ライフサイエンスコーパス: metalloenzyme

1 Urease is a ubiquitous nickel metalloenzyme.

2 which is inconsistent with the behavior of a metalloenzyme.

3 the mechanism of superoxide reduction by the metalloenzyme.

4 honoacetate hydrolase is also a two-zinc ion metalloenzyme.

5 catalytic mechanism of this quorum-quenching metalloenzyme.

6 through the action of this 3-DHS dehydratase metalloenzyme.

7 tors that are normally required to fold this metalloenzyme.

8 , thus establishing aspartoacylase as a zinc metalloenzyme.

9 had led to the conclusion that TrzN is not a metalloenzyme.

10 analogue of an iron enzyme, and a molybdenum metalloenzyme.

11 in superoxide dismutase-1 (SOD1), a dimeric metalloenzyme.

12 suggest that T. maritima DAHP synthase is a metalloenzyme.

13 reaction regulated by carbonic anydrase (CA) metalloenzyme.

14 xist in an experimentally studied artificial metalloenzyme.

15 is catalyzed by nitrogenase, a two-component metalloenzyme.

16 iscrimination at the buried metal centers of metalloenzymes.

17 ctive for MBLs when compared to other Zn(II) metalloenzymes.

18 usible way to reduce promiscuous activity of metalloenzymes.

19 electron transfer in P450 enzymes and other metalloenzymes.

20 re essential components of cofactors of many metalloenzymes.

21 teins including light-activated switches and metalloenzymes.

22 tion pathways that are analogous to those of metalloenzymes.

23 to be a key intermediate in numerous nonheme metalloenzymes.

24 eral mechanism of regulating the activity of metalloenzymes.

25 The present results can be extended to other metalloenzymes.

26 is of heavy metals and delivery of copper to metalloenzymes.

27 stitute for iron in activating at least some metalloenzymes.

28 ce both the structure and function of native metalloenzymes.

29 hestrating catalytic activity, especially in metalloenzymes.

30 potential pharmaceutical agents in targeting metalloenzymes.

31 against the X-ray crystal structures of five metalloenzymes.

32 ically relevant carbonic anhydrase (CA) zinc metalloenzymes.

33 used to identify inhibitors of at least some metalloenzymes.

34 oxidants in oxygen activation mechanisms of metalloenzymes.

35 herent reactivity of metal centres in native metalloenzymes.

36 sign of inhibitors targeting other binuclear metalloenzymes.

37 ity of function among this complex family of metalloenzymes.

38 s to expand cofactor diversity in artificial metalloenzymes.

39 not catalysed by native Fe-enzymes or other metalloenzymes.

40 files that can be truly unique to artificial metalloenzymes.

41 ets of proteins that defend their vulnerable metalloenzymes.

42 and highlights a possible mode of action for metalloenzymes.

43 and deliver Cu(+) to target transporters or metalloenzymes.

44 te structures of acutely radiation-sensitive metalloenzymes.

45 est in the existence of multiple oxidants in metalloenzymes, a more exhaustive study of the reactivit

46 Simulating such binuclear metalloenzymes accurately but computationally efficientl

47 A range of metalloenzymes achieve these challenging tasks in biolog

48 The ultrafast dynamics of a de novo metalloenzyme active site is monitored using two-dimensi

49 s (MOFs) mimic the electronic environment of metalloenzyme active sites, but little is known about th

50 a mechanism for exquisite spatial control of metalloenzyme activity.

51 rginase with the related binuclear manganese metalloenzymes agmatinase and proclavaminic acid amidino

52 The metalloenzyme aminopeptidase P catalyzes the hydrolysis

53 The structure shows that P4 is a metalloenzyme and that magnesium is the most likely meta

54 ement that serves as a catalytic cofactor in metalloenzymes and a structural element in proteins invo

55 points to a new direction for understanding metalloenzymes and designing new biomimetic catalysts.

56 ragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based

57 Unlike metalloenzymes and related biomimetics, the catalyst pro

58 ly down-regulate copper delivery to secreted metalloenzymes and suggest that proteins involved in met

59 of this research to the field of artificial metalloenzymes and synthetic biology.

60 elating antibiotic that inhibits a subset of metalloenzymes and that RNA polymerase is unlikely to be

61 the design of inhibitor libraries targeting metalloenzymes and the efficient optimization of leads i

62 catalytic/structural component used by many metalloenzymes and transcription factors.

