ライフサイエンスコーパス: metabolome

1 e genes (metagenome) and metabolic products (metabolome).

2 acets of Merlin in impacting the cancer cell metabolome.

3 selective detection of the entire accessible metabolome.

4 erapy (cART) exposure on the infants' immune metabolome.

5 ssic substrates in the cysteinyl leukotriene metabolome.

6 ative and quantitative analyses of the plant metabolome.

7 -MS), here used to examine the S. cerevisiae metabolome.

8 a greater effect on variations in the brain metabolome.

9 not previously been documented in the brain metabolome.

10 inishing with the most functional, i.e., the metabolome.

11 ew quantitative picture of the mitochondrial metabolome.

12 rstanding of the genetic determinants of the metabolome.

13 re of the genetic architecture of the plasma metabolome.

14 ns with each other, and contributions to the metabolome.

15 re instead highly represented in the Italian metabolome.

16 allow detailed measurements of the cellular metabolome.

17 technical replicate data set of human urine metabolome.

18 ssive reprogramming of the transcriptome and metabolome.

19 lity in the further exploration of the human metabolome.

20 se-6-phosphate levels and a sugar starvation metabolome.

21 nt differences in water soluble human plasma metabolome.

22 ical sensitivity and coverage of the urinary metabolome.

23 st if MetS is preceded by alterations in the metabolome.

24 with little loss of other components of the metabolome.

25 eriodontal clinical parameters, and salivary metabolome.

26 te and concomitant conditions on the oilseed metabolome.

27 or oxygen availability alters the bacterial metabolome.

28 (Tcf)-4 and beta-catenin, transcriptome, and metabolome.

29 ge fraction of the structurally unidentified metabolome.

30 ic analysis providing insights into the skin metabolome.

31 t-induced changes in gene expression and the metabolome.

32 omain contributions to the pathway-dependent metabolome.

33 h, along with anabolic changes of an altered metabolome.

34 n elevated metabolic rate and changes to the metabolome.

35 uting to the characterization of Glycyrrhiza metabolome.

36 as accompanied by MSH depletion in the thiol-metabolome.

37 programming role of vitamin D on the child's metabolome.

38 olome illustrates the complexity of the milk metabolome.

39 te structural diversity prevalent within the metabolome.

40 seful tool for the characterization of fruit metabolome.

41 diversity of fungal and bacterial secondary metabolomes.

42 re was a correlation between liver and serum metabolomes.

43 osapentaenoic acid, and docosahexaenoic acid metabolomes.

44 cyanobacteria and algae possess distinctive metabolomes.

45 rences, temporal patterns are evident in the metabolome (5.4% in plasma, 5.6% in saliva) and in sever

46 n sum, we have found that alterations in the metabolome accompany heritable IUGR, precede adult-onset

47 fates of these cells, demonstrating that the metabolome affects cell phenotypes in the embryo.

48 romote nonuniform genome, transcriptome, and metabolome alterations.

49 Transcriptome and metabolome analyses both identified the phosphatidylinos

50 gy, immunohistochemistry, transcriptome, and metabolome analyses were performed.

51 Based on transcriptome and metabolome analyses, ATG5-deficient mice produced higher

52 es, together with oral metatranscriptome and metabolome analyses, supports the viewpoint of dysbiosis

53 r, and redox balance, as revealed by hepatic metabolome analyses.

54 in SIRT6 null mice as revealed by circadian metabolome analyses.

55 The metabolome analysis (55 metabolites altered out of 673 d

56 adequate technique for P. taiwanensis VLB120 metabolome analysis based on quenching efficiency, extra

57 Here we report the optimization of metabolome analysis by nanoflow ultraperformance liquid

58 Heart beat rate analysis and metabolome analysis indicated sublethal effects consiste

59 The metabolome analysis resulted in an identification of a s

60 Untargeted metabolome analysis revealed profound differences in met

61 sted and evaluated for P. taiwanensis VLB120 metabolome analysis.

