ライフサイエンスコーパス: metabotropic

1 ization of compound 19f binding to the human metabotropic 2 glutamate (hmGlu2) site was established b

2 er, we demonstrate that these ionotropic and metabotropic 5-HT receptors have a synergistic effect th

3 it is known that serotonin release activates metabotropic 5-HT1A autoreceptors located on serotonin n

4 sion in the dorsal raphe nucleus mediated by metabotropic 5-HT1A autoreceptors may occur via point-to

5 We identify that both ionotropic and metabotropic 5-hydroxytryptamine (5-HT) receptors are ex

6 This pathway requires the metabotropic action of kainate receptors and activation

7 The metabotropic agonist, trans-(1S,3R)-1-amino-1,3-cyclopen

8 red by elevation of intracellular Ca(2+) via metabotropic and ionotropic receptors or direct UV-uncag

9 onse, particularly with regard to targets on metabotropic and ionotropic receptors.

10 ins are natural partners, accounting for the metabotropic effects of KARs.

11 attributable to an ion channel-independent, metabotropic form of NMDAR signaling.

12 rocytes actively modulate GAT expression via metabotropic GABA receptor signaling and highlight the i

13 This pro-longevity effect is mediated by the metabotropic GABAB receptor GBB-1, but not ionotropic GA

14 by ionotropic GABAA receptors (GABAARs) and metabotropic GABAB receptors (GABABRs).

15 been firmly established, the contribution of metabotropic GABAB receptors, which control excitatory n

16 Mechanisms controlling the metabotropic gamma-aminobutyric acid receptor (GABAB) ce

17 the NMDA receptor, the AMPA, kainate and the metabotropic GluRs may be targets for the development of

18 The metabotropic glutamate (Glu) receptors (mGluRs) play key

19 The group II metabotropic glutamate (mGlu II) receptors exert a well

20 Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mG

21 studies suggest that antagonists of group II metabotropic glutamate (mGlu) receptors (mGlu2 and mGlu3

22 The metabotropic glutamate (mGlu) receptors are a group of e

23 blished that selective activation of group I metabotropic glutamate (mGlu) receptors induces LTD of s

24 Metabotropic glutamate (mGlu) receptors play important r

25 ependent inverse agonism of group II and III metabotropic glutamate (mGlu) receptors results from inh

26 eveal that coincident activation of group II metabotropic glutamate (mGlu) receptors with betaARs in

27 egulation of the putative presynaptic type 2 metabotropic glutamate (mGlu2) receptors and the postsyn

28 Presynaptic GABA(B) and group II metabotropic glutamate (mGlu2/3) receptors exert marked

29 hat concurrent activation of D1 and group II metabotropic glutamate (mGluR2/3) receptors act to nulli

30 Metabotropic glutamate 1 (mGlu) receptor has been propos

31 racted withdrawal, characterized by elevated metabotropic glutamate 1/5 receptor function and Homer2

32 research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors

33 ng efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we h

34 Positive allosteric modulators of the metabotropic glutamate 2 receptor have generated great i

35 focuses on positive allosteric modulation of metabotropic glutamate 2 receptors (mGlu2Rs) and discuss

36 The metabotropic glutamate 5 receptor and the cannabinoid ty

37 itical for novelty detection, and perirhinal metabotropic glutamate 5 receptors (mGlu5) are downregul

38 Metabotropic glutamate 5 receptors, present at the posts

39 MDA-type iGluRs, as well as the fold-related metabotropic glutamate and GABAB receptors.

40 to the class C family that also includes the metabotropic glutamate and gamma-aminobutyric acid recep

41 Activation of orexin, neurotensin, and metabotropic glutamate Gq/11-linked receptors mimicked t

42 In melanoma, overexpression of the metabotropic glutamate receptor (GRM)-1 occurs frequentl

43 Metabotropic glutamate receptor (mGluR) 5 signaling acti

44 In mouse striatum, metabotropic glutamate receptor (mGluR) activation leads

45 genic phenotype that is triggered by group I metabotropic glutamate receptor (mGluR) activation.