63 We show here that ARD1 is an active metalloenzyme, and AGB1 and ARD1 both control embryonic

64 ring use of tailored nanoparticles, purified metalloenzyme, and synchrotron X-ray absorption spectros

65 s work demonstrates that avian QSOX is not a metalloenzyme, and that copper and zinc ions inhibit the

66 turally occurring iron- or copper-containing metalloenzymes, and extensive studies have revealed the

67 er of Zn from the protein to a recipient apo-metalloenzyme, apo-carbonic anhydrase (apo-CA) by direct

68 improving the knowledge of how these complex metalloenzymes are biosynthesized.

69 ons, which calculate nonbonded interactions, metalloenzymes are challenging because of the partial co

70 This study tested whether nonredox metalloenzymes are commonly charged with iron in vivo an

71 The active sites of metalloenzymes are often deeply buried inside a hydropho

72 We propose that Mn-metalloenzymes are particularly susceptible to hyperacti

73 Nitrile hydratase metalloenzymes are unique and important biocatalysts tha

74 Copper-dependent metalloenzymes are widespread throughout metabolic pathw

75 a protein scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late 197

76 Artificial metalloenzymes (ArMs) are hybrid catalysts that offer a

77 Artificial metalloenzymes (ArMs) formed by incorporating synthetic

78 on-producing what is known in the context of metalloenzymes as an 'entatic' state-might be a useful w

79 Thought to be metalloenzymes at first, some ribozymes proved more vers

80 dens our understanding on the mechanisms for metalloenzyme biosynthesis in the presence of oxygen.

81 AurF is a metalloenzyme, but its native enzymatic activity has not

82 ortedly in the amidohydrolase superfamily of metalloenzymes, but previous studies suggested that a me

83 y species in the catalytic cycles of nonheme metalloenzymes, but their chemical properties and reacti

84 l that function has evolved in these related metalloenzymes by strategically placing very few residue

85 the second coordination sphere of artificial metalloenzymes by using genetic modifications of the pro

86 tion is catalyzed by a complex two-component metalloenzyme called nitrogenase.

87 is a member of the well established class of metalloenzymes called "Radical-SAM." These enzymes use a

88 this reaction under ambient conditions using metalloenzymes called methane monooxygenases (MMOs).

89 Metalloenzymes can be identified through specific motif

90 global structures and chemical properties of metalloenzymes can be obtained concurrently, providing i

91 ntrol reactivity and selectivity, artificial metalloenzymes can modulate both the first and second co

92 hat the combination of photosensitizers with metalloenzymes can support a light-driven multielectron

93 ups (ZBGs) are reported as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

94 logically relevant human (h) isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

95 re prepared and assayed as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

96 low micromolar binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II).

97 In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently c

98 he analogous metal ion selectivity of a zinc metalloenzyme (carbonic anhydrase) is driven by changes

99 the action of antioxidants to industrial and metalloenzyme catalysis.

100 Metalloenzymes catalyze complex and essential processes,

101 The resulting metalloenzyme catalyzes the hydration of CO2 better than

102 de oxidoreductase (DPOR), a nitrogenase-like metalloenzyme, catalyzes the chemically challenging two-

103 Yeast cytosine deaminase, a zinc metalloenzyme, catalyzes the deamination of cytosine to

104 Yeast cytosine deaminase (yCD), a zinc metalloenzyme, catalyzes the hydrolytic deamination of c

105 The 8-17 DNAzyme is a DNA metalloenzyme catalyzing RNA transesterification in the

106 N and C termini that are not found in other metalloenzyme chaperone GTPases.

107 Thus, metalloenzyme chemistry is shown to be tuned by the seco

108 llide a by the nitrogenase-like multisubunit metalloenzyme, chlorophyllide a oxidoreductase (COR).

109 Artifical metalloenzymes combine the reactivity of small molecule

110 tion of metal affinity to the active site of metalloenzymes constitutes an integral part in the under

111 Here, we report a reconstituted artificial metalloenzyme containing an iridium porphyrin that exhib

112 irst report of the chemical preparation of a metalloenzyme containing two different isotopically enri

113 characterization of an isotopically enriched metalloenzyme containing two different metal isotopes.

