ライフサイエンスコーパス: metabolite

1 of kynurenic acid (KYNA), a neuroinhibitory metabolite.

2 noid alphitolic acid as the main antibiofilm metabolite.

3 pharmacological diversity of small molecule metabolites.

4 by secreting various nutrients and secondary metabolites.

5 n of a liposomal drug carrier as well as its metabolites.

6 s were used to identify differences in rumen metabolites.

7 to improve the production of the specialized metabolites.

8 n part through their conversion to bioactive metabolites.

9 identification and fingerprints of volatile metabolites.

10 otal antioxidant capacity or reactive oxygen metabolites.

11 eJ) could improve the synthesis of secondary metabolites.

12 on of the nutrient processing and release of metabolites.

13 nt and ability to produce numerous secondary metabolites.

14 l control of the biosynthesis of specialized metabolites.

15 amma) and the production of downstream toxic metabolites.

16 onent, and gamma-glutamyl amino acid-related metabolites.

17 -II metabolites as well as altered microbial metabolites.

18 entrations and measured various pathways and metabolites.

19 ast squares discriminate analysis of 9 lipid metabolites.

20 creased arachidonic acid and 12-lipoxygenase metabolites.

21 , accompanied by increased atherogenic lipid metabolites.

22 ), and the Baltic Sea Diet (BSD)] with serum metabolites.

23 olome and focused analysis of the detectable metabolites.

24 uction systems may affect the levels of food metabolites.

25 teria were also met for the major tacrolimus metabolite 13-O-desmethyl tacrolimus for AUC, but it fai

26 FC was dissected, extracted with ethanol and metabolite (13)C enrichments were measured.

27 ntified compounds correspond to a new fungal metabolite (29) and a new actinobacterial angucycline-de

28 o 2,5-dichlorobiphenyl (2,5-DCB), and its OH metabolite, 4'-OH-2,5-DCB, was then examined using whole

29 ve patterns in the accumulation of secondary metabolites according to the main diversification center

30 try, we show that sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the act

31 We propose that gradients of extracellular metabolites act as tumor morphogens that impose order wi

32 ty of endogenous and gut microbially derived metabolites affected by both diet and antibiotic treatme

33 Targeted measurements of both metabolites agreed well with the non-targeted measuremen

34 e, this method can still detect thousands of metabolites, allowing the analysis of a large fraction o

35 tography-mass spectrometry analysis of polar metabolites also revealed that many compounds were highl

36 Target metabolite analyses of sarcosine and its natural precurs

37 Blood metabolite analysis 60 min after injection of the tracer

38 Metabolite analysis of different developmental stages of

39 type CI9831, followed by gene expression and metabolite analysis revealed its role as an elicitor rec

40 alyses of the cell before, during, and after metabolite analysis.

41 Ochratoxin A (OTA) is a fungal metabolite and putative carcinogen which can contaminate

42 el the relation between each log-transformed metabolite and sodium intake.

43 Both metabolite and transcript levels were higher in skin tha

44 ted partial Pearson correlations between 617 metabolites and 55 foods, food groups, and vitamin suppl

45 a minimal medium containing only derivatized metabolites and chemicals for derivatization, and in a c

46 ange of small organic molecules, drugs, drug metabolites and drug-like molecules, including salicylat

47 To test the association between serum metabolites and dry eye disease (DED) using a hypothesis

48 ons in the oxidation states of intracellular metabolites and enzymes, have historically been consider

49 , inhibiting the production of toxic glucose metabolites and inducing mitochondrial biogenesis to res

50 Plasma metabolites and insulin were measured at baseline, 15, 3

51 etween exposure to the pesticide DDT and its metabolites and obesity to develop hazard identification

52 rylesters, etc.) are reserves of high-energy metabolites and other constituents for future needs.

53 and transcriptomics, the characterization of metabolites and proteins remains challenging both becaus

54 approach to install aromatic amino groups in metabolites and raises questions about the intermediacy

55 tributions of Q10 coefficients of individual metabolites and reaction fluxes.

