ライフサイエンスコーパス: metalloprotease

1 rich Mucin-like protein and a Zinc-dependent metalloprotease.

2 that are substrates for either thrombin or a metalloprotease.

3 tsH1, a homolog of a bacterial membrane AAA+ metalloprotease.

4 hese unique features, functions as an active metalloprotease.

5 ts and thus was tentatively proposed to be a metalloprotease.

6 after 8 h and was coding for a transmembrane metalloprotease.

7 of the M16A family of soluble zinc-dependent metalloproteases.

8 decorin, collagens, fibronectin, and matrix metalloproteases.

9 embrane and is carried out by membrane-bound metalloproteases.

10 nanthroline, suggesting the participation of metalloproteases.

11 flammatory response and inhibition of matrix metalloproteases.

12 pted the turnover of extracellular matrix by metalloproteases.

13 n actin cytoskeletal dynamics but not matrix metalloproteases.

14 longs to the M3A family of peptide-degrading metalloproteases.

15 hem is resistant to shedding by cell surface metalloproteases.

16 ge takes place on the cell surface by matrix metalloproteases.

17 Matrix metalloprotease-1 (MMP1) is an important mediator of tum

18 expression of alpha1 type I collagen, matrix metalloprotease-1, and platelet-derived growth factor-be

19 tly secreted (>80%); are cleaved with matrix metalloprotease-1; inhibit NF-kappaB driven transcriptio

20 The MMP-9/ tissue inhibitor of metalloproteases-1 (TIMP-1) complex presents as a major

21 as dependent on the sheddase disintegrin and metalloprotease 10 (ADAM10) and the gamma-secretase comp

22 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed

23 anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is required for shedding of

24 ne of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretas

25 was abrogated by an ADAM (A disintegrin and metalloprotease) 10 and 17 selective inhibitor, but not

26 M17 (TNF-alpha converting enzyme) and matrix metalloprotease 14 caused by a reduction in the expressi

27 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in experimental hyp

28 acid polymorphisms within a disintegrin and metalloprotease 17 (Adam17) can account, at least in par

29 A disintegrin and metalloprotease 17 (ADAM17) is a major sheddase involved

30 Lastly, a disintegrin and metalloprotease 17 (ADAM17; also known as TACE) was foun

31 metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signali

32 ADAM17 (a disintegrin and metalloprotease 17) controls pro- and anti-inflammatory

33 domain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulator of EGF-recept

34 dopodium function via upregulation of matrix metalloprotease 2 (MMP2) and MMP9 expression levels.

35 ase 9 (MMP9) as well as activation of matrix metalloprotease 2 (MMP2) and MMP9, whereas the ED peptid

36 ide (NO) production, which stimulates matrix metalloprotease-2 (MMP-2) and MMP-9 activity in the extr

37 nnexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracel

38 itically regulated by the activity of matrix metalloprotease 3 (MMP-3), in contrast to NMDAR-dependen

39 The collagenase matrix metalloprotease 9 (MMP-9), which is increased in patient

40 tion, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well as activation of matrix

41 ppaB and the expression of its target matrix metalloprotease 9 (MMP9).

42 expression of NF-kappaB target genes matrix metalloprotease 9 and interleukin 6.

43 thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release.

44 Consistently, IL-17 upregulated matrix-metalloprotease-9 and neutrophil elastase expression, tw

45 ected Wsh mice had reduced amounts of matrix metalloprotease-9 in BALF and were resistant to epitheli

46 ce proteins A and C (PspA and PspC) and zinc metalloprotease A and B (ZmpA and ZmpB) proteins.

47 w in different models of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (

48 ands, including amphiregulin, independent of metalloprotease a disintegrin and metalloproteinase 17 (

49 ns of the substrates, which in turn regulate metalloprotease access to the substrates' ectodomain and

50 An extracellular metalloprotease (AcPs) with high milk-clotting activity

51 of MrpC appeared to involve ATP-independent metalloprotease activity and may provide a mechanism for

52 ent with IL-1 significantly increased matrix metalloprotease activity in the conditioned media of eGF

53 Much is known about the metalloprotease activity of these enzymes, but noncanoni

54 feration and EGFR activation did not rely on metalloprotease activity.

