ライフサイエンスコーパス: metastasis suppressor

1 in invasion and metastasis (degradation of a metastasis suppressor).

2 ntly broadens the clinical relevance of this metastasis suppressor.

3 These results suggest that MTBP is a metastasis suppressor.

4 tosis-inducing TRAIL receptor (TRAIL-R) as a metastasis suppressor.

5 tein that has been identified as a tumor and metastasis suppressor.

6 DRIP130, a transcriptional coactivator, as a metastasis suppressor.

7 family and has been rediscovered as a cancer metastasis suppressor.

8 of bi-directional interaction with the nm23 metastasis suppressor.

9 ght to contain a gene that may function as a metastasis suppressor.

10 havbeta3 and down-regulating CD9, a putative metastasis suppressor.

11 e coding sequence of CD82 molecule (CD82), a metastasis suppressor.

12 asGAP gene, RASAL2, functions as a tumor and metastasis suppressor.

13 argets, including LIFR, a well-characterized metastasis suppressor.

14 s (BAR) domain protein family and a putative metastasis suppressor.

15 ng protein 1)-two genes that we implicate as metastasis suppressors.

16 tic 2 (NME2) as a key MSG from a pool of >30 metastasis suppressors.

17 hat members of the miR-196 family are potent metastasis suppressors.

18 DA-MB-435 when it is transfected with breast metastasis suppressor 1 (BRMS1) cDNA.

19 Breast cancer metastasis suppressor 1 (BRMS1) functions as a metastasi

20 Breast cancer metastasis suppressor 1 (BRMS1) inhibits formation of ma

21 Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppress

22 Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nucle

23 Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nucle

24 Breast cancer metastasis suppressor 1 (BRMS1) is decreased in non-smal

25 Breast cancer metastasis suppressor 1 (BRMS1) is downregulated in non-

26 Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis of

27 The metastasis suppressor breast cancer metastasis suppressor 1 (BRMS1) upregulates GJIC and dec

28 of the novel genes, designated breast-cancer metastasis suppressor 1 (BRMS1), which maps to human chr

29 Breast cancer metastasis suppressor 1 (BRMS1)-transfected MDA-MB-435 c

30 tic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a novel Akt2-regulate

31 Metastasis Suppressor 1 (MTSS1) was originally identifie

32 lling functional evidence that breast-cancer metastasis suppressor 1 is a novel mediator of metastasi

33 nced methylation of the BRMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene prom

34 We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, M

35 f the mechanism of action of KAI1 shows that metastasis suppressor activity can be dependent on inter

36 The ER gene, which has growth and metastasis suppressor activity in many different cell ty

37 uence-tagged site markers indicates that the metastasis suppressor activity is located in the q24.2 r

38 c-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue

39 /AKAP12, is a large scaffolding protein with metastasis suppressor activity.

40 have recently demonstrated a prostate cancer metastasis-suppressor activity encoded by a discontinuou

41 was sufficient to reverse aspects of SSeCKS metastasis-suppressor activity in both the experimental

42 is a kinase scaffolding protein that encodes metastasis-suppressor activity through the suppression o

43 Mechanisms by which metastasis suppressors alter tumor cells are well charac

44 GAP) for Rad revealed nm23, a putative tumor metastasis suppressor and a development gene in Drosophi

45 mono- and dimethylation of chromatin at key metastasis suppressor and EMT genes, defining a new mech

46 ying signalling pathways downstream of a key metastasis suppressor and indicate that analysis of gene

47 , highlights the importance of RKIP as a key metastasis suppressor and potential therapeutic agent.

