ライフサイエンスコーパス: metallothionein

1 ctivity and availability of free Zn(II) from metallothionein.

2 r Ca2+ decay, all of which were nullified by metallothionein.

3 elated protein biomarkers were attenuated by metallothionein.

4 rich region, with similarity to a Drosophila metallothionein.

5 eater than 1:1 with the cysteine residues of metallothionein.

6 redox and metal-binding states of mammalian metallothionein.

7 e expression of SmtA, a prokaryotic class II metallothionein.

8 dismutase (SOD1), and mammalian zinc-bonded metallothionein.

9 f this protein functions as a copper-binding metallothionein.

10 pper bound to cysteine-rich proteins such as metallothioneins.

11 y (designated as CvMT-I) of alphabeta-domain metallothioneins.

12 is likely bound to cytosolic proteins, like metallothioneins.

13 expression parallel those of the C. elegans metallothioneins.

14 us stimulation of PRRs induces expression of metallothioneins.

15 on the injury context and it is mediated by metallothionein 1 (MT1)-driven modulation of resistance

16 sed expression of antioxidant genes, such as metallothionein 1 (Mt1).

17 a7, and Slc39a8, and decreased expression of metallothionein 1 and 2.

18 proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- t

19 ings, these results suggest that blockade of metallothioneins 1 and 2 constitutes a promising approac

20 vivo We found that concomitant abrogation of metallothioneins 1 and 2 results in activation of the Ak

21 secretory leukocyte protease inhibitor, and metallothioneins 1 and 2.

22 The zinc-sensitive gene metallothionein-1 (MT-1 was up-regulated 7-fold, the opp

23 pathway is crucial for maintaining cellular metallothionein-1 levels to counteract ROS accumulation,

24 We report that human metallothionein 1a, well-known to coordinate 7 Zn(2+) or

25 interleukin-6 (IL-6; 14-fold, P < 0.001) and metallothionein-1A (MT-1A; 187-fold, P < 0.001) mRNA exp

26 such as versican, and novel ones, including metallothionein 1E (MT1E) and nicotinamide N-methyltrans

27 Here, we show that human metallothionein 1G (hMT1G) promoter is upregulated by E2

28 uses stable isotopically enriched (67)Zn(7) metallothionein 2 ((67)Zn(7)-MT-2) to quantitatively det

29 Cd(4)-alpha-domain was prepared from rabbit metallothionein-2 (MT 2), and its three-dimensional stru

30 usly established that ATP binds to mammalian metallothionein-2 (MT).

31 ed increased activity of the zinc-responsive metallothionein 2a (MT2a) promoter when ZnT5b was co-exp

32 Metallothionein 2A, a known CP-r gene, was among these 1

33 Metalation and demetalation of human metallothionein-2A (MT) with Cd(2+) is investigated by u

34 es and the mechanism for metalation of human metallothionein-2A (MT), an intrinsically disordered pro

35 1 (Uhmk1), insulin-induced gene 1 (Insig1), metallothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxir

36 hese treatments, three of these, neuronatin, metallothionein 3 and cystatin E/M, were frequently hype

37 (2)O(2) enhances cytosolic zinc content in a metallothionein-3 (MT-3)-requiring manner.

38 showed increased staining for PSMD11 and the metallothioneins 5 days post-SCI, along the peripheral r

39 Increased protein levels for PSMD11 and the metallothioneins 5 days post-SCI, specifically along the

40 ly weakly bound, with a log K of 7.7, making metallothionein a zinc donor in the absence of thionein.

41 contrasting agent for TEM, we have evaluated metallothionein, a small metal-binding protein, reacted

42 CXC), general stress (HSP70), metal-binding (metallothionein-A), and xenobiotic metabolism (Cyp1a1) u

43 or glutathione-related mechanisms, including metallothionein, across multiple populations.

44 partially mimicked the effects of glucose on metallothionein, although not ZiP, gene expression.

45 rophy were dramatically up-regulated (lipin, metallothionein, AMP deaminase, RNA helicase-related pro

46 s involved in copper homeostasis may include metallothionein and amyloid precursor protein.