55 We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ectodomain of Fcga

56 at two alpha-sites through a disintegrin and metalloprotease (ADAM) and at one beta-site through BACE

57 ally active members of the A Disintegrin And Metalloprotease (ADAM) family of membrane-anchored metal

58 s, especially those of the A disintegrin and metalloprotease (ADAM) family, can mediate NKG2D ligand

59 talloproteinase (MMP)- and a disintegrin and metalloprotease (ADAM)-family zinc metalloproteases mark

60 human Tim-3 is a target of A disintegrin and metalloprotease (ADAM)-mediated ectodomain shedding resu

61 The cytoplasmic domain of a disintegrin and metalloprotease (ADAM)10, a transmembrane metalloproteas

62 TLR4 ligand, we identified a disintegrin and metalloprotease (ADAM)15 as a novel TRIF-interacting par

63 As a disintegrin and metalloprotease (ADAM)s have been implicated in chemokin

64 he cell surface proteases "a disintegrin and metalloproteases" (ADAM)-10 and ADAM-17, as demonstrated

65 The transmembrane metalloprotease ADAM10 sheds a range of cell surface pro

66 is facilitated by the ITCH E3 ligase and the metalloprotease ADAM10, both of which are also secreted

67 hese tetraspanins directly interact with the metalloprotease ADAM10, regulate its exit from the endop

68 PrP(C) is shed at the plasma membrane by the metalloprotease ADAM10, yet the impact of this on prion

69 smembrane species with the integral membrane metalloprotease ADAM10, yet the mechanisms governing thi

70 increased susceptibility to cleavage by the metalloprotease ADAM10.

71 rocytes by increasing the active form of the metalloprotease ADAM10.

72 Here we demonstrate that the metalloproteases ADAM10 and ADAM17 can produce sgp130 by

73 ow that TIMP3 acts through inhibition of the metalloprotease ADAM17 and HB-EGF to regulate cerebral a

74 cally, we found that fibulin-3 activates the metalloprotease ADAM17 by competing with its endogenous

75 can be shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble peptide wit

76 ate the NRG1-ErbB4 pathway, possibly via the metalloprotease ADAM17, in skeletal muscle of diet-induc

77 R ligands are known substrates of the matrix metalloprotease ADAM17, suggesting stretch activates and

78 expression and phosphorylation ratio of the metalloprotease ADAM17, which is involved in NRG1 sheddi

79 dding from neutrophils via activation of the metalloprotease ADAM17.

80 cts toward the other tested Zn(2+)-dependent metalloproteases (ADAMs and meprins).

81 lecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated with high substrat

82 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases many important biologi

83 ssive cleavage of large VWF multimers by the metalloprotease ADAMTS-13 in an LVAD-driven circulation.

84 The metalloprotease ADAMTS13 cleaves von Willebrand factor (

85 The metalloprotease ADAMTS13 regulates blood coagulation by

86 VWF is regulated by the metalloprotease ADAMTS13, which in turn is conformationa

87 Recessive mutations in the secreted metalloprotease ADAMTS17 cause ectopia lentis and short

88 as well as by increased expression of matrix metalloproteases and bone-specific proteases.

89 osis and tissue remodeling, including matrix metalloproteases and collagen, were upregulated in chron

90 tor p300, preventing the induction of matrix metalloproteases and other p300-dependent genes required

91 tating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6).

92 ulates two functional forms of RANKL through metalloproteases and the JAK2/STAT5 pathway, and it help

93 s generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucleus via

94 neered requirements for activation by matrix metalloproteases and urokinase plasminogen activator int

95 F-beta1, collagen I, fibronectin, and matrix metalloproteases, and plasma PAI-1 levels correlated wit

96 re of sympathetic neurons to HNE resulted in metalloprotease- and gamma-secretase-dependent cleavage

97 ression on human neutrophils, whereas matrix metalloproteases are dispensable.

