ライフサイエンスコーパス: metaplastic

1 Metaplastic acinar structures were highly proliferative,

2 Metaplastic activation of ryanodine receptors (RyRs) in

3 We examined the extent of ectopy and metaplastic activity as risks for HPV16 acquisition in a

4 ization to evaluate the expression of p27 in metaplastic and dysplastic Barrett's epithelium and to a

5 message and protein parallel one another in metaplastic and dysplastic Barrett's epithelium, suggest

6 nodes but to a lesser extent in a subset of metaplastic and dysplastic Barrett's samples.

7 at present there is no direct evidence that metaplastic and dysplastic epithelia are clonal precurso

8 As infection progresses, metaplastic and dysplastic glands appear, which are resi

9 As disease progresses, metaplastic and dysplastic glands arise which express Fa

10 Metaplastic and dysplastic glands can be genetically rel

11 that dopamine may constitute a new player in metaplastic and homeostatic processes in the prefrontal

12 The overexpression of c-neu in the metaplastic and malignant neoplastic glands also correla

13 nts that result in the curative depletion of metaplastic and neoplastic cell populations in BE in ter

14 ed the pattern of CDX1 protein expression in metaplastic and neoplastic tissue to provide insight int

15 ffected organs showed variable hyperplastic, metaplastic, and connective tissue changes, indicating t

16 receptor were performed on normal, inflamed, metaplastic, and malignant esophageal mucosa.

17 lates LI-cadherin gene expression in normal, metaplastic, and neoplastic tissues of the gastrointesti

18 nt with those results, we observed that both metaplastic areas and (pre)malignant lesions of the esop

19 ia, we measured expression of these genes in metaplastic Barrett's and esophageal adenocarcinomas.

20 In metaplastic Barrett's epithelium, p27 protein and mRNA w

21 In a model of metaplastic basal-like breast carcinoma progression, we

22 of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and l

23 Furthermore, we show that the development of metaplastic breast cancer is attributable, in part, to t

24 tify mesenchymal TNBC are under development, metaplastic breast cancer serves as a clinically identif

25 associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negati

26 mal TNBC can be classified histologically as metaplastic breast cancer, a chemorefractory group of tu

27 Metaplastic breast cancers (MBC) are aggressive, chemore

28 Finally, we found that 63% of metaplastic breast cancers, a rare type of basal-like ca

29 Metaplastic breast carcinoma (MBC) is a rare histologica

30 Metaplastic breast carcinoma is an aggressive form of in

31 ed in clinical samples of human spindle cell metaplastic breast carcinoma.

32 na fide EMT, histologically similar to human metaplastic breast carcinomas.

33 iles," described for infiltrating lobular or metaplastic breast carcinomas.

34 ble, in part, to the transformation of these metaplastic breast epithelial cells.

35 Environmental factors are closely linked to metaplastic carcinogenesis.

36 comparison of orthologous genes with a human metaplastic carcinoma signature revealed a significant o

37 ole for Ccn6 deletion in the pathogenesis of metaplastic carcinomas with histological and molecular s

38 cinomas), and others very poor outcome (e.g. metaplastic carcinomas), whereas the broader immunohisto

39 gets in the diagnosis and treatment of human metaplastic carcinomas, and a new disease relevant model

40 e also rare types of breast cancers, such as metaplastic carcinomas, where tumor cells exhibit featur

41 uctal, 5 of 13 invasive lobular, and 1 of 13 metaplastic carcinomas.

42 which display similarities to human clinical metaplastic carcinomas.

43 flammation, parietal cell loss, atrophy, and metaplastic cell changes.

44 Metaplastic cell lineages in AR-/- mice showed increases

45 The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicob

46 It increased the number of squamous metaplastic cells and prolonged survival in mice consumi

47 c gastric glands atrophy and are replaced by metaplastic cells in response to chronic gastritis.

48 The metaplastic cells of Barrett's oesophagus are predispose

49 to those found in Dicer-deficient acini and metaplastic cells, namely induction of HNF6 and hepatic

50 /+) mice result from the clonal expansion of metaplastic cells.

51 ion for endocervical (columnar epithelial or metaplastic) cells and erythrocytes.

52 yofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic ef

53 cinoma may develop from Barrett esophagus, a metaplastic change of the esophageal epithelium from squ

54 Barrett's oesophagus is a metaplastic change of the lining of the oesophagus, such

55 n bronchial epithelium is a marker for early metaplastic changes and the loss of its expression is as

56 It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that o

57 mation of the gastric mucosa can progress to metaplastic changes in the stomach and to decreased colo

58 chial epithelial cells is a marker for early metaplastic changes induced by various toxicants/carcino

59 tion of biomarkers signifying progression of metaplastic changes.