114 Metalloenzymes containing [ nFe- nS] ( n = 2 or 4) clust

115 GH61s have already been shown to be unique metalloenzymes containing an active site with a mononucl

116 reveals necessary design features for future metalloenzymes containing one or more metals.

117 Mutations in the metalloenzyme copper-zinc superoxide dismutase (SOD1) ca

118 rent density suggest the advantages of using metalloenzymes covalently attached to polymer-functional

119 lly analogous to the active site pocket of a metalloenzyme, demonstrating that both the active site a

120 on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de n

121 The resulting artificial metalloenzyme displays significantly improved catalytic

122 e, 293 cells transfected with JAB1/MPN/Mov34 metalloenzyme domain-deleted CSN5 produced exosomes with

123 somal proteins in both a CSN5 JAB1/MPN/Mov34 metalloenzyme domain-dependent and -independent manner.

124 BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-spec

125 of many members of the OTU and JAB/MPN/Mov34 metalloenzyme DUB families and highlight that all USPs t

126 ved reactivity trends reported in artificial metalloenzymes employing iron porphyrin carbenes.

127 or halogenation is increasing, revealing new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (S

128 ate highly active, productive, and selective metalloenzymes for abiological reactions.

129 d their variants, but also can result in new metalloenzymes for biotechnological and pharmaceutical a

130 hemical characterization of oxygen-sensitive metalloenzymes from strictly anaerobic species in the Ar

131 importance of framework stability on normal metalloenzyme function and specific implications for the

132 To learn how this family of metalloenzymes functions, a structural analysis of desig

133 rical contact to the metal center of a redox metalloenzyme, galactose oxidase (GOase), by coordinatio

134 Moreover, this homodimeric metalloenzyme has been directly linked to both familial

135 , the scope of reactions catalysed by native metalloenzymes has been expanded recently to include abi

136 (H. pylori) KDO8P synthase, a Zn2+-dependent metalloenzyme, has recently been found to be a Class II

137 s the cofactor compared to Zn(2+)-LpxC; both metalloenzymes have a bell-shaped dependence on pH with

138 These metalloenzymes have a large distribution in nature, wher

139 Although artificial metalloenzymes have been developed that catalyze abiolog

140 arly 2000's, different aspects of artificial metalloenzymes have been extensively reviewed and highli

141 Artificial metalloenzymes have received increasing attention over t

142 reviously identified as a mononuclear Zn(II) metalloenzyme; however, LpxC is 6-8-fold more active wit

143 ineurin-like phosphoesterase (CLP) family of metalloenzymes; however, it cleaves a pyrophosphate bond

144 The binuclear manganese metalloenzyme human arginase I (HAI) is a potential prot

145 Catalysis by the zinc metalloenzyme human carbonic anhydrase II (HCA II) is li

146 tep of CO(2) hydration catalyzed by the zinc-metalloenzyme human carbonic anhydrase II, the binding o

147 und transition metals in the active sites of metalloenzymes if left unregulated.

148 ture as well as the postulated roles of this metalloenzyme in host-pathogen interactions.

149 We also describe an XNA-XNA ligase metalloenzyme in the FANA framework, establishing cataly

150 rt the creation of a bifunctional artificial metalloenzyme in which a glutamic acid or aspartic acid

151 IGPD is a metalloenzyme in which transition metals induce aggregat

152 c study of hydrides in a variety of reducing metalloenzymes in addition to nitrogenase.

153 ethodology for structure/function studies of metalloenzymes in general.

154 hat there is a unique selection pressure for metalloenzymes in the marine environment, and our discov

155 zyme cofactor is built and the role of these metalloenzymes in the physiology of the organism.

156 essential component of the cofactors of many metalloenzymes including nitrate reductase and Mo-nitrog

157 an essential step in the maturation of every metalloenzyme, including manganese superoxide dismutase

158 A panel of metalloenzymes, including carbonic anhydrase (hCAII), se

159 nhibitory activity of a broad group of known metalloenzyme inhibitors against a panel of metalloenzym

160 The results show that the metalloenzyme inhibitors are quite selective for their i

161 t can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas.

162 e results suggest that metal coordination by metalloenzyme inhibitors is a malleable interaction and

163 e utilized universally in the development of metalloenzyme inhibitors, they are considered to be poor

164 e metal-binding group (MBG) in this class of metalloenzyme inhibitors.