56 allows for robust profiling of mitochondrial metabolites and serves as a strategy generalizable to th

57 Profiles of metabolites and their rates of production/consumption we

58 ntified, including various free fatty acids, metabolites, and complex lipids such as ceramides, glyce

59 n quenching efficiency, extraction yields of metabolites, and experimental reproducibility.

60 biochemical structure and function of novel metabolites, and strategies for determining the true cli

61 ing the interactions between microbes, their metabolites, and the host will be discovered.

62 ulating human cells, their interactions with metabolites, and their genetic control is still lacking.

63 evaluation of a set of randomly selected 210 metabolites annotated using xMSannotator in an untargete

64 luorescent reporter and flux of a high-value metabolite are significantly enhanced using this genome-

65 These metabolites are indicative of changes in important bioch

66 Bacterial, fungal, and plant metabolites are promising sources of small molecules for

67 The generated metabolites are utilized by chromatin modifiers to affec

68 yltamoxifen), the most potent antiestrogenic metabolite, are reduced in women whose CYP2D6 genotypes

69 ising bioactivity of the tetraarsenic marine metabolite arsenicin A, the dimethyl analogue 2 and four

70 was developed to detect and quantify as many metabolites as possible.

71 and whether these white cells would use any metabolites as signal molecules to communicate with the

72 roscopy cannot distinguish the drug from its metabolites as they have the same emission spectra.

73 s presented higher levels of plasma phase-II metabolites as well as altered microbial metabolites.

74 ive phosphorylation and changes in TCA cycle metabolites, as well as decreased mitochondrial membrane

75 cholesterol (27OHC), an oxidized cholesterol metabolite associated with neurodegeneration.

76 methods are suited for samples that contain metabolites at final concentrations between 1 nM and 10

77 do not support the hypothesis that cytosolic metabolite availability alters the response of isoprene

78 Due to hydrolysis of pharmaceutical metabolites back to the parent compound, treatment syste

79 A combination of seven plasma metabolite biomarkers readily discriminates supraphysiol

80 sequences identified 49 putative specialized metabolite biosynthetic gene clusters.

81 AM and magnesium to form the fully collapsed metabolite-bound closed state of the SAM-I riboswitch.

82 ions that are indirectly related to dead-end metabolites but of biological importance to the target m

83 s a virulence factor produced as a secondary metabolite by the opportunistic human pathogen, Pseudomo

84 g a variety of plant and arthropod secondary metabolites by either ingesting them or anointing them t

85 Production of these metabolites by HIMECs required MFSD2A, which is required

86 Metabolites can be useful as early biomarkers and new ta

87 Metabolites can inhibit the enzymes that generate them.

88 s the characterization of microbiota-derived metabolites can represent innovative medicinal chemistry

89 s study was designed to evaluate serum lipid metabolite changes that are associated with the progress

90 The metabolites cis-10,11-dihydroxy-10,11-dihydrocarbamazepi

91 een shown to be modulated by the Krebs cycle metabolite citrate in Escherichia coli.

92 Using these 113 metabolites, combined with machine learning to segregate

93 ine betaine, N(epsilon)-trimethyllysine were metabolites common to all examined flours, whereas an un

94 ct of the agronomic production system on the metabolite composition of carrots and to build statistic

95 e gene expression in response to fluctuating metabolite concentrations.

96 Importantly, metabolites consistent with chronic inflammation, such a

97 ates, including chiral and achiral drugs and metabolites, constitutional isomers, stereoisomers, and

98 These metabolites contain an isopropyl group proposed to be fo

99 le preservation methods, regarding the total metabolites content, were vacuum packing and freezing fo

100 1 binding with full kinetic analysis using a metabolite-corrected arterial input function and to comp

101 A total of 139 of these metabolites could be identified by their HRMS spectra.

102 rentiated genotype, genotype-differentiating metabolites could potentially predict IBD risk.

103 By simplifying access to metabolite data, we hope that this system will help enab

104 Acteoside was the major metabolite detected from July to November while tricin-7

105 d that genetic differences might explain the metabolite differences.

