ライフサイエンスコーパス: metaplasticity

1 und changes that can be better described as "metaplasticity".

2 y to undergo a normal developmental shift in metaplasticity.

3 d is adjusted by overall neural activity via metaplasticity.

4 to their inability to undergo developmental metaplasticity.

5 riming protocol, in a manner consistent with metaplasticity.

6 olds, the slow dynamics of which account for metaplasticity.

7 memory and is achieved by mechanisms such as metaplasticity.

8 ethanol represents a form of NMDAR-mediated metaplasticity.

9 d by habituation, and is thus a paradigm for metaplasticity.

10 s important roles in synaptic plasticity and metaplasticity.

11 a novel spatially delimited form of synaptic metaplasticity.

12 adjust the threshold for plasticity, termed metaplasticity.

13 ticity and (2) the history of plasticity, or metaplasticity.

14 portant role in both information storage and metaplasticity.

15 uR7-RIM1alpha interactions underlies MF-SLIN metaplasticity.

16 ty, endocannabinoids (eCBs) act as agents of metaplasticity.

17 ticity, reduction of synaptic crosstalk, and metaplasticity.

18 form of plasticity has been referred to as 'metaplasticity', a modification of synapses reflected as

19 Here we studied metaplasticity affecting spike-timing-dependent plastici

20 DA-R function likely play a critical role in metaplasticity and in stabilizing activity levels in neu

21 scriptional coupling provides a mechanism of metaplasticity and may regulate capacity for synaptic mo

22 cetylase (HDAC) inhibition rescues GABAergic metaplasticity and normalizes AKAP signaling in MD anima

23 exhibit properties such as those observed in metaplasticity and synaptic scaling.

24 elayed expression of synaptic modifications, metaplasticity, and spacing effects.

25 However, the rules that govern synaptic metaplasticity are much less clear.

26 These data provide in vivo evidence for metaplasticity as a mechanism for binocular competition

27 behavioural relevance, induces differential metaplasticity at this synapse, attenuating its ability

28 at mossy fiber NMDARs mediate heterosynaptic metaplasticity between mossy fiber and associational-com

29 ortant regulators of synaptic plasticity and metaplasticity, but the exact mechanisms underlying thei

30 n (LTP) in visual cortex by a process termed metaplasticity, but the mechanism is unknown.

31 Furthermore, the enhancement of 'metaplasticity' by both GLYX-13 and ketamine may help ex

32 Overall, our results suggest that metaplasticity can provide a neural substrate for adapti

33 ines undergo activity-dependent changes with metaplasticity consequences on synaptic regulation.

34 Accordingly, we suggest that stress-induced metaplasticity could disrupt Ca2+ homeostasis and thus e

35 This work offers a new insight that metaplasticity defects are central to synaptic dysfuncti

36 tate dependence of the mechanisms underlying metaplasticity during behavior and pathology.

37 y depend on both the stage of plasticity and metaplasticity during memory formation.

38 n underlying mechanism for the regulation of metaplasticity during this time period.

39 ither necessary nor sufficient to induce the metaplasticity effect.

40 ty to induce subsequent synaptic plasticity (metaplasticity) has not been investigated.

41 ptability and precision can be mitigated via metaplasticity, i.e. synaptic changes that do not always

42 ent an important mechanism for bidirectional metaplasticity in BLA circuits and thus modulate the acq

43 P and the inability to undergo developmental metaplasticity in Tg mice.

44 mGluR7 surface expression governs a form of metaplasticity in the hippocampus, little is known about

45 ich nuclear to synaptic interactions induce "metaplasticity" in NAc MSNs, and we reveal the specific

46 compensation thus involves a novel form of 'metaplasticity' in the adult brain, in which the increas

47 Plasticity of plasticity (metaplasticity) in the CNS has been linked to group I me

48 y of neuronal response plasticity is called "metaplasticity." In suppressing synaptic inhibition and

49 tion of synaptic plasticity has been called "metaplasticity." In this report, we describe the facilit

50 This induction of local metaplasticity is a novel mechanism by which endocannabi

51 the underlying mechanism for this effect on metaplasticity is caused by caspase cleavage of the APP-

52 This type of metaplasticity is essential for navigation of experience

53 experience-dependent switch, a novel form of metaplasticity, is not dependent on NMDA receptors but m

54 Many in vitro studies have demonstrated metaplasticity-like effects whereby prior neuronal activ

55 tic homeostasis and is likely to function in metaplasticity, long-term regulation of the ability of a

56 Our results provide examples of how metaplasticity may play a key role in the ongoing modula

57 This persistent metaplasticity may promote the excessive amplification o

58 pull-push control of LTP/LTD form a general metaplasticity mechanism that may contribute to neuromod

59 gether, these results suggest a link between metaplasticity mechanisms in the hippocampus and the for

60 Thus, the rules of metaplasticity might manifest in opposite directions, de

61 isual experience on NMDAR EPSCs and prevents metaplasticity of LTP and LTD.

62 strongly suggest that group I mGluRs control metaplasticity of spinal learning through a PKC-dependen

63 her the underlying mechanisms are related to metaplasticity or depotentiation.

64 BCM-like metaplasticity over a shorter timescale has also been ob

65 es in AD mouse models may reflect defects in metaplasticity processes.

66 Recent treatments based on the notion of metaplasticity provide a powerful model for individual b

67 Our finding that the APP-ICD affects metaplasticity provides new insights into the altered re

68 Here we propose that reward-dependent metaplasticity (RDMP) can provide a plausible mechanism

69 Metaplasticity refers to an activity-dependent regulatio

70 Metaplasticity regulates the threshold for modification

71 Priming-induced metaplasticity requires mGluR5-mediated mobilization of

72 Hence, eCBs are also objects of metaplasticity, subject to higher levels of physiologica

73 xcitatory postsynaptic signaling and altered metaplasticity (temporal summation of NMDA receptor curr

74 us unreliability of synaptic changes evinces metaplasticity that can provide a robust mechanism for m

75 how that cocaine self-administration induces metaplasticity that inhibits further induction of synapt

76 nt CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation s

77 ephrine exposure mediates a form of synaptic metaplasticity that recalibrates fear memory processing.

78 Metaplasticity, the adaptive changes of long-term potent

79 Metaplasticity tunes the synapses to undergo changes tha

80 (WT) controls, but there was an inversion of metaplasticity, with increased GluN2B phosphorylation, w