165 at Crocosphaera's ability to reduce its iron-metalloenzyme inventory provides two advantages: It allo

166 ir utilization results in a lowered cellular metalloenzyme inventory that requires approximately 40%

167 Blastula protease 10 (BP10) is a metalloenzyme involved in sea urchin embryogenesis, whic

168 first mechanistic study of a tolloid-related metalloenzyme involved in sea urchin embryogenesis.

169 Alterations in the assembly of metalloenzymes involved in redox stress response might e

170 Synthesis of these metalloenzymes involves a complex series of biochemical

171 ird strategy, in which the native metal of a metalloenzyme is replaced with an abiological metal with

172 Thus, metallation of an estimated 30% of metalloenzymes is aided by metal delivery systems, with

173 e understanding of the native cofactor(s) of metalloenzymes is critical for the development of biolog

174 Choosing bacterial metalloenzymes is one possible approach that can increas

175 Proteins with JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) domains are widespread among a

176 intrinsic Mg(2+) dissociation constant from metalloenzyme (K(M) = 3.5 +/- 0.3 mm) was experimentally

177 lf-maximal concentration for P(i) binding to metalloenzyme ((K(p)(')=6.3+/-0.6 mM)) was significantly

178 The use of metalloenzyme-like zeolites as Lewis acid catalysts for

179 These results may shed light on how a metalloenzyme maintains its catalytic activity in an oxi

180 extended H-bond networks in designing other metalloenzymes may allow us to confer and fine-tune thei

181 ovides opportunities for the construction of metalloenzyme model complexes, peptide adducts, and chro

182 The JAMM (JAB1/MPN/Mov34 metalloenzyme) motif has been proposed to provide the ac

183 we report that the membrane-tethered matrix metalloenzyme MT1-MMP not only serves as an ECM-directed

184 been overexpressed in Escherichia coli, its metalloenzyme nature has been confirmed, and its catalyt

185 PepV is a monomeric metalloenzyme of approximately 55 kDa that preferentiall

186 ed by yeast cytosine deaminase (yCD), a zinc metalloenzyme of significant biomedical interest, has be

187 atase/diesterase, a promiscuous two-zinc ion metalloenzyme of the alkaline phosphatase enzyme superfa

188 Arginase, a key metalloenzyme of the urea cycle that converts L-arginine

189 efore, the two-step mechanism is observed in metalloenzymes of all classes, and this 8-17 DNAzyme pro

190 mase superfamily of proteins, which includes metalloenzymes of diverse activity, mechanism, and metal

191 Metalloenzymes often require elaborate metallocenter ass

192 omplexes, which are of importance in several metalloenzymes; one of them is the oxygen-evolving compl

193 No cDNAs encoding zinc-metalloenzymes or zinc-finger transcription factors were

194 d to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solven

195 d to study the noncovalent complexation of a metalloenzyme, phosphomannose isomerase (PMI), which cat

196 Enzymes that contain metal ions--that is, metalloenzymes--possess the reactivity of a transition m

197 rticulate MMO (pMMO) is an integral membrane metalloenzyme produced by all methanotrophs and is compo

198 The zinc metalloenzyme protein farnesyltransferase (FTase) cataly

199 cies is critical to both an understanding of metalloenzyme reactivity and related transition metal ca

200 drase XII (CA12), a gene that encodes a zinc metalloenzyme responsible for acidification of the micro

201 RNase P is the ubiquitous ribonucleoprotein metalloenzyme responsible for cleaving the 5'-leader seq

202 RPE65 is a key metalloenzyme responsible for maintaining visual functio

203 deformylase (PDF) is an essential bacterial metalloenzyme responsible for the removal of the N-formy

204 Artificial metalloenzymes result from anchoring an active catalyst

205 of reduced holomycin against zinc-dependent metalloenzymes revealed that it inhibits E. coli class I

206 is of this first de novo designed hydrolytic metalloenzyme reveals necessary design features for futu

207 e approach to the construction of artificial metalloenzymes since this is conveniently achieved by se

208 Thus, PDS readily detects alterations in metalloenzyme solution properties not easily deciphered

209 Crystal structures of the 5S metalloenzyme subunit, which catalyzes the second carbox

210 catalysts provide processing advantages over metalloenzymes such as an ability to work at higher temp

211 amily comprises a large number of hydrolytic metalloenzymes such as phosphatases and sulfatases.