48 R-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor lo

49 Our findings identify miRNA-196s as potent metastasis suppressors and reveal that the ratio of miR-

50 Genes affected by WNT5A include KISS-1, a metastasis suppressor, and CD44, involved in tumor cell

51 CD82 is a metastasis suppressor, and its expression is often downr

52 Tumour metastasis suppressors are inhibitors of metastasis but

53 In contrast to tumor suppressors, metastasis suppressors are rarely mutated or deleted, an

54 s suggest that PKD1 functions as a tumor and metastasis suppressor, at least partly by regulating Sna

55 The metastasis suppressor breast cancer metastasis suppresso

56 ely ten proteins have been characterized as 'metastasis suppressors', but how these proteins function

57 ndicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated c

58 e for post-translational downregulation of a metastasis suppressor by its ubiquitin ligase, resulting

59 that the miR-23b/-27b cluster functions as a metastasis-suppressor by decreasing HIP1R levels in pre-

60 Elucidating targets of physiological tumor metastasis suppressors can highlight key signaling pathw

61 The 'metastasis suppressor' CD82/KAI-1, a member of the tetra

62 Metastasis suppressors comprise a growing class of genes

63 of 10 of these genes, including the putative metastasis suppressor CST6, the apoptosis-inducer BIK, a

64 e showed that miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (

65 ry factor receptor (LIFR) as a breast cancer metastasis suppressor downstream of the microRNA miR-9 a

66 Expression of the invasion/metastasis suppressor, E-cadherin, is diminished or lost

67 sting that NMU might be a target of the lung metastasis suppressor effect of RhoGDI2.

68 Metastasis suppressor expression levels can impact tradi

69 asmic and nuclear compartments, modulated by metastasis suppressor expression.

70 iosemicarbazone, but was independent of this metastasis suppressor for di-2-pyridylketone 4-cyclohexy

71 RKIP has been implicated as a metastasis suppressor for prostate cancer, but the mecha

72 These results suggest that CD44 is a metastasis suppressor for prostatic cancer and that decr

73 The human gene CC3 is a metastasis suppressor for small cell lung carcinoma (SCL

74 Human gene CC3 is a metastasis suppressor for variant small cell lung carcin

75 n, but importantly, dramatically reduces the metastasis suppressor function of BRMS1 in both in vitro

76 ogether, our data indicate that the invasion/metastasis suppressor function of E-cadherin is frequent

77 The powerful metastasis suppressor function of KiSS1 gene products ha

78 ll growth and apoptosis, how PTEN exerts the metastasis suppressor function remains largely unknown.

79 However, how Drg-1 exerts its metastasis suppressor function remains unknown.

80 RRM1 is the most likely candidate gene with metastasis suppressor function.

81 support the novel hypothesis that IRS-1 has metastasis suppressor functions for breast cancer.

82 KiSS-1 has been shown to function as a tumor metastasis suppressor gene and reduce the number of meta

83 The mechanisms through which the metastasis suppressor gene BRMS1 functions are poorly un

84 tion and transcriptional repression of tumor metastasis suppressor gene BRMS1, highlights a new mecha

85 murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that alleli

86 entified a novel anti-tumor activity for the metastasis suppressor gene CC3.

87 NA-methyltransferase (MGMT) and the putative metastasis suppressor gene death-associated protein kina

88 the tumor suppressor gene p16, the putative metastasis suppressor gene death-associated protein kina

89 The tumor metastasis suppressor gene Drg-1 has been shown to suppr

90 These studies implicate MKK4/SEK1 as a metastasis suppressor gene encoded by human chromosome 1

91 Erk kinase 1 (MKK4/SEK1) gene as a candidate metastasis suppressor gene encoded by the approximately

92 KAI1 is a metastasis suppressor gene for human prostate cancer and

93 s strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may s

94 Previous studies demonstrated that CD44 is a metastasis suppressor gene for prostate cancer and that

95 e human chromosome 8p21-p12 region encodes a metastasis suppressor gene for rat prostate cancer.

96 uman chromosome 8p21-p12 region contains the metastasis suppressor gene for the AT6.3 cells.

97 Studies of metastasis suppressor gene function are providing a crit

98 are example demonstrating the relevance of a metastasis suppressor gene function utilized in a develo

99 Here we show that the metastasis suppressor gene homolog Nm23/awd is a negativ

100 tumor suppressor genes Tbx5 and Pten and the metastasis suppressor gene Hoxd10 are significantly upre

101 results show that KiSS-1 also functions as a metastasis suppressor gene in at least some human breast

102 tastasis suppressor 1 (BRMS1) functions as a metastasis suppressor gene in breast cancer and melanoma

103 ytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC.

