ライフサイエンスコーパス: metabotropic receptor

1 and GABA signal through both ionotropic and metabotropic receptors.

2 NMDA as well as non-NMDA receptors, but not metabotropic receptors.

3 trocytes contain BDNF and increase levels of metabotropic receptors.

4 hyperpolarization with activation of group I metabotropic receptors.

5 can an abnormal activation of glutamatergic metabotropic receptors.

6 ity that also depends on activation of these metabotropic receptors.

7 e downstream actions for both ionotropic and metabotropic receptors.

8 e, serotonin, and norepinephrine) signal via metabotropic receptors.

9 Presynaptic Ca2+ channels are inhibited by metabotropic receptors.

10 mine diffuses to more distant, slower-acting metabotropic receptors.

11 ntly in response to activation of excitatory metabotropic receptors.

12 ing of striatal neurons relies critically on metabotropic receptors.

13 nervous system and is typically mediated via metabotropic receptors.

14 s mediate diffuse signaling at extrasynaptic metabotropic receptors.

15 tal neurons is tightly controlled by various metabotropic receptors.

16 ase was potentiated by activation of group I metabotropic receptors.

17 litate release of norepinephrine to activate metabotropic receptors.

18 Selective antagonists of the metabotropic receptors 1 (mGluR1), +/-2-methyl-4-carboxy

19 utation analysis revealed that the glutamate metabotropic receptor 3 (GRM3) gene gained a premature s

20 Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults.

21 This plasticity was not specific to the metabotropic receptor activating the GIRK channels, as d

22 The excitatory effects of metabotropic receptor activation in the LGN appear to be

23 hanism by which ionotropic signals can shape metabotropic receptor activity in neurons and influence

24 Lastly, we applied the metabotropic receptor agonist DHPG to dendrites and obse

25 A selective group II metabotropic receptor agonist inhibited NMDA-stimulated

26 , 3-dicarboxylic acid (ACPD, a glutamatergic metabotropic receptor agonist), serotonin, or 2-methylth

27 , the effects of an intrastriatally injected metabotropic receptor agonist, trans-(1S,3R)-1-amino-1,3

28 how little sequence homology with most other metabotropic receptors and are important modulators of s

29 ient increase in phosphorylation mediated by metabotropic receptors and attenuated by inhibitors of c

30 e, bipolar neurones, have glutamate APB-type metabotropic receptors and can be identified by the pres

31 Rather, the potentiation involves metabotropic receptors and intracellular Ca2+ release fr

32 t NMDA receptor glutamate recognition sites, metabotropic receptors and opioid binding sites.

33 They express ionotropic and metabotropic receptors, and can release gliotransmitters

34 neurotransmitters, through the activation of metabotropic receptors, and can release the gliotransmit

35 The metabotropic receptor antagonist AP-3 was without effect

36 To evoke a transduction current, the metabotropic receptor antagonist LY341495 was applied to

37 xylic acid (AIDA) but not by the presynaptic metabotropic receptor antagonists alpha-methyl-4-phospho

38 s well as by the non-selective and selective metabotropic receptor antagonists L-(+)-2-amino-3-phosph

39 the protein-synthesis-dependent functions of metabotropic receptors are exaggerated in fragile X synd

40 NMDAR and metabotropic receptors bidirectionally regulate TNiK pho

41 ionic environment, or (b) by stimulation of metabotropic receptors; brief oscillations can even occu

42 postulate that activation of ionotropic and metabotropic receptors by C-fiber nociceptor afferents a

43 mate to the IP(3) signaling pathway, group I metabotropic receptors can increase intracellular Ca(2+)

44 s, an all-or-none activation profile, and no metabotropic receptor component, thought to be a main in

45 (EPSPs), a graded activation profile, and a metabotropic receptor component; thought to be modulator

46 alent hypothesis proposes that activation of metabotropic receptors coupled to the phosphatidylinosit

47 injected with mRNA for GirK2 and the mGluR1a metabotropic receptor, exposure to glutamate potentiated

48 ta suggest that glutamate, acting at several metabotropic receptors expressed by astrocytes, could mo

49 es of membrane receptors, the ionotropic and metabotropic receptor families, which differ in their st

50 In addition to their physiological function, metabotropic receptors for neurotransmitter gamma-aminob

51 Although the ionotropic and metabotropic receptors for synaptically released glutama

52 ge number of genes coding for ionotropic and metabotropic receptors for various neurotransmitters-glu

53 Stimulation of gamma-aminobutyric acid B metabotropic receptors (GBRs) by baclofen reduces the in

54 ed by presynaptically expressed Gi/o-coupled metabotropic receptor (Gi/o-GPCR) activation.

55 K-801) glutamate receptor antagonists, and a metabotropic receptor glutamate agonist (ACPD), decrease

56 ereas modulators also are likely to activate metabotropic receptors having a slow and prolonged posts

57 were used to investigate the role of group I metabotropic receptors in late-phase long-term potentiat

58 (GCP II) in order to explore a role for the metabotropic receptors in schizophrenia therapeutics.

59 Many metabotropic receptors in the nervous system act through

60 the presence of ionotropic and cell surface metabotropic receptor inhibitors.