62 cificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effective

63 wing the analysis of a large fraction of the metabolome and focused analysis of the detectable metabo

64 maternal metabolic environment on the fetal metabolome and genome.

65 tudy extends the map of loci influencing the metabolome and highlights the importance of heterozygous

66 Changes in its membership impact the gut metabolome and host susceptibility to pathogens.

67 esults in alterations in the gut microbiome, metabolome and immune responses.

68 a mechanistic link between the human urinary metabolome and innate immune function.

69 , we quantified the Saccharomyces amino acid metabolome and its response to systematic gene deletion.

70 n 24 hours of hospitalization, we determined metabolome and microbiome profiles and their association

71 organs and the complexity of the associated metabolome and microbiome.

72 Overall, metabolome and proteome disturbances showed a substantia

73 Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further

74 pi of ketamine-treated mice were analysed by metabolome and proteome profiling to delineate ketamine

75 for associations between the exhaled breath metabolome and sonographic lung abnormalities as well as

76 found that MitoQ treatment alters the brain metabolome and that the response to MitoQ treatment is c

77 The combinatory evaluation of the metabolome and the transcriptome suggests the possible i

78 Here, we integrate metabolome and transcriptome analyses of Stevia to explo

79 The integration of metabolome and transcriptome analysis indicated that the

80 We investigated the responses of the metabolome and transcriptome and polysome loading, as a

81 In addition to genomic data, metabolome and transcriptome are increasingly receiving

82 The global metabolome and transcriptome track these zone-specific c

83 ned to analyze changes in the transcriptome, metabolome, and activation of p38 MAPK, ERK1/2, Akt, and

84 s for hibernation by comparing the proteome, metabolome, and hematological features of blood from hib

85 l diet structures the offspring's epigenome, metabolome, and intestinal microbiome.

86 olorectal cancer cell growth, transcriptome, metabolome, and kinome in response to paracrine signals

87 robiome with its transcriptome, proteome and metabolome, and more distal influences, including releva

88 rs were found to harbor the most specialized metabolome, and most unique metabolites of anthers and o

89 ted for the largest proportions of the brain metabolome, and their concentrations varied across the l

90 iquid chromatography-mass spectrometry-based metabolome annotation.

91 all sample size in the mouse study, the BALF metabolome appeared to be more affected by CS than plasm

92 es in metabolomics, large parts of the human metabolome are still unexplored.

93 hypothesize that these changes in the plasma metabolome are suggestive of liver dysfunction, could pr

94 ions including daily monitoring of the sweat metabolome as health indicators, discovering sweat-based

95 ly unknown reorganization of the single-cell metabolome as the dorsal progenitor cell from the 8-cell

96 y extends the breadth of the mammalian brain metabolome as well as our knowledge of functional brain

97 Transcriptome and metabolome assays provide a basis for zooming in on the

98 findings suggest that maternal BMI-offspring metabolome associations are likely to be largely due to

99 -fed rats, destined for MetS, had a distinct metabolome at weaning (randomForest analysis; class erro

100 ery ligation model, we profiled the F2 serum metabolome at weaning [postnatal day (d)21; n = 76] and

101 workflow for in-depth profiling of the milk metabolome based on chemical isotope labeling (CIL) and

102 We also describe a procedure for metabolome-based BVC profiling via dynamic (i.e., contin

103 s provide the materials to construct it, the metabolome can be viewed as the physiology that powers i

104 food-derived metabolites (the so-called food metabolome) can be characterized in human biospecimens t

105 models can be used to interrogate human lung metabolome changes.

106 ted changes to the intestinal metagenome and metabolome, characterized by reduced synthesis of satura

107 rm analytical reproducibility and facilitate metabolome comparison among different data sets.

