ライフサイエンスコーパス: metanephric mesenchyme

1 ially modulates nephron development from the metanephric mesenchyme.

2 o-epithelial transition in cultured isolated metanephric mesenchyme.

3 s with FGF receptors in the ureteric bud and metanephric mesenchyme.

4 d in tubular structures that derive from the metanephric mesenchyme.

5 wth and do not express GDNF in the uninduced metanephric mesenchyme.

6 ium, whereas alpha8beta1 is expressed in the metanephric mesenchyme.

7 so isolated and characterized cells from rat metanephric mesenchyme.

8 of the c-ret Rtk, is not detected in Eya1-/- metanephric mesenchyme.

9 l signaling between the ureteric bud and the metanephric mesenchyme.

10 gnaling can prevent apoptosis in explants of metanephric mesenchyme.

11 initial induction of Pax-2 expression in the metanephric mesenchyme.

12 cell-cell or cell-ECM interactions with the metanephric mesenchyme.

13 the epithelium of the ureteric duct and the metanephric mesenchyme.

14 f2) is required for the specification of the metanephric mesenchyme.

15 s the expression of both Eya1 and Wt1 in the metanephric mesenchyme.

16 the interaction of the ureteric bud and the metanephric mesenchyme.

17 fian duct branches and invades the overlying metanephric mesenchyme.

18 activate expression of Six2 and Gdnf in the metanephric mesenchyme.

19 ngle isolated bud and its recombination with metanephric mesenchyme.

20 tage E12.5 in the murine ureteric bud and/or metanephric mesenchyme.

21 of the progenitor cell population within the metanephric mesenchyme.

22 ogether are critical for normal formation of metanephric mesenchyme.

23 anch, and the mice do not develop an obvious metanephric mesenchyme.

24 interaction between the ureteric bud and the metanephric mesenchyme.

25 and renal progenitors that are derived from metanephric mesenchyme.

26 uired for the earliest inductive response in metanephric mesenchyme.

27 ic buds, which branched independently of the metanephric mesenchyme.

28 interaction between the ureteric bud and the metanephric mesenchyme.

29 ephric duct and its derivatives, but not the metanephric mesenchyme.

30 itioning of the ureteric bud, the inducer of metanephric mesenchyme.

31 by controlling the expression of Gdnf in the metanephric mesenchyme.

32 red for the expression of these genes in the metanephric mesenchyme.

33 functions downstream of Eya1 and Six1 in the metanephric mesenchyme.

34 ced sevenfold more glomeruli than did intact metanephric mesenchyme (5 glomeruli, 127 tubules).

35 f8 expression was reduced in early-stage DKO metanephric mesenchyme, accompanied by reduced levels of

36 It is believed that Gdnf, produced in the metanephric mesenchyme, activates Ret signaling in the W

37 Kidney epithelia develop from the metanephric mesenchyme after receiving inductive signals

38 nt and in response to inductive signals, the metanephric mesenchyme aggregates, becomes polarized, an

39 5 results in improper differentiation of the metanephric mesenchyme and absence of essential developm

40 Normally, GDNF is secreted by the metanephric mesenchyme and acts via receptors on the Wol

41 They are expressed in the early metanephric mesenchyme and are required for the inductio

42 nectin-deficient ureteric buds to invade the metanephric mesenchyme and begin branching.

43 cell line thought to originate in the early metanephric mesenchyme and glial cell line-derived neuro

44 signaling molecule GDNF is expressed in the metanephric mesenchyme and has recently been implicated

45 hat PDGFR beta localizes to undifferentiated metanephric mesenchyme and is later expressed in the cle

46 e enriched in the ureteric bud compared with metanephric mesenchyme and predicted to code for secrete

47 pment have considered the interaction of the metanephric mesenchyme and the ureteric bud to be the ma

48 ined its ability both to promote survival of metanephric mesenchyme and to induce nephrogenesis in cu

49 tion of two embryonically distinct analages, metanephric mesenchyme and ureteric bud.

50 ity preferentially in epithelia derived from metanephric mesenchyme, and defects in kidney architectu

51 Mice lacking Odd1 do not form metanephric mesenchyme, and do not express several other

52 posterior intermediate mesodermal cells, the metanephric mesenchyme, and induces the formation of the

53 prouty1 and WT1 overlapped in the developing metanephric mesenchyme, and Sprouty1, like WT1, plays a

54 teractions between the ureteric bud (UB) and metanephric mesenchyme are crucial for tubulogenesis dur

55 ractions between the ureteric epithelium and metanephric mesenchyme are essential for kidney morphoge

56 ions between the ureteric epithelium and the metanephric mesenchyme are needed to drive growth and di

57 dicate that Sall1-dependent signals from the metanephric mesenchyme are required to modulate ureteric