60 interact to generate striking bidirectional metaplastic changes.

61 tions from stratified squamous epithelium to metaplastic columnar epithelium that predisposes individ

62 xpression of IVL, KRTDAP, DSG1, and GRHL1 in metaplastic compared to squamous epithelia.

63 d led to the persistence of acinar-to-ductal metaplastic complexes, with prolonged Sox9 expression an

64 Barrett esophagus (BE) is a human metaplastic condition that is the only known precursor t

65 breast cells could acquire invasiveness in a metaplastic context.

66 In gastrointestinal epithelium, metaplastic conversion between predominant cell types is

67 function in the pancreas by antagonizing the metaplastic conversion of acinar cells toward a ductal f

68 that MLE may be a transitional stage in the metaplastic conversion of squamous to columnar epitheliu

69 Furthermore, we show that intestinal metaplastic crypts are clonal, possess multiple stem cel

70 the pathways responsible for dysplastic and metaplastic development, selection of patient population

71 uodenal reflux in the etiology of esophageal metaplastic development.

72 sions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesopha

73 man pancreatic intraepithelial neoplasia and metaplastic duct lesions in human and mouse.

74 s studying the transition of acinar cells to metaplastic ductal cells in vivo is complicated by analy

75 ofound hyperglycemia and/or proliferation of metaplastic ductal epithelium.

76 up-regulated Pdx1 expression in premalignant metaplastic ductal epithelium.

77 g pancreatic epithelium through formation of metaplastic ductal intermediates.

78 These metaplastic ductal lesions (MDL) are called tubular comp

79 Three different types of metaplastic ductal lesions are observed and analyzed.

80 Metaplastic ductal lesions are seen in pancreatitis as w

81 Pancreatic metaplastic ducts are usually associated with pancreatit

82 H. pylori was detected inside metaplastic, dysplastic, and neoplastic epithelial cells

83 Here we demonstrate metaplastic effect of a change in NMDA receptor (NMDAR)

84 Stress and glucocorticoids appear to exert a metaplastic effect through the modulation of Ca2+ levels

85 Experience-dependent, pathway-specific metaplastic effects in a cortical structure have broad i

86 alignancy, but the cells of origin for these metaplastic epithelia and subsequent malignancies remain

87 so have the potential to induce formation of metaplastic epithelia in the pancreas.

88 se 7 (MMP-7), a proteinase expressed in most metaplastic epithelia in vivo.

89 ther analyses of these cells, in healthy and metaplastic epithelia, is required.

90 eration was elevated in undifferentiated and metaplastic epithelial cells in H/K-IFN-gamma transgenic

91 esence of one or more columnar epithelial or metaplastic epithelial cells or the presence of more tha

92 rat cholangiocarcinomas and in a majority of metaplastic epithelial cells within earlier formed preca

93 in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zo

94 n to Pdx1 gene activation, TGF-alpha-induced metaplastic epithelium demonstrated a pluripotent differ

95 h pathway is characterized by persistence of metaplastic epithelium expressing markers of pancreatic

96 lium and in putative precancerous intestinal metaplastic epithelium induced in the liver of furan-tre

97 Therefore, genotyping of Barrett's metaplastic epithelium may supplement the histopathologi

98 oth in esophageal adenocarcinomas and in the metaplastic epithelium of Barrett's esophagus.

99 have identified serum proteins secreted from metaplastic epithelium that can be used to predict disea

100 GLA-13(+) cells may give rise to respiratory metaplastic epithelium where GBCs are eliminated.

101 Most EAs arise in a metaplastic epithelium, Barrett's esophagus (BE), which

102 To assess Pdx1 gene expression in normal and metaplastic epithelium, we performed in vivo reporter ge

103 ch cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's

104 on was found at every evaluated level of the metaplastic epithelium.

105 Metaplastic esophageal columnar epithelium that does not

106 influence the initiation and maintenance of metaplastic events in pancreatic epithelium, explaining

107 n in normal pancreata they display PanIN and metaplastic features, such as expression of Shh and gast

108 The same changes were observed even in some metaplastic foci adjacent to dysplasia.

109 Metaplastic gastric mucosa was analyzed by dual immunost

110 on-neoplastic cells, including in intestinal metaplastic, gastritis and inflammatory cells.