106 Importantly as metabolites differentiated genotype, genotype-differenti

107 Metabolite disruptions were not explained by altered exp

108 r results suggested that D-galactose and its metabolites disturbed the spindle structure and chromoso

109 in modulating maternal circulating vitamin D metabolites during pregnancy.Nested within a feeding stu

110 Melatonin and its metabolites enhanced the DNA repair in melanocytes expos

111 ions were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzoph

112 Increased levels of tryptophan metabolites-especially of quinolinic acid-indicated a hi

113 le concentration step typically occurs after metabolite extraction, when dried samples are reconstitu

114 pothesize that these discrepancies arise for metabolites far from the lower limit of the mass scan ra

115 several transporters are involved in ion and metabolite flux across membranes of cells or intracellul

116 s via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis.

117 In keeping with the role of reactive metabolite formation in APAP-induced chemical stress, bo

118 CatA) inhibitors attenuated L-ala,SP prodrug metabolite formation, yet exacerbated L-ala,SP + amiodar

119 its hydroxypropranolol glucuronide phase II metabolites from a rat thin tissue section was also illu

120 selection operator" (Lasso), we analyzed all metabolites from the DESI-MS data and identified parsimo

121 trol transcription initiation of specialized metabolite gene clusters have been identified, those aff

122 Moreover, endogenous metabolites generated from basic cellular processes such

123 and to de novo sequencing of purified plant metabolite glycoconjugates, showing that the anomeric si

124 th directly and not directly light-dependent metabolite groups.

125 The pharmacokinetics of sofosbuvir and its metabolite GS-331007 were evaluated by intensive plasma

126 f sofosbuvir, ledipasvir, and the sofosbuvir metabolite GS-331007.

127 Primary and secondary ATBC metabolites had detection frequencies (% DF) in finger n

128 Although bacterial bioactive metabolites have been one of the most prolific sources o

129 olesterol and triglycerides).Choline and its metabolites have differential associations with cardiome

130 The amino acid metabolite homocysteine activates mTORC1 to inhibit auto

131 tabolic components and circulating vitamin D metabolites [i.e., LDL-related protein 2 (LRP2, also kno

132 For metabolite identification, a library of DnsHz-labeled st

133 nd significant depletion of 1 other putative metabolite in resistant strains.

134 ally ingested UFP promoted atherogenic lipid metabolites in both the intestine and plasma via altered

135 ools that are capable of monitoring ions and metabolites in cell populations or whole animals.

136 tion to its proinflammatory role, SP and its metabolites in combination with insulin-like growth fact

137 had a strong positive correlation with 2040 metabolites in common, suggesting that mouse models can

138 The observed metabolites in fish were N-ethyl perfluorooctane sulfona

139 ichlorodiphenyltrichloroethane (DDT) and its metabolites in intermediate and deep ocean water masses.

140 ematically examine the fluxes of circulating metabolites in mice, and find that lactate can be a prim

141 ed metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenat

142 evaluate serum levels of tryptophan and its metabolites in patients with inflammatory bowel diseases

143 For measurements of nonpolar metabolites in positive ionization mode, the application

144 co-related alkaloids, carcinogens, and their metabolites in raw wastewater, including anabasine (ANAB

145 efects, supporting a role for TAG and/or its metabolites in spore wall morphogenesis.

146 concentration is associated with circulating metabolites in various metabolic pathways, particularly

147 role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-pr

148 ures (positive ion mode), including 70 known metabolites, in single dorsal and ventral cells in 8-to-

149 together with the accumulation of secondary metabolites including phenolic compounds, of which the c

150 Urinary arsenosugars and their metabolites (including dimethyl arsenate (DMA), thio-dim

151 ke is associated with changes in circulating metabolites, including gut microbial, tryptophan, plant

152 llus nidulans synthesizes numerous secondary metabolites, including sterigmatocystin (ST).

