ライフサイエンスコーパス: metalloid

1 rolyze trinucleotide, even in the absence of metalloid.

2 ments, making it a major sink for this toxic metalloid.

3 ArsD at 1.4 A and a model for its binding of metalloid.

4 , as opposed to release and rebinding of the metalloid.

5 sO)(n), (SbO)(n), or a co-polymer of the two metalloids.

6 been shown to facilitate uptake of trivalent metalloids.

7 eric ArsD, with only one site releasing free metalloids.

8 quality limits, mainly with heavy metals and metalloids.

9 voltaic cells crucially depend on metals and metalloids.

10 n of the rates of binding and affinities for metalloids.

11 ing responses to toxic transition metals and metalloids.

12 nce mechanisms became hypersensitive to both metalloids after expression of LmAQP1.

13 Arsenic trioxide is a toxic metalloid and carcinogen that is also used as an antican

14 of glycerol, this is the first report where metalloid and glycerol transport can be dissected by a s

15 s-172 controls the affinity of this site for metalloid and hence the efficiency of metalloactivation

16 of ATP hydrolysis is slow in the absence of metalloid and is accelerated by metalloid binding.

17 ATP hydrolysis is slow in the absence of metalloid and is accelerated by metalloid binding.

18 cellular sensitivity to arsenicals and other metalloids and can modulate intracellular glutathione me

19 k because of the low concentration of metals/metalloids and the correspondingly high molecular chemic

20 orrelation between the content of metals and metalloids and the storage time of opened cans.

21 ter shell electronic structure of metals and metalloids and the viscoelasticity and fragility thereof

22 Because arsenic and antimony are related metalloids, and arsenical resistant Leishmania strains a

23 amples of microbial metabolism of metals and metalloids; and expanded the types of information it inc

24 anic anions (MRP1 substrates) as well as the metalloid antimonite (K(i) 2.8 microM).

25 c results in cross-resistance to the related metalloid antimony, present in the pentavalent state as

26 e) minerals determines the fate of the toxic metalloid arsenic (As) in many subsurface environments.

27 The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adapti

28 The toxic metalloid arsenic has been environmentally ubiquitous si

29 Exposure to the toxic metalloid arsenic is associated with diabetes and cancer

30 obic respiration of ferric iron or the toxic metalloid arsenic is well known to affect water quality

31 The toxic metalloid arsenic is widely distributed in food, water,

32 e majority of the transport of the trivalent metalloid arsenic trioxide.

33 common iron oxides and a sink for the toxic metalloid arsenic.

34 ce to trivalent and pentavalent salts of the metalloid arsenic.

35 ce to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia

36 ce to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia

37 The toxicity of the metalloids arsenic and antimony is related to uptake, wh

38 r cells to survive exposure to the trivalent metalloids arsenic and antimony.

39 common heavy metal contaminant lead and the metalloids arsenic and selenium in mine tailings and con

40 on H2S production and the leaching of metals/metalloids (arsenic, copper, chromium, and boron) from t

41 73 confers resistance to the toxic trivalent metalloids arsenite [As(III)] and antimonite [Sb(III)].

42 p has been shown to facilitate uptake of the metalloids arsenite and antimonite, and the Escherichia

43 s responsible for the transport of trivalent metalloids, arsenite and antimonite.

44 Reductive release of the potentially toxic metalloid As from Fe(III) (oxyhydr)oxides has been ident

45 ), Cd(II), Cu(II), Ni(II) and Zn(II) and the metalloid As(V).

46 higher levels of the heavy metal Cd and the metalloid As, it does not increase the accumulation pote

47 e ArsAB pump that catalyzes extrusion of the metalloids As(III) and Sb(III), conferring metalloid res

48 s the ArsAB extrusion pump for the trivalent metalloids As(III) and Sb(III).

49 ter DNA by binding of the compounds with the metalloids As(III) or Sb(III).

50 s trace metals (Cd, Co, Cu, Mn, Ni, and Zn), metalloids (As) and nonmetals (Se) in their shoots.

51 s a metallochaperone that delivers trivalent metalloids [As(III) or Sb(III)] to the ArsA ATPase, the

52 Although the metalloids, As(III) and Sb(III), are believed to be tran

53 The ArsD metallochaperone delivers trivalent metalloids, As(III) or Sb(III), to the ArsA ATPase, the

54 ave assessed the major uses of 56 metals and metalloids, assigning each use to one of three categorie

55 to better understand the form of metals and metalloids associated with the glass beads.

