ライフサイエンスコーパス: metallopeptidase

1 consistent with the suggestion that it is a metallopeptidase.

2 ursor is synthesized as a latent form of the metallopeptidase.

3 Dase, or NAAG peptidase) is a catalytic zinc metallopeptidase.

4 locked by o-phenanthroline and thus required metallopeptidases.

5 sence of an HXXEH motif found in a subset of metallopeptidases.

6 ctivity against structurally homologous zinc metallopeptidases.

7 ctive site helices, are conserved with other metallopeptidases.

8 process involving o-phenanthroline-sensitive metallopeptidases.

9 P. falciparum and the unusual M16 family of metallopeptidases.

10 of many zinc-dependent metalloproteases and metallopeptidases.

11 a member of the M3 or thimet family of zinc metallopeptidases.

12 rotein and a member of the M1 family of zinc metallopeptidases.

13 proposed assay was demonstrated using matrix metallopeptidase 1 (MMP-1), a protease of the same famil

14 nuclear factor-kappaB activation and matrix metallopeptidase 1 expression.

15 r factor-kappaB activation leading to matrix metallopeptidase 1 up-regulation.

16 LR2) expression, oxidative stress, or matrix metallopeptidase 12 (MMP-12) expression.

17 -associated phosphoprotein 1 (SKAP1), matrix metallopeptidase 12 (MMP12)/MMP13, catenin alpha3 (CTNNA

18 marked increase in the expression of matrix metallopeptidase 13 (MMP13) and tartrate-resistant acid

19 Matrix metallopeptidase 13 (MMP13) was identified as a direct t

20 connective tissue growth factor, and matrix metallopeptidase 13, etc.) and a key regulator of osteoc

21 Matrix metallopeptidase-13 (MMP-13) is a highly active and an a

22 However, matrix metallopeptidase 14 was identified as the most distincti

23 EGFR) and ADAM17 (a membrane disintegrin and metallopeptidase 17) in lung epithelial cells.

24 ein 2alpha (AP-2alpha) and consequent matrix metallopeptidase 2 (MMP2) gene expression.

25 -catenin and production of its target matrix metallopeptidase 2 (MMP2), a secreted enzyme involved in

26 ses, mRNA levels of the gene encoding matrix metallopeptidase 2 are lower in mutant-infected tissue.

27 reased the expression and activity of matrix metallopeptidase 2 in aortas without affecting metabolic

28 3-HAA upregulated matrix metallopeptidase 2 via transcription factor nuclear fact

29 1; transforming growth factor-beta1; matrix metallopeptidase 2, 7, and 9; inhibitor of metalloprotei

30 e knockdown in mice restrained 3-HAA, matrix metallopeptidase 2, and resultant AAA formation by angio

31 osis factor alpha, interleukin-1beta, matrix metallopeptidase 2, heparan sulfate d-glucosaminyl 3-O-s

32 vealed that ANG expression stimulated matrix metallopeptidase-2 (MMP2) expression through the phospho

33 ptidase of unknown function belonging to the metallopeptidase 20 family.

34 ecessive mutations in MMP21 (encoding matrix metallopeptidase 21) in nine index cases with heterotaxy

35 gration-associated genes, such as the matrix metallopeptidase 3 (MMP3).

36 IL-24 induced the expression of matrix metallopeptidase 7 (MMP7) in SCC cells in culture.

37 modeling, associated with high expression of metallopeptidase-7, -9, and -12, diverged from anabolic

38 pressed on Myeloid cells (TREM-1) and Matrix MetalloPeptidase 9 (MMP-9) are detected via direct assay

39 ssue revealed decreased expression of matrix metallopeptidase 9 (MMP-9) in mice exhibiting positive r

40 Levels of IL-8, matrix metallopeptidase 9 (MMP-9), and biomarkers of glucocorti

41 , monocyte chemoattractant protein-1, matrix metallopeptidase 9 (MMP-9), and fibroblast growth factor

42 acidic protein (GFAP) and a protease, matrix metallopeptidase 9 (MMP-9).

43 necrosis factor a (TNF-alpha)-induced matrix metallopeptidase 9 (MMP9) activity mediates formation of

44 rs and determined that DP103 elevates matrix metallopeptidase 9 (MMP9) levels, which are associated w

45 In addition, beta-catenin and matrix metallopeptidase 9 (MMP9) protein levels and reactive ox

46 olony-stimulating factor (GM-CSF) and matrix metallopeptidase 9 (MMP9).