98 Here, we show that both lectican-degrading metalloproteases are present in these brain regions and

99 oprotease (ADAM) family of membrane-anchored metalloproteases are synthesized as proenzymes, in which

100 We observe increased expression of matrix metalloproteases as well as decreased expression of tiss

101 me profiling identifies a gene encoding a Zn-metalloprotease, as a candidate effecting copper recycli

102 ne, which encodes variants of the mTLD/BMP-1 metalloproteases, as a critical regulator of alpha3beta1

103 virulence-related protein families, such as metalloproteases-associated paralogs, were exclusively i

104 ng S. aureus infection and discover that the metalloprotease aureolysin plays a critical role in modu

105 Among a panel of metalloproteases, BDM44768 selectively inhibits IDE.

106 sequence similarity to previously described metalloproteases, but instead have been reported as bein

107 re, glycosylated, and proteolytically active metalloprotease, capable of cleaving macromolecular subs

108 ific proteases, including complement, matrix metalloproteases, caspases, and granzymes, and carried b

109 tructure of the CAAX protease Ste24p, a zinc metalloprotease catalyzing two proteolytic steps in the

110 sts that these proteins represent an ancient metalloprotease clan regulating cellular communications

111 ange of the dimerization partners that allow metalloprotease cleavage in the extracellular space.

112 We identify the metalloprotease cleavage site 3 aa upstream of the predi

113 Notch activation requires unmasking of a metalloprotease cleavage site remote from the site of li

114 regulatory switch results in sensitivity to metalloprotease cleavage, and bound ligands induce Notch

115 Metalloprotease-cleaved CD95L (cl-CD95L) is released int

116 dings establish a prometastatic function for metalloprotease-cleaved CD95L in TNBCs, revisiting its r

117 ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), the

118 in motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 a

119 decreased expression of tissue inhibitor of metalloproteases confined to sinusoidal endothelial cell

120 iotensin-I converting enzyme (ACE) is a zinc metalloprotease consisting of two catalytic domains (N-

121 We found that the isoform associates with metalloprotease-containing exosomes and stimulates their

122 Adam13/33 is a cell surface metalloprotease critical for cranial neural crest (CNC)

123 High expression levels of ADAM8, a metalloprotease disintegrin, are correlated with poor cl

124 AMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture

125 attributed to a family of a disintegrin and metalloprotease domain (ADAM) metalloproteases, includin

126 nd GABA neurotransmission: a disintegrin and metalloprotease domain 22 (Adam22) and heat shock protei

127 ese rare structural features in the ADAMDEC1 metalloprotease domain impact the proteolytic activity,

128 lly designed amino acid substitutions in the metalloprotease domain of wild type (wt) BoNT/C1.

129 We demonstrate that the putative zinc metalloprotease domain SprT in Spartan directly interact

130 teolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombospondin type-1 motif,

131 t pro-domain processing between the pro- and metalloprotease domain, but nevertheless, cause signific

132 A disintegrin and metalloprotease domain-containing protein 12 (ADAM-12) i

133 re with an odd number of Cys residues in the metalloprotease domain.

134 f activated T-cells; ADAM, a disintegrin and metalloprotease domain; OTM, orthodontic tooth movement.

135 daptor molecule (STAM) (AMSH) is a conserved metalloprotease DUB in eukaryotes.

136 the catalytic domain of the light chain (LC) metalloprotease (E224 > A and Y366 > A), designed to pro

137 lated with degradation, while the inhibiting metalloproteases eliminated degradation and lung metasta

138 d invasiveness indirectly by inducing matrix metalloprotease enzyme 9 production, whereas drug resist

139 A number of metalloproteases, especially those of the A disintegrin

140 lycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cancer cells

141 ts to develop potent compounds against these metalloproteases failed to achieve selectivity against h

142 Tiki represents a new metalloprotease family that is dependent on Mn(2+)/Co(2+

143 ed DNA-dependent and DNA replication-coupled metalloprotease for DPC repair.

144 our knowledge, this is the first report on a metalloprotease from T. clypeatus, and the results indic

145 anicum, and BmK1, the C-terminal domain of a metalloprotease from the filarial worm Brugia malayi.

146 A recombinant leptospiral metalloprotease from the thermolysin family cleaved C3 i

147 status of the PsbP-like protein and the zinc metalloprotease FtsH as well as the presence of high sal

148 cus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance

149 like proteins and a 70-kD ATP-dependent zinc metalloprotease, FtsH.