58 s between the embryonic ureteric bud and the metanephric mesenchyme are the basis for kidney developm

59 ng molecules, we developed an assay in which metanephric mesenchymes are rescued from apoptosis by fa

60 g kidney, Six1 is expressed in the uninduced metanephric mesenchyme at E10.5 and in the induced mesen

61 Eya1 expression was unaffected in Six1(-/-) metanephric mesenchyme at E10.5, indicating that Eya1 ma

62 Sall1 expression was markedly reduced in the metanephric mesenchyme at E10.5, indicating that Six1 is

63 a8 integrin-null mutants specifically in the metanephric mesenchyme at the time of ureteric bud invas

64 pm7 is essential for kidney development from metanephric mesenchyme but not ureteric bud.

65 lling is not active in the early nephrogenic metanephric mesenchyme, but instead provide expressional

66 , the ureteric bud grows out and invades the metanephric mesenchyme, but it fails to initiate branchi

67 bryos by specifically expressing Six1 in the metanephric mesenchyme, but not the ureter, under contro

68 be traced to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early s

69 cterized an explant culture system, in which metanephric mesenchyme can grow and completely different

70 ble factor(s) in the conditioned medium of a metanephric mesenchyme cell line is essential for multip

71 eiotrophin, from the conditioned medium of a metanephric mesenchyme cell line that induces isolated u

72 ctors present in the conditioned medium of a metanephric mesenchyme cell line.

73 ble factors derived from an embryonic kidney metanephric mesenchyme cell line.

74 In branching UBs induced by whole metanephric mesenchyme cell-conditioned medium, prolifer

75 8 gene is expressed together with Hoxa 11 in metanephric mesenchyme cells, and mutation of Integrin a

76 Indeed, when applied to isolated rat metanephric mesenchyme, CLF-1/CLC (3 nM) induced mature

77 Osr1, Eya1, Pax2 or Wt1 gene function in the metanephric mesenchyme compromises the formation of the

78 During kidney development, the metanephric mesenchyme contributes to emerging epitheliu

79 As a result of this induction, most of the metanephric mesenchyme converts into epithelium of a nep

80 The metanephric mesenchyme-derived signals that control gene

81 l morphogenesis of both the ureteric bud and metanephric mesenchyme-derived structures.

82 Despite the restricted expression of Pbx1 in metanephric mesenchyme, developing nephrons, and stroma,

83 Although, in vivo, metanephric mesenchyme development occurs simultaneously

84 In the embryonic kidney, progenitors in the metanephric mesenchyme differentiate into specialized re

85 Furthermore, the mutant metanephric mesenchyme displayed a normal capacity to di

86 Smad4-deficient metanephric mesenchyme does not display defects in induc

87 onship between Pax, Eya and Six genes in the metanephric mesenchyme during early kidney development i

88 al, proliferation and differentiation of the metanephric mesenchyme during kidney development.

89 In situ, the ureteric bud expressed LIF, and metanephric mesenchyme expressed its receptors.

90 me and proper demarcation of mesonephric and metanephric mesenchyme from the WD depends on RetY1015 s

91 nd/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are s

92 Metanephric mesenchyme gives rise to both the epithelial

93 vitro and in vivo, a fraction of the induced metanephric mesenchyme in Cad-6 mutant kidneys fails to

94 survival factors (EGF, bFGF) and inducers of metanephric mesenchyme, including the ureteric bud, spin

95 During kidney development, factors from the metanephric mesenchyme induce the growth and repeated br

96 senchyme to differentiate into nephrons, and metanephric mesenchyme, inducing the ureteric bud to gro

97 ells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into n

98 the subsequent invasion of the bud into the metanephric mesenchyme initiate the process of metanephr

99 As such, the metanephric mesenchyme is a renal progenitor cell popula

100 By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and

101 We demonstrate that Pax2 expression in the metanephric mesenchyme is independent of induction by th

102 egrin, invasion by the ureteric bud into the metanephric mesenchyme is inhibited, resulting in renal

103 cular mechanism for induction of Gdnf in the metanephric mesenchyme is not completely defined.

104 ow that both Eya1 and Six1 expression in the metanephric mesenchyme is preserved in Pax2(-/-) embryos

105 Differentiation of metanephric mesenchyme is triggered by an inductive sign

106 between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium

107 oligonucleotides reduced condensation of the metanephric mesenchyme, leading to a decreased number of

108 he overexpression of beta-catenin within the metanephric mesenchyme leads to ectopic and disorganized

109 Second, beta-catenin overexpression in the metanephric mesenchyme leads to elevated levels of trans

110 inactivation of p53 in the UB but not in the metanephric mesenchyme lineage recapitulated the duplex

111 phric capillaries express Tie genes, whereas metanephric mesenchyme, maturing tubules, and mature pod

112 Mutual interaction between the metanephric mesenchyme (MM) and the ureteric bud (UB) in

113 sence of a conditioned medium derived from a metanephric mesenchyme (MM) cell line.