153 A selection of metabolites, including time-sensitive metabolites involv

154 The metabolites induced during treatment, such as AMP, reduc

155 studies to identify bacterial components and metabolites interacting with the innate and adaptive imm

156 ion of metabolites, including time-sensitive metabolites involved in energy regulation in the brain,

157 oids represent a large family of specialized metabolites involved in plant growth, development, and a

158 Exudation of metabolites is in part mediated by ATP-binding cassette

159 asures the concentration of ammonia in polar metabolite isolates used for metabolomic studies, and (2

160 ntified QTLs regulating seven of those polar metabolites (L-serine, L-leucine, glucose, fructose, myo

161 rom tumor cells eliminated lactate-dependent metabolite labeling, confirming tumor-cell-autonomous la

162 The primary measure was metabolite level changes between baseline and 24 weeks s

163 which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a promisi

164 Stem-cell fate can be influenced by metabolite levels in culture, but it is not known whethe

165 ot known whether physiological variations in metabolite levels in normal tissues regulate stem-cell f

166 The metabolite levels were measured using LC-MS following tr

167 ta (e.g. gene expression, protein abundance, metabolite levels).

168 PtabZIP1L also resulted in modulation of key metabolites like proline, asparagine, valine and several

169 ning, highly modified, macrocyclic secondary metabolites made from ribosomally synthesized precursor

170 ed producers of a diverse array of secondary metabolites, many of which are of pharmacological import

171 Lipid metabolites may partially explain the inverse associatio

172 These active metabolites may prolong the parent compound's psychotrop

173 To this end, the mass spectra of unlabeled metabolites measured in two media are necessary: in a mi

174 n spiked quality control (QC) samples 82% of metabolite measurements had an interlaboratory precision

175 s and dams were collected for choline/methyl metabolite measurements, immunoblotting or gene expressi

176 A total of 233 metabolite measures were quantified using nuclear magnet

177 podocytes had higher levels of toxic glucose metabolites, mitochondrial dysfunction and apoptosis.

178 We developed urinary metabolite models for each diet and identified the assoc

179 modated to allow for true real-time, on-line metabolite monitoring and cellularity estimation.

180 re known to bioactivate APAP to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI).

181 and was able to identify 14 fungus secondary metabolites, namely aflatoxin B1, aflatoxin G1, aspergil

182 obustly increases the myocardial levels of 3 metabolites, nicotinic acid adenine dinucleotide, methyl

183 ol that facilitates structural annotation of metabolites not described in databases.

184 r determining the true clinical relevance of metabolites observed in association with cardiovascular

185 elevations in trough levels of nitric oxide metabolites occurred with KNO3 (visit 2: 199.5, 95% CI 9

186 5-dihydroxyvitamin D3 [1alpha,25-(OH)2D3], a metabolite of 25(OH)D3.

187 ed between deoxyguanosine and a diol epoxide metabolite of BaP, with subsequent mutation of critical

188 g, and between monocarboxynonyl phthalate, a metabolite of di-isodecyl phthalate (DIDP), and wheezing

189 Retinoic acid, an active metabolite of dietary vitamin A, acts as a ligand for nu

190 identify the ditiocarb-copper complex as the metabolite of disulfiram that is responsible for its ant

191 (hm(5)C) was recently identified as a direct metabolite of m(5)C in RNA.

192 ting of macromolecules and lipids apart from metabolites of interest, was used for quantitation.

193 Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermen

194 cluding the parent forms and the major human metabolites of mephedrone, methadone, cocaine, heroin, c

195 ion between obesity and hepatic C18 oxylipin metabolites of omega-6 (omega6) and omega-3 (omega3) fat

196 even UV filters (UV-Fs), including 3 hydroxy-metabolites of oxybenzone (benzophenone 3, BP3) were cha

197 l short-chain fatty acid in the fermentation metabolites of S. epidermidis.

198 ically relevant, lumisterogenic pathway, the metabolites of which display biological activity.

199 hases and the determination of the secondary metabolites of xpp1 deletion and overexpression strains

200 nsulin sensitivity more accurately than each metabolite on its own or other published metabolic signa

201 Lipid metabolite oscillations were strongly attenuated upon si

202 the plasma concentration of (-)-epicatechin metabolites over time was higher after the co-ingestion

203 species- and condition-dependent changes in metabolite oxidation states and elucidation of the mecha

204 the variation in fold changes of urinary PAH metabolites (p < 0.002).