150 erize the genomic organization of duplicated metalloprotease genes (patristacins) recruited into the

151 BI, the highest mRNA levels for the alkaline metalloprotease genes (termed prtA1 to prtA4) occurred f

152 sect host, while two serine protease and two metalloprotease genes had their highest mRNA levels duri

153 Metalloprotease gp63 (Leishmania donovani gp63 (Ldgp63))

154 Secreted metalloproteases have diverse roles in the formation, re

155 Metzincin metalloproteases have major roles in intercellular commu

156 om degradation by the symbiotically relevant metalloprotease HrrP (host range restriction peptidase),

157 Intramembrane metalloproteases (IMMPs) are conserved from bacteria to

158 Intramembrane metalloproteases (IMMPs) control critical biological pro

159 reased the levels and activity of the ADAM12 metalloprotease in a Notch signaling-dependent manner, l

160 role of selected serine proteases and matrix metalloproteases in chemokine processing has long been k

161 RNF213 down-regulated expressions of matrix metalloproteases in endothelial cells, but not in fibrob

162 However, the inhibition of metalloproteases in in vitro aging experiments by EDTA r

163 of the inner membrane-embedded ATP-dependent metalloproteases in mitochondria of Arabidopsis (Arabido

164 urons, and expression of wild-type but not a metalloprotease-inactive version of pappaa restores habi

165 isintegrin and metalloprotease domain (ADAM) metalloproteases, including ADAM17.

166 Here we report a novel metalloprotease-independent, channel-modulating function

167 tors that stimulate the production of matrix metalloprotease, inflammatory cell recruitment, and dend

168 Suppression of virus by metalloprotease inhibition varied among tested cell line

169 growth factor receptor tyrosine kinase, the metalloprotease inhibitor batimastat, and methyl-beta-cy

170 of the substrate resembles that of an insect metalloprotease inhibitor in thermolysin.

171 ivity in endothelial cells by inhibiting the metalloprotease inhibitor TIMP3; this resulted in increa

172 The general matrix metalloprotease inhibitor, GM6001, blocked agonist induc

173 oduction of sIL-27Ralpha is inhibited by the metalloprotease inhibitors GM6001 and TAPI-0.

174 Broad-spectrum metalloprotease inhibitors have failed clinically, and t

175 st exploited strategy to develop potent zinc-metalloprotease inhibitors relies on a core zinc chelato

176 GDP dissociation inhibitor Arhgdib, and the metalloprotease inhibitors Timp1 and Timp2.

177 lved to escape from inhibition by endogenous metalloprotease inhibitors.

178 nd metalloproteinase domain 10 (ADAM10) is a metalloprotease involved in cleavage of various cell sur

179 (MT1-MMP or MMP-14) is a zinc-transmembrane metalloprotease involved in the degradation of extracell

180 se-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan

181 Secretion of exosomes and metalloproteases is essential for extracellular matrix r

182 the proposition that one function of meprin metalloproteases is to modulate inflammation by inactiva

183 PAPP-AA encodes an extracellular metalloprotease known to increase IGF bioavailability, t

184 AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promot

185 CNTs are AB toxins with an N-terminal zinc-metalloprotease light chain that is linked by a disulfid

186 sin-1) is a putative ADAM (a disintegrin and metalloprotease)-like metalloprotease with an unknown ph

187 tory pathways involving inhibition of matrix metalloproteases, liver X receptor/retinoid X receptor,

188 The proximal metalloprotease (M), disintegrin-like (D), thrombospondi

189 of membrane RANKL through downregulation of metalloproteases mainly a disintegrin and metalloprotein

190 egrin and metalloprotease (ADAM)-family zinc metalloproteases markedly decreased both entry and cell-

191 s is that therapeutic inhibition of specific metalloproteases may help support NK-cell-based cancer t

192 Metalloprotease-mediated cleavage of CD95L expressed by

193 with HER2 triggers HER2 phosphorylation and metalloprotease-mediated ectodomain shedding, activating

194 nd a non-cell-autonomous mechanism involving metalloprotease-mediated release of a presumed EGF recep

195 umor cells impede NK-mediated recognition by metalloprotease-mediated shedding of B7-H6.