47 Immunohistochemistry showed that metallothionein and keratin 14 proteins were overexpress

48 mediated through reductive zinc insertion by metallothionein and subsequent proteolysis involving a c

49 olecular structures and redox chemistries of metallothionein and thionein determine Zn(II) availabili

50 d system to identify a putative cotton fiber metallothionein and to confirm it as a protein that coul

51 Induction of metallothioneins and alpha-crystallin/small heat shock p

52 efenses (catalase, glutathion S-transferase, metallothionein), and genotoxicity are the most sensitiv

53 ranscripts included serum amyloid A1 and A2, metallothionein, and apolipoprotein D.

54 xpressed significantly higher levels of p21, metallothionein, and hemoglobin alpha1 proteins by Weste

55 ensitive mutants, cup1Delta cells lacking Cu-metallothionein, and particularly sod1Delta cells lackin

56 centration in brain is in part controlled by metallothionein, and zinc is released in the hippocampus

57 ledge of the evolutionary diversification of metallothioneins, and indicate differences in metal-bind

58 al first the existence of multiple bacterial metallothioneins, and second proteins with SmtA-like lon

59 se in gene expression of UPP components, the metallothioneins, and the protease inhibitor, SLPI, with

60 Metallothioneins are a family of small, cysteine rich pr

61 Metallothioneins are considered to be the primary player

62 Ferritins and metallothioneins are known to sequester intracellular ir

63 Metallothioneins are potential markers of neurologic dis

64 Metallothioneins are proteins that are involved in intra

65 Metallothioneins are typically low relative molecular ma

66 (II), cause dissociation of Zn(II) ions from metallothionein at pH 7.4 (Zn(7)T <==> Zn(7-n)T + nZn(2+

67 Expression of metallothionein B, which has known roles in inflammation

68 -induced transcription at an inducible gene, metallothionein B.

69 Importantly, the beneficial effects of metallothionein blockade on muscle mass and function was

70 We therefore investigated the effect of metallothionein blockade on skeletal muscle anabolism in

71 Pase efflux pump (Bxa1) and an intracellular metallothionein (BmtA).

72 Here we describe related bacterial metallothioneins (BmtA) from Anabaena PCC 7120, Pseudomo

73 These genes include metallothionein, cadherin and iroquois gene families, as

74 yte viability, such as BCL2-related protein, metallothioneins, CD71, and SOCS3, was up-regulated at 4

75 A clone for a type 1 metallothionein (cgMT1) was isolated from a Casuarina gl

76 duction of genes encoding the Cu-detoxifying metallothionein (Cmt) proteins.

77 ne the influence of protein concentration on metallothionein conformation, the isolated Cd(4)-alpha-d

78 Overexpression of metallothioneins correlated with measures of disease pro

79 at thionein, the reduced, metal-free form of metallothionein, could function as a reducing system for

80 lymer chains using the N- and C-termini of a metallothionein derived from a pea plant.

81 A second extensive subfamily of oyster metallothioneins (designated as CvMT-II) has apparently

82 hat are unable to produce the major forms of metallothionein do not produce lead inclusion bodies, wh

83 Metallothionein expression during disease progression an

84 These results demonstrate dysregulated metallothionein expression in ascending aortic smooth mu

85 s, our findings implicate a role of elevated metallothionein expression in the clinical behavior of M

86 In vitro studies indicated that metallothionein expression is regulated in response to o

87 lls are stimulated continually through PRRs; metallothionein expression was up-regulated in human and

88 in G93A SOD1 mice is dependent on levels of metallothionein expression.

89 of Slc39a6 and Slc39a7 but not Slc39a8, nor metallothionein expression.

90 opper toxicity and fail to up-regulate MtnA (metallothionein) expression in response to excess Cu.

91 ents and control donors; 8 were genes of the metallothionein family.

92 ied by a unique ultrastructure and by copper-metallothionein fluorescence.

93 d in the ubiquitin proteasome pathway (UPP), metallothionein function, and protease inhibition.

94 fish Danio rerio, evaluated by assessment of metallothionein gene (mt2) expression, was reduced in th

95 Metallothionein gene expression and protein expression w

96 plementation increases intestinal copper and metallothionein gene expression, and Ctr1 protein levels

97 othesize that this is due to similarities in metallothionein gene expression.