205 BoostGAPFILL uses metabolite patterns in the incomplete network captured u

206 Metabolite patterns were distinct from nitrogen starvati

207 for QTL mapping analysis may be adopted for metabolites-phenotypes association analysis due to the s

208 ymatic steps with vitamin B5 as the starting metabolite, phosphorylated by pantothenate kinase.

209 Finally, virtual screening of 29332 metabolites predicted 146 competitive OCT1 ligands, of w

210 We show for the first time that raspberry metabolites present in the GIB fraction significantly in

211 g KDM5B in response to dosing with TCA cycle metabolite pro-drug esters, suggesting that the high lev

212 Enterobactin is a secondary metabolite produced by Enterobacteriaceae for acquiring

213 Phlorotannins are secondary metabolites produced by brown seaweed, which are known f

214 The role of metabolites produced from stem cell metabolism has been

215 stigated the effects of hypoxia on secondary metabolite production and observed a shift away from the

216 The shift to soluble sugar, secondary metabolite production, and activation of ROS eliminating

217 nce compatibility with synthetic protein and metabolite production.

218 bone turnover, promoted a favorable estrogen metabolite profile (2-OH:16alpha-OH), and stimulated equ

219 ted with a specific microbiota and bacterial metabolite profile.

220 Exhaled breath condensate (EBC) metabolite profiles also correlated with serum hormone c

221 the associations between altered cerebellar metabolite profiles and brain injury topography, severit

222 etabotyping) in urine samples confirmed that metabolite profiles in mdr1a (-/-) mice were remarkably

223 Metabolite profiles of mcrA deletant, mcrA overexpressin

224 ribosomal RNA gene amplicon sequencing, and metabolite profiles were analyzed by ultrahigh-performan

225 for the investigation of individual cellular metabolite profiles with its exquisite sensitivity, larg

226 ovides a robust method for the comprehensive metabolite profiling of non-sterile rhizosphere soil, wh

227 through enzyme assays and customized (13) C metabolite profiling showed that both targets are functi

228 med the effect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neop

229 Unbiased, "nontargeted" metabolite profiling techniques hold considerable promis

230 This is also the first reported use of metabolite profiling to characterise the physiological i

231 (1)H HR-MAS NMR metabolite profiling was achieved from a small sample of

232 Biolog phenotype microarrays and comparative metabolite profiling we demonstrate the impact of the we

233 rosterone, and testosterone), progestins and metabolites (progesterone, medroxyprogesterone acetate,

234 Changes in metabolite quantities were not the result of changes of

235 Pharmacotherapy provision based on Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) m

236 Visualization of metabolites, reactions and pathways in genome-scale meta

237 Structural annotation of metabolites relies mainly on tandem mass spectrometry (M

238 revisiae Ydr109c and human FGGY could act as metabolite repair enzymes, serving to re-phosphorylate f

239 umption rates were simulated to characterize metabolite responses to ischemia.

240 Analysis of polar metabolites revealed a reduction in glycolysis, pentose

241 lyses coupled with structural elucidation of metabolites revealed that acylsugar assembly is not cons

242 Metabolite sampling, followed by mass spectrometry measu

243 By structural elucidation of the pathway metabolite scytalone in A. nidulans, we provided chemica

244 arum bv viciae strain 3841, and these detect metabolites secreted by roots in space and time.

245 Specialized secondary metabolites serve not only to protect plants against abi

246 Metabolite set enrichment analyses suggest reduced antio

247 understanding of mechanisms enabling defense metabolite signaling.

248 s fungi produce a diverse array of secondary metabolites (SMs) critical for defense, virulence, and c

249 re capable of distinguishing CPT-11 from its metabolite SN-38.