196 nd metalloprotease (ADAM)10, a transmembrane metalloprotease mediating ectodomain shedding of diverse

197 receptor cleavage by ADAM (A Disintegrin And Metalloprotease) metalloproteases promotes murine sensor

198 analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix prot

199 al astrogliosis and increases in activity of metalloproteases MMP-2 and MMP-9 in the spinal cord were

200 ung and aged mice were treated with a matrix metalloprotease (MMP) inhibitor and systemic sFasL was n

201 Surface expression of matrix metalloprotease (MMP)-14 on ovarian cancer cells stimula

202 nd were analysed for a panel of novel matrix metalloprotease (MMP)-degraded ECM proteins, by ELISA-ba

203 biomaterial design in BMP delivery, a matrix metalloprotease (MMP)-sensitive hyaluronic acid (HA)-bas

204 results in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type 1-MMP express

205 ir phagocytic rate, without affecting matrix metalloproteases (MMP)2 and MMP9 activity.

206 se in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G pro

207 FN, Snail, N-cadherin, vimentin, the matrix metalloprotease MMP2, alpha-smooth muscle actin and phos

208 , by decreasing the expression of the matrix metalloprotease MMP9.

209 Matrix Metalloproteases (MMPs) are an important family of prote

210 Matrix metalloproteases (MMPs) are endopeptidases that regulate

211 Matrix metalloproteases (MMPs) have attracted considerable atte

212 Matrix metalloproteases (MMPs) have recently emerged as importa

213 The group of matrix metalloproteases (MMPs) is responsible for multiple proc

214 Matrix metalloproteases (MMPs) MMP-2 and MMP-9 have been implic

215 Matrix metalloproteases (MMPs) regulate innate immunity acting

216 Applied to matrix metalloproteases (MMPs) with highly conserved catalytic

217 s dependent on Mn(2+)/Co(2+) but lacks known metalloprotease motifs.

218 Here we investigated the role of the metalloprotease Mpl in the dissemination process.

219 e in PlcB processing and vacuole escape, the metalloprotease Mpl is required for ActA processing and

220 The pattern of expression of metalloproteases (MPs) was analyzed by single-cell rever

221 cle cargo such as the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicles.

222 ce the surface expression of membrane type 1 metalloprotease (MT1-MMP) via down-regulating the kinesi

223 ) of critical cargos (membrane-type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) required f

224 endent recycling of the transmembrane matrix metalloprotease, MT1-MMP to promote invasive behaviour l

225 We conclude that zinc metalloproteases must be considered potential contributo

226 n and missense mutations in MME encoding the metalloprotease neprilysin in 19 index case subjects dia

227 Meprin beta is an endogenous zinc-dependent metalloprotease now shown to cleave the N-terminal regio

228 oteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shed

229 previously demonstrated that ATP-independent metalloprotease Oma1 mediates degradation of hypohemylat

230 itors of cysteine proteases, acid proteases, metalloproteases, or aminopeptidases abolished the effec

231 cer biomarkers shed from the cell surface by metalloproteases overexpressed in numerous cancers.

232 These results suggest that one or more metalloproteases participate in limiting isoaspartyl for

233 ulated folding, using the endogenous E. coli metalloprotease PepQ.

234 different from those of other intramembrane metalloproteases, perhaps reflecting differences in the

235 Members of the ADAMTS family of secreted metalloproteases play crucial roles in modulating the ex

236 e integrity, as well as by modulating matrix metalloprotease processing.

237 immunoglobulin A1 protease (IgA1P), a Zn(2+) metalloprotease produced on the extracellular surface of

238 ion and fibrous cap thinning, by heightening metalloprotease production.

239 by ADAM (A Disintegrin And Metalloprotease) metalloproteases promotes murine sensory axons loss of r

240 Both murine Notch1 and Notch2 require the metalloprotease protease Adam17, but not Adam10 during l

241 a, much less is known about whether/how this metalloprotease regulates adaptive immunity.

242 s the production of reactive oxygen species, metalloprotease release, and chemotaxis.

243 The M1 family of metalloproteases represents a large number of exopeptida

244 d by defects in MBTPS2, which encodes site-2 metalloprotease (S2P).

245 es encoding the following proteins: alkaline metalloprotease secretion protein AprE, a BglB family tr

246 Activation of Wss1 results in metalloprotease self-cleavage and proteolysis of associa

247 This induces ectodomain shedding of metalloprotease-sensitive cell surface proteins.

248 IA-negative S. epidermidis 1457Deltaica, the metalloprotease SepA is required for Aap-dependent S. ep

249 rocess, we examined the localisation of FtsH metalloproteases, some of which are directly involved in

250 leavage activity than 1,10-phenanthroline, a metalloprotease-specific inhibitor.