108 iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications

109 ificant differences in male and female sweat metabolomes could be detected, demonstrating the possibi

110 However, wide metabolome coverage has proven difficult to achieve, mos

111 bolic profiling studies aim to achieve broad metabolome coverage in specific biological samples.

112 sample reconstitution solvent composition on metabolome coverage in untargeted LC-MS metabolomics.

113 econstitution step has a clear impact on the metabolome coverage of MeOH extracted biological samples

114 he present study, the response of the plasma metabolome coverage to specific methodological choices o

115 duce an alternative approach to benchmarking metabolome coverage which relies on mixed Escherichia co

116 tion step has not been optimized for maximal metabolome coverage.

117 fforts are nevertheless made to maximize the metabolome coverage.

118 forming an integrative analysis of miRNA and metabolome data for the NCI-60 cell line panel, we ident

119 y requires a quantitative method to generate metabolome data over an extended period with high techni

120 Multivariate and univariate analyses of the metabolome data revealed a location-dependence character

121 TL), transcriptome, proteome, metagenome and metabolome data sets--by far the largest coherent phenom

122 Statistical analysis of the urine metabolome data showed a clear separation between the bl

123 wn endogenous human metabolites in the Human Metabolome Database (HMDB) (8,021 metabolites) and their

124 Tests with 719 metabolites from the Human Metabolome Database (HMDB) show that 100% of the metabol

125 e (SMPDB) and chemical shifts from the Human Metabolome Database (HMDB).

126 nnotated terpenoid metabolites in the public metabolome database for Catharanthus roseus.

127 positively or putatively identified based on metabolome database searches, including 20 pairs positiv

128 rce phenomena for all compounds in the Human Metabolome Database to generate a theoretical in-source

129 gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with biological me

130 rom the literature and an open-source saliva-metabolome database, we obtained concentrations of 1,233

131 rted previously as a part of the Human Serum Metabolome Database.

132 dation program that uses a combination of 14 metabolome databases in addition to an enzyme promiscuit

133 ion, 1333 peak pairs could be matched to the metabolome databases with most of them belonging to the

134 mass-matched to chemical structures in human metabolome databases.

135 ntified and 2716 metabolites mass-matched to metabolome databases.

136 The most pronounced metabolome differences between NK603 and its isogenic co

137 While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances amon

138 umber of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycero

139 Xenopus laevis) and microextraction of their metabolomes enabled the identification of 40 metabolites

140 The microbial secondary metabolome encompasses great synthetic diversity, empowe

141 andida and Rhodotorula) and a distinct fecal metabolome enriched for pro-inflammatory metabolites.

142 ified conserved soil type-specific secondary metabolome enrichment patterns despite significant sampl

143 Here, we present a study of metabolome evolution conducted in three brain regions an

144 pecies, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skel

145 The metabolome examinations of muscle and blood revealed 163

146 pected diversity of the human microbiome and metabolome far exceeds the complexity of the human genom

147 ternal pre-pregnancy BMI and offspring serum metabolome from 3 European birth cohorts (offspring age

148 Studies of the cell metabolome greatly improve our understanding of cell bio

149 Recent genome-, transcriptome-, and metabolome-guided gene discovery and enzyme characteriza

150 Genetic factors modifying the blood metabolome have been investigated through genome-wide as

151 However, their metabolomes have not yet been investigated comprehensive

152 the First International Workshop on the Food Metabolome held in Glasgow.

153 Changes in the metabolome highlight the influence of different training

154 nd by monitoring transcriptome, proteome and metabolome in a repertoire of 16 Saccharomyces cerevisia

155 In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in

156 effect of fatty acids on the dynamics of the metabolome in INS-1 cells following exposure to [U-(13)C

157 We profiled the brain metabolome in male Wistar rats at different ages (day 1

158 To this end, we analyzed the fasting plasma metabolome in metabolically characterized human voluntee

159 stic characterization of S. cerevisiae pheno-metabolome in must fermentative conditions.