47 rowth factor (VEGF), BCL2, BCLXL, and matrix metallopeptidase 9 [MMP9]) were increased in pediatric p

48 Osteoclast markers (matrix metallopeptidase 9 and cathepsin K) were up-regulated at

49 trophoblast phenotype, including the matrix metallopeptidase 9 gene (Mmp9).

50 etin 1), ANG2 (angiopoietin 2), MMP9 (matrix metallopeptidase 9), TSP1 (thrombospondin 1), etc.

51 e generation of interleukin-1beta and matrix metallopeptidase 9.

52 coordinate with constitutively active matrix metallopeptidase-9 (MMP-9), a protease that cleaves oste

53 at the known hematopoietic modulators matrix metallopeptidase-9 (MMP9) and kit ligand (KITL) were dec

54 higher expression of CD49d (P = .02), matrix metallopeptidase-9 (P = .004), CD38 (P = .009), CD80 (P

55 ) and reduced inflammatory biomarkers matrix metallopeptidase-9 and myeloperoxidase in plasma and spu

56 ature matrix as well as expression of matrix metallopeptidase-9 MMP-9.

57 totrophoblast cytoskeletal integrity, matrix metallopeptidase-9 secretion, invasion, and differentiat

58 del incorporating 3 serum biomarkers (matrix metallopeptidase-9, neuron-specific enolase, and vascula

59 lar endothelin growth factor, IL-17a, matrix metallopeptidase-9, or C-reactive protein.

60 ubstitutions in many, but not all, conserved metallopeptidase active sites recapitulated the hydrogen

61 two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only h

62 erestingly, examination of the ATP-dependent metallopeptidase activity responsible for degradation of

63 A novel metallopeptidase activity, falcilysin, was purified from

64 ) and another co-expressing Pvalb with three metallopeptidases Adamts8, Adamts15 and Mme (PV-MP).

65 ledge, this is the first model of a Zn(2)(+) metallopeptidase and its substrate.

66 ftsH (PG0047) encoding an ATP-dependent zinc metallopeptidase and ptpA (PG1641) encoding a putative t

67 tified six new PG proteins, including an M48 metallopeptidase and two Absence of bc1 complex (ABC1) a

68 of direct antimicrobial activity by a matrix metallopeptidase, and describes a new antimicrobial pept

69 Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2)

70 We have investigated the role of a metallopeptidase (At1g09300) from Arabidopsis (Arabidops

71 These aminopeptidases are cocatalytic zinc metallopeptidases belonging to the peptidase family M28.

72 f A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and

73 ins of gelsolin (actin cytoskeleton), matrix metallopeptidases (collagen degradation), platelet funct

74 mes, and offer a catalytic mechanism for M23 metallopeptidases consistent with available structural a

75 , the reaction could be inhibited by an ADAM metallopeptidase domain 17 (Adam 17) active site inhibit

76 MerTK is susceptible to ADAM metallopeptidase domain 17 (ADAM17)-mediated cell-surfac

77 ng, we identified null mutations in the ADAM metallopeptidase domain 9 (ADAM9) gene in four consangui

78 rd lead concentration and expression of ADAM metallopeptidase domain 9 (ADAM9), reticulon 4 (RTN4), a

79 t of only two amino acid residues within the metallopeptidase domain of Yta12 allows its assembly int

80 n ATPase domain of the AAA family and an H41 metallopeptidase domain.

81 sACE comprises two homologous metallopeptidase domains, N and C, joined by an inter-do

82 tin (betaARRs) 1 and 2 and the transmembrane metallopeptidases ECE-1c and ECE-1d.

83 These metallopeptidases exhibit unique specificity for the sub

84 e otherwise unrelated astacin and fragilysin metallopeptidase families.

85 nding motif characteristic of members of the metallopeptidase family M16.

86 motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial

87 Fxna is a transmembrane metallopeptidase from family M28, localized to the endop

88 al sequence analysis predicted that it was a metallopeptidase from the presence of a motif conserved

89 Here we characterize a approximately 47 kDa metallopeptidase, from the hydrogenosome-bearing, unicel

90 d changes in the protein structure with Zn2+ metallopeptidase gene function.

91 xpression patterns for a group of fungalysin metallopeptidase genes, a gene family thought to be invo

92 vide support for MtfA as a prototypical zinc metallopeptidase (gluzincin clan).