56 stal structure of ArsA shows two other bound metalloid atoms, one liganded to Cys-172 and His-453, an

57 The relation between metalloid binding by ArsA and transport through ArsB is

58 The metalloid binding domain is connected to the two nucleot

59 ng a nucleotide binding domain, and a single metalloid binding or activation domain is located at the

60 422A)B in less than 1 week, showing that the metalloid binding site confers an evolutionary advantage

61 st that there is only a single high-affinity metalloid binding site in ArsA, and second that Cys-172

62 Four are close to metalloid binding site residues Cys-12, Cys-13 and Cys-1

63 face involves one surface of helix 1 and the metalloid binding site.

64 -422 have been shown to form a high-affinity metalloid binding site.

65 In this study, direct metalloid binding to ArsA was examined.

66 The kinetics of metalloid binding were determined by stopped flow spectr

67 e absence of metalloid and is accelerated by metalloid binding.

68 e absence of metalloid and is accelerated by metalloid binding.

69 tagenesis of residues His-148 and Ser-420 on metalloid binding.

70 onnects the nucleotide-binding domain to the metalloid-binding domain.

71 ves are two nucleotide-binding domains and a metalloid-binding domain.

72 I) displacement by As(III) revealed that the metalloid-binding sites behave differentially, with the

73 nic (As) is considered the most common toxic metalloid, but its molecular mode of action is not well

74 ation of metalloid, high affinity binding of metalloid by ArsA is not obligatory for transport or res

75 ntrol the distribution of these toxic metals/metalloids by affecting their mobility in soils.

76 ntrolling factor elucidation of toxic metals/metalloids by introducing an index, enrichment factor (E

77 olving the sequential binding and release of metalloids by the four binding sites of dimeric ArsD, wi

78 hoate >> tau-fluvalinate), then trace metals/metalloids (cadmium, arsenic), followed by the fungicide

79 In this study, eight toxic metals/metalloids (Cd, Cr, Pb, Ni, Cu, Zn, As, and Hg) in Everg

80 In the mine impacted environment, metals and metalloids commonly coexist in a variety of species.

81 in combination with one or two metal and/or metalloid components as the catalyst.

82 y an effective tool for evaluating metal and metalloid concentrations but can suffer from poor replic

83 sIII oxidation and AsIII/SbIII resistance at metalloid concentrations inhibitory to the Deltaacr3-1 m

84 course experiments following the changes in metalloid-containing anion concentrations.

85 The metalloid-containing anions examined were selenocyanate,

86 olecular-level speciation of heavy metal and metalloid contaminants in various environmental settings

87 suggests that in addition to Hg other metals/metalloids could also potentially be an environmental pr

88 13 pair was required for the majority of the metalloid-dependent quenching of Trp-97 fluorescence.

89 r species, the formal oxidation state of the metalloid diminishes from III, to II, to I, and finally

90 ponent compounds of metals and chalcogens or metalloids, doped fullerenes and organic charge-transfer

91 This is the first report of the uptake of a metalloid drug by an aquaglyceroporin in Leishmania, sug

92 s As during crystallization and retains this metalloid during the transformation from struvite, can a

93 te and metabolism of Se (and other metal and metalloids) during anuran development and the implicatio

94 measurement site are enriched in metals and metalloids (e.g., arsenic, lead, and cadmium) and water-

95 were found to have elevated levels of metals/metalloids (e.g., mercury, arsenic, and lead) with separ

96 roviding homeostasis of essential metals and metalloid elements.

97 ance of DOM sulfurization to trace metal and metalloid (especially mercury) fate in the environment.

98 Arsenic, a toxic metalloid, exists in the natural environment and its org

99 control microbiomes are suppressed by metal/metalloid field exposure, including eradication of the h

100 D to ArsA, consistent with channeling of the metalloid from one protein to the other, as opposed to r

101 nce for and accumulation of heavy metals and metalloids from soil by expressing an Arabidopsis thalia

102 Recently, metals and metalloids have been observed at elevated concentrations

103 to reduce the intracellular concentration of metalloid, high affinity binding of metalloid by ArsA is

104 Arsenite is a well known metalloid human carcinogen, and epidemiological evidence

105 deposits and record the accumulation of this metalloid in the food chain.