160 In contrast to the transcriptome, the metabolome in ndhR cells was similar to that of wild-typ

161 dose-dependent increases in the blood NAD(+) metabolome in the first clinical trial of NR pharmacokin

162 of protein deficiency on both microbiome and metabolome in this model, we now describe the specific g

163 predictive modeling of the gastrointestinal metabolome in vivo and in vitro, offering a window to re

164 he objective of the study was to capture the metabolome in vivo, evaluate the feasibility of the appr

165 ry (ESI-IMMS) was used to study the striatal metabolomes in a Parkinson's like disease (PD-like) rat

166 ced defense signaling, on transcriptomes and metabolomes in apomictic common dandelion (Taraxacum off

167 form accurate relative quantification of the metabolomes in comparative samples with high coverage.

168 ifies the degree of congruence between these metabolomes in human and mouse, and determines how molec

169 dent response of the global oxidative stress metabolome, including the thioredoxin, glutathione, and

170 The metabolome increased in complexity, but while PD samples

171 The rpaA-null metabolome indicates that these cells are reductant-star

172 ocedure for translating metabolite profiles (metabolome) into the set of metabolic fluxes (fluxome) f

173 between Clostridium difficile and the host's metabolome is believed to influence the severity of infe

174 0 compounds known in various foods, the food metabolome is extremely complex, with a composition vary

175 eous profiling and quantitation of the human metabolome is feasible.

176 nsive and accurate characterization of brain metabolome is fundamental to brain science, but has been

177 Here, we show that the wild-type metabolome is very stable throughout the night, and this

178 the endoparasite has a simplified secondary metabolome, it produces a novel peptaibiotic family that

179 er risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated

180 ir gut microbiome, our findings on the Hadza metabolome lend support to the notion of an alternate mi

181 Using accurate mass search against human metabolome libraries, we putatively identified an additi

182 pairs with their masses matched to the human metabolome libraries.

183 one metabolic reaction in the Evidence-based Metabolome Library (EML) (375,809 predicted metabolites)

184 t was provided after weaning, and the plasma metabolome, liver histopathology, liver enzyme activity,

185 unit (NICU) impacted the gut microbiota and metabolome long-term.

186 rine samples revealed dynamic changes in the metabolome makeup, associated with the gut bacterial col

187 gating to the proteome and scaling up at the metabolome, metabolic background dependencies reveal the

188 rhamnolipids in feces, setting the stage for metabolome-microbiome-wide association studies (MMWAS).

189 llustrate the reprogramming of the secondary metabolome, nostopeptolides were identified as the predo

190 ugh the genome, transcriptome, proteome, and metabolome of 386 individuals in the BXD mouse reference

191 ect of colistin/doripenem combination on the metabolome of A. baumannii.

192 ach was used to profile the arachidonic acid metabolome of amniotic fluid.

193 We hypothesized that the plasma metabolome of asthma would reveal metabolic consequences

194 The cell wall composition and metabolome of ccr1 ProSNBE:CCR1 still exhibited many sim

195 l proportion of the variation in the urinary metabolome of children is specific to the individual, un

196 e), mitochondrial performance and the muscle metabolome of congeneric lizards that naturally partitio

197 The metabolome of each A. baumannii strain was measured usin

198 ometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients a

199 stigation we follow longitudinally the urine metabolome of ex-germ-free mice, which are colonized wit

200 action (DI-SPME) was employed to capture the metabolome of living plant specimens, using apple (Malus

201 es in the gut microbial community and in the metabolome of mice susceptible to C. difficile infection

202 ile analytical information on changes in the metabolome of muscle, kidney and liver from chickens sub

203 ng evidence of gross changes in the volatile metabolome of one line of APP mice, we utilized three un

204 (1)H NMR spectroscopy to analyze the urinary metabolome of patients with acute intermittent porphyria

205 ique to identify changes in the exposome and metabolome of roach (Rutilus rutilus) exposed to a final

206 n though it was not present in the predicted metabolome of S. elongatus.