212 ity of oxygen-containing metal complexes and metalloenzymes, such as the oxygen-evolving complex in p

213 een linked with mutations to the antioxidant metalloenzyme superoxide dismutase (SOD1).

214 monooxygenase (pMMO) is an integral membrane metalloenzyme that catalyses the conversion of methane t

215 disintegrin and metalloprotease (ADAM) 17, a metalloenzyme that catalyzes ectodomain shedding of rece

216 Nitrogenase is an essential metalloenzyme that catalyzes the biological conversion o

217 homocysteinase (LuxS) is an Fe(2+)-dependent metalloenzyme that catalyzes the cleavage of the thioeth

218 minopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes the committed step in the f

219 Nitrogenase is a multicomponent metalloenzyme that catalyzes the conversion of atmospher

220 ) is a mononuclear cysteinate-ligated nickel metalloenzyme that catalyzes the disproportionation of s

221 Deoxyhypusine hydroxylase (DOHH) is a novel metalloenzyme that catalyzes the final step of the post-

222 ysteine dioxygenase (CDO) is a non-heme iron metalloenzyme that catalyzes the first committed step in

223 e II (HCA II) is a monomeric zinc-containing metalloenzyme that catalyzes the hydration of CO(2) to f

224 Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginin

225 Arginase is a manganese metalloenzyme that catalyzes the hydrolysis of L-arginin

226 Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginin

227 TE) from Pseudomonas diminuta is a binuclear metalloenzyme that catalyzes the hydrolysis of organopho

228 Phosphotriesterase (PTE) is a binuclear metalloenzyme that catalyzes the hydrolysis of organopho

229 Cytidine deaminase (CDA) is a zinc metalloenzyme that catalyzes the hydrolytic deamination

230 man carbonic anhydrase II (HCA II) is a zinc-metalloenzyme that catalyzes the reversible interconvers

231 monooxygenase (pMMO) is an integral membrane metalloenzyme that converts methane to methanol in metha

232 Superoxide reductase is a nonheme iron metalloenzyme that detoxifies superoxide anion radicals

233 Dihydroorotase (DHO) is a zinc metalloenzyme that functions in the pathway for the bios

234 extracellular transmembrane homodimeric zinc metalloenzyme that has been validated as a prognostic ma

235 se (PTE) from Pseudomonas diminuta is a zinc metalloenzyme that hydrolyzes a variety of organophospho

236 Nitrogenase is a versatile metalloenzyme that is capable of catalyzing two importan

237 bdenum cofactor (Moco)-dependent homodimeric metalloenzyme that is vitally important for autotrophic

238 ane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in metha

239 ane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in metha

240 superoxide dismutase (NiSOD) is a bacterial metalloenzyme that possesses a mononuclear Ni-center and

241 Arginase is a binuclear manganese metalloenzyme that serves as a therapeutic target for th

242 This enzyme is an Mg(2+)/Mn(2+)-dependent metalloenzyme that undergoes dramatic activation upon re

243 teine methyltransferase-2 (BHMT-2) is a zinc metalloenzyme that uses S-methylmethionine (SMM) as a me

244 ve obligate requirements for trace metals in metalloenzymes that catalyse important biogeochemical re

245 Hydrogenases are metalloenzymes that catalyze 2H(+) + 2e(-) <--> H(2).

246 u(2+), has been harnessed by a wide array of metalloenzymes that catalyze electron transfer reactions

247 Carbonic anhydrases (CAs) are zinc metalloenzymes that catalyze the interconversion of CO2

248 Carbonic anhydrases (CA) are zinc-containing metalloenzymes that catalyze the reversible hydration of

249 [NiFe] hydrogenases are metalloenzymes that catalyze the reversible oxidation of

250 Consequently, all hydrogenases are metalloenzymes that contain at least one iron atom in th

251 t recently discovered member of the class of metalloenzymes that detoxify the superoxide radical in a

252 a novel design for supramolecular artificial metalloenzymes that exploits the promiscuity of the cent

253 ossible role of unusually low valent iron in metalloenzymes that feature iron-sulfur clusters.