250 ely alter the association for the top-ranked metabolites.Sodium intake is associated with changes in

251 yme that converts the bioactive sphingolipid metabolite sphingosine to sphingosine-1-phosphate, and s

252 By supplanting the use of authentic metabolite standards, traditionally used to calibrate (1

253 ntified the interplay between transcript and metabolite subnetworks linked to lipid metabolism, infla

254 Yeast metabolites such as acetaldehyde and pyruvate participat

255 idate and evaluate the simple combination of metabolites that effectively predict ADG.

256 acteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and

257 s generate large families of natural product metabolites that have related molecular structures as a

258 ene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristi

259 nd pathway enrichment, we have identified 28 metabolites that showed statistically significant change

260 to influence gastrointestinal motility, and metabolites that stimulate the "gut-brain axis" to alter

261 ectroscopy at 7T, which allows separation of metabolites that would otherwise overlap at lower field

262 Only trace levels of the known toxic metabolite, thio-DMA, were observed, across individuals.

263 ence for the potential of bacteria and their metabolites to be used for the prevention of asthma and

264 The ratio of CBZ metabolites to CBZ was highest in fruits (up to 2.5) and

265 nes to biosynthesize resistance related (RR) metabolites to contain the pathogen to spikelet infectio

266 his field and is a strong indicator that the metabolites under consideration are strongly correlated

267 x Balance Analysis that allows prediction of metabolite variations.

268 ards, traditionally used to calibrate (13)C6-metabolites via liquid chromatography-tandem mass spectr

269 Putative identification of a total of 32 metabolites was accomplished in blood using time-of-flig

270 Extraction of metabolites was carried out with acetonitrile-water-form

271 The biological activity of methylone and its metabolites was then compared using in vitro transporter

272 the gut and recognize microbiota-associated metabolites, we assessed their potential to induce IL-22

273 Both DNAN and a glycosylated metabolite were subsequently photolyzed within leaf tiss

274 Five metabolites were associated with microbiome diversity an

275 lular breakdown and arachidonic acid cascade metabolites were associated with sonographic evidence of

276 Only a small number of leaf transcripts and metabolites were changed in response to genotype, and ce

277 Strikingly, when these three metabolites were combined into one signature, they class

278 in wheat gofio and that none of the selected metabolites were detected in any of the samples.

279 al communities as well as shift of microbial metabolites were driven by biogeographic location.

280 Further, these compounds and their metabolites were investigated by LC/ESI-Orbitrap-MS in u

281 One hundred ninety-six salivary metabolites were mapped into 49 metabolic pathways and c

282 concentrations of estradiol, estrone, and 13 metabolites were measured in 1,298 postmenopausal cases

283 e identities and quantities of the generated metabolites were observed between adults and larvae.

284 Proteins and metabolites were placed in their biological context (spa

285 Metabolites were quantified in sequential plasma samples

286 -tandem mass spectrometry (LC-MS/MS), (13)C6-metabolites were radiocalibrated by their (14)C-isotopol

287 cted BGCs (i.e., those lacking an associated metabolite) were no more coexpressed than the null distr

288 sed to support the biosynthesis of secondary metabolites, while the comparatively reduced Calvin-Bens

289 differences in levels of RNAs, proteins, and metabolites will facilitate future functional studies of

290 At the end of the experiment some metabolites will have incorporated the labelling isotope

291 crystal structure of the synthetic secondary metabolite with the eukaryotic 80S ribosome.

292 dustrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, and lif

293 dards was constructed, including 78 carbonyl metabolites with each containing MS, retention time (RT)

294 odels to evaluate the association of the PFR metabolites with IVF outcomes, accounting for multiple I

295 ions influencing 13 primary and 19 secondary metabolites with large effects at high resolution.

296 -line type enzymes that synthesize secondary metabolites with pharmaceutical applications.

297 ibosomal peptides represent a large class of metabolites with pharmaceutical relevance.

298 origin and influence of microbiome-modulated metabolites, with an emphasis on immune cell development

299 foliar concentrations of secondary phenolic metabolites, with important functions for pathogen defen

300 intracellularly and reduced to the dead-end metabolite xylitol.