104 d site markers, and this analysis placed the metastasis suppressor gene in the interval between D8S22

105 cancer patients and suggest that there is a metastasis suppressor gene in this region that may play

106 lls, similar to the overexpression of KiSS-1 metastasis suppressor gene in those cells.

107 We hypothesize that metastasis suppressor gene inactivation or down-regulati

108 l four susceptibility loci: 11q23.3 CADM1, a metastasis suppressor gene involved in modifying tumour

109 This suggests that an additional metastasis suppressor gene is located within the human c

110 s, combined with recent studies of the tumor metastasis suppressor gene KAI1 and plasminogen activato

111 The metastasis suppressor gene KAI1 was identified by its ab

112 Metastin, the gene product of metastasis suppressor gene KiSS-1, is the endogenous lig

113 The metastasis suppressor gene known as Nm23-H1 regulates tu

114 state cancer, which suggests that our target metastasis suppressor gene may also play an important ro

115 a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitiv

116 The expression levels of the metastasis suppressor gene Nm23 have been shown to corre

117 Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastati

118 was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2.

119 KAI1 is a metastasis suppressor gene on human chromosome 11p11.2 t

120 RMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene promoter via direct recruitme

121 KiSS1 is a metastasis suppressor gene that has been shown to inhibi

122 KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting

123 These findings define caspase-8 as a metastasis suppressor gene that, together with integrins

124 We conclude that RRM1 functions as a metastasis suppressor gene through induction of PTEN exp

125 parental (C8161) metastatic cells, the KISS1 metastasis suppressor gene was isolated.

126 cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene whose mechanisms of action ar

127 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer pro

128 static cancer cells to map the location of a metastasis suppressor gene(s).

129 These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human

130 To define further the region harboring the metastasis suppressor gene, a truncated human chromosome

131 Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions

132 Loss of the metastasis suppressor gene, KiSS-1 has been strongly cor

133 ether the recently discovered human melanoma metastasis suppressor gene, KiSS-1, which maps to chromo

134 on of the cell cycle inhibitor, p21, and the metastasis suppressor gene, NDRG1 (N-myc downstream-regu

135 ic lineage for the identification of a novel metastasis suppressor gene, serum deprivation response (

136 with a potential oncogenic function of this metastasis suppressor gene.

137 ) kinase 4 (JNKK1/MKK4) as a prostate cancer metastasis suppressor gene.

138 e, is thought to be a tumor suppressor and a metastasis suppressor gene.

139 quely acts by transcriptionally activating a metastasis suppressor gene.

140 e also tested whether chromosome 6 harbors a metastasis-suppressor gene for breast cancer as observed

141 y also indicate that chromosome 11 encodes a metastasis-suppressor gene for human breast cancer.

142 Expression of nm23-H1 (NME1), a known metastasis-suppressor gene in this breast cancer cell li

143 Conventional dogma has regarded E-cad as a metastasis-suppressor gene involved in epithelial-mesenc

144 Decreased expression of the human KAI1 metastasis-suppressor gene is involved in the progressio

145 The finding that DLC-1 can act as a metastasis-suppressor gene supports an influential role

146 ranscript (>300 kb) running antisense to the metastasis-suppressor gene TFPI-2.

147 We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is ass

148 rids, which suggests the presence of a novel metastasis-suppressor gene(s) or novel function of a kno

149 d symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published.

150 g cascade, has been identified recently as a metastasis-suppressor gene.