98 ding possible metal-binding ligands from the metallothionein gene family, and a P-type ATPase that is

99 integration of avian retrovirus DNA into the metallothionein gene, before and after its induction to

100 A type 2 metallothionein gene, SsMT2, was cloned from Suaeda sals

101 We identified two metallothionein genes (CMT1 and CMT2), encoding cysteine

102 A binding, and transcriptional activation of metallothionein genes (MT genes) by MTF-1.

103 Metallothionein genes are highly expressed under various

104 tor-1 (MTF-1) was required for regulation of metallothionein genes in human MDMs.

105 propriate expression level of the endogenous metallothionein genes is achieved only when the activiti

106 We exploited the robust response of the metallothionein genes to heavy metal as a model for tran

107 Metallothionein genes were significantly overexpressed i

108 ary for basal and zinc-induced expression of metallothionein genes.

109 for basal and zinc-induced transcription of metallothionein genes.

110 Finally, an earthworm metallothionein-GFP construct could be activated in C. e

111 Finally, metallothionein-gold complexes visualized in the TEM sho

112 nts with a polymorphism in a gene regulating metallothionein had lower platinum concentrations and sh

113 The dearth of other reported bacterial metallothioneins has been surprising.

114 Oyster metallothioneins have been characterized as cDNA and as

115 control of the copper-inducible C. glabrata metallothionein I (MT-1) promoter.

116 ction significantly decreased zinc-dependent metallothionein I (MT-I) gene transcription without alte

117 Metallothionein I and II are small metal binding protein

118 d in their accumulation; and 2) unlike mouse metallothionein I and zip4 mRNAs, the abundance of zip1,

119 Metallothionein I as a direct link between therapeutic h

120 DAC) synergistically activate the methylated metallothionein I gene (MT-I) promoter in mouse lymphosa

121 EnT) under the control of an inducible mouse metallothionein I promoter.

122 croglia and the Bergmann glial expression of metallothionein I/II and the hyaluronan receptor CD44 we

123 on factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals.

124 ts of mouse MTF-1 to regulate the endogenous metallothionein-I (MT-I) gene in cells lacking endogenou

125 The expression of metallothionein-I (MT-I), a known antioxidant, was suppr

126 The robust induction of metallothionein-I and II (MT-I and MT-II) genes by sever

127 ssociation of transcription factors with the metallothionein-I promoter was examined using chromatin

128 eporter plasmids containing the native mouse metallothionein-I proximal promoter.

129 n of genes involved in metal ion regulation (metallothionein-I, metallothionein-III, ferritin-H, and

130 Recently, we found that metallothionein-I/-II double knockout (metallothionein-n

131 hionein IIa to five times higher levels than metallothionein Ig.

132 Lens metallothioneins (Ig, If, Ih, Ie, and IIa) and alpha-cry

133 The levels of lens metallothioneins (Ig, If, Ih, Ie, and IIa) and alpha-cry

134 n of cyan fluorescent protein (CFP), chicken metallothionein II (MT-II), and yellow fluorescent prote

135 Chemoattraction toward a gradient of metallothionein II was calcium-dependent, required the e

136 In these in vivo studies, metallothionein II was shown to enhance epidermal nerve

137 Conversely, only one LRP ligand, metallothionein II, was found to be chemoattractive.

138 te that both LRP1 and LRP2 are necessary for metallothionein II-mediated chemotactic signal transduct

139 Similar responses of the metallothionein IIa gene were detected in identically tr

140 Cd(2+) and Zn(2+) induced metallothionein IIa to five times higher levels than met

141 oglobulin, tissue plasminogen activator, and metallothionein III.

142 Recent studies have shown that metallothionein-III (MT-III), but not MT-I or -II, antag

143 ntracellular Zn(2+)-binding proteins such as metallothionein-III (MT-III).

144 in metal ion regulation (metallothionein-I, metallothionein-III, ferritin-H, and ferritin-L) at 4 mo

145 nant species at micromolar concentrations of metallothionein in cells.

146 The functional importance of metallothioneins in cadmium trafficking was highlighted

147 ke receptors 5 and 9 increase the effects of metallothioneins in MDMs.

148 We hypothesized that manipulation of metallothioneins in vivo might alter the disease phenoty

149 omeostasis (Menkes Copper ATPase (Atp7a) and metallothionein) in the duodenal epithelium of iron-defi

150 tation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the gen

151 in-knockout and wild-type mice, indicating a metallothionein-independent zinc protection.