106 haracterize the criticality of 62 metals and metalloids in a 3D "criticality space" consisting of sup

107 ting ATPase that confers resistance to those metalloids in Escherichia coli.

108 t roles in detoxification of heavy metal and metalloids in plants and other living organisms.

109 e effects of anthropogenic sources on metals/metalloids in soils.

110 ribution and potential risks of toxic metals/metalloids in the Everglades.

111 Arsenic (As) is one of four metals/metalloids in tobacco being considered for regulation.

112 oduction is induced by a range of metals and metalloids including arsenate.

113 equestering a wide range of heavy metals and metalloids, including arsenic.

114 z1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitin

115 concern to organisms that bioaccumulate the metalloid into their tissues.

116 of genes for resistance to heavy metals and metalloids is usually transcriptionally regulated by the

117 yotes are known to grow on and respire toxic metalloids of arsenic (i.e., arsenate and arsenite).

118 n about the pollution status of toxic metals/metalloids of potential concern, except for Hg.

119 d to ArsD and then to ArsAB, which pumps the metalloid out of the cell.

120 (Pb), whereas greater than 97% of metals and metalloids present were associated with the glass matrix

121 te that ArsB is an antiporter that catalyzes metalloid-proton exchange.

122 A/C422A)B genes had an intermediate level of metalloid resistance and accumulation between those expr

123 e metalloids As(III) and Sb(III), conferring metalloid resistance.

124 us species harvested from the environment is metalloid resistant and, when grown anaerobically in com

125 in a 3.8-kb chromosomal DNA fragment from a metalloid-resistant thermophile, Geobacillus stearotherm

126 s-119-Cys-120 had no effect on repression or metalloid responsiveness in vivo or in vitro.

127 f the steady-state fluorescence of ArsD with metalloids revealed positive cooperativity, with a Hill

128 nzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a

129 F, facilitates the uptake and sensitivity to metalloid salts.

130 risk due to plant uptake of the contaminant metalloids (Sb) and arsenic (As).

131 uptake of As(III) or Sb(III) correlated with metalloid sensitivity of the wild type and drug-resistan

132 The contribution of those putative metalloid sites was examined.

133 n exhibited varying levels of both basal and metalloid-stimulated activity, indicating that neither A

134 y similar to that of the wild type but lacks metalloid-stimulated activity.

135 Binding of metalloids stimulates ATPase activity.

136 P]-triphosphate at 4 degrees C indicate that metalloid stimulation correlates with a >10-fold increas

137 The results indicate that, whereas metalloid stimulation of ArsA activity enhances the abil

138 Trivalent metalloids, such as arsenic, have been proposed to cause

139 Although analysis of metals and metalloids, such as arsenic, is widely spread in many di

140 The metalloid tellurite is highly toxic to microorganisms.

141 Arsenic is a metalloid that generates various biological effects on c

142 Antimony (Sb) is a metalloid that has been exploited by humans since the be

143 entially form separate binding sites for the metalloids that trigger dissociation of ArsD from the op

144 esistance is proposed to be formation of the metalloid-thiol pump substrates, so that increased synth

145 ne adducts with concomitant reduction of the metalloid to active Sb(III) species.

146 ArsD transfers trivalent metalloids to ArsA, the catalytic subunit of an As(III)/

147 ally, various mechanisms for heavy metal and metalloid tolerance and virulence point to a lifestyle w

148 on of a plasmid containing AQP9 reverses the metalloid tolerance of the deletion strain.

149 to alanine, aspartate and glutamine affected metalloid transport in the order, wild-type > E152Q > E1

150 Besides metalloid transport, LmAQP1 is also permeable to water,

151 (MDR)-1 is the key factor in the failure of metalloid treatment in kala-azar patients infected with

152 mperative for us to understand mechanisms of metalloid uptake and detoxification.

153 may help better understand the mechanisms of metalloid uptake, tolerance and detoxification in plants

154 Accumulation of metalloid was assayed in intact cells, where reduced upt

155 Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followe

156 Arsenic is a metalloid whose name conjures up images of murder.

157 Arsenic (As) is a redox-active metalloid whose toxicity and mobility in soil depend on

158 c is a ubiquitous, naturally occurring toxic metalloid widely distributed in soil and groundwater.

159 e predominant emission source for metals and metalloids, with Cd released to such extents that PEC (1