61 We also achieve 2P photoactivation of a metabotropic receptor, LimGluR3, with a new mGluR-specif

62 receptor on the neurones was identified as a metabotropic receptor linked to activation of phospholip

63 te and generated by stimulation of glutamate metabotropic receptors linked to G proteins and activati

64 on of mGluR5, demonstrating that H1b affects metabotropic receptor localization via a direct protein-

65 uctural sites that have been associated with metabotropic receptor localization.

66 rning mechanisms, and suggest that targeting metabotropic receptors may be useful in treating psychia

67 inputs activating very slow EPSPs (i.e., via metabotropic receptors) may be able to inactivate I(T) w

68 Glutamate metabotropic receptor mediated mechanisms have been impl

69 Glia demonstrated no evidence of NMDA or metabotropic receptor-mediated currents or membrane cond

70 Activation of the metabotropic receptor mGluR1 and inhibition of I(h) chan

71 ainate receptor (GluR5, GluR6, and GluR7) or metabotropic receptor (mGluR1-6) subtypes.

72 ut the AMPA receptor subunit, GluR4, and the metabotropic receptor, mGluR1 alpha, were found only at

73 icroscopic analysis reveals that the group I metabotropic receptor mGluR1alpha is significantly enric

74 t GluR1, the NMDA receptor subunit NR2A, the metabotropic receptor mGluR1alpha, the plasticity factor

75 Presynaptic group II metabotropic receptors (mGluR2 and mGluR3) are among dif

76 spartylglutamate (NAAG) activates a group II metabotropic receptor, mGluR3.

77 signaling mediated by the group 1 glutamate metabotropic receptor, mGluR5, contributes to the longer

78 e cation channels, an effect mediated by the metabotropic receptor mGluR6.

79 ent of spinal glutamate receptors, including metabotropic receptors (mGluRs) and NMDA, in 5-HT(2A)R-i

80 Blockade of group III metabotropic receptors (mGluRs) counteracted the effect

81 Activation of group I metabotropic receptors (mGluRs) is required for anti-Heb

82 es indicate that glutamate may also activate metabotropic receptors (mGluRs) to modulate the excitabi

83 a protective role may be played by group III metabotropic receptors (mGluRs), which are uniquely loca

84 entually understand the molecular aspects of metabotropic receptor modulation of the N-type Ca2+ chan

85 ouple with this G-protein (group I glutamate metabotropic receptors, neurotensin type 1) could simila

86 nstrate that hypothalamic astrocytes contain metabotropic receptors of the metabotropic glutamate rec

87 cone stimuli suppress glutamate release onto metabotropic receptors of the S cone bipolar cell dendri

88 rom climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-

89 m cortex and brainstem are known to activate metabotropic receptors on relay cell dendrites at which

90 that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal.

91 )) channels in retinal neurons by means of a metabotropic receptor pathway.

92 Inhibitory metabotropic receptors reduce Ca(2+) entry through activ

93 as recently demonstrated that a rat group II metabotropic receptor (rm-GluR2) is capable of coupling

94 extrasynaptic activation of the slow-acting metabotropic receptor, SER-2.

95 onsible for the use-dependent termination of metabotropic receptor signaling in embryonic sensory neu

96 in regulating affective states by modulating metabotropic receptor signaling pathways and neural acti

97 Moreover, metabotropic receptor stimulation evidently exerts oppos

98 These results suggest that metabotropic receptor stimulation leads to the death of

99 The consequences of metabotropic receptor stimulation, including activation

100 Acting at a single metabotropic receptor subtype, ACh exerts two opposing a

101 layed >10000-fold selectivity over all other metabotropic receptor subtypes plus a wide range of othe

102 ls are sensitive to the action of glycine at metabotropic receptors, suggesting this signal regulates

103 In FXS, sAPPalpha signals through the metabotropic receptor that, activating the MAP kinase pa

104 ion of glutamate and acetylcholine acting on metabotropic receptors that are central to hippocampal f

105 PFs activate glutamate metabotropic receptors that increase phosphoinositide tu

106 le in the kinetics of G-protein cascades for metabotropic receptors throughout the body.

107 d onto retinal ON bipolar neurons binds to a metabotropic receptor to activate a heterotrimeric G-pro

108 thelium, confirming the localization of this metabotropic receptor to gustatory cells.

109 ion, synaptically released glutamate acts on metabotropic receptors to excite neurons on a slower tim

110 Further more, the coupling of specific metabotropic receptors to the various neuronal-specific

111 gamma subunits) are critical for coupling of metabotropic receptors to their downstream effectors.

112 ising Galpha and Gbetagamma subunits, couple metabotropic receptors to various downstream effectors a

113 ells that are engineered to express a chosen metabotropic receptor, use the G(q) protein-coupled rece

114 tive agonists indicated that the predominant metabotropic receptor was the L-2-amino-4-phosphonobutyr

115 At this synapse, glutamate binds to a metabotropic receptor which couples to the closure of a

116 ntracellular calcium following activation of metabotropic receptors, which may trigger glutamate secr

117 dritic spines of neurons, local retention of metabotropic receptors within dendritic ER provides a po

118 Thus, Group II metabotropic receptors within or very near the amygdala