46 ing inhibition was abolished by group II/III metabotropic glutamate receptor (mGluR) antagonists in w

47 e impairments were rescued by treatment with metabotropic glutamate receptor (mGluR) antagonists or l

48 combination of P2 purinergic and group I/II metabotropic glutamate receptor (mGluR) antagonists redu

49 The metabotropic glutamate receptor (mGluR) is required in I

50 whether activation of one particular GPCR, a metabotropic glutamate receptor (mGluR), can reduce cone

51 )-knockout (KO) mice, and treatment with the metabotropic glutamate receptor (mGluR)-5 antagonist MTE

52 how increases in basal protein synthesis and metabotropic glutamate receptor (mGluR)-dependent long-t

53 ddition to the spine changes at basal state, metabotropic glutamate receptor (mGluR)-induced dendriti

54 eceptors (CP-AMPARs) and a switch in group I metabotropic glutamate receptor (mGluR)-mediated suppres

55 tein-coupled receptors, specifically via the metabotropic glutamate receptor (mGluR).

56 By contrast, the metabotropic glutamate receptor (mGluR)5 antagonist MPEP

57 Furthermore, Group I metabotropic glutamate receptor (mGluR1) mRNA levels wer

58 Type 1 metabotropic glutamate receptor (mGluR1)-dependent signa

59 ased from DN1s and perceived in LNvs via the metabotropic glutamate receptor (mGluRA).

60 ith movement execution, EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, fac

61 elanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes.

62 Metabotropic glutamate receptor 1 (mGluR1) function in P

63 an excellent PET radioligand for quantifying metabotropic glutamate receptor 1 (mGluR1) in monkey bra

64 The metabotropic glutamate receptor 1 (mGluR1) is abundantly

65 well as the emergence of glutamate-activated metabotropic glutamate receptor 1 (mGluR1) signaling, ar

66 Through metabotropic glutamate receptor 1 (mGluR1)-mediated syna

67 utamate to the ionotropic AMPA receptors and metabotropic glutamate receptor 1 and members of group 2

68 iated protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino

69 There were female-specific changes in metabotropic glutamate receptor 1, NMDA receptor 2A, alp

70 nctional evidence that ERbeta interacts with metabotropic glutamate receptor 1a (mGluR1a) signaling t

71 estrogen receptor beta interacting with the metabotropic glutamate receptor 1a.

72 ogenous beta-III spectrin interacts with the metabotropic glutamate receptor 1alpha (mGluR1alpha) and

73 Metabotropic glutamate receptor 1alpha (mGluR1alpha), a

74 L-ITCcs are GABAergic, and strongly express metabotropic glutamate receptor 1alpha and GABAA recepto

75 Positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) are a potenti

76 Here, we find that metabotropic glutamate receptor 2 (mGluR2) signaling, wh

77 vation process observed biophysically on the metabotropic glutamate receptor 2 homodimer.

78 We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric mo

79 ggest that positive allosteric modulators of metabotropic glutamate receptor 2 should be considered f

80 ynaptic long-term depression mediated by the metabotropic glutamate receptor 2/3 (mGluR2/3-LTD) remai

81 ies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect perform

82 The metabotropic glutamate receptor 4 (mGluR4) is an emergin

83 Metabotropic glutamate receptor 5 (mGlu5) has also been

84 Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential

85 regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is si

86 entified a novel role of GluD1 in regulating metabotropic glutamate receptor 5 (mGlu5) signaling in t

87 e allosteric modulators (NAMs) targeting the metabotropic glutamate receptor 5 (mGlu5) subtype are cu

88 Metabotropic glutamate receptor 5 (mGlu5)-positive allos

89 lnesses, including disorders associated with metabotropic glutamate receptor 5 (mGluR5) and dopaminer

90 Here we investigated how Gq-protein-coupled metabotropic glutamate receptor 5 (mGluR5) and oxytocin

91 ly (within 30 min) and require activation of metabotropic glutamate receptor 5 (mGluR5) and protein s

92 Pretreatment with metabotropic glutamate receptor 5 (mGluR5) and Src antag

93 sts with or without prior treatment with the metabotropic glutamate receptor 5 (mGluR5) antagonist 2-

94 Here we advance the novel concept that metabotropic glutamate receptor 5 (mGluR5) fails to enga

95 PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protei

96 Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been imp

97 Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeu

98 Deleting metabotropic glutamate receptor 5 (mGluR5) in mice pertu

99 The metabotropic glutamate receptor 5 (mGluR5) is a high-int

100 For example, the metabotropic glutamate receptor 5 (mGluR5) is concentrat

101 While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved i

102 Metabotropic glutamate receptor 5 (mGluR5) is widely exp

103 over of synaptic glutamate, which stimulates metabotropic glutamate receptor 5 (mGluR5) on a small po