152 and induced expression of a gene encoding a metallothionein involved in detoxification by metal ion

153 Metallothionein is a poorly characterized, metal-binding

154 ere it is shown that the previously reported metallothionein is a prototypical member of a subfamily

155 e Zn(3)S(9) and Zn(4)S(11) clusters of human metallothionein is in a tetrathiolate coordination envir

156 f high copper exposure, Ctr1 is endocytosed, metallothionein is induced, and ATP7A moves to a more ba

157 This novel fusion between Dps and metallothionein is unique to and conserved in all Borrel

158 olecular-weight proteins like calmodulin and metallothioneins is challenging and requires modificatio

159 evidence that the transcriptional control of metallothioneins is fundamentally divergent in lower inv

160 sponse that manifested in elevated levels of metallothionein isoform and zinc transporter 1 (ZnT1) tr

161 n events that have led to the development of metallothionein isoforms containing one to four alpha-do

162 by the analysis of a mixture of rabbit liver metallothionein isoforms.

163 ionein null allele, as well as RNAi mediated metallothionein knock-downs.

164 y restored bacterial clearance to MDMs after metallothionein knockdown.

165 on by Zn-depletion conditions is dampened in metallothionein knockout mice, suggesting that intracell

166 ac hypertrophy and fibrosis were produced in metallothionein-knockout (MT-KO) mice fed an alcohol-con

167 Metallothionein-knockout and wild-type 129/Sv mice were

168 hepatic tumor necrosis factor-alpha in both metallothionein-knockout and wild-type mice, indicating

169 ntributed to the regulation in expression of metallothioneins, levels of zinc, autophagy, and bacteri

170 homology with IDS1 with similarity to type 2 metallothionein like protein.

171 The small Arabidopsis genome contains nine metallothionein-like (MT) sequences with classic, cystei

172 Deletion of a C-terminal metallothionein-like Cys-rich domain impacted neither nu

173 ribution in two subcellular fractions (i.e., metallothionein-like proteins and metal-rich granules).

174 l, which includes metallothioneins (MTs) and metallothionein-like proteins and peptides (MTLPs), appe

175 sporters, copper ion chaperones and putative metallothionein-like proteins were significantly more ab

176 ess are exemplified by jasmonate-responsive, metallothionein-like, late-embryogenesis-abundant (LEA)

177 hemokines, antiviral proteins, histones, and metallothioneins, many of which were also induced by inf

178 Collectively, our data demonstrated that metallothionein may alleviate aging-induced cardiac cont

179 Poor production of metallothionein may predispose human populations to lead

180 These data suggest that metallothionein may protect against high-fat diet-induce

181 Metallothionein mice showed a longer life span (by appro

182 stribution of gold atoms bound to individual metallothionein molecules.

183 Aged metallothionein mouse myocytes were more resistant to th

184 During fasting, metallothionein mRNA increased dramatically, mRNAs for e

185 n(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip1

186 Zip14 siRNA treatment also decreased metallothionein mRNA levels, suggesting that compensator

187 5Y cells, and the neuroprotective effects of metallothionein (MT) against salsolinol toxicity in MT o

188 genic mice that overexpress cardiac-specific metallothionein (MT) are highly resistant to diabetes-in

189 Metallothionein (MT) as a potent antioxidant prevents th

190 ce-coupled proteins transferrin, albumin, or metallothionein (MT) as well as the toxic cadmium-MT (Cd

191 It represents a new metallothionein (MT) fold with a protein chain where the

192 ce and cells, lacking the major forms of the metallothionein (MT) gene, was compared to wild-type (WT

193 at single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual

194 anosensor to study the potential function of metallothionein (MT) in metal transfer and its interacti

195 transgenic overexpression of the antioxidant metallothionein (MT) in pancreatic beta cells provided b

196 ed overexpression of the antioxidant protein metallothionein (MT) in the heart.

197 The metal binding protein metallothionein (MT) is a target for nitric oxide (NO),

198 identification and characterization of human metallothionein (MT) isoforms in complex cell cultures u

199 Studies have shown that metallothionein (MT) may play an important role in modul

200 ia and whether the inhibition is mediated by metallothionein (MT) or is independent of MT.

