initial focus on HIF-mediated effect

300 l role in digestion, nutrient absorption and metabolism, with individual regions of the intestine hav