207 yotherapy would impact the transcriptome and metabolome of skeletal muscle.

208 d metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's

209 olysis, and polyols to translate the glucose metabolome of the heart into the fluxome.

210 The metabolome of the hippocampus of pallid mice was analyse

211 The observed differences in the metabolome of these neurons underscore the striking cell

212 ve compared the proteome, transcriptome, and metabolome of two cell lines: the human breast epithelia

213 rometry to map the proteomes, lipidomes, and metabolomes of 174 yeast strains, each lacking a single

214 rrelative analysis of the transcriptomes and metabolomes of 36 different E. purpurea tissues and orga

215 We also analyzed serum metabolomes of 535 patients with biopsy-proven NAFLD (35

216 s spectral networking was used to assess the metabolomes of a series of pathway mutants.

217 tis, as well as C57Bl/6 mice (controls); the metabolomes of all samples were determined.

218 the taxonomic diversity and the PCP-derived metabolomes of both the cultivable fungi and the fungal

219 d to be generally applicable to profile milk metabolomes of different species (cow, goat, and human)

220 s illustrated in an example of comparing the metabolomes of human urine samples collected before and

221 182 with NASH) and compared them with serum metabolomes of mice.

222 In an analysis of serum metabolomes of patients with NAFLD and MAT1A-KO mice wit

223 r several hours in the dark and compared the metabolomes of wild-type and rpaA-null strains to identi

224 ation-dependence characteristic of the sweat metabolome, offering a possibility of mapping the sweat

225 een in the mitochondrial proteomes, cellular metabolomes, or transcriptomes between ndufv1 and ndufs4

226 try is a dominant tool for interrogating the metabolomes, peptidomes, and proteomes of a diversity of

227 ity induces distinct alterations in the lung metabolome, perhaps contributing to aberrant pH1N1 immun

228 approach is compatible with complex cellular metabolome, permits specific detection of the reactive (

229 esting their performances on the analysis of metabolome-phenotype associations.

230 g capacity, abnormal epithelial lining fluid metabolome profile, increased proportions of SAE secreto

231 isotope labeling (CIL) LC-MS for mapping the metabolome profiles of sweat samples collected from skin

232 Nasopharyngeal airway metabolome profiles significantly differed by bronchioli

233 he relations among the nasopharyngeal airway metabolome profiles, microbiome profiles, and severity i

234 activation patterns, fecal microbiota, urine metabolome profiles, serum markers of inflammation, neur

235 Using transcriptome and metabolome profiles, we identified biological pathways r

236 Metabolome profiling identified 390 distinct metabolites

237 Importantly, metabolome profiling in the Mtb surrogate, Mycobacterium

238 Metabolome profiling showed significant changes in plasm

239 ned from clinical swab analysis with mucosal metabolome profiling using desorption electrospray ioniz

240 For urine metabolome profiling where the sample amount was not lim

241 of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurot

242 novel mechanism by which a helminth-modified metabolome promotes susceptibility to bacterial coinfect

243 ding whole genome sequences; clinical tests, metabolomes, proteomes, and microbiomes at three time po

244 mass spectrometric profiling of the mucosal metabolome provides a broader window into the mucosal ec

245 e, transcriptome, epigenome, microbiome, and metabolome, providing fodder for systems biology approac

246 er created browsable maps of a 3D microbiome/metabolome reconstruction map on a radiological image of

247 cts on cellular metabolism, including on the metabolome, redox state, and glucose utilization.