201 sperm genomes contain several genes encoding metallothionein (MT) proteins that can bind metals inclu

202 Metallothionein (MT) releases zinc under oxidative stres

203 ice that overexpress the antioxidant protein metallothionein (MT) specifically in podocytes (Nmt mice

204 m zinc toxicity by inducing proteins such as metallothionein (MT) that bind it tightly, by sequesteri

205 Metallothionein (MT), a stress-response protein, is sign

206 ke growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alp

207 ne depletion and the free radical scavenger, metallothionein (MT), on cardiac function.

208 ripheral blood, we evaluated the response of metallothionein (MT), zinc transporter, and cytokine gen

209 pe (WT) and MT-knockout (MT-KO) mice lacking metallothionein (MT)-1 and MT-2 were exposed to three at

210 Of 15,000 mouse cDNA fragments studied, metallothionein (Mt)-1 and Mt2 emerged as candidate gene

211 at was up-regulated under both conditions is metallothionein (MT)-I.

212 Administration of LPS to metallothionein (MT)-knockout (MT-KO) mice and 129/Sv wi

213 We evaluated metallothionein (MT)-mediated cardioprotection from angi

214 Previous studies using metallothionein (MT)-overexpressing transgenic mice have

215 Previous studies using a cardiac-specific metallothionein (MT)-overexpressing transgenic mouse mod

216 phy and massive foveolar hyperplasia in both metallothionein (MT)-TGFalpha mice and patients with Men

217 ich was induction of the antioxidant protein metallothionein (Mt).

218 ic hearts overexpressing antioxidant protein metallothionein (MT).

219 g to investigate the transcriptome, we found metallothionein (MT, particularly MT-I) transcripts were

220 ted with transcriptionally silent methylated metallothionein (MT-I) promoter in the mouse lymphosarco

221 Metallothioneins (MT) are potent scavengers of free radi

222 Metallothioneins (MT), induced at high levels by oxidati

223 The serum sample containing metallothionein(MT)-bound and non-MT-bound Cd(II) was ac

224 s (UBE3C, Atrogin-1, MURF1, and PSMD11), the metallothioneins (MT1A, MT1F, MT1H), and the protease in

225 detoxifying and antioxidant genes, including metallothioneins MT1H, MT1M, and MT1X that have previous

226 nematode Caenorhabditis elegans has only two metallothioneins, mtl-i and mtIl-2, thus making it an id

227 pools, whereas the MMW pool, which includes metallothioneins (MTs) and metallothionein-like proteins

228 In this context metallothioneins (MTs) appear to play a central gate-kee

229 Metallothioneins (MTs) are cytoplasmic proteins that seq

230 Metallothioneins (MTs) are low-molecular-weight, cystein

231 Metallothioneins (MTs) are small cysteine-rich proteins

232 Metallothioneins (MTs) are typically low molecular weigh

233 sequestered labile Zn by inducing binding to metallothioneins (MTs) in a STAT3 and STAT5 transcriptio

234 induced protein expression of Hspa5 but not metallothioneins (MTs) in astrocytes.

235 examined the profiling of gene expression of metallothioneins (MTs) in human tissues from cadaver eye

236 Metallothioneins (MTs) in the brain and retina are belie

237 The metallothioneins (MTs) represent a family of zinc bindin

238 Here, we show that IL-27 induces metallothioneins (MTs) that in turn prevent Tr1 cell dev

239 e gene family of proteins, the metal binding metallothioneins (MTs), out of more than 10,500 cDNAs sc

240 The Cd(2+)-inducible metallothionein (MTT1) gene was cloned from Tetrahymena

241 es a gene that encodes the copper-protective metallothionein MymT, was highly induced in wild-type Mt

242 olution structure of Neurospora crassa Cu(6)-metallothionein (NcMT) polypeptide backbone was determin

243 scent protein (GFP) expressing transgenes, a metallothionein null allele, as well as RNAi mediated me

244 etate were tested in groups (n = 25) of male metallothionein-null and WT mice receiving drinking wate

245 Thus, the metallothionein-null mice cannot form renal inclusion bo

246 more common and more severe in lead-exposed metallothionein-null mice than in WT mice.

247 ntly observed in WT mice but did not form in metallothionein-null mice.

248 ll carcinoma also occurred in a lead-treated metallothionein-null mouse, whereas none occurred in WT

249 that metallothionein-I/-II double knockout (metallothionein-null) mice that are unable to produce th

250 The originally reported metallothionein of the American oyster, Crassostrea virg

251 This study examined the role of antioxidant metallothionein on cardiomyocyte function, superoxide ge

252 ate the impact of the free radical scavenger metallothionein on high-fat diet-induced myocardial, int

253 Measures of metallothionein or cellular zinc transporters may fulfil

254 does not resemble the published spectra for metallothionein or glutathione.