151 Twelve metastasis suppressor genes (MSGs) have been identified

152 Although >30 metastasis suppressor genes (MSGs) that negatively regul

153 uggesting that there are tumor suppressor or metastasis suppressor genes encoded by this chromosomal

154 city, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome

155 However, the discovery of new metastasis suppressor genes in breast cancer using genom

156 We reveal these genes to be novel metastasis suppressor genes in breast cancer.

157 Metastasis suppressor genes inhibit one or more steps re

158 The loss of function of metastasis suppressor genes is a major rate-limiting ste

159 To discover novel metastasis suppressor genes that are clinically relevant

160 t revealed a novel regulatory network of two metastasis suppressor genes, NDRG1 and KAI1, which toget

161 ocused on genetic mechanisms for the loss of metastasis suppressor genes, our results provide new evi

162 pG island promoter methylation, invasion and metastasis suppressor genes, telomere shortening, and ge

163 NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the disseminat

164 NAi screening strategy to identify candidate metastasis suppressor genes.

165 g strategy that enables the discovery of new metastasis suppressor genes.

166 dentifying therapeutic targets downstream of metastasis suppressor genes.

167 t has been demonstrated to repress tumor and metastasis suppressor genes.

168 Metastasis-suppressor genes are attractive candidates fo

169 nctional characterization of prostate cancer metastasis-suppressor genes are discussed.

170 t regulate metastasis, and the importance of metastasis-suppressor genes in this process.

171 SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby red

172 l facilitate the identification of candidate metastasis-suppressor genes.

173 ther a control vector (C-100) or the Nm23-H1 metastasis suppressor (H1-177).

174 BRMS1, like other metastasis suppressors, halts ectopic growth (metastasis

175 Our findings reveal CIC as a conserved metastasis suppressor, highlighting new anti-metastatic

176 tion of the metastasis inducer Snail and the metastasis suppressor/immunosurveillance cancer gene pro

177 is a member of the GDI family that acts as a metastasis suppressor in a variety of cancer types; howe

178 hibitor 2 (RhoGDI2) has been identified as a metastasis suppressor in bladder and possibly other canc

179 , our data suggest that KISS1 functions as a metastasis suppressor in PCas and may serve as a useful

180 protein-coupled-receptor-1 (OGR1) is a tumor metastasis suppressor in prostate cancer (PCa).

181 traspanin protein, was first identified as a metastasis suppressor in prostate cancer.

182 ator in Fas-mediated apoptosis pathway and a metastasis suppressor in solid tumors and that metastati

183 Although KISS1 functions as a metastasis suppressor in various cancers, its expression

184 any system, that SPDEF functions as a tumor metastasis suppressor in vivo.

185 ation and invasion in vitro and acts a tumor metastasis suppressor in vivo.

186 ide a mechanism for its role as a tumor- and metastasis-suppressor in breast cancer.

187 determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we asses

188 e inhibitor (Maspin) represents an important metastasis suppressor initially identified in breast can

189 Additionally, an iron-regulated metastasis suppressor interacts with the epidermal growt

190 The BRMS1 metastasis suppressor interacts with the protein AT-rich

191 When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis d

192 Cancer metastasis suppressor KAI1/CD82 belongs to the tetraspan

193 ssociates with and targets the transmembrane metastasis suppressor, KAI1 (also known as CD82), for de

194 ast cancer may account for the loss of tumor metastasis suppressor KiSS-1 expression and thus increas

195 The mechanism of action of the metastasis suppressor KiSS1 and its receptor GPR54 is st

196 lity, and ceramide is proposed to serve as a metastasis-suppressor lipid in ovarian cancer.

197 s correlated with elevated expression of the metastasis suppressor Maspin, the ablation of which rest

198 miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer.

199 00 family, and the pleiotropic nature of the metastasis suppressor miR-31.

200 ng the expression and functions of the tumor metastasis suppressors miR-200a and miR-141.

201 propose that therapeutic replacement of the metastasis suppressor miRNA-768-3p holds clinical promis

202 The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1

203 tion, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1

204 We further show that SGK3 targets the metastasis suppressor NDRG1 for degradation by Fbw7.

205 ytic function of VHL is mediated through the metastasis suppressor Nm23, a protein known to regulate

206 issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apopt

207 It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely relat

208 Reduced expression of the metastasis suppressor NM23-H1 is associated with aggress

209 altering the transcription activities of the metastasis suppressor Nm23-H1.

210 altering the transcription activities of the metastasis suppressor Nm23-H1.

211 rs by targeting and altering the role of the metastasis suppressor Nm23-H1.