248 4 distinct metabolites in the FHM skin mucus metabolome representing a large number of metabolite cla

249 The metabolome represents a large part or all metabolites in

250 Studying the milk metabolome represents an important application of metabo

251 olite databases provide a unique window into metabolome research allowing the most commonly searched

252 An investigation of the isolate's secondary metabolome resulted in the purification of a 22-mer pept

253 Analysis of the metabolome revealed significant differences between male

254 Metabolome Searcher, a web-based tool, facilitates putat

255 sis of the sex specificity of the skin mucus metabolome showed it to be highly sexually dimorphic wit

256 Examination of the cellular metabolome showed that FLT3 inhibition by itself causes

257 ion, a comprehensive analysis of the retinal metabolome showed that phototransduction also influences

258 l parameters of lung epithelial lining fluid metabolome, small airway epithelial (SAE) cell different

259 We report a universal metabolome-standard (UMS) method, in conjunction with ch

260 In addition, metabolome studies have been instrumental in disclosing

261 n causes systemic perturbations in the serum metabolome that can be ascribed to mycolactone.

262 - and heteronuclear NMR spectra of the serum metabolome that compare favorably to other methods for p

263 foodomics approach evidenced a diverse fruit metabolome that could be associated to a different physi

264 Asthmatics have a unique plasma metabolome that distinguishes them from healthy controls

265 pproaches have uncovered a poorly understood metabolome that originates solely or in part from bacter

266 nts a step change in coverage of the urinary metabolome, thereby increasing the potential for biomark

267 ted the impact DENV has on the host cellular metabolome to identify metabolic pathways that are criti

268 nstrating the possibility of using the sweat metabolome to reveal biological variations among differe

269 s elucidate the ability of reprogramming the metabolome to slow photoreceptor degeneration.

270 tive quantification of the individual sample metabolome to UMS.

271 idering the physicochemical diversity of the metabolome, untargeted metabolomics will inevitably disc

272 The high-coverage analysis of the milk metabolome using CIL LC-MS should be very useful in futu

273 s from each subject for examining day-to-day metabolome variations.

274 Instead, the metabolome varied along a C-peptide-driven continuum fro

275 can offer deep quantitative insight into the metabolome via easy-to-acquire biofluid samples such as

276 resent study, we tested whether the volatile metabolome was altered by mutations of the Alzheimer's d

277 By contrast, the gut metabolome was shaped mostly by diet, with specific non-

278 The Nox4 cardiac metabolome was then investigated by (1)H nuclear magneti

279 ere, by indexing the Pseudomonas specialized metabolome, we report the molecular-networking-based dis

280 th approaches, blood transcriptome and serum metabolome were analysed.

281 Gene expression and the metabolome were studied in the livers and plasma from th

282 Fecal, urinary, and plasma metabolomes were assessed by (1)H-nuclear magnetic reson

283 ium and/or with decreasing aeration, and the metabolomes were examined by nuclear magnetic resonance

284 que is to comprehensively measure the entire metabolome, which constitutes a largely undefined set of

285 microbiome, antibiotics alter the intestinal metabolome, which includes both host- and microbe-derive

286 Metabolome-wide analysis is challenging as it requires g

287 Metabolome-wide association analyses of BCAA-raising all

288 iotensin-converting-enzyme inhibitors in our metabolome-wide association analysis (p = 1.56 x 10(-4)

289 , transcriptome-wide association studies and metabolome-wide association studies for the six agronomi

290 tics; genome-, proteome-, transcriptome- and metabolome-wide experimental studies; structural genomic

291 ions that can be used for database queries, metabolome-wide internal standardization, and statistica

292 Transcriptome-, proteome- and metabolome-wide measurements have revealed widespread ci

293 This approach illuminates metabolome-wide relationships between molecules and the

294 rogen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, P =

295 ed of the 222 metabolites, but did not reach metabolome-wide significance.

296 s to be associated with DED, although not at metabolome-wide significance.

297 European descent, we find 4,068 genome- and metabolome-wide significant (Z-test, P < 1.09 x 10(-9))

298 A strong and metabolome-wide significant association with DED was fou

299 henotype and the analysis of the nutritional metabolome will drive future development of personalized

300 ng metabolites are an important class of the metabolome with diverse structures and physical/chemical