93 me-2 (ECE-2), a member of M13 family of zinc metallopeptidases, has previously been shown to process

94 e present study was to ascertain if Lit is a metallopeptidase, identify residues essential for Lit ac

95 IDE is an unusual metallopeptidase in that it is allosterically activated

96 nts the minimum structure of a Glu-zincin (a metallopeptidase in which the third zinc ligand is a glu

97 eatures characteristic of clan ME family M16 metallopeptidases, including an "inverted" HXXEH active

98 s significant sequence identity to mammalian metallopeptidases, including endothelin-converting enzym

99 not Leu, and were inhibited by conventional metallopeptidase inhibitors and some divalent cations.

100 Neprilysin is a metallopeptidase known to degrade amyloid in Alzheimer d

101 omains: an alpha+beta domain inserted in the metallopeptidase-like domain and a C-terminal circularly

102 firmed that CA_C2195 contained an N-terminal metallopeptidase-like domain.

103 2 protein consisted of a single, zincin-like metallopeptidase-like domain.

104 ntiation process through induction of matrix metallopeptidase (MMP)13.

105 iR-181b showed that miR-181b enhanced matrix metallopeptidases (MMP)2 and MMP9 activity and promoted

106 with other peptidases, with only a putative metallopeptidase motif, H(160)EXXH, giving an indication

107 tidines as well as other residues within the metallopeptidase motif.

108 conserved H(149)E(150)XXH(153)+E(212)+Y(205) metallopeptidase motif.

109 h for structural models of integral-membrane metallopeptidases (MPs), we discovered three related pro

110 ocalized to the cell envelope; these include metallopeptidases, multidrug-resistant efflux (MDR) pump

111 It was identified as a metallopeptidase named "adipocyte-derived leucine" or "p

112 myloid-beta degrading enzyme, the endogenous metallopeptidase neprilysin, which is fused to albumin t

113 zymatic degradation by two membrane-bound Zn-metallopeptidases, neprilysin (NEP, EC 3.4.24.11) and am

114 The zinc metallopeptidase neurolysin is shown by x-ray crystallog

115 erall fold first seen in the closely related metallopeptidase neurolysin.

116 Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24

117 copy gene in Arabidopsis thaliana, encodes a metallopeptidase originally identified via its affinity

118 e substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and

119 Suppressed metallopeptidases, reflected in low expression of carbox

120 One such is LasA, an M23 metallopeptidase related to autolytic glycylglycine endo

121 edicted that part of the protein contained a metallopeptidase-related domain.

122 Zswim5); and Adamts5 [a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin t

123 their substrates, three structurally related metallopeptidases require the specific recognition of O-

124 Zinc metallopeptidase STE24 (ZMPSTE24) is a transmembrane met

125 dases RAS Converting Enzyme1 (RCE1) and zinc metallopeptidase STE24 and lacks canonical CaaX activity

126 s-peptide bond are well conserved within the metallopeptidase subfamily M9B.

127 ts by several experts in the field of matrix metallopeptidases suggests that this approach will signi

128 This enzyme is a Zn-containing metallopeptidase that catalyzes the degradation of the m

129 I-converting enzyme (ACE, or DCP1) is a zinc metallopeptidase that converts angiotensin I into the va

130 n-degrading enzyme (IDE) is an atypical zinc-metallopeptidase that degrades insulin and the amyloid s

131 ndopeptidase (NEP) is a genetically distinct metallopeptidase that degrades the natriuretic peptides.

132 homolog of glutamate carboxypeptidase II, a metallopeptidase that has been intensively studied as a

133 ng enzyme-1 (ECE-1) is a membrane-bound zinc-metallopeptidase that is related to neprilysin in amino

134 ding enzyme (IDE) is a highly conserved zinc metallopeptidase that is ubiquitously distributed in hum

135 Thimet oligopeptidase (TOP) is a zinc metallopeptidase that metabolizes a number of bioactive

136 degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive pept

137 nked homodimeric multidomain type-I membrane metallopeptidase that sheds membrane-bound cytokines and

138 .4.24.16) are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptid

139 Homology of PEX to the M13 family of Zn2+ metallopeptidases which include neprilysin (NEP) as prot

140 amily of structurally-related Zn(2+)-binding metallopeptidases which play a major role in a wide rang

141 idue propeptide, the shortest reported for a metallopeptidase, which lacks cysteines.

142 hrrP encodes an M16A family metallopeptidase whose catalytic activity is required fo

143 imental evidence that it is a zinc-dependent metallopeptidase with a catalytic mechanism similar to t

144 ; 20 min) hexameric ( approximately 270-kDa) metallopeptidase with a pH optimum of 8.5 to 9.5.

145 hout known mechanism, such as ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13) f

146 cted two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) a

147 d Pyrococcus furiosus carboxypeptidase--zinc metallopeptidases with no detectable sequence similarity