212 in phosphatase 2A (PP2A), and inhibiting the metastasis suppressor nm23-H1.

213 of the tumor suppressor PP2A, as well as the metastasis suppressor nm23-H1.

214 tosis-related genes Bad and Siva, as well as metastasis suppressor NM23-H2.

215 Here, we demonstrate that the metastasis suppressor, NM23-H1, is degraded by lysosomal

216 t STK15 associates with a putative tumor and metastasis suppressor, NM23-H1.

217 Surprisingly, here we found occupancy of the metastasis suppressor non-metastatic 2 (NME2) within the

218 icated in inhibiting metastasis is the tumor metastasis suppressor nonmetastatic protein 23 homologue

219 entify novel crosstalk between oncogenic and metastasis suppressor pathways, thereby providing mechan

220 ed protein kinase kinase 4 (JNKK1/MKK4) as a metastasis suppressor protein in a mouse xenograft model

221 K1/SEK1, hereafter referred to as MKK4) as a metastasis suppressor protein in ovarian carcinoma.

222 The cancer metastasis suppressor protein KAI1/CD82 is a member of t

223 that deferasirox increased expression of the metastasis suppressor protein N-myc downstream-regulated

224 tein kinase pathway coimmunoprecipitated the metastasis suppressor protein Nm23-H1.

225 Furthermore, the metastasis suppressor protein PDCD4 (programmed cell dea

226 Diminished expression of the metastasis suppressor protein RKIP was previously report

227 sor 1 (MTSS1) was originally identified as a metastasis suppressor protein whose expression is lost i

228 E-cadherin is a metastasis-suppressor protein and its loss of function i

229 a transcriptional regulatory network for the metastasis suppressor Raf kinase inhibitory protein (RKI

230 Expression levels of the novel tumor and metastasis suppressor Raf-1 kinase inhibitor protein (RK

231 To identify downstream targets of the metastasis suppressor Raf-1 kinase inhibitory protein (R

232 the lung but are growth-inhibited unless the metastasis suppressor region is lost.

233 the lung but are growth-inhibited unless the metastasis-suppressor region is lost.

234 d by the presence of the approximately 70-cM metastasis-suppressor region will facilitate the identif

235 a mouse xenograft model to determine how the metastasis suppressor RKIP influences transcription in a

236 two novel signaling pathways targeted by the metastasis suppressor RKIP that regulate remodeling of t

237 reviously unsuspected mechanism by which the metastasis-suppressor RKIP regulates tumor invasiveness,

238 rdingly, ATF3 promoted the expression of the metastasis suppressor SHARP1 in mutp53-expressing cells.

239 The individual genetic loss of the metastasis suppressor, SSeCKS/Gravin/AKAP12 or Rb, genes

240 BC is characterized by reduced expression of metastasis suppressors such as Raf kinase inhibitory pro

241 Therefore, TRAIL-R is a novel metastasis suppressor, suggesting that TRAIL-related tum

242 roteins that interact with a breast tumor or metastasis suppressor, SYK (spleen tyrosine kinase).

243 ell stiffness by restoring expression of the metastasis suppressor TbetaRIII/betaglycan decreases inv

244 ulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory e

245 These findings identify LIFR as a metastasis suppressor that functions through the Hippo-Y

246 CC3 is a metastasis suppressor that inhibits metastasis of the va

247 0, also called CC3 or Htatip2, is a putative metastasis suppressor that promotes apoptosis and inhibi

248 These results suggest that miR-23b/-27b are metastasis suppressors that might serve as novel biomark

249 tyrosine kinase (Syk) is a candidate tumor (metastasis) suppressor that is highly expressed in mamma

250 downregulates miR-452, which acts as a novel metastasis suppressor to directly target the SNAI2 3'-un

251 inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.

252 RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b editin

253 Maspin is a type II tumour metastasis suppressor which has multiple cellular effect

254 The human orthologue of Ndk is the NM23 metastasis suppressor, which we found to exhibit a simil

255 nstream regulated gene 1 (NDRG1) is a potent metastasis suppressor with an undefined role in the stre