104 cally, neurons release glutamate to activate metabotropic glutamate receptor 5 (mGluR5) on astrocytes

105 clinical data suggest that inhibition of the metabotropic glutamate receptor 5 (mGluR5) receptor migh

106 Specifically, the metabotropic glutamate receptor 5 (mGluR5) represents a

107 ligation induces a re-emergence of immature metabotropic glutamate receptor 5 (mGluR5) signaling in

108 We generated mutant mice in which the metabotropic glutamate receptor 5 (mGluR5) was specifica

109 PrP(C) interacts physically with metabotropic glutamate receptor 5 (mGluR5), and this int

110 The most recently identified include the metabotropic glutamate receptor 5 (mGluR5), dipeptidyl-p

111 mouse model of Rett syndrome (Mecp2 KO) that metabotropic glutamate receptor 5 (mGluR5)- and protein-

112 esult from glutamate spillover, initiating a metabotropic glutamate receptor 5 (mGluR5)-dependent inc

113 h the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent syn

114 exaggerated protein synthesis downstream of metabotropic glutamate receptor 5 (mGluR5).

115 is to reveal the cell-autonomous role of the metabotropic glutamate receptor 5 (mGluR5).

116 brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5).

117 lopment is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5).

118 11 directly binds to the cytoplasmic tail of metabotropic glutamate receptor 5 (mGluR5).

119 posed of cellular prion protein (PrP(C)) and metabotropic glutamate receptor 5 (mGluR5).

120 Thus, the interaction between metabotropic glutamate receptor 5 and cellular prion pro

121 FMRP in adult-born neurons and rescued by an metabotropic glutamate receptor 5 antagonist.

122 Metabotropic glutamate receptor 5 is of considerable int

123 r prion protein associates via transmembrane metabotropic glutamate receptor 5 with the intracellular

124 induced in GABA cells that was dependent on metabotropic glutamate receptor 5, and cannabinoid recep

125 GluR1, GABABR1, and GABABR2 levels, whereas metabotropic glutamate receptor 5, NMDA receptor 2B, Glu

126 on domain containing protein 12, mitofusin2, metabotropic glutamate receptor 5, p21-activated kinase

127 gamma-aminobutyric acidergic dysfunction and metabotropic glutamate receptor 5-associated long-term d

128 blockade of either cellular prion protein or metabotropic glutamate receptor 5.

129 ed from photoreceptors in the dark activates metabotropic glutamate receptor 6 (mGluR6) receptors in

130 bipolar cell glutamatergic transmission, the metabotropic glutamate receptor 6 and voltage-dependent

131 as normal in the Rs1-KO retina; however, the metabotropic glutamate receptor 6/transient receptor pot

132 ctively regulated homotypic synapses through metabotropic glutamate receptor activation.

133 y, reducing glutamate release by the group 2 metabotropic glutamate receptor agonist LY379268 amelior

134 Our experiments show metabotropic glutamate receptor and endocannabinoid 2-ar

135 d by systemic administration of the group II metabotropic glutamate receptor antagonist LY341495.

136 om a therapeutic standpoint because numerous metabotropic glutamate receptor antagonists are availabl

137 g by stimulating release-regulating group II metabotropic glutamate receptor autoreceptors to inhibit

138 The metabotropic glutamate receptor family includes many pot

139 ate does not interact with NMDA receptors or metabotropic glutamate receptor group I.

140 tingly, eCB-LTD in PE animals was rescued by metabotropic glutamate receptor I activation, suggesting

141 tudy demonstrates that expression of GRM3, a metabotropic glutamate receptor mainly expressed in mamm

142 e AMPA-type glutamate receptor GLR-1 and the metabotropic glutamate receptor MGL-1 in one of the prim

143 ippocampal subfields, we speculated that the metabotropic glutamate receptor mGlu5 may regulate infor

144 SCA28 mice, partial genetic silencing of the metabotropic glutamate receptor mGluR1 decreased Ca(2)(+

145 show that agonist activation of the group I metabotropic glutamate receptor mGluR1 increases the str

146 Glutamate directs GAD67 expression via the metabotropic glutamate receptor mGluR1beta on GABApre te

147 Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the het

148 ment, we detect excess "gain of function" of metabotropic glutamate receptor signaling at an importan

149 hypothesized that the activation of group I metabotropic glutamate receptor signaling though the fra

150 lso highlight emerging evidence that altered metabotropic glutamate receptor signalling and disrupted

151 Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5) have e

152 The metabotropic glutamate receptor subtype 5 (mGlu5) is a c

153 is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5).