111 We investigated whether cells within a metaplastic gland share a common origin, whether glands

112 lly expand by fission, and determine if such metaplastic glands are genetically related to the associ

113 The metaplastic glands expressed markers of SPEM and IM, and

114 be three to four times higher in intestinal metaplastic glands in precancerous cholangiofibrotic tis

115 ial cells of both early-appearing intestinal metaplastic glands in precancerous hepatic cholangiofibr

116 Metaplastic glands were derived from the same clone-all

117 Cytochrome c oxidase-deficient (CCO(-)) metaplastic glands were identified using a dual enzyme h

118 In comparison, epithelium from intestinal metaplastic glands within furan-induced hepatic cholangi

119 Mist1-Kras mice developed metaplastic glands, which completely replaced normal fun

120 or of apoptosis, is expressed in LPS-induced metaplastic goblet cells of rat airways.

121 During lactation, the mice develop multiple metaplastic growths which, surprisingly, do not spontane

122 y explores the role of mGluRs and PKC in the metaplastic inhibition of spinal cord learning using a c

123 Finally, a PKC inhibitor blocked the metaplastic inhibition of spinal learning produced by a

124 ound to be both necessary and sufficient for metaplastic inhibition of spinal learning.

125 carcinogenesis, being more pronounced in the metaplastic intestinal glands of cholangiofibrotic tissu

126 tinal-type cholangiocarcinomas as well as of metaplastic intestinal glands that precede their develop

127 haron, ectropion, entropion, trichiasis, and metaplastic lashes also were analyzed.

128 n in 8% (2/25; P = 0.47), and trichiasis and metaplastic lashes in 24% (6/25; P = 0.03) eyes.

129 ession was significantly higher in bronchial metaplastic lesions (23 of 49 lesions, 47%) than in hist

130 d2-null tumors contain severe dysplastic and metaplastic lesions and express aberrant amounts of beta

131 Whereas the majority of metaplastic lesions are not of acinar origin, acinar-to-

132 stric cancer by gene expression profiling of metaplastic lesions from patients.

133 are prominently overexpressed in intestinal metaplastic lesions in early putative precancerous chola

134 nking early putative precancerous intestinal metaplastic lesions in liver to later-developed mucin-pr

135 generation of normal tissue and formation of metaplastic lesions of a ductal phenotype.

136 Up-regulated transcripts in metaplastic lesions were confirmed by immunostaining ana

137 n normal oxyntic mucosa, rare in established metaplastic lesions, and lost in intraepithelial neoplas

138 However, it accounts for only a minority of metaplastic lesions.

139 tion is identified in a minority of mucinous metaplastic lesions.

140 cer using gene expression profiling of human metaplastic lesions.

141 t airways was not caused by an inflammatory, metaplastic-like response: bronchial-alveolar lavage leu

142 of Mist1-Kras mice led to the full range of metaplastic lineage transitions, including SPEM and IM.

143 the fundic mucosa leads to the emergence of metaplastic lineages associated with an increased suscep

144 tissues, whereas it was detected in <10% of metaplastic lung tissues, squamous cell carcinoma, and a

145 These findings reveal a novel metaplastic mechanism through which group II mGlu recept

146 We propose that RyR-mediated metaplastic mechanisms can be considered as a possible t

147 ng psoriatic plaques to hard palate, a novel metaplastic model is presented.

148 Finally, we found that metaplastic models are robust to changes in model parame

149 lity estimation task, we found that superior metaplastic models perform close to optimally for a wide

150 e Carlo simulations we identified 'superior' metaplastic models that can substantially overcome the a

151 ntiated and highly aggressive carcinoma with metaplastic morphology.

152 esophagus, we took biopsy specimens from the metaplastic mucosa before and after esophageal perfusion

153 Initially, at least 95% ablation of the metaplastic mucosa was achieved in all treated patients.

154 ected wild-type mice had severe atrophic and metaplastic mucosal changes.

155 its expression is responsible for sustaining metaplastic mucous cells.

156 may maintain MCM by preventing cell death in metaplastic mucous cells.

157 cells in the corpus and the appearance of a metaplastic mucous epithelium.

158 t maximum MCM, that IFN-gamma induces Bax in metaplastic mucus cells, and that Bax plays a critical r

159 n and the role of regulators of apoptosis in metaplastic mucus cells.