114 canonical Wnt signaling is not activated in metanephric mesenchyme (MM) during its conversion to the

115 neage tracing studies suggest that condensed metanephric mesenchyme (MM) gives rise to nephronic epit

116 disruptions led to more medially positioned metanephric mesenchyme (MM) in midgestation.

117 The embryonic mammalian metanephric mesenchyme (MM) is a unique tissue because i

118 We find that the expression of Grem1 in the metanephric mesenchyme (MM) is Six1-dependent.

119 ssed in the ureteric bud (UB) epithelium and metanephric mesenchyme (MM) lineages.

120 owth factor receptors (Fgfrs) 1 and 2 in the metanephric mesenchyme (MM) of mice leads to a virtual a

121 Analysis of the progression of the metanephric mesenchyme (MM) through four stages of tubul

122 dneys, aberrant cell death occurs within the metanephric mesenchyme (MM), particularly in the cortica

123 s likely due to a defect in induction of the metanephric mesenchyme (MM), which along with the ureter

124 ival and maintenance of the undifferentiated metanephric mesenchyme (MM).

125 ed medium secreted by cells derived from the metanephric mesenchyme (MM).

126 s dynamically regulated in cultured isolated metanephric mesenchyme (MM).

127 sis of the ureteric bud (UB) [induced by the metanephric mesenchyme (MM)] is necessary for normal kid

128 ured UB was recombined with freshly isolated metanephric mesenchyme, nephric units were induced in th

129 The ureteric bud invades the metanephric mesenchyme normally, but subsequent bud bran

130 The metanephric mesenchyme of mutant embryos lacking a urete

131 The metanephric mesenchyme of these mutants fails to express

132 lator has yet been identified to specify the metanephric mesenchyme or blastema within the intermedia

133 e or together with Bmp7) maintained isolated metanephric mesenchyme or sorted nephron progenitors tha

134 both DLG1 and CASK either 1) globally, 2) in metanephric mesenchyme, or 3) in nephron progenitors.

135 human embryos, OFD1a immunolocalized to the metanephric mesenchyme, oral mucosa, nasal and cranial c

136 f metanephric fate and in the maintenance of metanephric mesenchyme proliferation and survival by act

137 n which the elevation of beta-catenin in the metanephric mesenchyme results in cell-autonomous and no

138 Co-culture of isolated ureteric buds and metanephric mesenchyme show that the primary defect is i

139 ance of Wnt-ll expression are independent of metanephric mesenchyme-specific factors.

140 ent in a conditioned medium derived from the metanephric mesenchyme that supports non-branching growt

141 clusters of epithelial progenitors from the metanephric mesenchyme, thereby separating them from the

142 Signals from the ureter induce the metanephric mesenchyme to condense and proliferate aroun

143 etween the ureteric bud epithelium, inducing metanephric mesenchyme to differentiate into nephrons, a

144 vates the expression of Six2 and Gdnf in the metanephric mesenchyme to drive nephrogenesis.

145 , mimicking the effect of BMP-7 on embryonic metanephric mesenchyme to generate epithelium.

146 for the normal nephrogenesis response of the metanephric mesenchyme to inductive signals from the ure

147 types of epithelial cells differentiate from metanephric mesenchyme to populate nephrons.

148 renal collecting system induces surrounding metanephric mesenchyme to proliferate and differentiate

149 k by antagonizing inductive signals from the metanephric mesenchyme to the illegitimate sites on the

150 angial cell precursors from undifferentiated metanephric mesenchyme to the mesangial area.

151 Metanephric mesenchyme was atrophic, had reduced cell re

152 owth factor receptors (fgfrs) 1 and 2 in the metanephric mesenchyme, we generated conditional knockou

153 by isolating epithelial progenitors from the metanephric mesenchyme, we show that they are targeted b

154 When separated 13 dpc rat metanephric mesenchymes were cultured in serum-free cond

155 are thought to play an important role in the metanephric mesenchyme, when cells aggregate to form the

156 ficient to trigger tubulogenesis in isolated metanephric mesenchyme, whereas Wnt-11 which is expresse

157 In vivo, the bl/bl bud fails to invade metanephric mesenchyme which undergoes involution, event

158 ney, the epithelial ureteric bud invades the metanephric mesenchyme, which directs the ureteric bud t

159 its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to grow and different

160 Hoxa11 expression is restricted to the early metanephric mesenchyme, which induces ureteric bud forma

161 een the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to f

162 yet to be identified) factor produced by the metanephric mesenchyme, which mediates the inductive eff