154 The metabotropic glutamate receptor subtype 7 (mGlu7) is an

155 dvance the novel concept that a breakdown of metabotropic glutamate receptor subtype mGluR5 and endoc

156 s in the discovery of allosteric ligands for metabotropic glutamate receptor subtypes 1-5 and 7 (mGlu

157 r-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.

158 recently showed marked global reductions in metabotropic glutamate receptor type 5 (mGluR5) binding

159 ng cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expressi

160 Coapplication of an antagonist of metabotropic glutamate receptor type 5 (mGluR5) or its d

161 sponses, some receptors, such as the group 1 metabotropic glutamate receptor, mGlu5, are also localiz

162 s, synaptic transmission is initiated by the metabotropic glutamate receptor, mGluR6, that signals vi

163 finity, selective antibody antagonist of the metabotropic glutamate receptor-1 (BBB-mGluR1), a widely

164 roteins: ankyrin-R, cell adhesion molecules, metabotropic glutamate receptor-1 (mGluR1), voltage-gate

165 n in the NAc via bilateral injections of the metabotropic glutamate receptor-2/3 agonist LY379268 red

166 t is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation.

167 absence of FMRP in neurons abolishes group 1 metabotropic glutamate receptor-dependent DGK activity c

168 oreover, hippocampal NMDAR-dependent but not metabotropic glutamate receptor-dependent plasticity is

169 DISC1 disruption resulted in an increase of metabotropic glutamate receptor-induced intracellular ca

170 and behavioral measures to demonstrate that metabotropic glutamate receptor-induced sensitization of

171 ivity through the loss of cAMP regulation of metabotropic glutamate receptor-mediated intracellular C

172 Accordingly, metabotropic glutamate receptor-mediated long-term depre

173 ough the system Xc- antiporter to activate a metabotropic glutamate receptor.

174 nucleus accumbens core (NAcore) to stimulate metabotropic glutamate receptor5 (mGluR5) on neuronal ni

175 "MAG" PTLs for ionotropic and metabotropic glutamate receptors (GluRs) are based on an

176 Antagonists at Group II metabotropic glutamate receptors (Group II mGluR: mGlu2,

177 ssive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu1/5) is a core pat

178 Group II metabotropic glutamate receptors (mGluR) decrease synapt

179 am and downstream signaling specificities of metabotropic glutamate receptors (mGluR), we have examin

180 ssion (LTD) elicited by activation of type-I metabotropic glutamate receptors (mGluR-LTD).

181 However, changes in group I metabotropic glutamate receptors (mGluR1 and mGluR5) and

182 Group II metabotropic glutamate receptors (mGluR2 and mGluR3) may

183 Based on rodent studies, group II metabotropic glutamate receptors (mGluR2 and mGluR3) wer

184 Group II metabotropic glutamate receptors (mGluR2/3), which coupl

185 Here, we examine the significance of type 5 metabotropic glutamate receptors (mGluR5s) for behaviora

186 indings show that EAAC1 limits activation of metabotropic glutamate receptors (mGluRIs) in the striat

187 Activation of Group I metabotropic glutamate receptors (mGluRs) activates sign

188 quires co-activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and Ca(2+) -pe

189 e, is a potent agonist against the group III metabotropic glutamate receptors (mGluRs) and, thus, is

190 In principle, metabotropic glutamate receptors (mGluRs) are also suita

191 Although group 1 metabotropic glutamate receptors (mGluRs) are critical f

192 Metabotropic glutamate receptors (mGluRs) are dimeric cl

193 Metabotropic glutamate receptors (mGluRs) are mainly kno

194 Metabotropic glutamate receptors (mGluRs) are mandatory

195 Metabotropic glutamate receptors (mGluRs) are, in princi

196 evoked responses, we show that activation of metabotropic glutamate receptors (mGluRs) by general and