160 found that cortical inclusion cysts lined by metaplastic Mullerian epithelium abundantly express the

161 In NP, IL-19 is highly expressed in the metaplastic nasal epithelium when compared to normal or

162 nts in the development of malignancy: benign metaplastic never-dysplastic Barrett's esophagus (NDBE;

163 were verified as being expressed in squamous metaplastic NHTBE cells but not in normal mucous NHTBE o

164 ASF) from aberrantly differentiated squamous metaplastic normal human tracheobronchial epithelial (NH

165 e lining epithelia transform into a squamous metaplastic phenotype in vitamin A-deficient animals.

166 acute parietal cell loss revealed that this metaplastic phenotype might arise in part through transd

167 t predict a shift in the gastric mucosa to a metaplastic phenotype.

168 ent microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal cha

169 metriosis, by definitively demonstrating the metaplastic potential of stem cells within the peritonea

170 In the case of BE, which is a metaplastic precursor to esophageal adenocarcinoma (EAC)

171 for the clonal expansion and propagation of metaplastic premalignant lesions.

172 ins that are uniquely secreted from squamous metaplastic primary human bronchial epithelial cells cul

173 mechanisms are slowly emerging, much of the metaplastic process remains unknown.

174 n clinical course and has been regarded as a metaplastic process.

175 pithelium by a columnar epithelium through a metaplastic process.

176 veral infiltrating immune populations in the metaplastic progression following inflammation.

177 We calculated metaplastic rate as the difference in ectopy between vis

178 Metaplastic rate between the two visits before HPV16 det

179 stochemistry that gene expression changes in metaplastic recombinants reflected human urothelium unde

180 e whether specific EGFR ligands regulate the metaplastic response to oxyntic atrophy.

181 estrogen depletion might change the squamous metaplastic response to vitamin A deficiency and affect

182 M) computational model, which incorporates a metaplastic sliding threshold for LTP induction, account

183 y at the transformation zone, a region where metaplastic squamous cells are detected in otherwise col

184 expressed in the lower portions of normal or metaplastic squamous mucosa but that telomerase positive

185 ells undergoing transition to a precancerous metaplastic state in mouse and human stomach.

186 levels of synaptic activation will induce a metaplastic state that spreads across dendritic compartm

187 In particular, for binary synapses with metaplastic states, we demonstrate for the first time th

188 eal epithelium, mainly by directly affecting metaplastic stem cells.

189 cently been documented in tumors of the rare metaplastic subtype, here we report that rare Id1-expres

190 c glutamate receptor subtype 7 (mGluR7) is a metaplastic switch at MF-SLIN synapses, whose activation

191 fic response to inflammation, we postulate a metaplastic switch by which prepsoriatic skin is convert

192 erneuron (SLIN) synapses, mGluR7 serves as a metaplastic switch controlling bidirectional plasticity.

193 ggests that mGluR2 activation may serve as a metaplastic switch to permit the induction of LTD by inh

194 p, we investigated a biophysically inspired, metaplastic synaptic model within the context of a well-

195 In contrast, DNA from matched normal or metaplastic tissue (containing genetic material of both

196 otein; however, adjacent areas of intestinal metaplastic tissue intensely stained for CDX1.

197 However, squamous metaplastic tissue may be more influential.

198 Finally, we found that normal and metaplastic tissues from patients with evidence of assoc

199 Fifty-two women with metaplastic TNBC (median age, 58 years; range, 37-79 yea

200 Using metaplastic TNBC as a surrogate for mesenchymal TNBC, DA

201 should be performed to test DAT and DAE for metaplastic TNBC, as well as nonmetaplastic, mesenchymal

202 rson Cancer Center of patients with advanced metaplastic TNBC.

203 in and bevacizumab in patients with advanced metaplastic TNBC.

204 s no expression was found in either squamous metaplastic tracheal epithelium or in sections of human

205 e the existence of CD10(+) breast cells with metaplastic traits that can give rise to skin and epider

206 miR-32 increases proliferation and promotes metaplastic transformation in mouse prostate epithelium,

207 lial cells; these cells probably arise via a metaplastic transformation of preexisting endothelium.

208 e a microenvironment that sets the scene for metaplastic transformation of the oesophageal epithelium

209 romoted more extensive gastric inflammation, metaplastic transformation, and tumorigenesis than obser

210 , MMP-7 progressively accumulates during the metaplastic transition, resulting in a concomitant incre

211 bust to changes in model parameters and that metaplastic transitions are crucial for adaptive learnin

212 However, the mechanisms regulating metaplastic transitions in adult epithelia are largely u

213 (+) cells results in the development of rare metaplastic tumors reminiscent of the claudin-low subtyp