254 o isatinate and belongs to a novel family of metalloenzymes that include the bacterial kynurenine for

255 Carbonic anhydrases (CAs) are zinc metalloenzymes that interconvert CO2 and HCO3 (-) In pla

256 Sulfite oxidases are metalloenzymes that oxidize sulfite to sulfate at a moly

257 n-binding scaffolds can be adapted to obtain metalloenzymes that provide the reactivity of the introd

258 Lipoxygenases are mononuclear non-heme metalloenzymes that regio- and stereospecifically conver

259 Oxygen-tolerant [NiFe] hydrogenases are metalloenzymes that represent valuable model systems for

260 is a member of a newly established class of metalloenzymes that use S-adenosyl-l-methionine (AdoMet)

261 a member of a recently established class of metalloenzymes that use S-adenosyl-l-methionine (SAM) as

262 Unlike the metalloenzyme, the flavoprotein is not associated tightl

263 Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes recei

264 The key metalloenzyme to degrade ROS in B. burgdorferi is SodA.

265 The ability of many copper metalloenzymes to activate O2 and transfer it to organic

266 The triphosphate tunnel metalloenzyme (TTM) superfamily represents a group of en

267 Triphosphate tunnel metalloenzymes (TTMs) are a newly recognized superfamily

268 Triphosphate tunnel metalloenzymes (TTMs) are a superfamily of phosphotransf

269 Triphosphate tunnel metalloenzymes (TTMs) are present in all kingdoms of lif

270 Inhibitors of metalloenzymes typically contain a group that binds to t

271 production of the highly abundant and active metalloenzyme urease for colonization of the human stoma

272 uman stomach, requires the nickel-containing metalloenzymes urease and NiFe-hydrogenase to survive th

273 The enzyme was found to be a Zn-containing metalloenzyme using inductively coupled plasma mass spec

274 ar docking can identify potential ligands of metalloenzymes using a "standard" scoring function, we h

275 idized and reduced forms of this 414-residue metalloenzyme via hydrogen-deuterium exchange kinetics (

276 the structure and physical properties of the metalloenzyme vs the NiSOD metallopeptide-based models.

277 The in silico design of the artificial metalloenzyme was confirmed by X-ray crystallography.

278 of nature's approach to catalysis, a Zn(II) metalloenzyme was prepared using de novo design.

279 metalloenzyme inhibitors against a panel of metalloenzymes was evaluated.

280 s enzyme, which has the characteristics of a metalloenzyme, was purified approximately 200-fold from

281 nravel mechanistic questions associated with metalloenzymes, we are developing methods for rapid deli

282 Enolase is a dimeric metal-activated metalloenzyme which uses two magnesium ions per subunit:

283 te motif has been found in a number of other metalloenzymes which catalyze a variety of oxygenase rea

284 hosphoglucose isomerase (PfPGI), an archaeal metalloenzyme, which catalyses the interconversion of gl

285 se of its central role in the functioning of metalloenzymes, which utilize O2 to perform a number of

286 mes do not synthesize an active Zn(II)-bound metalloenzyme, while the as-isolated ribosomes do.

287 reminiscent of MiaB, another tRNA-modifying metalloenzyme whose active form was shown to bind two ir

288 zation of GlcNAc-PI de-N-acetylase as a zinc metalloenzyme will facilitate the rational design of ant

289 The rational design of inhibitors targeting metalloenzymes will benefit greatly from a deeper unders

290 e factors that govern the properties of this metalloenzyme with a goal of eventually improving the ca

291 erization revealed that NaaA is a hydrolytic metalloenzyme with a narrow substrate range.

292 ron catalytic site; pMMO is a membrane-bound metalloenzyme with a unique tricopper cluster as the sit

293 YpdF is shown to be a metalloenzyme with Xaa-Pro aminopeptidase activity and l

294 being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the

295 rison of M-S(Cys) bonding in NiSOD and other metalloenzymes with sulfur ligation is provided.

296 verse micelle (ICRM) produced an artificial "metalloenzyme" with highly unusual catalytic properties.

297 carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 family of carboxype

298 ATP7A transfers the copper cofactor to metalloenzymes within the secretory pathway; inactivatio

299 to bind zinc, and these metals dominate the metalloenzymes without metal delivery systems.

300 some enzymes that are not recognized as zinc metalloenzymes, zinc binding inhibits rather than activa