251 Here we identify the metalloprotease SPRTN as the DPC protease acting in meta

252 erevisiae that highlighted a role for the ER metalloprotease Ste24.

253 peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid pepti

254 CSN5 is the zinc metalloprotease subunit of the COP9 signalosome (CSN), w

255 ve examined the role of the conserved Rpn11p metalloprotease subunit of the proteasome, which couples

256 13 had excellent selectivity over other zinc metalloproteases such as TACE, MMP2, MMP3, MMP13, and MM

257 nM) and a weak inhibitor of other mammalian metalloproteases such as TNFalpha converting enzyme (TAC

258 indirectly through activation of a secreted metalloprotease, suggestive of the involvement of a prot

259 acillus subtilis SpoIVFB is an intramembrane metalloprotease that cleaves Pro-sigma(K) during sporula

260 0) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions f

261 -Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiqui

262 Furthermore, YghJ is a highly conserved metalloprotease that influences intestinal colonization

263 , the protein encoded by SPRTN, is a nuclear metalloprotease that is involved in the repair of DNA-pr

264 Neprilysin (NEP) is a zinc-dependent metalloprotease that is one of the key Abeta-degrading e

265 Immune inhibitor A1 (InhA1) is a secreted metalloprotease that is unique to pathogenic members of

266 ith thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VW

267 ADAMs are cell surface metalloproteases that control multiple biological proces

268 le hydrophobic S1' specificity pocket of the metalloprotease thermolysin with purposefully designed l

269 Tissue inhibitor of metalloprotease (TIMP)-3 was expressed in CD146(+) TSCs

270 or batimastat but not by tissue inhibitor of metalloproteases (TIMP)-1, TIMP-2, or the N-terminal inh

271 he expression of the endogenous inhibitor of metalloproteases tissue inhibitors of metalloproteinase

272 mediated by activation of the tmTNF cleavage metalloprotease TNF-alpha-converting enzyme via p38 MAP

273 lated NK cells increases the activity of the metalloprotease TNF-alpha-converting enzyme.

274 ablished that proteolysis of p75(NTR) by the metalloprotease TNFalpha-converting enzyme and gamma-sec

275 by their ability to secrete a zinc-dependent metalloprotease toxin, B. fragilis toxin (BFT).

276 strates are associated with their respective metalloproteases under both basal or cleavage-stimulated

277 es and MHV S proteins, suggesting a role for metalloprotease use in strain-dependent tropism.

278 assay has limited the investigation of this metalloprotease virulence factor.

279 uding chemokines, growth factors, and matrix metalloproteases, was increased, a signature resembling

280 eptidase STE24 (ZMPSTE24) is a transmembrane metalloprotease whose catalytic activity is critical for

281 DAM (a disintegrin and metalloprotease)-like metalloprotease with an unknown physiological role, sele

282 A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13)

283 ilot approach, identifying a disintegrin and metalloprotease with thrombospondin motifs 4 (ADAMTS4) a

284 ne network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) genes as cen

285 These results identify A disintegrin and metalloprotease with thrombospondin motifs-3 as a VEGF-C

286 -kDa form of VEGF-C by the A disintegrin and metalloprotease with thrombospondin motifs-3 protease, r

287 eins belong to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats)-like family

288 ifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin type 1 motif 13 (ADA

289 inine >2.25 mg/dL, and (3) a disintegrin and metalloprotease with thrombospondin type 1 motif, 13 (AD

290 re deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, memb

291 rotein S, antithrombin and A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats-13 (A

292 elial surface by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats)-medi

293 The yeast metalloprotease Wss1 clears chromatin-bound sumoylated p

294 unction that had only been attributed to the metalloprotease Wss1 in budding yeast.

295 n this proteolytic pathway involves the zinc metalloprotease YaeL; V. cholerae cells lacking YaeL acc

296 known chelators that can disrupt the BoNT/A metalloprotease zinc-containing active site, thus impedi

297 hat the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC volume

298 ic cleavage of CD2831 and CD3246 by the zinc metalloprotease ZmpI, whose expression is controlled by

299 Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin proce

300 of HIV protease inhibitors on the human zinc metalloprotease ZMPSTE24.