255 all zinc reserve that includes zinc bound to metallothionein or zinc stored in the Golgi or in other

256 tocin (STZ) (150 mg/kg) in cardiac-specific, metallothionein-overexpressing transgenic (MT-TG) mice a

257 Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice a

258 This substantiates the notion that metallothioneins play a pivotal role in the protection f

259 We hypothesize that metallothionein plays a pivotal role in the response of

260 in, high MeHg and iHg concentrations induced metallothionein production.

261 human RET oncogene under the control of the metallothionein promoter (MT/ret mice)].

262 CBS cDNA under control of the zinc-inducible metallothionein promoter (Tg-CBS).

263 expression of Bcl-2 in transgenic mice by a metallothionein promoter caused increased LPS-induced go

264 an Arf transgene driven by a zinc-inducible metallothionein promoter, sumoylation of endogenous Mdm2

265 Ex5/+KTS) under the control of the inducible metallothionein promoter.

266 transfected with OATP2 under regulation of a metallothionein promoter.

267 o episomal vectors predictably re-programmed metallothionein-promoter-driven reporter expression.

268 haromyces cerevisiae, the genes encoding the metallothionein protein Cup1 are located in a tandem arr

269 to assign metal ion binding sites for human metallothionein protein MT-2a.

270 mpassing 19 known genes including 9 encoding metallothionein proteins.

271 At thionein/metallothionein ratios > 0.75, free Zn(II) ions are belo

272 CUP1 encodes a metallothionein required for cell growth at high copper

273 Analysis of metallothioneins revealed that certain CvMT-I isoforms s

274 plasmin, complement components, lipocalin-2, metallothionein, serine protease inhibitor-2, transferri

275 gh levels of copper induce the expression of metallothioneins, small sulfhydryl-rich proteins with hi

276 Bacterial metallothionein, SmtA from Synechococcus PCC 7942, seque

277 st report of a possible single-"superdomain" metallothionein structure for Zn(2+) and Cd(2+) binding

278 nscript levels of a constitutively expressed metallothionein, suggesting increased copper chelation c

279 Metallothionein suppresses Ang II-induced NOX-dependent

280 of a small molecule chemical analogue of the metallothionein system in which an N-O reactant serves t

281 In yeast, the CUP1 gene encodes a copper metallothionein that is strongly induced in response to

282 to the sequestration of cytosolic copper by metallothioneins that are markedly up-regulated in Atp7b

283 nction module is downstream of intracellular metallothioneins that regulate zinc metabolism and can b

284 y of the chemical and enzymatic oxidation of metallothionein/thionein.

285 es in the levels of intracellular free zinc, metallothionein transcripts, inhibition of thioredoxin r

286 FVB and metallothionein transgenic mice were fed a high- or low-

287 ich may contribute to prolonged life span in metallothionein transgenic mice.

288 mo) FVB wild-type (WT) and cardiac-specific metallothionein transgenic mice.

289 ptible to oxidative stress, and induction of metallothionein under oxidative stress was reduced in BA

290 in, and analysis of Zn(II) dissociation from metallothionein using the fluorescent chelating agents F

291 NMR determination of the structure of Cd(7)-metallothionein was done previously using a relatively l

292 Metallothionein was often found associated with the oute

293 id percussion, analysis of the metal load of metallothionein was used as an indicator of changes in c

294 expression of the prioritized gene family of metallothioneins was evaluated in postmortem patient bra

295 s of the proteasome subunit (PSMD11) and the metallothioneins were increased 5 days post-SCI.

296 (2+) and Zn(2+), but not Cu(2+), induced the metallothioneins, whereas Cd(2+) and Cu(2+), but not Zn(

297 ed the expression of multiple genes encoding metallothioneins, which bind and regulate levels of intr

298 y accelerated in G93A SOD1 mice deficient in metallothioneins with regard to onset (MT-I and MT-II) o

299 chondrial and cell signaling were negated by metallothionein, with the exception of pFoxo3a.

300 ein has been identified as a zinc-containing metallothionein (Zn-MT).