197 Blocking group I/II metabotropic glutamate receptors (mGluRs) during suprath

198 Metabotropic glutamate receptors (mGluRs) function as di

199 cordings, we show that activation of Group I metabotropic glutamate receptors (mGluRs) induces long-t

200 hippocampal synapses, activation of group I metabotropic glutamate receptors (mGluRs) induces long-t

201 Inhibition of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGl

202 gonists of ionotropic glutamate receptors or metabotropic glutamate receptors (mGluRs) or orthosteric

203 Group I metabotropic glutamate receptors (mGluRs) play important

204 Stimulation of synaptic metabotropic glutamate receptors (mGluRs) reactivates tr

205 st synapse in the visual system, presynaptic metabotropic glutamate receptors (mGluRs) regulate cone

206 Activating Group 1 (Gp1) metabotropic glutamate receptors (mGluRs), including mGl

207 Of the eight metabotropic glutamate receptors (mGluRs), mGluR5 is the

208 diverse ligand response specificities among metabotropic glutamate receptors (mGluRs), we combined c

209 single-molecule subunit counting on class C metabotropic glutamate receptors (mGluRs), we map dimeri

210 ed in adult mice with antagonists of group I metabotropic glutamate receptors (mGluRs), which have be

211 otein tags to create a family of light-gated metabotropic glutamate receptors (mGluRs).

212 se D, and 12-lipoxygenase, as well as type I metabotropic glutamate receptors (mGluRs).

213 plasticity induced at excitatory synapses by metabotropic glutamate receptors (mGluRs).

214 ologically inhibited and genetically ablated metabotropic glutamate receptors (mGluRs, especially mGl

215 c and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus) have been used

216 glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are clas

217 tic potential of antagonists of the group II metabotropic glutamate receptors (mGlus).

218 Here, we examined the role of group I metabotropic glutamate receptors 1 and 5 (mGluRs1/5) in

219 The presynaptic inhibitory metabotropic glutamate receptors 2 and 3 (mGluR2/3) are

220 ITCcs are innervated by fibers enriched with metabotropic glutamate receptors 7a and/or 8a.

221 ed signaling pathways, activated via Group I metabotropic glutamate receptors and cholecystokinin 2 r

222 Vasoconstriction required metabotropic glutamate receptors and CYP omega-hydroxyla

223 ranscriptionally dysregulated ionotropic and metabotropic glutamate receptors and glutamate transport

224 Metabotropic glutamate receptors are class C G-protein-c

225 The metabotropic glutamate receptors have a wide range of mo

226 ublished for the transmembrane domain of two metabotropic glutamate receptors in complex with negativ

227 Activation of the FMRP pathway by group I metabotropic glutamate receptors is involved in regulati

228 At the same time, metabotropic glutamate receptors mediate 20-hydroxyeicos

229 arly gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5.

230 We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) c

231 the tonic activation of presynaptic group II metabotropic glutamate receptors on inhibitory nerve ter

232 glutamate receptor 1 and members of group 2 metabotropic glutamate receptors on the plasma membrane.

233 when coupled with concomitant activation of metabotropic glutamate receptors postsynaptic to cortica

234 h-power state because blocking ionotropic or metabotropic glutamate receptors results in high-power L

235 c to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic

236 ntagonists targeting multiple ionotropic and metabotropic glutamate receptors, and intracellular casc

237 umption in a manner requiring intact group 1 metabotropic glutamate receptors, Homer2, phospholipase

238 atergic transmission, through ionotropic and metabotropic glutamate receptors, is necessary for the c

239 Conventional signalling by the group I metabotropic glutamate receptors, mGluR1 and mGluR5, occ

240 t comprehensive structural comparison of all metabotropic glutamate receptors, placing selective nega

241 Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is

242 trasynaptic signaling through ionotropic and metabotropic glutamate receptors, ultimately resulting i

243 o LAC responsiveness (leptin receptors Lepr, metabotropic glutamate receptors-2 mGlu2, neuropeptide-Y

244 cohol may be related, in part, to changes in metabotropic glutamate receptors-subtype 5 (mGluR5) in t

245 strocytic glutamate release, and presynaptic metabotropic glutamate receptors.

246 ent inhibition via the activation of group I metabotropic glutamate receptors.

247 nsmission, through the activation of type 1a metabotropic glutamate receptors.

248 vagal afferent fibre-dependent activation of metabotropic glutamate receptors.

249 Ca(2+) -permeable AMPA receptors and group I metabotropic glutamate receptors.

250 f glutamate release by presynaptic Group III metabotropic glutamate receptors.

251 esponses were depressed by the activation of metabotropic glutamate receptors.

252 Thus, before the onset of hearing, metabotropic glutamate signalling establishes a local ne

253 Antagonism of the postsynaptic metabotropic glutamate subtype 5 receptor is a novel app

254 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu5) receptor negative

255 e effects of ketamine on ligand binding to a metabotropic glutamatergic receptor (mGluR5) in individu

256 The metabotropic glutamatergic receptor subtype 5 (mGluR5) m

257 imaged the acute effect of ketamine on brain metabotropic glutamatergic receptor subtype 5 with a hig

258 xime, a negative allosteric modulator of the metabotropic glutamatergic receptor subtype 5.

259 occurred upon coactivating NMDAR and group I metabotropic glutamatergic receptors.

260 ar injury or synaptic transmitters acting at metabotropic Gq-coupled receptors.

261 A similar loss of ionotropic and metabotropic KAR function was observed in Neto1, but not

262 ontaneous KAR-mediated synaptic currents and metabotropic KAR signaling were absent in CA3 pyramidal

263 Owing to the dual ionotropic/metabotropic nature of alpha7 receptors, signaling pathw

264 us, to explore the role of ionotropic versus metabotropic NMDAR signaling in LTD, we examined the eff

265 gion is dependent on ionotropic, rather than metabotropic, NMDAR signaling.

266 Abnormal function of the metabotropic, or Gq-coupled, glutamate receptor 5 (mGlu5

267 enosine mediates analgesia via activation of metabotropic P1 receptors.

268 These ionotropic and metabotropic P2 purinergic receptors modulate a variety

269 Metabotropic P2Y receptors are G-protein-coupled, wherea

270 ed through both ionotropic P2X receptors and metabotropic P2Y receptors.

271 esponse depends on both ionotropic (P2X) and metabotropic (P2Y) purinergic receptors, binding ATP rel

272 tivated Ca(2+) entry following activation of metabotropic purinergic receptors in microglia.

273 ed by presynaptically expressed Gi/o-coupled metabotropic receptor (Gi/o-GPCR) activation.

274 utation analysis revealed that the glutamate metabotropic receptor 3 (GRM3) gene gained a premature s

275 Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults.

276 This plasticity was not specific to the metabotropic receptor activating the GIRK channels, as d

277 the presence of ionotropic and cell surface metabotropic receptor inhibitors.

278 in regulating affective states by modulating metabotropic receptor signaling pathways and neural acti

279 Acting at a single metabotropic receptor subtype, ACh exerts two opposing a

280 In FXS, sAPPalpha signals through the metabotropic receptor that, activating the MAP kinase pa

281 We also achieve 2P photoactivation of a metabotropic receptor, LimGluR3, with a new mGluR-specif

282 Activation of group I metabotropic receptors (mGluRs) is required for anti-Heb

283 a protective role may be played by group III metabotropic receptors (mGluRs), which are uniquely loca

284 ge number of genes coding for ionotropic and metabotropic receptors for various neurotransmitters-glu

285 rom climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-

286 gamma subunits) are critical for coupling of metabotropic receptors to their downstream effectors.

287 They express ionotropic and metabotropic receptors, and can release gliotransmitters

288 trocytes contain BDNF and increase levels of metabotropic receptors.

289 hyperpolarization with activation of group I metabotropic receptors.

290 e, serotonin, and norepinephrine) signal via metabotropic receptors.

291 ing of striatal neurons relies critically on metabotropic receptors.

292 and GABA signal through both ionotropic and metabotropic receptors.

293 tal neurons is tightly controlled by various metabotropic receptors.

294 tects and converts mechanical stimuli into a metabotropic response.

295 upregulates molecular chaperones through the metabotropic serotonin receptor SER-1.

296 echanistic insights into spine remodeling by metabotropic signaling and identify alpha-actinin-4 as a

297 synaptic factor, probably intersecting with metabotropic signaling and translational regulation.

298 nthesis and release in response to glutamate metabotropic stimulation.

299 At metabotropic synapses, the molecular mechanisms underlyi

300 Metabotropic transmission typically occurs through the s